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公开(公告)号：WO0100041A3
公开(公告)日：2002-10-03
申请号：PCT/NL0000451
申请日：2000-06-28
摘要： The invention relates to a method for the preparation of protein agglomerates, by introducing CO2 in an aqueous protein-containing solution. According to the invention CO2 is gradually and while mixing supplied yielding spherical protein agglomerates, after which the pressure is reduced with a rate such that the spherical nature of the protein agglomerates is substantially maintained. The invention also relates to a food product and a pharmaceutical compound containing such protein preparations.
摘要翻译： 本发明涉及通过在含蛋白质水溶液中引入CO 2来制备蛋白质聚集体的方法。 根据本发明，CO 2逐渐地进行混合，产生球形蛋白质聚集体，之后压力降低，使得蛋白质聚集体的球形性质基本保持不变。 本发明还涉及含有这种蛋白质制剂的食品和药物化合物。
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公开(公告)号：WO2007024133A1
公开(公告)日：2007-03-01
申请号：PCT/NL2006/050208
申请日：2006-08-23
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , WOERLEE, Geert Feye , HOFLAND, Gerard Willem , VERMEULEN, Pieter Sebastiaan
IPC分类号： B01J13/16
CPC分类号： B01J13/04
摘要： The present invention relates to a process for the preparation of encapsulates, which process employs: • a pumpable emulsion comprising (i) a continuous phase containing a solvent and a matrix-forming solute dissolved in said solvent and (ii) a dispersed phase; • an extractant comprising supercritical, subcritical or liquefied gas; said solvent being substantially more soluble in the extractant than said matrix-forming solute and said process comprising the successive steps of: a. combining the pumpable emulsion with the extractant under mixing conditions; b. allowing the formation of particulate encapsulates in which the dispersed phase is encased in a solid matrix of the matrix-forming solute; c. collecting the encapsulates and separating them from the extractant. The present processes is particularly suitable for producing particles containing active ingredients that are very sensitive, e.g. ingredients whose activity is adversely affected by exposure to oxygen, light, moisture, heat and/or friction.
摘要翻译： 本发明涉及一种制备包封物的方法，该方法采用：可泵送乳液，其包含（i）含有溶剂和溶解在所述溶剂中的基质形成溶质的连续相和（ii）分散相; 包括超临界，亚临界或液化气体的萃取剂; 所述溶剂在所述萃取剂中比所述基质形成溶质基本上更易溶，所述方法包括以下连续步骤：a。 将可泵送乳液与萃取剂在混合条件下结合; 湾 允许形成其中分散相被包裹在基质形成溶质的固体基质中的颗粒包封物; C。 收集封装物并将其与萃取剂分离。 本发明方法特别适用于生产含有非常敏感的活性成分的颗粒，例如， 活性受到暴露于氧气，光线，水分，热量和/或摩擦力的不利影响的成分。
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公开(公告)号：WO2005122776A1
公开(公告)日：2005-12-29
申请号：PCT/NL2005/000439
申请日：2005-06-16
申请人： FEYECON DEVELOPMENT & IMPLEMENTATION B.V. , AGTEROF, Wilhelmus, Gerardus, Maria , BHATIA, Rajni , HOFLAND, Gerard, Willem
IPC分类号： A23B7/02
CPC分类号： A23B4/033 , A23B7/0205 , A23L5/23
摘要： The present invention relates to a method of dehydrating pieces of intact plant or animal tissue, said pieces containing at least 30 wt. % of water, the method comprising (i) contacting the pieces of intact tissue with a pressurised gas to reduce the water contenit of the pieces by at least 50 %, said pressurised gas having a pressure of at least 0.5xP c and a temperature of at least T c -60 °C, P c representing the critical pressure of the gas and T c representing the critical temperature of the gas, and (ii) separating the pressurised gas from the dehydrated pieces, wherein at least 80 wt. %, preferably at least 90 wt. % of the matter removed by the gas from the pieces of intact plant or animal tissue is water. The invention also provides a method of dehydrating a material containing at least 30 wt. % of water, using a method as described before, followed by drying the separated pressurised gas by contacting said pressurised gas with a water absorbent water adsorbent; and recirculating the dried pressurised gas to the partially dehydrated material.
摘要翻译： 本发明涉及使完整植物或动物组织的片段脱水的方法，所述片含有至少30wt。 ％的水，所述方法包括（i）使完整组织的片与加压气体接触，以将块的水容量减少至少50％，所述加压气体具有至少0.5×Pc的压力和在 最小Tc-60℃，表示气体的临界压力的Pc和表示气体的临界温度的Tc，和（ii）从脱水片分离加压气体，其中至少80wt。 ％，优选至少90wt。 通过气体从完整植物或动物组织的块去除的物质的百分比是水。 本发明还提供一种使包含至少30wt。 ％的水，使用如前所述的方法，然后通过使所述加压气体与吸水性水吸附剂接触来干燥分离的加压气体; 并将干燥的加压气体再循环到部分脱水的材料。
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公开(公告)号：WO2005001437A1
公开(公告)日：2005-01-06
申请号：PCT/NL2004/000462
申请日：2004-06-30
IPC分类号： G01N1/30
CPC分类号： G01N1/31 , B01J3/008 , B01L7/00 , G01N1/30 , G01N1/36 , Y02P20/544 , Y10T436/25
摘要： The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous throughput and that eliminates the use of toxic solvents such as xylene. Provided is a method for processing a biological sample for histological analysis, comprising contacting the sample with a composition comprising a supercritical or near supercritical fluid followed by impregnating the sample under a pressure of more than 1 bar with an embedding medium, preferably paraffin. Also provided is a processor (1) for preparing at least one sample (10) for histological analysis, comprising at least one process reactor (9) for the at least one sample (10), characterized in that the processor (1) comprises supplying means (4) for supplying to the reactor (9) at least one substance of which at least one is in supercritical phase or near supercritical phase and at least one supplying means (7) for adding the embedding medium to the reactor (9) through conduit (8).
摘要翻译： 本发明涉及用于组织学分析的生物样品的加工。 特别地，本发明涉及一种快速的自动化处理系统，其可以连续生产并且消除使用有毒溶剂如二甲苯。 提供了一种用于处理用于组织学分析的生物样品的方法，包括使样品与包含超临界或接近超临界流体的组合物接触，然后在大于1巴的压力下用包埋介质，优选石蜡浸渍样品。 还提供了一种用于制备用于组织学分析的至少一个样品（10）的处理器（1），其包括用于所述至少一个样品（10）的至少一个工艺反应器（9），其特征在于，所述处理器（1）包括供应 用于向反应器（9）供应至少一种物质的至少一种物质在超临界相或接近超临界相中的装置（4）和至少一种用于将包埋介质加入到反应器（9）中的至少一个供应装置（7） 导管（8）。
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公开(公告)号：WO2009011584A2
公开(公告)日：2009-01-22
申请号：PCT/NL2008/050490
申请日：2008-07-17
CPC分类号： B01J3/008 , A61K9/145 , Y02P20/544
摘要： The present invention relates to a method of preparing a pharmaceutical co-crystal composition, said method comprising the steps of: a. simultaneously contacting a supercritical or liquefied gas with solid particles of a pharmaceutically active component and with solid particles of a co-builder to form a co -crystallisation medium containing dissolved pharmaceutically active component and dissolved co-builder as well as solid particles of the pharmaceutically active component and solid particles of the co-builder; b. transforming the solid particles of the pharmaceutically active component and the solid particles of the co-builder into co-crystals of said pharmaceutically active component and said co-builder by keeping the supercritical or liquefied gas in a supercritical or liquid state until at least 80 wt.% of the pharmaceutically active component is incorporated in the crystal matrix of said co-crystals; and c. separating said co-crystals from the supercritical or liquefied gas wherein at least a fraction of the pharmaceutically active component and at least a fraction of the co-builder remain in an undissolved state during the co-crystallisation. The present method enables easy preparation of a pharmaceutical co-crystal composition containing virtually no solvent residue and can suitably be used to prepare co-crystals of highly labile pharmaceutically active components.
摘要翻译： 本发明涉及制备药物共晶组合物的方法，所述方法包括以下步骤：a。 同时使超临界或液化气体与药学活性组分的固体颗粒和共助洗剂的固体颗粒接触以形成含有溶解的药物活性组分和溶解的共助洗剂的共结晶介质以及药物活性组分的固体颗粒 共助洗剂的组分和固体颗粒; 湾 通过将超临界或液化的气体保持在超临界状态或液体状态，将药物活性成分的固体颗粒和共助洗剂的固体颗粒转化成所述药物活性成分和所述共助洗剂的共晶，直至至少80重量％ ％的药物活性组分掺入所述共晶体的晶体基质中; 和c。 从超临界或液化气体中分离所述共晶体，其中至少一部分药物活性组分和至少一部分共助洗剂在共结晶过程中保持未溶解状态。 本发明的方法能够容易地制备几乎不含溶剂残余物的药物共晶组合物，并且可以适用于制备高度不稳定的药物活性组分的共晶体。
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公开(公告)号：WO2010014011A1
公开(公告)日：2010-02-04
申请号：PCT/NL2009/050475
申请日：2009-07-31
申请人： Feyecon Development & Implementation B.V. , Friesland Brands B.V. , Poortinga, Albert Thijs , Trambitas, Daniela Oana , Hofland, Gerard Willem
CPC分类号： A61K9/5089 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5052 , B01J13/043
摘要： The present invention relates to a microencapsulate comprising microcapsules having a diameter of 0.1 µm to 25 μm, said microcapsules comprising: -a core particle having a diameter of 90 nm to 23 μm and containing at least 3% of the active component by weight of said core particle; and -a coating that fully envelops the core particle and containing at least 20 wt.% of a hydrophobic polymer selected from cellulosic ethers, cellulosic esters, zein, shellac, gluten, polylactide, hydrophobic starch derivatives,polyvinyl acetate polymers, polymers or copolymers derived from an acrylic acid ester and/or a methacrylic acid ester and combinations thereof; wherein the core particle contains a release trigger component and/or the coating contains a release trigger component, said release trigger component being selected from: -a water-swellable polymer having a water-uptake capacity at 37 ºC and pH 7.0 of less than 20 wt.% and a water-uptake capacity at 37 ºC and pH 2.0 of at least 50 wt.%; and -an edible salt having a water solubility at 37 ºC and a pH of 7.0 of less than 1 mg/ml and a water solubility at 37 ºC and a pH of 2.0 of at least 5mg/ml; The microencapsulate of the present invention does not release the encapsulated active component when incorporated in water-containing foodstuffs, beverages,nutritional compositions or pharmaceutical compositions. Following ingestion, however, the active component is released rapidly.
摘要翻译： 本发明涉及一种包含直径为0.1μm至25μm的微胶囊的微胶囊，所述微胶囊包括： - 直径为90nm至23μm的核心颗粒，并含有至少3重量％的所述活性组分 核心颗粒; 和 - 完全包封核心颗粒并含有至少20重量％的选自纤维素醚，纤维素酯，玉米醇溶蛋白，虫胶，谷蛋白，聚丙交酯，疏水性淀粉衍生物，聚乙酸乙烯酯聚合物，聚合物或共聚物的疏水性聚合物的涂层 来自丙烯酸酯和/或甲基丙烯酸酯及其组合; 其中所述核心颗粒含有释放触发组分和/或所述涂层含有释放触发组分，所述释放触发组分选自： - 水溶胀性聚合物，其在37℃和pH 7.0下的吸水能力小于20 在37℃和pH 2.0下的吸水能力至少为50重量％; 和 - 在37℃下具有水溶解度和7.0的pH小于1mg / ml的食用盐和在37℃的水溶性和2.0的pH至少为5mg / ml的食用盐; 当掺入含水食品，饮料，营养组合物或药物组合物中时，本发明的微胶囊剂不释放包封的活性组分。 然而，摄入后，活性成分迅速释放。
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公开(公告)号：WO2009011584A3
公开(公告)日：2009-07-16
申请号：PCT/NL2008050490
申请日：2008-07-17
CPC分类号： B01J3/008 , A61K9/145 , Y02P20/544
摘要： The present invention relates to a method of preparing a pharmaceutical co-crystal composition, said method comprising the steps of: a. simultaneously contacting a supercritical or liquefied gas with solid particles of a pharmaceutically active component and with solid particles of a co-builder to form a co -crystallisation medium containing dissolved pharmaceutically active component and dissolved co-builder as well as solid particles of the pharmaceutically active component and solid particles of the co-builder; b. transforming the solid particles of the pharmaceutically active component and the solid particles of the co-builder into co-crystals of said pharmaceutically active component and said co-builder by keeping the supercritical or liquefied gas in a supercritical or liquid state until at least 80 wt.% of the pharmaceutically active component is incorporated in the crystal matrix of said co-crystals; and c. separating said co-crystals from the supercritical or liquefied gas wherein at least a fraction of the pharmaceutically active component and at least a fraction of the co-builder remain in an undissolved state during the co-crystallisation. The present method enables easy preparation of a pharmaceutical co-crystal composition containing virtually no solvent residue and can suitably be used to prepare co-crystals of highly labile pharmaceutically active components.
摘要翻译： 本发明涉及制备药物共晶组合物的方法，所述方法包括以下步骤：a。 同时使超临界或液化气体与药物活性组分的固体颗粒与共助洗剂的固体颗粒接触以形成含有溶解的药物活性组分和溶解的助洗剂以及药物活性物质的固体颗粒的共结晶培养基 助剂的组分和固体颗粒; 湾 通过将超临界或液化气体保持在超临界或液态，将药物活性组分的固体颗粒和共助洗剂的固体颗粒转化成所述药物活性组分和所述共助洗剂的共晶体，直至至少80wt 药物活性成分的％被掺入所述共晶体的晶体基质中; 和c。 将所述共晶体与超临界或液化气体分离，其中至少一部分药物活性组分和至少一部分共助洗剂在共结晶期间保持未溶解状态。 本方法能够容易地制备几乎不含溶剂残留物的药物共晶组合物，并且可以适当地用于制备高度不稳定的药物活性成分的共晶体。
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公开(公告)号：WO2012091572A1
公开(公告)日：2012-07-05
申请号：PCT/NL2011/050909
申请日：2011-12-28
IPC分类号： B01D53/26 , B01D53/28 , A23B7/022 , A23L3/42 , C10M133/08
CPC分类号： F26B5/00 , A23B7/02 , A23B7/0205 , A23B7/022 , A23L3/0155 , A23L3/3526 , A23L3/40 , A23L3/42 , B01D53/263 , B01D53/28
摘要： The invention relates to a process for dehydrating a water- containing medium, said medium being a pressurized gas having a pressure of at least 0.5 MPa, said process comprising: - contacting the water-containing medium with a dry ionic liquid choline salt to dehydrate the water-containing medium; and - separating a dehydrated medium from the hydrated ionic liquid choline salt. Ionic liquid choline salts offer the advantage that they can be regenerated very easily as they are surprisingly heat-stable. Furthermore, these liquid choline salts offer the advantage that they are non-toxic and largely inert. Thus, these ionic liquid choline salts can suitably be used to dehydrate water-containing media that are subsequently employed in the production of foodstuffs, beverages, nutritional formulations, pharmaceutical preparations etc.
摘要翻译： 本发明涉及一种使含水介质脱水的方法，所述介质是压力为至少0.5MPa的加压气体，所述方法包括：使含水介质与干燥的离子液体胆碱盐接触，使 含水介质; 和 - 从水合离子液体胆碱盐中分离脱水培养基。 离子液体胆碱盐具有非常容易再生的优点，因为它们令人惊奇地是热稳定的。 此外，这些液体胆碱盐提供的优点是它们是无毒的并且很大程度上是惰性的。 因此，这些离子液体胆碱盐可适当地用于脱水随后用于生产食品，饮料，营养制剂，药物制剂等的含水介质。
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公开(公告)号：WO2011102723A1
公开(公告)日：2011-08-25
申请号：PCT/NL2011/050117
申请日：2011-02-18
申请人： COÖPERATIE AVEBE U.A. , GIUSEPPIN, Marco Luigi Federico , SMITS, Peter Jan , HOFLAND, Gerard Willem
摘要： A method is provided for producing a dehydrated biopolymer powder, said method comprising the successive steps of: a) providing a filter cake comprising biopolymer material and 30 to 60 wt.% of water; b) contacting said filter cake with a pressurised gas to extract water from the filter cake, said pressurised gas having a pressure and a temperature below the critical point of the gas; c) separating water-containing pressurised gas from the dehydrated filter cake; and d) collecting a dehydrated biopolymer powder wherein the pressurised gas has a pressure of at least 0.6 MPa (6 bar) and up to 6 MPa (60 bar), and a temperature of 10 to 40 0C.
摘要翻译： 提供了一种用于生产脱水生物聚合物粉末的方法，所述方法包括以下连续步骤：a）提供包含生物聚合物材料和30至60重量％水的滤饼; b）使所述滤饼与加压气体接触以从滤饼中提取水，所述加压气体具有低于气体临界点的压力和温度; c）从脱水滤饼中分离含水加压气体; 和d）收集脱水生物聚合物粉末，其中加压气体具有至少0.6MPa（6bar）和高达6MPa（60bar）的压力，以及10至40℃的温度。
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