公开(公告)号：WO2021226469A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/031314

申请日：2021-05-07

Applicant: LOUIE, Stan G. ,  HUMAYUN, Mark S. ,  MARTINEZ-CAMARILLO, Juan Carlos ,  VOJIR, Jhung Won

Inventor： LOUIE, Stan G. ,  HUMAYUN, Mark S. ,  MARTINEZ-CAMARILLO, Juan Carlos ,  VOJIR, Jhung Won

IPC: C12Q1/6883 ,  A61P27/02 ,  A61F9/008

Abstract: The effect of laser stimulation, e.g., R:GEN, of the RPE and its impact on MMPs and RAAS pathways are used to guide patient therapies. Certain biomarkers, namely MMPs, TIMPs, and components associated with RAAS, are effective indicators of healing response levels generated by the patients undergoing the therapy. An eye disease is diagnosed in a patient and a first biomarker sample is obtained from a biomatrix, e.g., patient's blood in containers with protease inhibitors. An initial subthreshold laser treatment is then performed on the eye. By monitoring the presence, amount, and relative levels of one or more of the above biomarkers as the patient heals, it is determined when the patient's body has sufficiently responded to the previous treatment, such that retreatment may be appropriate. The present disclosure demonstrates effective treatment of eye diseases, e.g., dry age-related macular degeneration, which utilize laser treatment alone or in combination with other treatments.

公开(公告)号：WO2021222888A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/030447

申请日：2021-05-03

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  LOUIE, Stan G. ,  HUMAYUN, Mark S. ,  ASANTE, Isaac ,  LAZZI, Gianluca ,  BOUTEILLER, Jean-Marie Charles

Inventor： LOUIE, Stan G. ,  HUMAYUN, Mark S. ,  ASANTE, Isaac ,  LAZZI, Gianluca ,  BOUTEILLER, Jean-Marie Charles

IPC: C07D239/47 ,  C07D487/04 ,  C07D519/00

Abstract: The disclosure provides a rapidly deployable nanoscale biodegradable system using hydroxypropyl beta cyclodextrin based combination product. Cyclodextrin is an amphiphilic polymer suitable to develop an agnostic barrier blocking pathogenic microbes that has localized on the mucocutaneous lining of the conjunctiva, mouth and nose, lung, or gastrointestinal tract. The cyclodextrin may bind the viral particles and/or disrupt viral entry mechanisms by removing cholesterol from viral particles to reduce infectivity. Cyclodextrins also may facilitate removal of the viral cholesterol molecules, thus rendering them less viable. Cyclodextrin activity may be further enhanced when used in combination with certain minerals and/or antioxidant compounds.

公开(公告)号：WO2016145068A1

公开(公告)日：2016-09-15

申请号：PCT/US2016/021544

申请日：2016-03-09

Applicant: DEBOER, Charles ,  HUMAYUN, Mark ,  TAI, Yu-Chong

Inventor： DEBOER, Charles ,  HUMAYUN, Mark ,  TAI, Yu-Chong

IPC: A61F2/16 ,  G02C7/02

CPC classification number: A61F2/1659 ,  A61F2/1637 ,  A61F2002/1699 ,  A61F2250/0004 ,  A61F2250/0053

Abstract: Embodiments of intraocular lenses described herein include features that enhance depth of focus and/or reduce chromatic aberration. These features may include different optical fluids, multiplexed or asymmetric lens arrangement, dispersive or diffusive elements, and others.

Abstract translation: 本文所述的眼内透镜的实施例包括增强焦点深度和/或减少色差的特征。 这些特征可以包括不同的光学流体，多路复用或不对称的透镜布置，分散或漫射元件等。

公开(公告)号：WO2012158773A3

公开(公告)日：2013-03-21

申请号：PCT/US2012038102

申请日：2012-05-16

Applicant: ICO INC ,  CAFFEY SEAN ,  DEBOER CHARLES ,  HUMAYUN MARK

Inventor： CAFFEY SEAN ,  DEBOER CHARLES ,  HUMAYUN MARK

IPC: A61F9/00 ,  A61F2/16

CPC classification number: A61F2/1662 ,  A61F2/1635 ,  A61F9/0008 ,  A61F2250/0002 ,  A61F2250/0003

Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens (125) may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console (200) to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post" operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.

Abstract translation: 公开了用于植入和调节调节液体透镜的灌装设备，手持工具，手术技术和术中生物测定的进展。 透镜（125）可以附接到或保持在手持式手术工具中，该手术工具可以流体地连接到填充控制台（200）以用液体填充透镜。 在各种实施例中，填充控制台便于将液体从透镜吸出，以确保在手术期间以及在后期“透镜的操作调整”期间不存在残留气泡和填充透镜。在外科医生的作用下， 灌装控制台可以从透镜吸出流体，并在插入后将流体注入透镜。

公开(公告)号：WO2012149468A2

公开(公告)日：2012-11-01

申请号：PCT/US2012/035654

申请日：2012-04-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF CALIFORNIA AT SANTA BARBARA ,  HUMAYUN, Mark ,  AHUJA, Ashish ,  TAI, Yu-Chong ,  HINTON, David ,  GRUBBS, Robert ,  BRANT, Rodrigo ,  WELLS, Trent

Inventor： HUMAYUN, Mark ,  AHUJA, Ashish ,  TAI, Yu-Chong ,  HINTON, David ,  GRUBBS, Robert ,  BRANT, Rodrigo ,  WELLS, Trent

IPC: A61B17/00 ,  A61B17/28 ,  A61K35/12 ,  A61L27/56 ,  A61F2/00

CPC classification number: A61B17/2909 ,  A61B2017/2937 ,  A61B2017/2945 ,  A61B2017/305 ,  A61F2/14 ,  A61F2/4601 ,  A61F9/0017 ,  A61F9/00736 ,  A61K35/50 ,  A61L27/16 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/50 ,  A61L2430/16 ,  A61M1/12 ,  A61M5/14 ,  A61M2202/09 ,  C12N5/0621 ,  C12N2506/02 ,  C12N2533/30 ,  C12N2533/40 ,  C12N2533/50 ,  C08L65/04 ,  C08L89/00

Abstract: Disclosed herein are instruments and methods for delivery of substrates, including cell- seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract translation: 本文公开了用于将底物（包括细胞接种的底物）递送至需要治疗诱导细胞死亡，损伤或丧失功能的各种疾病的靶组织的仪器和方法。 衬底被配置为提供包括干细胞的细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

公开(公告)号：WO2012099873A1

公开(公告)日：2012-07-26

申请号：PCT/US2012/021540

申请日：2012-01-17

Applicant: MINIPUMS, LLC ,  JOURNEY, Michelle ,  CAFFEY, Sean ,  HUMAYUN, Mark ,  HUCULAK, John

Inventor： JOURNEY, Michelle ,  CAFFEY, Sean ,  HUMAYUN, Mark ,  HUCULAK, John

IPC: A61B17/30 ,  A61B17/28

CPC classification number: A61B17/30 ,  A61B17/282 ,  A61B2017/00858 ,  A61B2017/00893 ,  A61B2017/00995 ,  A61B2017/2845 ,  A61B2017/2945 ,  A61B2017/2946 ,  A61F9/0008 ,  A61F2013/51071

Abstract: Surgical introducers aid surgeons in the implantation of medical devices. The introducer provides support and an even distribution of force for ease of insertion and prevention of damage to the medical device while protecting the tissue into which the device implanted. A representative embodiment includes or consists of a locking device, a pair of forceps, a specially configured and/or angled head with a seat for the device to be implanted, and a gripping area.

Abstract translation: 手术介绍人员帮助外科医生植入医疗器械。 引导器提供支撑和均匀的力分布，以便易于插入并防止对医疗装置的损伤，同时保护装置植入的组织。 代表性实施例包括锁定装置，一对镊子，具有用于待植入装置的座的特别构造和/或成角度的头部以及夹持区域。

公开(公告)号：WO2011085127A1

公开(公告)日：2011-07-14

申请号：PCT/US2011/020415

申请日：2011-01-06

Applicant: DOHENY EYE INSTITUTE ,  HUMAYUN, Mark ,  DEBOER, Charles ,  MCCORMICK, Matthew ,  BHADRI, Prashant ,  CICCHELLA, Joel ,  KERNS, Ralph

Inventor： HUMAYUN, Mark ,  DEBOER, Charles ,  MCCORMICK, Matthew ,  BHADRI, Prashant ,  CICCHELLA, Joel ,  KERNS, Ralph

IPC: A61B19/02

CPC classification number: A61B50/33 ,  A61B17/00 ,  A61B50/13 ,  A61B90/30 ,  A61B90/40 ,  A61B90/98 ,  A61B2017/00225 ,  A61B2017/00539 ,  A61B2017/00544 ,  A61B2017/00734 ,  A61B2017/00973 ,  A61B2050/3008 ,  A61F9/00736 ,  A61F9/00763 ,  A61M1/0066 ,  A61M3/0254 ,  A61M3/0262 ,  A61M2205/123 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/505 ,  Y10T137/8376 ,  Y10T137/86035

Abstract: A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray.

Abstract translation: 无菌手术托盘包括用于接收多个外科器械的结构。 无菌手术托盘还可以包括附接到托盘的电输入和输出连接器。

公开(公告)号：WO2011037941A1

公开(公告)日：2011-03-31

申请号：PCT/US2010/049722

申请日：2010-09-21

Applicant: DOHENY EYE INSTITUTE ,  KERNS, Ralph ,  BHADRI, Prashant ,  MCCORMICK, Matthew ,  PINTO, Anderson, Gustavo Teixeira ,  HUMAYUN, Mark ,  ARANA, Luis

Inventor： KERNS, Ralph ,  BHADRI, Prashant ,  MCCORMICK, Matthew ,  PINTO, Anderson, Gustavo Teixeira ,  HUMAYUN, Mark ,  ARANA, Luis

IPC: A61M31/00

CPC classification number: A61B17/3439 ,  A61B17/3431 ,  A61B2017/00398 ,  A61B2017/00867 ,  A61F9/007 ,  A61F9/00736

Abstract: Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end.

Abstract translation: 提供各种可调套管系统。 该系统可以包括能够膨胀和/或收缩的可调式套管，其具有带有远端和近端的细长主体。 可调套管可以联接到上壳体和下壳体，使得上壳体的旋转导致可调插管的膨胀或收缩。 可调插管还可以具有近端，其具有大于远端腔的腔。 多个凸缘可以通过多个狭缝形成在细长主体中，所述多个狭缝跨过插管的一段长度的大部分，包括沿着或靠近其近端和远端。

公开(公告)号：WO2010047703A2

公开(公告)日：2010-04-29

申请号：PCT/US2008/080832

申请日：2008-10-22

Applicant: DOHENY EYE INSTITUTE ,  HUMAYUN, Mark ,  DEBOER, Charles ,  MCCORMICK, Matthew ,  BHADRI, Prashant ,  CICCHELLA, Joel ,  KERNS, Ralph

Inventor： HUMAYUN, Mark ,  DEBOER, Charles ,  MCCORMICK, Matthew ,  BHADRI, Prashant ,  CICCHELLA, Joel ,  KERNS, Ralph

IPC: A61B19/02 ,  A61F9/007

CPC classification number: A61F9/00736 ,  A61B42/00 ,  A61B42/50 ,  A61B50/13 ,  A61B50/33 ,  A61B2017/00115 ,  A61B2050/3008 ,  A61B2090/0813

Abstract: A sterile surgical tray (10) includes structure (12) for receiving a plurality of surgical instruments (14), a pump fluid reservoir (30) within the tray (10), a pump (40) contained within the sterile tray (30) and connected to the pump fluid reservoir (30), and a motor (42) contained within the sterile tray and connected to the pump (40). Sterile surgical tray (10) also may include electrical input and output connectors attached to tray (10).

Abstract translation: （10）包括用于接收多个手术器械（14）的结构（12），在所述托盘（10）内的泵流体储存器（30），泵（40），所述泵 包含在无菌托盘（30）内并连接到泵流体储存器（30），以及包含在无菌托盘内并连接到泵（40）的马达（42）。 无菌手术盘（10）也可以包括连接到托盘（10）的电输入和输出连接器。

公开(公告)号：WO2009089094A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/030019

申请日：2009-01-02

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  MENG, Ellis ,  HUMAYUN, Mark ,  LO, Ronalee ,  LEE, Po-Ying ,  SAATI, Saloomeh

Inventor： MENG, Ellis ,  HUMAYUN, Mark ,  LO, Ronalee ,  LEE, Po-Ying ,  SAATI, Saloomeh

IPC: A61M5/158 ,  A61F7/00

CPC classification number: A61M5/427 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/158 ,  A61M5/46 ,  A61M39/0208 ,  A61M2005/14284 ,  A61M2039/0238 ,  A61M2205/3523 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/6054 ,  A61M2205/6063 ,  A61M2209/045 ,  A61M2210/0612

Abstract: In various embodiments, a needle is employed in refilling drug-delivery devices.

Abstract translation: 在各种实施方案中，使用针来重新填充药物递送装置。