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    AN OPTICAL IMAGE PROBE
    3.
    发明申请
    AN OPTICAL IMAGE PROBE 审中-公开
    光学图像探测器

    公开(公告)号：WO2010004493A1

    公开(公告)日：2010-01-14

    申请号：PCT/IB2009/052900

    申请日：2009-07-03

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  KUIPER, Stein ,  HENDRIKS, Bernardus, H., W. ,  MIHAJLOVIC, Nenad

    Inventor： KUIPER, Stein ,  HENDRIKS, Bernardus, H., W. ,  MIHAJLOVIC, Nenad

    IPC: G02B3/14 ,  G02B23/24

    CPC classification number: G02B23/2438 ,  A61B1/0019 ,  G02B3/14

    Abstract: The invention relates to an optical image probe(20) for particularly suited for miniature application e.g. in-vivo. A fluid lens(5) is positioned a housing (19),the fluid lens having a changeable optical power. An image collector (40) is positioned within the housing, the collector being arranged on an optical path of the fluid lens, the collector being displaceable along the said optical path by an actuator (42, 70, 80, 90) in various ways. It is highly advantageous in obtaining a compact optical image probe and which simultaneously has a high zoom factor. Due the possible displacement of the image collector and the changeable optical power of the fluid lens, and cooperation between these two elements, it is possible to obtain a compact endoscope with a wide dynamic range of zoom factor with satisfactory focusing properties.

    Abstract translation: 本发明涉及一种特别适用于微型应用的光学图像探针（20）。 被检体内。 液体透镜（5）定位在壳体（19）上，流体透镜具有可变光学功率。 图像收集器（40）定位在壳体内，集电器布置在流体透镜的光路上，集电器可以通过致动器（42,70,80,90）以各种方式沿着所述光路移动。 在获得紧凑型光学图像探针并且同时具有高变焦系数方面是非常有利的。 由于图像收集器的可能位移和流体透镜的可变光学功率以及这两个元件之间的协调，可以获得具有良好聚焦性能的宽动态范围的变焦系数的紧凑型内窥镜。

    A HIGHER ORDER DISPERSION COMPENSATION DEVICE
    4.
    发明申请
    A HIGHER ORDER DISPERSION COMPENSATION DEVICE 审中-公开
    更高排序补偿装置

    公开(公告)号：WO2009144635A2

    公开(公告)日：2009-12-03

    申请号：PCT/IB2009/052114

    申请日：2009-05-20

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  HET HOOFT, Gert ,  HENDRIKS, Bernardus, H., W. ,  MEGENS, Mischa

    Inventor： HET HOOFT, Gert ,  HENDRIKS, Bernardus, H., W. ,  MEGENS, Mischa

    CPC classification number: G02B5/00 ,  G02B5/04 ,  G02B27/095 ,  G02B2207/117 ,  H01S3/0057

    Abstract: The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (Pl, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost- effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.

    Abstract translation: 本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如， 一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。 补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散 。 本发明有利于获得构造和使用相对简单的高阶色散补偿装置，使其成为一种非常具有成本效益的装置。 本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。 在多光子成像系统中。

    AN OPTICAL PROBE
    7.
    发明申请
    AN OPTICAL PROBE 审中-公开
    光学探头

    公开(公告)号：WO2009087522A1

    公开(公告)日：2009-07-16

    申请号：PCT/IB2008/055460

    申请日：2008-12-19

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  HENDRIKS, Bernardus, H., W. ,  'T HOOFT, Gert

    Inventor： HENDRIKS, Bernardus, H., W. ,  'T HOOFT, Gert

    IPC: A61B1/04 ,  A61B1/07 ,  A61B5/00 ,  G02B6/00

    CPC classification number: A61B5/0062 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00183 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084

    Abstract: The invention relates an optical probe (1) suitable for non- linear optics such as two-photon imaging for medical purposes. The probe has an optical guide (2) and a lens system (6) positioned rigidly at an end portion (2a) of the optical guide. Additionally, a housing (3) with a cavity for the optical guide (2) and the lens system (6), the housing having at its distal end a transparent window (4), is comprised in the probe. The optical guide (2) with the lens system (6) is displaceably mounted within the housing, preferably in a transverse direction. Also, the housing (3) has an auxiliary, peripheral optical guide (5) optically connected to the transparent window (4). The invention is advantageous for obtaining an optical probe with a significantly larger collection efficiency. The optical probe may advantageous be applied in connection with two-photon spectroscopy where both ballisitic photons and diffusing fluorescence photons can be used in the detection of an event.

    Abstract translation: 本发明涉及适用于非线性光学的光学探针（1），例如用于医疗目的的双光子成像。 探针具有光导件（2）和刚性地定位在光导的端部（2a）处的透镜系统（6）。 此外，具有用于光导（2）和透镜系统（6）的空腔的壳体（3），其外壳在其远端处具有透明窗口（4），其包括在探针中。 具有透镜系统（6）的光导（2）优选地在横向方向上可移动地安装在壳体内。 另外，壳体（3）具有与透明窗（4）光学连接的辅助外周光导（5）。 本发明有利于获得具有显着更大收集效率的光学探针。 结合双光子光谱可以有利地应用光探针，其中可以使用Ballisitic光子和扩散荧光光子来检测事件。

    TUMOR DEMARCATION USING TARGETED FLUORESCENT PROBE AND PHOTONIC NEEDLE
    8.
    发明申请
    TUMOR DEMARCATION USING TARGETED FLUORESCENT PROBE AND PHOTONIC NEEDLE 审中-公开
    使用指定的荧光探针和光子针头进行肿瘤分解

    公开(公告)号：WO2009050667A1

    公开(公告)日：2009-04-23

    申请号：PCT/IB2008/054253

    申请日：2008-10-16

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  VAN DER MARK, Martinus, B. ,  HENDRIKS, Bernardus, H., W.

    Inventor： VAN DER MARK, Martinus, B. ,  HENDRIKS, Bernardus, H., W.

    IPC: A61B5/00

    CPC classification number: A61B90/39 ,  A61B2090/306 ,  A61B2090/3908 ,  A61B2090/3941

    Abstract: The present invention refers to the field of image-guided percutaneous needle biopsies, in particular to a light guiding hook wire comprising a light-guiding optical fiber (LGM, LGHW) for transferring light from one end on which a beam of input light are incident to another end placed in a cancerous tissue region around the tip of the hookwire, thereby providing an output light assignable to the intensity of the input light; and a liquid guiding device for providing a liquid to the region of interest. The present invention further refers to a method for excising non-palpable pathological tissue regions in the interior of a patient's body, especially tissue regions indicative of breast or prostate cancer, by using such a hookwire. A targeted contrast agent fluorescent in the visible or near-infrared spectrum of light can be used to mark cancerous tissue anomalies, and a light-guiding optical fiber (LGM, LGHW) may provide the light needed for an excitation of this tissue.

    Abstract translation: 本发明涉及图像引导的经皮针活检领域，特别涉及一种导光钩线，其包括用于从输入光束入射的一端传输光的导光光纤（LGM，LGHW） 到另一端放置在钩线尖端周围的癌组织区域中，从而提供可分配给输入光强度的输出光; 以及用于向感兴趣区域提供液体的液体引导装置。 本发明还涉及通过使用这种钩线来切除患者身体内部，特别是指示乳腺癌或前列腺癌的组织区域中的不可触知的病理组织区域的方法。 在可见光或近红外光谱中荧光的靶向对比剂可用于标记癌组织异常，并且导光光纤（LGM，LGHW）可提供激发该组织所需的光。

    METHOD AND SYSTEM FOR IMAGING SAMPLES
    9.
    发明申请
    METHOD AND SYSTEM FOR IMAGING SAMPLES 审中-公开
    用于成像样本的方法和系统

    公开(公告)号：WO2009016548A3

    公开(公告)日：2009-03-26

    申请号：PCT/IB2008052950

    申请日：2008-07-23

    Applicant: KONINKL PHILIPS ELECTRONICS NV ,  DE BOER RUTH W I ,  HENDRIKS BERNARDUS H W

    Inventor： DE BOER RUTH W I ,  HENDRIKS BERNARDUS H W

    IPC: G01N21/64 ,  G02B21/00

    CPC classification number: G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G02B21/16 ,  G02B21/244

    Abstract: The invention provides a method for imaging samples, at least comprising: - staining of a sample with a first marker material and with a second marker material; - utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and - utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.

    Abstract translation: 本发明提供了一种用于成像样品的方法，至少包括： - 用第一标记材料和第二标记材料对样品进行染色; - 在聚焦步骤中利用第一标记物材料以使成像装置相对于样本聚焦; 以及 - 利用在聚焦步骤中聚焦的第二标记材料和成像装置在成像步骤中获取样本的图像。 本发明还涉及一种用于成像样本的系统。

    SWITCHABLE OPTICAL ELEMENT
    10.
    发明申请
    SWITCHABLE OPTICAL ELEMENT 审中-公开
    可切换光学元件

    公开(公告)号：WO2006131888A3

    公开(公告)日：2007-03-29

    申请号：PCT/IB2006051811

    申请日：2006-06-07

    Applicant: KONINKL PHILIPS ELECTRONICS NV ,  KUIPER STEIN ,  HENDRIKS BERNARDUS H W

    Inventor： KUIPER STEIN ,  HENDRIKS BERNARDUS H W

    IPC: G02B6/26

    CPC classification number: G02B26/02 ,  G02B6/3538 ,  G02B6/3552

    Abstract: A switchable optical element has an optical axis. The element includes a chamber, a wave front modifier having a face defining an interior surface of the chamber (the face extending transverse the optical axis), a first fluid and a second fluid. The fluids are immiscible and in contact over an interface. The optical element is switchable between a first discrete state in which the first fluid substantially covers the face of the wave front modifier, and a second discrete state in which the second fluid substantially covers the face of the wave front modifier, wherein the chamber encloses both fluids in both discrete states, and the interlace extends transverse the optical axis in the first discrete state.

    Abstract translation: 可切换光学元件具有光轴。 元件包括腔室，波前修改器，其具有限定腔室的内表面的面（横向于光轴延伸的面），第一流体和第二流体。 流体是不混溶的并且通过界面接触。 光学元件可在第一离散状态（其中第一流体基本上覆盖波前修改器的表面）和第二离散状态之间切换，其中第二流体基本上覆盖波前修改器的表面，其中，腔室包围两者 在离散状态下的流体，并且交错在第一离散状态下横向于光轴延伸。

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