公开(公告)号：WO2010129184A2

公开(公告)日：2010-11-11

申请号：PCT/US2010/032035

申请日：2010-04-22

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  FLANAGAN, Aiden ,  HARRISON, Kent ,  ATANASOSKA, Liliana ,  SOGARD, David J. ,  DAVIS, Liza J.

Inventor： FLANAGAN, Aiden ,  HARRISON, Kent ,  ATANASOSKA, Liliana ,  SOGARD, David J. ,  DAVIS, Liza J.

IPC: A61K9/00

CPC classification number: A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

Abstract: A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

Abstract translation: 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

公开(公告)号：WO2010027426A3

公开(公告)日：2010-03-11

申请号：PCT/US2009/004842

申请日：2009-08-26

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  HARRISON, Kent, D. ,  SUTERMEISTER, Derek, C. ,  OSTROOT, Tim

Inventor： HARRISON, Kent, D. ,  SUTERMEISTER, Derek, C. ,  OSTROOT, Tim

IPC: A61N1/05 ,  A61M25/00

Abstract: Apparatuses, systems, and methods for electrically conductive pathways in medical devices. One embodiment of a medical device can include an elongate polymeric body (102) having a proximal end and a distal end. Discrete particles of an electrically conductive material in the elongate polymeric body can form an electrically conductive pathway (108) that extends at least partially between the proximal end and the distal end of the elongate polymeric body.

公开(公告)号：WO2007024615A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/032107

申请日：2006-08-17

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

Inventor： SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

IPC: A61B17/00 ,  A61B17/06

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0443 ,  A61B2017/06171 ,  A61B2017/0647 ,  A61B2017/3488

Abstract: Methods, apparatus, and systems for occluding a multiplicity of parallel membranes, such as found in a patent foramen ovale (PFO) . Methods, apparatus, and systems include the use of a positioning device (222,422) that can be seated on the limbus(114) of the septum secundum (SS). The positioning device includes a piercing member (27-0) that can pierce the SS and septum premium (SP). The positioning device also includes a fastening member (272) that can engage the SS and SP to fasten the tissues and thereby occlude a PFO.

Abstract translation: 闭塞多个平行膜的方法，装置和系统，例如在卵孔专利（PFO）中发现的。 方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘（114）上的定位装置（222,422）。 该定位装置包括能刺穿SS和隔垫溢价（SP）的穿孔构件（27-0）。 定位装置还包括紧固构件（272），其可以接合SS和SP以紧固组织，从而遮挡PFO。

公开(公告)号：WO2005002478A3

公开(公告)日：2005-04-28

申请号：PCT/US2004019992

申请日：2004-06-23

Applicant: SCIMED LIFE SYSTEMS INC ,  HARRISON KENT

Inventor： HARRISON KENT

IPC: A61B17/00 ,  A61F7/10 ,  A61F7/12

CPC classification number: A61F7/12 ,  A61B2017/00867 ,  A61F7/10 ,  A61F2007/126

Abstract: A medical device has a structure deployable from its distal end to cool a target tissue region inside the body, such as tissue within a chamber of the heart. Also, a method of cooling a target tissue region inside a body includes introducing a distal portion of a catheter having a deployable structure at a distal end into the body. The method also includes positioning the distal catheter portion near a target tissue region, deploying the deployable structure, and placing the deployed structure in contact with the target tissue region to cool the target tissue region.

Abstract translation: 医疗装置具有可从其远端部署的结构，以冷却身体内的目标组织区域，例如心脏腔室内的组织。 而且，冷却身体内的目标组织区域的方法包括将具有可展开结构的导管的远侧部分在远侧端部引入主体中。 该方法还包括将远端导管部分定位在目标组织区域附近，展开可展开结构，以及将展开结构放置成与目标组织区域接触以冷却目标组织区域。

公开(公告)号：WO2005002478A2

公开(公告)日：2005-01-13

申请号：PCT/US2004/019992

申请日：2004-06-23

Applicant: SCIMED LIFE SYSTEMS, INC. ,  HARRISON, Kent

Inventor： HARRISON, Kent

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61B2017/00867 ,  A61F7/10 ,  A61F2007/126

Abstract: A medical device has a structure deployable from its distal end to cool a target tissue region inside the body, such as tissue within a chamber of the heart. Also, a method of cooling a target tissue region inside a body includes introducing a distal portion of a catheter having a deployable structure at a distal end into the body. The method also includes positioning the distal catheter portion near a target tissue region, deploying the deployable structure, and placing the deployed structure in contact with the target tissue region to cool the target tissue region.

Abstract translation: 医疗装置具有从其远端展开的结构，以冷却身体内的目标组织区域，例如心脏腔室内的组织。 此外，冷却身体内的目标组织区域的方法包括将具有可展开结构的导管的远侧部分在远端引入体内。 该方法还包括将远端导管部分定位在目标组织区域附近，展开可部署结构，以及将展开的结构与目标组织区域接触以冷却目标组织区域。

公开(公告)号：WO2010129184A3

公开(公告)日：2011-09-22

申请号：PCT/US2010032035

申请日：2010-04-22

Applicant: BOSTON SCIENT SCIMED INC ,  FLANAGAN AIDEN ,  HARRISON KENT ,  ATANASOSKA LILIANA ,  SOGARD DAVID J ,  DAVIS LIZA J

Inventor： FLANAGAN AIDEN ,  HARRISON KENT ,  ATANASOSKA LILIANA ,  SOGARD DAVID J ,  DAVIS LIZA J

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51

CPC classification number: A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

Abstract: A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

Abstract translation: 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

公开(公告)号：WO2007024514A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/031427

申请日：2006-08-11

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

Inventor： SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/3488

Abstract: Methods, apparatus, and systems for locating a patent foramen ovale (PFO) with a positioning device (222, 422) that can be configured to occlude the PFO. Methods, apparatus, and systems include the use of a positioning device that can be seated on the limbus of a septum secundum (SS). The positioning device includes a piercing member that can pierce (270) the SS and a septum primum.

Abstract translation: 用于通过定位装置（222,422）定位专利孔卵泡（PFO）的方法，装置和系统，所述定位装置可被配置成闭塞所述PFO。 方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘上的定位装置。 所述定位装置包括刺穿（270）所述SS和隔膜的穿孔构件。

公开(公告)号：WO2011008534A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/040362

申请日：2010-06-29

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  ATANASOSKA, Liliana ,  FLANAGAN, Aiden ,  DAVIS, Liza J. ,  HARRISON, Kent ,  SOGARD, David J.

Inventor： ATANASOSKA, Liliana ,  FLANAGAN, Aiden ,  DAVIS, Liza J. ,  HARRISON, Kent ,  SOGARD, David J.

IPC: A61M31/00 ,  A61N1/30

CPC classification number: A61M5/14276

Abstract: In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.

Abstract translation: 在一个实施方案中，本公开提供了一种用于预防或减少再灌注损伤的可生物降解的自供电医疗装置，包括原电池，所述原电池包括：第一可生物降解的电极构件; 以及包含可生物降解的导电聚合物和电极可释放的治疗剂的第二可生物降解的电极构件，其中所述原电池产生足以使所述电极可释放的治疗剂从所述可生物降解的导电聚合物释放并洗脱至目标位置的电力 。 该装置还可以包括含有爆发释放治疗剂的贮存器材料。

公开(公告)号：WO2010065175A1

公开(公告)日：2010-06-10

申请号：PCT/US2009/056666

申请日：2009-09-11

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  KHIEU, Aaron ,  HORN, Daniel James ,  VRBA, Anthony C. ,  BLIX, John ,  HARRISON, Kent ,  LEY, Timothy J.

Inventor： KHIEU, Aaron ,  HORN, Daniel James ,  VRBA, Anthony C. ,  BLIX, John ,  HARRISON, Kent ,  LEY, Timothy J.

IPC: A61F6/22 ,  A61B17/12

CPC classification number: A61B17/12022 ,  A61B17/12 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00867 ,  A61F6/00 ,  A61F6/20 ,  A61F6/22 ,  A61F6/225

Abstract: A device for occluding a target body lumen, comprises a wire structure (108) defining a wire structure lumen (116) extending therethrough and movable between a reduced diameter insertion configuration and an expanded diameter deployed configuration and a basket structure (104) extending across the wire structure lumen and including therein a cell growth promoting agent (106) to promote cell growth across the wire structure lumen to occlude the target body lumen.

Abstract translation: 用于闭塞目标体腔的装置包括限定延伸穿过其中并且可在直径缩小的插入构型和扩展直径展开构型之间移动的线结构腔（116）的线结构（108） 线结构腔，并且其中包括细胞生长促进剂（106），以促进穿过线结构腔的细胞生长以封闭目标体腔。

公开(公告)号：WO2010027692A1

公开(公告)日：2010-03-11

申请号：PCT/US2009/054486

申请日：2009-08-20

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  WEBER, Jan ,  HARRISON, Kent, D.

Inventor： WEBER, Jan ,  HARRISON, Kent, D.

IPC: A61M25/00 ,  A61M25/10 ,  A61F2/84 ,  H01L41/00 ,  A61B1/00 ,  A61B17/32 ,  A61M29/02

CPC classification number: A61M25/1006 ,  A61B1/00082 ,  A61B5/0215 ,  A61B2017/00871 ,  A61B2017/22001 ,  A61F2/856 ,  A61F2/958 ,  A61M25/005 ,  A61M25/0054 ,  A61M25/0067 ,  A61M25/008 ,  A61M2025/0058 ,  A61M2025/0079 ,  A61M2025/0183 ,  A61M2025/1015 ,  A61M2025/1045 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/1093 ,  A61M2205/0288

Abstract: An activation circuit (90) for selectively providing an electrical current to one or more electroactive polymers (74) (EAPs) in a medical device is disclosed. The activation circuit may include a sensor (92) for sensing a measure related to a parameter of an elongated member (11) and/or a balloon (14) of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator (96) for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter.

Abstract translation: 公开了一种用于选择性地向医疗装置中的一种或多种电活性聚合物（EAP）提供电流的激活电路（90）。 激活电路可以包括用于感测与医疗装置的细长构件（11）和/或气囊（14）的参数有关的措施的传感器（92）。 可以根据感测到的细长构件的参数和/或医疗装置的气囊将电流提供给一个或多个EAP。 在一些情况下，激活电路可以包括比较器（96），用于将感测的测量值与阈值进行比较，以确定电流何时被施加到EAP。 该参数可以是压力，流体流量，温度和/或其它合适的参数。