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    ANALYTE FILTER METHOD AND APPARATUS
    1.
    发明申请
    ANALYTE FILTER METHOD AND APPARATUS 审中-公开
    分析滤波方法和装置

    公开(公告)号：WO2006017700A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2005027818

    申请日：2005-08-05

    Applicant: SENSYS MEDICAL INC ,  RUCHTI TIMOTHY L ,  LORENZ ALEXANDER D ,  HAZEN KEVIN H

    Inventor： RUCHTI TIMOTHY L ,  LORENZ ALEXANDER D ,  HAZEN KEVIN H

    IPC: G01J3/28 ,  A61B5/00 ,  G01J3/42 ,  G01J3/427 ,  G01N33/48

    CPC classification number: G01N21/274 ,  G01J3/28 ,  G01J3/433 ,  G01N21/359 ,  G01N2201/129 ,  G01N2201/1293

    Abstract: The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.

    Abstract translation: 本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。 更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。 随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

    METHOD AND APPARATUS FOR NONINVASIVE GLUCOSE CONCENTRATION ESTIMATION THROUGH NEAR-INFRARED SPECTROSCOPY
    3.
    发明申请
    METHOD AND APPARATUS FOR NONINVASIVE GLUCOSE CONCENTRATION ESTIMATION THROUGH NEAR-INFRARED SPECTROSCOPY 审中-公开
    通过近红外光谱法测定非葡萄糖浓度估算方法和装置

    公开(公告)号：WO2006047273A2

    公开(公告)日：2006-05-04

    申请号：PCT/US2005/037860

    申请日：2005-10-20

    Applicant: SENSYS MEDICAL, INC. ,  ACOSTA, George, M. ,  ABUL-HAJ, N., Alan ,  RUCHTI, Timothy, L. ,  MONFRE, Stephen, L. ,  BLANK, Thomas, B. ,  HAZEN, Kevin, H.

    Inventor： ACOSTA, George, M. ,  ABUL-HAJ, N., Alan ,  RUCHTI, Timothy, L. ,  MONFRE, Stephen, L. ,  BLANK, Thomas, B. ,  HAZEN, Kevin, H.

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  A61B2560/0233

    Abstract: A near-infrared spectrometer-based analyzer attaches continuously or semi­continuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.

    Abstract translation: 基于近红外光谱仪的分析仪连续地或半连续地连接到人类受试者并用于收集组织样本的光谱测量。 光谱读数用于非侵入性地估计采样组织中的生物学参数，如葡萄糖浓度。 优选的装置是近红外分析器，其包括与通信束连接在一起的基本模块和样本模块。 基本模块包含分析仪的大部分，例如光谱仪和具有用于将光信号转换为葡萄糖浓度的算法的中央处理单元。 样品模块通常在与组织样品接口的较小模块中。 样品模块优选是手持式的，并且由于热或压力而提供最小的采样失真。

    PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION
    4.
    发明申请
    PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
    非挥发性葡萄糖浓度测定的制备工具

    公开(公告)号：WO2005122880A2

    公开(公告)日：2005-12-29

    申请号：PCT/US2005019347

    申请日：2005-06-02

    Applicant: SENSYS MEDICAL INC ,  MONFRE STEPHEN L ,  HAZEN KEVIN H

    Inventor： MONFRE STEPHEN L ,  HAZEN KEVIN H

    IPC: A61B5/00 ,  B01L99/00

    CPC classification number: A61B5/14532 ,  A61B90/80 ,  A61B2562/24 ,  A61B2562/242 ,  A61B2562/245

    Abstract: The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.

    Abstract translation: 本发明涉及一种用于与近红外，无创葡萄糖浓度分析仪结合使用的试剂盒。 优选的试剂盒包含用于制备样品位点和/或用于取样过程中的一组元素。 本发明包括一种试剂盒，其包括用于与非侵入性葡萄糖浓度分析仪组合使用的引导剂，塞子，粘合剂，对准工具，清洁剂，接触流体和包装中的任何一种。

    METHOD AND APPARATUS FOR NONINVASIVE GLUCOSE CONCENTRATION ESTIMATION THROUGH NEAR-INFRARED SPECTROSCOPY
    6.
    发明申请
    METHOD AND APPARATUS FOR NONINVASIVE GLUCOSE CONCENTRATION ESTIMATION THROUGH NEAR-INFRARED SPECTROSCOPY 审中-公开
    通过近红外光谱法测定非葡萄糖浓度估算方法和装置

    公开(公告)号：WO2006047273A3

    公开(公告)日：2007-02-22

    申请号：PCT/US2005037860

    申请日：2005-10-20

    Applicant: SENSYS MEDICAL INC ,  ACOSTA GEORGE M ,  ABUL-HAJ N ALAN ,  RUCHTI TIMOTHY L ,  MONFRE STEPHEN L ,  BLANK THOMAS B ,  HAZEN KEVIN H

    Inventor： ACOSTA GEORGE M ,  ABUL-HAJ N ALAN ,  RUCHTI TIMOTHY L ,  MONFRE STEPHEN L ,  BLANK THOMAS B ,  HAZEN KEVIN H

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  A61B2560/0233

    Abstract: A near-infrared spectrometer-based analyzer attaches continuously or semi­continuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.

    Abstract translation: 基于近红外光谱仪的分析仪连续地或半连续地连接到人类受试者并用于收集组织样本的光谱测量。 光谱读数用于非侵入性地估计采样组织中的生物学参数，如葡萄糖浓度。 优选的装置是近红外分析器，其包括与通信束连接在一起的基本模块和样本模块。 基本模块包含分析仪的大部分，例如光谱仪和具有用于将光信号转换为葡萄糖浓度的算法的中央处理单元。 样品模块通常在与组织样品接口的较小模块中。 样品模块优选是手持式的，并且由于热或压力而提供最小的采样失真。

    PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION
    8.
    发明申请
    PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
    制备无血清葡萄糖浓度测定试剂盒

    公开(公告)号：WO2005122880B1

    公开(公告)日：2007-04-12

    申请号：PCT/US2005019347

    申请日：2005-06-02

    Applicant: SENSYS MEDICAL INC ,  MONFRE STEPHEN L ,  HAZEN KEVIN H

    Inventor： MONFRE STEPHEN L ,  HAZEN KEVIN H

    IPC: A61B5/00 ,  B01L99/00

    CPC classification number: A61B5/14532 ,  A61B90/80 ,  A61B2562/24 ,  A61B2562/242 ,  A61B2562/245

    Abstract: The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.

    Abstract translation: 本发明涉及与近红外非侵入式葡萄糖浓度分析仪结合使用的试剂盒。 优选的试剂盒包含用于制备样品地点和/或用于取样过程的一组元素。 本发明包括套件，其包括与无创葡萄糖浓度分析仪组合使用的引导件，塞子，粘合剂，对准工具，清洁器，接触流体和包装中的任一种。

    ANALYTE FILTER METHOD AND APPARATUS
    9.
    发明申请
    ANALYTE FILTER METHOD AND APPARATUS 审中-公开
    分析滤波方法和装置

    公开(公告)号：WO2006017700A2

    公开(公告)日：2006-02-16

    申请号：PCT/US2005/027818

    申请日：2005-08-05

    Applicant: SENSYS MEDICAL, INC. ,  RUCHTI, Timothy, L. ,  LORENZ, Alexander, D. ,  HAZEN, Kevin, H.

    Inventor： RUCHTI, Timothy, L. ,  LORENZ, Alexander, D. ,  HAZEN, Kevin, H.

    IPC: G01J3/28

    CPC classification number: G01N21/274 ,  G01J3/28 ,  G01J3/433 ,  G01N21/359 ,  G01N2201/129 ,  G01N2201/1293

    Abstract: The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.

    Abstract translation: 本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。 更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。 随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

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