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公开(公告)号：WO2007104789A3
公开(公告)日：2007-09-20
申请号：PCT/EP2007/052456
申请日：2007-03-15
Applicant: NOVO NORDISK A/S , HANSEN, Thomas Kruse , SCHÄFFER, Lauge , LAU, Jesper
Inventor： HANSEN, Thomas Kruse , SCHÄFFER, Lauge , LAU, Jesper
IPC: C07K14/575
Abstract: The present invention relates to novel amylin derivatives having a protracted action profile, to pharmaceutical compositions comprising these derivatives and to the use of the derivatives for the treatment of diseases related to obesity, diabetes and other metabolic disorders.
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公开(公告)号：WO2006097536A3
公开(公告)日：2006-12-28
申请号：PCT/EP2006060854
申请日：2006-03-20
Applicant: NOVO NORDISK AS , CHRISTENSEN LEIF , LAU JESPER , SPETZLER JANE , HANSEN THOMAS KRUSE
Inventor： CHRISTENSEN LEIF , LAU JESPER , SPETZLER JANE , HANSEN THOMAS KRUSE
IPC: A61K47/48 , A61K38/26 , A61P3/10 , C07K14/605
CPC classification number: C07K14/605 , A61K38/00 , A61K47/60 , A61K47/65 , C07K14/57563
Abstract: Dimerization of GLP-1 agonists and therapeutic uses thereof.
Abstract translation: GLP-1激动剂的二聚化及其治疗用途。
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公开(公告)号：WO2006005667A3
公开(公告)日：2006-10-12
申请号：PCT/EP2005052874
申请日：2005-06-21
Applicant: NOVO NORDISK AS , DOERWALD FLORENCIO ZARAGOZA , SCHIOEDT CHRISTINE BRUUN , HANSEN THOMAS KRUSE , MADSEN KJELD
Inventor： DOERWALD FLORENCIO ZARAGOZA , SCHIOEDT CHRISTINE BRUUN , HANSEN THOMAS KRUSE , MADSEN KJELD
CPC classification number: A61K47/48061 , A61K31/41 , A61K38/27 , A61K47/54 , A61K47/545 , C07D257/04 , C07K1/006 , C07K1/113 , C07K14/61
Abstract: Method for increasing (protracting) half-life of LGP analogs in plasma and novel derivatives of such peptides based on covalently linking them to a tetrazole moiety which acts as a carboxylic acid bioisostere.
Abstract translation: 基于将它们共价连接到充当羧酸生物电子等排体的四唑部分，增加（延伸）血浆中LGP类似物的半衰期和这种肽的新衍生物的方法。
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公开(公告)号：WO2006005667A2
公开(公告)日：2006-01-19
申请号：PCT/EP2005/052874
申请日：2005-06-21
Applicant: NOVO NORDISK A/S , DÖRWALD, Florencio Zaragoza , SCHIØDT, Christine Bruun , HANSEN, Thomas Kruse , MADSEN, Kjeld
Inventor： DÖRWALD, Florencio Zaragoza , SCHIØDT, Christine Bruun , HANSEN, Thomas Kruse , MADSEN, Kjeld
CPC classification number: A61K47/48061 , A61K31/41 , A61K38/27 , A61K47/54 , A61K47/545 , C07D257/04 , C07K1/006 , C07K1/113 , C07K14/61
Abstract: Method for increasing half-life of compounds in plasma and novel derivatives of such compounds.
Abstract translation: 增加血浆中化合物半衰期的方法和这些化合物的新型衍生物。
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公开(公告)号：WO2005030797A3
公开(公告)日：2005-09-09
申请号：PCT/DK2004000657
申请日：2004-09-29
Applicant: NOVO NORDISK AS , CONDE-FRIEBOES KILIAN WALDEMAR , SENSFUSS ULRICH , MADSEN KJELD , JOHANSEN NILS LANGELAND , CHRISTENSEN LEIF , HANSEN THOMAS KRUSE , WULFF BIRGITTE SCHJELLERUP
Inventor： CONDE-FRIEBOES KILIAN WALDEMAR , SENSFUSS ULRICH , MADSEN KJELD , JOHANSEN NILS LANGELAND , CHRISTENSEN LEIF , HANSEN THOMAS KRUSE , WULFF BIRGITTE SCHJELLERUP
Abstract: Small cyclic peptides of the formula X1-X2-X3-X4-X5-X6-X7-R comprising 7-12 amino acid residues are provided. Said peptides are MC4 receptor agonists, and thus useful in the treatment of obesity and related diseases.
Abstract translation: 提供了包含7-12个氨基酸残基的式X1-X2-X3-X4-X5-X6-X7-R'的小环肽。 所述肽是MC4受体激动剂，因此可用于治疗肥胖症和相关疾病。
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Patent Agency Ranking
公开(公告)号：WO2005051894A1
公开(公告)日：2005-06-09
申请号：PCT/DK2004/000304
申请日：2004-05-04
Applicant: NOVO NORDISK A/S , OLESEN, Preben, Houlberg , HANSEN, Thomas, Kruse , CHRISTIANSEN, Lise, Brown , HANSEN, Holger, Claus
Inventor： OLESEN, Preben, Houlberg , HANSEN, Thomas, Kruse , CHRISTIANSEN, Lise, Brown , HANSEN, Holger, Claus
IPC: C07C235/64
CPC classification number: C07D333/60 , C07C235/64 , C07C255/60 , C07D333/38
Abstract: Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity.
Abstract translation: 新型水杨酸酯是化学解偶联剂，例如有用的。 用于治疗肥胖。
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公开(公告)号：WO2005027978A2
公开(公告)日：2005-03-31
申请号：PCT/DK2004000624
申请日：2004-09-17
Applicant: NOVO NORDISK AS , LAU JESPER , HANSEN THOMAS KRUSE , MADSEN KJELD , BLOCH PAW , DOERWALD FLORENCIO ZARAGOZA , JOHANSEN NILS LANGELAND
Inventor： LAU JESPER , HANSEN THOMAS KRUSE , MADSEN KJELD , BLOCH PAW , DOERWALD FLORENCIO ZARAGOZA , JOHANSEN NILS LANGELAND
IPC: A61K38/00 , A61K47/48 , C07K14/605
CPC classification number: C07K14/605 , A61K38/00 , A61K38/26 , A61K47/54 , A61K47/542 , A61K47/60 , C07K14/001
Abstract: Novel polypeptide derivatives having protracted profile of action
Abstract translation: 新型多肽衍生物具有延长的作用特征
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公开(公告)号：WO1998003473A1
公开(公告)日：1998-01-29
申请号：PCT/DK1997000314
申请日：1997-07-17
Applicant: NOVO NORDISK A/S , PESCHKE, Bernd , ANKERSEN, Michael , HANSEN, Thomas, Kruse , THOGERSEN, Henning
Inventor： NOVO NORDISK A/S
IPC: C07C237/16
CPC classification number: C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
Abstract: The present invention relates to novel compounds of general formula (I), pharmaceutical compositions containing them, a method of stimulating the release of growth hormone from the pituitary, a method for increasing the rate and extent of growth of animals to increase their milk and wool production, or for the treatment of ailments, and to use of the compounds for the preparation of medicaments.
Abstract translation: 本发明涉及通式（I）的新化合物，含有它们的药物组合物，刺激生长激素从垂体释放的方法，增加动物生长速度和程度以增加其牛奶和羊毛的方法 生产或治疗疾病，以及使用化合物制备药物。
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公开(公告)号：WO1997040023A1
公开(公告)日：1997-10-30
申请号：PCT/DK1997000186
申请日：1997-04-24
Applicant: NOVO NORDISK A/S , HANSEN, Thomas, Kruse , PESCHKE, Bernd , ANDERSEN, Knud, Erik
Inventor： NOVO NORDISK A/S
IPC: C07D241/08
CPC classification number: C07D241/04 , C07K5/06078
Abstract: The present invention relates to novel compounds of general formula (I) which can be used for treating medical disorders resulting from a deficiency in growth hormone.
Abstract translation: 本发明涉及可用于治疗由生长激素缺乏引起的医学疾病的通式（I）的新化合物。
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公开(公告)号：WO1996022997A1
公开(公告)日：1996-08-01
申请号：PCT/DK1996000045
申请日：1996-01-26
Applicant: NOVO NORDISK A/S , LAU, Jesper , PESCHKE, Bernd , HANSEN, Thomas, Kruse , JOHANSEN, Nils, Langeland , ANKERSEN, Michael
Inventor： NOVO NORDISK A/S
IPC: C07K05/02
CPC classification number: C07D271/06 , A61K38/00 , C07C233/38 , C07C237/22 , C07C237/32 , C07C237/36 , C07D211/62 , C07D271/10 , C07D277/56 , C07D401/12 , C07D413/12 , C07D417/12 , C07K14/60
Abstract: There are disclosed novel synthetic peptides of general formula (I), where the abbreviations A, B, D, E, F, G, J and m, n, p are further defined in the description. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient thereof, methods of stimulating the release of growth hormone as well as use of such compounds of formula (I) are also disclosed.
Abstract translation: 公开了通式（I）的新型合成肽，其中缩写A，B，D，E，F，G，J和m，n，p在说明书中进一步定义。 式（I）化合物促进人和动物中生长激素的释放。 还公开了含有式（I）化合物作为其活性成分的生长促进组合物，刺激生长激素释放的方法以及使用式（I）化合物。
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