公开(公告)号：WO2007030611A2

公开(公告)日：2007-03-15

申请号：PCT/US2006/034846

申请日：2006-09-11

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  SYMMANS, W., Fraser ,  HATZIS, Christos ,  ANDERSON, Keith ,  PUSZTAI, Lajos

Inventor： SYMMANS, W., Fraser ,  HATZIS, Christos ,  ANDERSON, Keith ,  PUSZTAI, Lajos

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N33/743 ,  G01N2333/723 ,  G01N2800/52 ,  G06F19/18 ,  G06F19/20

Abstract: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.

Abstract translation: 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。

公开(公告)号：WO2007120806A2

公开(公告)日：2007-10-25

申请号：PCT/US2007009096

申请日：2007-04-13

Applicant: NUVERA BIOSCIENCES ,  UNIV TEXAS ,  HATZIS CHRISTOS ,  SYMMANS FRASER W ,  PUSZTAI LAJOS

Inventor： HATZIS CHRISTOS ,  SYMMANS FRASER W ,  PUSZTAI LAJOS

IPC: G01N33/50

CPC classification number: G01N33/57484 ,  G01N33/574 ,  G01N33/57415

Abstract: Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.

Abstract translation: 公开了一种通过根据切除标本中所述肿瘤的原发肿瘤床的二维直径确定残留癌症负担指数来确定进行肿瘤治疗的患者的存活和复发的方法，原发性肿瘤床面积的比例 包括侵袭性癌，包含转移性癌的局部淋巴结数目，区域性淋巴结中最大转移的直径; 和淋巴结大小的分数减少每个添加阳性淋巴结。

公开(公告)号：WO2004096020A2

公开(公告)日：2004-11-11

申请号：PCT/US2004/013318

申请日：2004-04-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  SILICO INSIGHTS ,  LEACHMAN, Sancy ,  HATZIS, Christos ,  PADUKONE, Nandan ,  ERICKSON, Harold ,  PORTER-GILL, Patricia

Inventor： LEACHMAN, Sancy ,  HATZIS, Christos ,  PADUKONE, Nandan ,  ERICKSON, Harold ,  PORTER-GILL, Patricia

IPC: A61B

CPC classification number: G01N33/5743 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2800/52

Abstract: Methods are provided for estimating the risk of developing melanoma and related malignancies in an individual. Methods and compositions for diagnosing, treating, and preventing melanoma and related malignancies also are provided.

Abstract translation: 提供了用于估计个体发生黑素瘤和相关恶性肿瘤风险的方法。 还提供了用于诊断，治疗和预防黑素瘤和相关恶性肿瘤的方法和组合物。

公开(公告)号：WO2011130495A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/032462

申请日：2011-04-14

Applicant: NUVERA BIOSCIENCES, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  HATZIS, Christos ,  SYMMANS, W., Fraser

Inventor： HATZIS, Christos ,  SYMMANS, W., Fraser

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/68 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2333/91205 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G06F19/34 ,  H04L67/00

Abstract: A method of evaluating a cancer patient comprising evaluating gene expression levels in a patient sample, calculating a predictor score using the gene expression levels, and assessing the likelihood of a therapeutic outcome using the predictor score is disclosed.

Abstract translation: 一种评估癌症患者的方法，包括评估患者样品中的基因表达水平，使用基因表达水平计算预测因子评分，以及使用预测因子评分评估治疗结果的可能性。

公开(公告)号：WO2007120806A3

公开(公告)日：2007-10-25

申请号：PCT/US2007/009096

申请日：2007-04-13

Applicant: NUVERA BIOSCIENCES ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  HATZIS, Christos ,  SYMMANS, Fraser, W. ,  PUSZTAI, Lajos

Inventor： HATZIS, Christos ,  SYMMANS, Fraser, W. ,  PUSZTAI, Lajos

IPC: G01N33/574

Abstract: Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.

公开(公告)号：WO2004096020A3

公开(公告)日：2005-07-07

申请号：PCT/US2004013318

申请日：2004-04-29

Applicant: UNIV UTAH RES FOUND ,  SILICO INSIGHTS ,  LEACHMAN SANCY ,  HATZIS CHRISTOS ,  PADUKONE NANDAN ,  ERICKSON HAROLD ,  PORTER-GILL PATRICIA

Inventor： LEACHMAN SANCY ,  HATZIS CHRISTOS ,  PADUKONE NANDAN ,  ERICKSON HAROLD ,  PORTER-GILL PATRICIA

IPC: A61B20060101 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G01N33/567 ,  G01N33/574

CPC classification number: G01N33/5743 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2800/52

Abstract: Methods are provided for estimating the risk of developing melanoma and related malignancies in an individual. Methods and compositions for diagnosing, treating, and preventing melanoma and related malignancies also are provided.

Abstract translation: 提供了用于估计个体发生黑素瘤和相关恶性肿瘤风险的方法。 还提供了用于诊断，治疗和预防黑素瘤和相关恶性肿瘤的方法和组合物。

公开(公告)号：WO2009089521A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/030719

申请日：2009-01-12

Applicant: NUVERA BIOSCIENCES, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  SYMMANS, W., Fraser ,  HATZIS, Christos ,  PUSZTAI, Lajos

Inventor： SYMMANS, W., Fraser ,  HATZIS, Christos ,  PUSZTAI, Lajos

IPC: G01N33/574

CPC classification number: G01N33/57484 ,  G01N2800/52 ,  G01N2800/60 ,  G06F19/20 ,  G06F19/28

Abstract: Embodiments of the invention include methods of evaluating a patient and determining the likelihood of a treatment outcome to one or four categories of residual cancer burden classification.

Abstract translation: 本发明的实施方案包括评估患者并确定治疗结果对一种或四类残留癌症负担分类的可能性的方法。

公开(公告)号：WO2008073629A9

公开(公告)日：2008-09-25

申请号：PCT/US2007083651

申请日：2007-11-05

Applicant: UNIV TEXAS ,  NUVERA BIOSCIENCES INC ,  HATZIS CHRISTOS ,  SYMMANS FRASER W ,  PUSZTAI LAJOS

Inventor： HATZIS CHRISTOS ,  SYMMANS FRASER W ,  PUSZTAI LAJOS

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

Abstract: The present invention provides the identification of genes that are expressed in tumors to indicate responsiveness or resistance to an agent or class of agents. More particularly, these genes show expression associated with responsiveness to one agent or class of agents is inversely related to expression in association with another class of agents. One or more of theses genes of the present invention can be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by the responsive agent as well as to identify tumors that should avoid treatment by the resistant agent.

公开(公告)号：WO02072871A3

公开(公告)日：2003-02-20

申请号：PCT/US0207858

申请日：2002-03-13

Applicant: ASHNI NATURACEUTICALS INC ,  SILICO INSIGHTS ,  HATZIS CHRISTOS ,  PRAKASH PANKAJ ,  BABISH JOHN G ,  PACIORETTY LINDA M

Inventor： HATZIS CHRISTOS ,  PRAKASH PANKAJ ,  BABISH JOHN G ,  PACIORETTY LINDA M

IPC: G01N33/48 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/50 ,  G01N33/68 ,  G06F19/20 ,  G06F19/28 ,  G06G7/48 ,  C12P19/34 ,  C12P21/06 ,  C12Q1/00 ,  G01N33/53

CPC classification number: G01N33/6842 ,  G01N33/6803 ,  G06F19/20 ,  G06F19/28

Abstract: The present invention provides methods for identifying relationships between gene expression and protein modifications in a cell by determining gene expression generated in the cell, determining protein modifications generated in the cell, and coordinating the gene expression and protein modifications generated in the cell. Also provided by the present invention is a computer system for identifying such a relationship between gene expression and protein modifications. The present inventive methods and computer systems are useful for investigating a variety of physiological or pathophysiological processes, including metabolic pathways, typing of diseased cells, and identifying biological activities of test materials.

Abstract translation: 本发明提供了通过确定在细胞中产生的基因表达，确定细胞中产生的蛋白质修饰以及协调细胞中产生的基因表达和蛋白质修饰来鉴定细胞中基因表达和蛋白质修饰之间的关系的方法。 本发明还提供了一种用于鉴定基因表达和蛋白质修饰之间的这种关系的计算机系统。 本发明的方法和计算机系统可用于研究各种生理或病理生理过程，包括代谢途径，患病细胞的分型以及鉴定测试材料的生物学活性。

公开(公告)号：WO2010127338A1

公开(公告)日：2010-11-04

申请号：PCT/US2010/033359

申请日：2010-05-03

Applicant: NUVERA BIOSCIENCES, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  SYMMANS, W., Fraser ,  HATZIS, Christos ,  PUSZTAI, Lajos

Inventor： SYMMANS, W., Fraser ,  HATZIS, Christos ,  PUSZTAI, Lajos

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G06F19/20

Abstract: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.

Abstract translation: 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能由该试剂或类别的试剂例如激素或内分泌治疗或化学疗法成功治疗的肿瘤。