公开(公告)号：WO2012061017A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/056857

申请日：2011-10-19

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  JENSON, Mark L. ,  HILL, Jason P. ,  FENG, James Q. ,  SOGARD, David J. ,  WARNER, Robert W. ,  HAVERKOST, Patrick A

Inventor： JENSON, Mark L. ,  HILL, Jason P. ,  FENG, James Q. ,  SOGARD, David J. ,  WARNER, Robert W. ,  HAVERKOST, Patrick A

IPC: A61B17/00 ,  A61B17/06

CPC classification number: A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/06185

Abstract: A device for sealing an opening in a vessel includes an anchor (20) attached to a suture (30). The anchor is inserted through the opening into the vessel, and the suture pulls the anchor against the vessel wall, forming a seal. A plug (40) is inserted over the suture and is axially compressed toward the anchor, locking the elements in place. The suture is braided or woven outside of the anchor so that it may be stored and handled easily, and is unbraided, unwoven and/or untangled at its distal end inside the anchor, so that individual filaments within the suture may extend laterally within the anchor. The laterally extending filaments subtend a larger footprint within the anchor than a comparable footprint if the suture were to remain braided or tied into a knot within the anchor, which may more effectively distribute the retaining forces within the anchor. In some cases, the plug material is formed from fibers of a mechanically strong material blended into a quick-dissolving material.

Abstract translation: 用于密封容器中的开口的装置包括附接到缝合线（30）的锚固件（20）。 锚固件通过开口插入容器中，并且缝合线将锚固件拉靠在血管壁上，形成密封。 塞子（40）插入缝合线上并朝向锚固件轴向压缩，将元件锁定就位。 该缝合线被编织或编织在锚定体之外，使得其可以容易地储存和处理，并且在其锚固体内部的远端处是未被覆盖的，无纺的和/或解开的，使得缝合线内的单个细丝可以在锚定件内横向延伸 。 横向延伸的长丝在锚固体内对着较大的覆盖区域，而不是如果缝合线保持编织或连接到锚固体内的结，这可以更有效地将锚定力分配在锚固体内。 在一些情况下，插塞材料由掺入快速溶解材料的机械强度材料的纤维形成。

公开(公告)号：WO2011008534A1

公开(公告)日：2011-01-20

申请号：PCT/US2010/040362

申请日：2010-06-29

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  ATANASOSKA, Liliana ,  FLANAGAN, Aiden ,  DAVIS, Liza J. ,  HARRISON, Kent ,  SOGARD, David J.

Inventor： ATANASOSKA, Liliana ,  FLANAGAN, Aiden ,  DAVIS, Liza J. ,  HARRISON, Kent ,  SOGARD, David J.

IPC: A61M31/00 ,  A61N1/30

CPC classification number: A61M5/14276

Abstract: In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.

Abstract translation: 在一个实施方案中，本公开提供了一种用于预防或减少再灌注损伤的可生物降解的自供电医疗装置，包括原电池，所述原电池包括：第一可生物降解的电极构件; 以及包含可生物降解的导电聚合物和电极可释放的治疗剂的第二可生物降解的电极构件，其中所述原电池产生足以使所述电极可释放的治疗剂从所述可生物降解的导电聚合物释放并洗脱至目标位置的电力 。 该装置还可以包括含有爆发释放治疗剂的贮存器材料。

公开(公告)号：WO2007084726A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/001541

申请日：2007-01-19

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SOGARD, David, J. ,  HARRISON, Kent, D. ,  RICHARDSON, Leonard, B.

Inventor： SOGARD, David, J. ,  HARRISON, Kent, D. ,  RICHARDSON, Leonard, B.

IPC: A61B17/00

CPC classification number: A61B17/00234 ,  A61B17/0469 ,  A61B17/0482 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0472 ,  A61B2017/06057 ,  A61F2/2445 ,  A61F2/2457

Abstract: Methods, apparatus, and systems for altering the configuration of a heart valve. Methods, apparatus, and systems include the use of a cord delivered into the heart by a delivery catheter that can be manipulated by a receiving catheter so as to improve the heart valve function.

Abstract translation: 用于改变心脏瓣膜构造的方法，装置和系统。 方法，装置和系统包括通过可由接收导管操纵的输送导管输送到心脏中的绳索的用途，以便改善心脏瓣膜功能。

公开(公告)号：WO2006071715A2

公开(公告)日：2006-07-06

申请号：PCT/US2005/046531

申请日：2005-12-21

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  WEBER, Jan ,  EIDENSCHINK, Tracee E.J. ,  SOGARD, David J. ,  WASDYKE, Joel M. ,  HOLMAN, Thomas J.

Inventor： WEBER, Jan ,  EIDENSCHINK, Tracee E.J. ,  SOGARD, David J. ,  WASDYKE, Joel M. ,  HOLMAN, Thomas J.

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61F2/24 ,  A61F2/2493 ,  A61F2/86 ,  A61F2002/018 ,  A61F2002/068 ,  A61F2230/0006 ,  A61F2230/0067

Abstract: Improved methods and apparatus for capturing emboli and subsequently removing or immobilizing the captured emboli are described. Emboli can be captured within a blood vessel and can be withdrawn to a position exterior to the blood vessel. Some filters can remain within a blood vessel yet direct emboli to a position exterior to the blood vessel.

Abstract translation: 描述了用于捕获栓子并随后去除或固定捕获的栓子的改进的方法和设备。 栓子可以被捕获在血管内并且可以被撤回到血管外部的位置。 一些过滤器可以保留在血管内，还可以将栓塞指向血管外部的位置。

公开(公告)号：WO2010129184A2

公开(公告)日：2010-11-11

申请号：PCT/US2010/032035

申请日：2010-04-22

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  FLANAGAN, Aiden ,  HARRISON, Kent ,  ATANASOSKA, Liliana ,  SOGARD, David J. ,  DAVIS, Liza J.

Inventor： FLANAGAN, Aiden ,  HARRISON, Kent ,  ATANASOSKA, Liliana ,  SOGARD, David J. ,  DAVIS, Liza J.

IPC: A61K9/00

CPC classification number: A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

Abstract: A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

Abstract translation: 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

公开(公告)号：WO2007024615A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/032107

申请日：2006-08-17

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

Inventor： SOGARD, David, J. ,  RICHARDSON, Leonard, B. ,  HARRISON, Kent, D. ,  SHEAHEN, Diane, M.

IPC: A61B17/00 ,  A61B17/06

CPC classification number: A61B17/0057 ,  A61B17/00234 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0443 ,  A61B2017/06171 ,  A61B2017/0647 ,  A61B2017/3488

Abstract: Methods, apparatus, and systems for occluding a multiplicity of parallel membranes, such as found in a patent foramen ovale (PFO) . Methods, apparatus, and systems include the use of a positioning device (222,422) that can be seated on the limbus(114) of the septum secundum (SS). The positioning device includes a piercing member (27-0) that can pierce the SS and septum premium (SP). The positioning device also includes a fastening member (272) that can engage the SS and SP to fasten the tissues and thereby occlude a PFO.

Abstract translation: 闭塞多个平行膜的方法，装置和系统，例如在卵孔专利（PFO）中发现的。 方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘（114）上的定位装置（222,422）。 该定位装置包括能刺穿SS和隔垫溢价（SP）的穿孔构件（27-0）。 定位装置还包括紧固构件（272），其可以接合SS和SP以紧固组织，从而遮挡PFO。

公开(公告)号：WO2013020134A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/049759

申请日：2012-08-06

Applicant: AMS RESEARCH CORPORATION ,  ALLEN, John J. ,  MUJWID, James R. ,  FELTON, Jessica E. ,  SOGARD, David J.

Inventor： ALLEN, John J. ,  MUJWID, James R. ,  FELTON, Jessica E. ,  SOGARD, David J.

IPC: A61F2/00

CPC classification number: A61F2/0045 ,  A61B17/0401 ,  A61B17/3468 ,  A61B2017/00805 ,  A61B2017/00867 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0417 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06176 ,  A61F2/0036 ,  A61F2210/0014 ,  A61F2220/0016

Abstract: Systems and methods are provided and adapted to engage and pull (e.g., pull up) or reposition urethral support tissue, such as the portion of the perineal membrane above or below the urethra. The perineal membrane intersects the urethra and vagina at the midurethra or distal location and can thus be stabilized or controlled in a manner that helps restore continence.

Abstract translation: 系统和方法被提供并适于接合和拉动（例如拉起）或重新定位尿道支持组织，例如会阴膜上的尿道上方或下方的部分。 会阴膜在尿道或远端位置与尿道和阴道相交，因此可以以有助于恢复控制的方式稳定或控制。

公开(公告)号：WO2007142914A3

公开(公告)日：2008-07-17

申请号：PCT/US2007012623

申请日：2007-05-25

Applicant: BOSTON SCIENT SCIMED INC ,  SOGARD DAVID J ,  HAVERKOST PATRICK A ,  SAHOLT DOUGLAS R ,  KVEEN GRAIG L

Inventor： SOGARD DAVID J ,  HAVERKOST PATRICK A ,  SAHOLT DOUGLAS R ,  KVEEN GRAIG L

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/08 ,  A61B17/10 ,  A61B17/11 ,  A61B17/12 ,  A61B17/128 ,  A61N1/05

CPC classification number: A61N1/057 ,  A61B17/0057 ,  A61B17/083 ,  A61B17/10 ,  A61B17/11 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00805 ,  A61B2017/00862 ,  A61N1/375

Abstract: The present disclosure relates generally to devices, systems, and methods for use with tissue, more particularly the present disclosure relates to a device including a frame with a surface defining a pinch point region with a predefined shape. The device also includes a tab with an opening defining an anchor attachment on the frame. The frame can elastically deform under a stress to alter the predefined shape of the pinch point region.

Abstract translation: 本公开一般涉及用于组织的装置，系统和方法，更具体地，本公开涉及一种包括具有限定具有预定形状的夹点区域的表面的框架的装置。 该装置还包括具有限定框架上的锚附件的开口的突出部。 框架可以在应力下弹性变形以改变夹点区域的预定形状。

公开(公告)号：WO2010129184A3

公开(公告)日：2011-09-22

申请号：PCT/US2010032035

申请日：2010-04-22

Applicant: BOSTON SCIENT SCIMED INC ,  FLANAGAN AIDEN ,  HARRISON KENT ,  ATANASOSKA LILIANA ,  SOGARD DAVID J ,  DAVIS LIZA J

Inventor： FLANAGAN AIDEN ,  HARRISON KENT ,  ATANASOSKA LILIANA ,  SOGARD DAVID J ,  DAVIS LIZA J

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51

CPC classification number: A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

Abstract: A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

Abstract translation: 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

公开(公告)号：WO2010077355A1

公开(公告)日：2010-07-08

申请号：PCT/US2009/006746

申请日：2009-12-30

Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SOGARD, David, J. ,  HILL, Jason, P. ,  SMITH, Scott ,  HAVERKOST, Patrick, A. ,  SHOEMAKER, Susan, M.

Inventor： SOGARD, David, J. ,  HILL, Jason, P. ,  SMITH, Scott ,  HAVERKOST, Patrick, A. ,  SHOEMAKER, Susan, M.

IPC: B32B15/00 ,  A61F2/04

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0066 ,  B32B3/14 ,  B32B3/266 ,  B32B7/12 ,  B32B9/02 ,  B32B15/00 ,  B32B15/04 ,  B32B15/08 ,  B32B15/18 ,  B32B27/16 ,  B32B27/281 ,  B32B27/283 ,  B32B27/302 ,  B32B27/304 ,  B32B27/32 ,  B32B27/36 ,  B32B27/365 ,  B32B27/40 ,  B32B2250/44 ,  B32B2307/50 ,  B32B2307/51 ,  B32B2307/514 ,  B32B2307/542 ,  B32B2307/546 ,  B32B2307/554 ,  B32B2535/00 ,  B32B2605/08 ,  B32B2605/18 ,  Y10T29/49826 ,  Y10T428/24273 ,  Y10T428/24479

Abstract: A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling.

Abstract translation: 一种复合生物材料，其具有连续金属板，其具有限定第一开窗图案的弓形构件，以及在所述连续金属板的至少一个表面上的聚合物层。 弓形部件弹性拉伸，以允许连续的金属片在多于一个轴线上弯曲而没有弯曲或起皱。