公开(公告)号：WO2019126177A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/066244

申请日：2018-12-18

申请人： DEVICOR MEDICAL PRODUCTS, INC.

发明人： KELLER, Bryan R.

IPC分类号： A61B10/02 ,  A61B10/00 ,  G01N1/28

CPC分类号： A61B10/0266 ,  A61B10/0096 ,  A61B10/0275 ,  A61B10/0283 ,  B01L3/5029 ,  B01L3/5055 ,  G01N1/06 ,  G01N1/312 ,  G01N1/36

摘要： An apparatus includes a tissue processing cassette and a biopsy device. The tissue processing cassette is sized to be used in a pathology laboratory for purposes of dehydrating, embedding and sectioning. The tissue processing cassette has at least one distal opening through which tissue samples are received and having a floor with a plurality of openings. The biopsy device is for cutting tissue samples and has a cassette holder configured to translate relative to a proximal end of the biopsy device. The cassette holder is adapted to receive the tissue processing cassette. The cassette holder has a fluid path adapted to be coupled to a vacuum source and be in fluid communication with the interior of the tissue processing cassette through the openings of the floor such that the vacuum from the vacuum source facilitates the transfer of the cut tissue samples into the received tissue processing cassette.

公开(公告)号：WO2019102504A1

公开(公告)日：2019-05-31

申请号：PCT/IT2018/000138

申请日：2018-10-26

申请人： COMETTO, Sergio ,  SERRA, Marisa

发明人： COMETTO, Sergio ,  SERRA, Marisa

IPC分类号： G01N1/36 ,  G01N1/06

CPC分类号： G01N1/36 ,  G01N1/06 ,  G01N2001/366

摘要： A disposable process chamber (10) for processing biologic material is described, comprising: a containing body (11) for housing the biologic material; holding means (12) for holding the biologic material in the containing body (11) to prevent its movement; closing means (14) associated with liquid seal to the containing body (11); and access means (15) to allow introducing and removing liquids in the disposable process chamber (10), the containing body (11) comprising an upper part (21) configured for housing the closing means (14), and a removable base (16) to allow, at the end of a embedding phase, accessing to the embedded biologic material and perform its cutting, once having removed the removable base (16).

公开(公告)号：WO2019005827A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039548

申请日：2018-06-26

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： CLARK, Joshua ,  STORBECK, Gene T. ,  KENWOOD, Shannon Smith ,  BENNING, Christopher A. ,  CURRAN, Sean ,  HEIGHTON, Sarah Jean

IPC分类号： C12N15/10 ,  B01L3/00 ,  G01N33/49 ,  B01L9/00 ,  G01N1/40 ,  C12M3/06 ,  C12M1/12

CPC分类号： G01N1/31 ,  A61B10/0283 ,  B01L3/5021 ,  B01L9/52 ,  B01L2300/0618 ,  B01L2300/0681 ,  B01L2300/12 ,  B01L2300/16 ,  B01L2400/0409 ,  C12M3/062 ,  C12M33/14 ,  C12M47/02 ,  G01N1/36 ,  G01N1/4077 ,  G01N33/5088 ,  G01N2001/2873 ,  G01N2001/4088

摘要： A cell filtration assembly adapted to capture cells from a biological sample during centrifugation includes a filter support member including a sample well and a filter membrane that spans the sample well. In some cases, the filter support member and/or the filter membrane may be adapted to be sectioned. In some cases, a protective element may be disposed over at least a portion of the filter support member in order to protect the filter support member from tissue processing reagents during processing of the cells captured from the biological sample.

公开(公告)号：WO2017190101A1

公开(公告)日：2017-11-02

申请号：PCT/US2017/030285

申请日：2017-04-28

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： CHUNG, Kwanghun ,  KU, Taeyun ,  SWANEY, Justin, Mark ,  PARK, Jeong, Yoon

IPC分类号： G01N1/30 ,  G01N1/36 ,  G01N33/68 ,  G01N33/48 ,  G01N33/58 ,  C08J3/075 ,  C08J3/21 ,  G02B21/34

CPC分类号： G01N1/30 ,  G01N1/36 ,  G01N1/38 ,  G01N33/56966

摘要： This disclosure provides methods for producing size- adjustable tissue-hydrogel hybrids or cell-hydrogel hybrids for imaging cellular and subcellular details and system-scale (e.g., tissue or organism level) intercellular connectivity.

公开(公告)号：WO2017096248A1

公开(公告)日：2017-06-08

申请号：PCT/US2016/064751

申请日：2016-12-02

申请人： CLEARLIGHT DIAGNOSTICS LLC

发明人： GOODMAN, Laurie ,  DEISSEROTH, Karl A.

IPC分类号： G01N1/28 ,  G01N1/30 ,  G01N1/31 ,  G01N1/34 ,  G01N1/36 ,  G01N21/01 ,  G01N27/26

CPC分类号： G01N21/6458 ,  G01N1/30 ,  G01N1/36 ,  G01N21/6428 ,  G01N27/44726 ,  G01N2001/4038 ,  G01N2021/6439 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/30024 ,  G06T2207/30096

摘要： The present invention provides methods for processing and analyzing large intact biological samples, including tumor tissue samples. The methods have a variety of uses, including for the diagnosis and monitoring of tumors and tumor metastasis.

摘要翻译： 本发明提供用于处理和分析大型完整生物样品（包括肿瘤组织样品）的方法。 这些方法有多种用途，包括诊断和监测肿瘤和肿瘤转移。

公开(公告)号：WO2017025767A1

公开(公告)日：2017-02-16

申请号：PCT/IB2015/002010

申请日：2015-08-11

申请人： VOGEL, Ulrich Felix

发明人： VOGEL, Ulrich Felix

IPC分类号： G01N1/36 ,  G01N35/00

CPC分类号： G01N1/36 ,  G01N2035/00772 ,  G01N2035/00831

摘要： The invention relates to coded agar bodies for being poured together with specimens into agar blocks or for being processed together with the specimens in a sealed container. The agar bodies may be coded by shape, e.g. stellate, rectangular, cylindrical, color, embedded e.g. cylindrical color codes or figures, such as numbers or letters. Thus, the specimens are marked and individualized independently of the containers at all steps of tissue processing and evaluation.

摘要翻译： 本发明涉及用于与样品一起倾倒在琼脂块中或与密封容器中的样品一起加工的编码琼脂体。 琼脂体可以通过形状编码，例如， 星形，矩形，圆柱形，彩色，嵌入式 圆柱形颜色代码或数字，如数字或字母。 因此，在组织处理和评估的所有步骤中，标本和容器都独立于容器进行标记和个体化。

公开(公告)号：WO2017023666A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/044379

申请日：2016-07-28

申请人： BIOPATH AUTOMATION, L.L.C.

发明人： WILLIAMSON IV, Warren, P.

IPC分类号： G01N1/31 ,  B01L3/00 ,  G01N1/00 ,  G01N1/28

CPC分类号： G01N1/312 ,  B01L3/50825 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/069 ,  G01N1/06 ,  G01N1/36 ,  G01N2001/315 ,  G01N2001/366

摘要： A histologic tissue sample support device (200) includes a tissue cassette (112), a frame (14), and a lid (118"). The tissue cassette (112) has a recess (112b) including a body (112a) with at least one side wall and a bottom wall (112c) and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette (112) is movably coupled to the frame (14). The lid (118") is separably coupled to a peripheral portion (16) of the frame (14). When the lid (118") is separated from the peripheral portion (16), the lid (118") and the tissue cassette (112) are capable of moving from a first position to a second position with respect to the frame (14), and in the second position the bottom wall (112c) and at least a portion of the side wall extend beyond a bottom edge of the frame (14) for sectioning in the microtome.

摘要翻译： 组织样本支持装置（200）包括组织盒（112），框架（14）和盖子（118“），所述组织盒（112）具有凹部（112b），所述凹部包括主体（112a） 至少一个侧壁和底壁（112c），并且由可以成功地切片在切片机中的材料形成并且耐受用于固定，处理和污染组织的溶剂和化学品的降解，组织盒（112）是 可移动地联接到框架（14）上。盖（118“）可分离地联接到框架（14）的周边部分（16）。 当盖（118“）与周边部分（16）分离时，盖（118）和组织带（112）能够相对于框架（14）从第一位置移动到第二位置， ，并且在第二位置中，底壁（112c）和侧壁的至少一部分延伸超过框架（14）的底部边缘以在切片机中切片。

公开(公告)号：WO2016034859A1

公开(公告)日：2016-03-10

申请号：PCT/GB2015/052482

申请日：2015-08-27

申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

发明人： LUCOCQ, John

IPC分类号： G01N1/36 ,  G01N1/28

CPC分类号： G01N1/36 ,  G01N1/2813

摘要： A method of preparing an analytical sample comprising a particulate analyte, for use in microscopy. Disclosed is a method of preparing an analytical sample comprising a particulate analyte, for use in microscopy. A liquid composition is prepared which comprises an embedding medium and the particulate analyte. The liquid composition is consolidated so as to form an analytical sample in which the particulate analyte is immobilized and dispersed within the embedding medium. The resulting analytical sample includes a dispersion of the particulate analyte within an embedding medium, which is representative of the particulate analyte when present in the liquid composition. Optionally, the analytical sample may be stained and/or calibrated using a particulate calibrant. The method is not susceptible to perturbations which might otherwise result in the properties of the analyte in the analytical sample, such as the particle size, particle size distribution, concentration or relative concentration of particles within the particulate analyte differing from those of the analyte in the liquid composition.

摘要翻译： 一种制备包含颗粒分析物的分析样品的方法，用于显微镜。 公开了一种制备包含用于显微镜的颗粒分析物的分析样品的方法。 制备包含嵌入介质和颗粒分析物的液体组合物。 将液体组合物固结以形成分析样品，其中颗粒分析物固定并分散在嵌入介质中。 所得到的分析样品包括颗粒分析物在嵌入介质中的分散体，其表示当存在于液体组合物中时颗粒分析物。 任选地，分析样品可以使用颗粒校准物染色和/或校准。 该方法不易受扰动，否则可能导致分析样品中分析物的性质，例如颗粒分析物中颗粒尺寸，颗粒分布，颗粒分析物中颗粒的浓度或相对浓度与 液体组成。

公开(公告)号：WO2015095403A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/070973

申请日：2014-12-17

申请人： ALESSI TECHNOLOGIES, INC.

发明人： ORFIELD, Nolan ,  RICH, Collin ,  ALESSI, Vincent

IPC分类号： G01N1/06

CPC分类号： G01N1/36 ,  G01N1/06 ,  G01N1/2813 ,  G01N1/312 ,  G01N1/44 ,  G01N35/00029 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2001/061 ,  G01N2035/00039 ,  G01N2035/00138 ,  G01N2035/00831

摘要： A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.

摘要翻译： 一种用于将截面安装在基底上的系统和方法，所述系统包括：流体通道，其包括：流体通道入口，其接收通过位于流体通道入口附近的样品分段模块从大块嵌入样品处理的部分， 在流体通道入口下游的安装区域和在区段安装区域下游的流体通道出口; 与流体通道出口流体连通的储存器; 以及歧管，其流体地联接到储存器，其将流体从储存器输送到流体通道入口，从而传输流体流动，其驱动区段从流体通道入口向区段安装区域的输送。

公开(公告)号：WO2015034178A1

公开(公告)日：2015-03-12

申请号：PCT/KR2014/006952

申请日：2014-07-29

申请人： 국립암센터

发明人： 장희진 ,  김선영 ,  백지연 ,  여현양

IPC分类号： C12Q1/00 ,  G01N1/28

CPC分类号： G01N33/57484 ,  G01N1/36 ,  G01N2800/54

摘要： 본 발명은 혈중암세포 진단을 위한 파라핀 블록을 제작함에 있어서 사용되는 혈중 세포 응집용 물질 및 이를 이용한 파라핀 블록의 제작방법에 관한 것으로, 보다 상세하게는 혈액 내에 미량으로 존재하는 혈중암세포(CTC)를 파라핀 블록으로 제작함에 있어서 혈액 시료의 채취를 통해 혈액 내 존재하는 혈중암세포를 검출하는 방법이며, 비침습적이고 간단하기 때문에 암의 재발 및 전이암의 진단 및 예후 예측에 매우 유용하며, 암 발병, 전이 및 재발 기전의 분석을 통해 암 치료의 획기적인 전기를 마련할 수 있다.

摘要翻译： 本发明涉及用于制备用于诊断循环肿瘤细胞的石蜡块（CTC）中用于聚集血细胞的材料，以及通过使用它们制备石蜡块的方法，更具体地，涉及一种用于 通过血液样本收集检测血液中存在的CTC，从CTC制备石蜡块，其以非常少的量存在于血液中。 本发明是非侵入性和简单的，因此对于癌症复发和转移癌的诊断和预后预测非常有用，并且可以通过分析发病，转移和复发机制的癌症治疗中的显着突破 癌症。