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公开(公告)号：WO2012097177A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/021116
申请日：2012-01-12
申请人： VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC. , HOWBERT, James, Jeffry , HERSHBERG, Robert
IPC分类号： C07D403/10 , C07D403/12 , C07D223/14 , A61K31/55 , A61P37/00
CPC分类号： C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译： 提供可用于调节通过Toll样受体TLR7和/或TLR8的信号传导的组合物和方法。 该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，传染病，炎症性疾病，移植排斥或移植物抗宿主病。
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公开(公告)号：WO2011022508A2
公开(公告)日：2011-02-24
申请号：PCT/US2010045934
申请日：2010-08-18
申请人： VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
发明人： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC分类号： C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC分类号： A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：WO2006055525A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041269
申请日：2005-11-15
申请人： CEPTYR INC , BLASKOVICH MARK A , BAUGHMAN TED , LITTLE THOMAS , PATT WILLIAM , QABAR MAHER , SCHULTZ LAURI , HONG FENG , NAGULA GANGADHAR , GAGE JENNIFER LYNN , HOWBERT JAMES JEFFRY
发明人： BLASKOVICH MARK A , BAUGHMAN TED , LITTLE THOMAS , PATT WILLIAM , QABAR MAHER , SCHULTZ LAURI , HONG FENG , NAGULA GANGADHAR , GAGE JENNIFER LYNN , HOWBERT JAMES JEFFRY
IPC分类号： A61K31/675 , A61K31/66
CPC分类号： C07F9/6541 , C07F9/3808 , C07F9/4006 , C07F9/5721 , C07F9/5728 , C07F9/591 , C07F9/65517
摘要： The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
摘要翻译： 本发明提供了可用于调节蛋白酪氨酸磷酸酶-1b（PTP1B）酶的生物学活性的式（I）和式（II）的化合物。 本发明的化合物可用于治疗其中PTP1B酶是因子的疾病和/或病症。 这些疾病和/或病症包括但不限于1型糖尿病，2型糖尿病，葡萄糖耐量不足，胰岛素抵抗，肥胖症，高脂血症，高甘油三酯血症，高胆固醇血症，低HDL水平，动脉粥样硬化，血管再狭窄，炎性肠病， 胰腺炎，脂肪细胞瘤，脂肪细胞癌，脂肪肉瘤，血脂异常，癌症和神经变性疾病。
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公开(公告)号：WO2012097177A3
公开(公告)日：2012-10-26
申请号：PCT/US2012021116
申请日：2012-01-12
IPC分类号： C07D403/10 , A61K31/55 , A61P37/00 , C07D223/14 , C07D403/12
CPC分类号： C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。
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公开(公告)号：WO2011022509A3
公开(公告)日：2011-06-16
申请号：PCT/US2010045935
申请日：2010-08-18
申请人： VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
发明人： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC分类号： C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
CPC分类号： C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：WO2011022508A3
公开(公告)日：2011-02-24
申请号：PCT/US2010/045934
申请日：2010-08-18
申请人： VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC. , HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , LYSSIKATOS, Joseph, P. , NEWHOUSE, Brad , YANG, Hong, Woon
发明人： HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , LYSSIKATOS, Joseph, P. , NEWHOUSE, Brad , YANG, Hong, Woon
IPC分类号： C07D401/14 , C07D403/10 , C07D223/14 , A61K31/454 , A61K31/4025 , A61K31/55 , A61P35/00 , A61P31/00
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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公开(公告)号：WO2006055525A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041269
申请日：2005-11-15
申请人： CEPTYR, INC. , BLASKOVICH, Mark A. , BAUGHMAN, Ted , LITTLE, Thomas , PATT, William , QABAR, Maher , SCHULTZ, Lauri , HONG, Feng , NAGULA, Gangadhar , GAGE, Jennifer Lynn , HOWBERT, James Jeffry
发明人： BLASKOVICH, Mark A. , BAUGHMAN, Ted , LITTLE, Thomas , PATT, William , QABAR, Maher , SCHULTZ, Lauri , HONG, Feng , NAGULA, Gangadhar , GAGE, Jennifer Lynn , HOWBERT, James Jeffry
摘要： The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
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公开(公告)号：WO2012097173A3
公开(公告)日：2012-09-20
申请号：PCT/US2012021110
申请日：2012-01-12
IPC分类号： C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D403/10
CPC分类号： C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译： 提供了用于调节通过Toll样受体TLR7和/或TLR8的信号转导的组合物和方法。 该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，传染病，炎症性疾病，移植排斥或移植物抗宿主疾病。
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公开(公告)号：WO2012097173A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/021110
申请日：2012-01-12
IPC分类号： C07D223/16 , C07D403/10 , A61K31/55 , A61P35/00 , A61P29/00
CPC分类号： C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：WO2011022509A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/045935
申请日：2010-08-18
申请人： VENTIRX PHARMACEUTICALS, INC. , ARRAY BIOPHARMA, INC , HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , DOHERTY, George, A. , EARY, C. Todd , GRONEBERG, Robert, D. , JONES, Zachary
发明人： HOWBERT, James, Jeffry , DIETSCH, Gregory , HERSHBERG, Robert , BURGESS, Laurence, E. , DOHERTY, George, A. , EARY, C. Todd , GRONEBERG, Robert, D. , JONES, Zachary
IPC分类号： C07D403/10 , C07D403/14 , C07D401/14 , C07D223/14 , A61K31/4025 , A61K31/55 , A61P35/00 , A61P31/00
CPC分类号： C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供用于调节通过Toll样受体TLR7和/或TLR8的信号传导的组合物和方法。 该组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎症性疾病，移植排斥反应和移植物抗宿主疾病。
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