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    CRYSTALLINE FEBUXOSTAT PIDOLATE SALT AND METHOD FOR PREPARING SAME
    1.
    发明申请
    CRYSTALLINE FEBUXOSTAT PIDOLATE SALT AND METHOD FOR PREPARING SAME 审中-公开
    CRYSTALLINE FEBUXOSTAT PIDOLATE盐及其制备方法

    公开(公告)号：WO2016104960A3

    公开(公告)日：2016-09-15

    申请号：PCT/KR2015012595

    申请日：2015-11-23

    申请人： J2H BIOTECH ,  HUONS CO LTD

    发明人： RYU HYUNG CHUL

    IPC分类号： C07D277/56 ,  C07D277/24

    CPC分类号： C07D277/24 ,  C07D277/56

    摘要： The present invention relates to a novel febuxostat pidolate salt used as a gout therapeutic agent and a method for preparing same. In preparing the febuxostat pidolate salt of the present invention, an equivalent and stirring time of the pidolate is adjusted in a special solvent environment, thereby enabling the obtaining of a novel crystalline salt of optimal ratio with excellent purity and yield. The novel febuxostat pidolate salt of the present invention has a chemical purity and manufacturing yield that is more excellent than a conventional febuxostat free base, exhibits excellent acid base, thermal stability, and photostability, has a solubility that is more excellent than a conventional febuxostat free base, and the particle size thereof is finer and more homogeneous than a conventional febuxostat free base, and thus is very pharmaceutically useful.

    摘要翻译： 本发明涉及用作痛风治疗剂的新型非布索坦吡酮酯盐及其制备方法。 在制备本发明的非布索坦吡酮酸盐时，在特定溶剂环境下调节吡酮酸盐的当量和搅拌时间，由此能够获得具有优异纯度和收率的最佳比例的新型结晶盐。 本发明的新型非布索坦吡酮酯盐具有比常规非布索坦游离碱更优异的化学纯度和制造产率，表现出优异的酸碱，热稳定性和光稳定性，其溶解度比常规非布司他自由基 并且其粒度比常规非布索坦游离碱更精细和更均匀，因此是非常药学上有用的。

    METHOD FOR PREPARING A USEFUL SECONDARY METABOLITE BY EFFECTIVE ELIMINATION OF BIOLOGICAL BY-PRODUCTS
    2.
    发明申请
    METHOD FOR PREPARING A USEFUL SECONDARY METABOLITE BY EFFECTIVE ELIMINATION OF BIOLOGICAL BY-PRODUCTS 审中-公开
    通过有效消除生物副产物制备有用的次生代谢物的方法

    公开(公告)号：WO2006098585A1

    公开(公告)日：2006-09-21

    申请号：PCT/KR2006/000926

    申请日：2006-03-15

    申请人： SUNGKYUNKWAN UNIVERSITY FOUNDATION CORPORATE COLLABORATION ,  HUONS CO., LTD. ,  SIM, Sang-Jun ,  PARK, Sang-Woo ,  YOON, Sung-Tae

    发明人： SIM, Sang-Jun ,  PARK, Sang-Woo ,  YOON, Sung-Tae

    IPC分类号： C12P1/04

    CPC分类号： C12P17/181

    摘要： The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more particularly, in order to efficiently eliminate biological by-products formed during the culture of Soragium cellulosum , the present invention relates to a method for producing epothilones comprising that a cation exchange resin is added to said culture medium or said culture broth is recirculated through a column charged with a cation exchagen resin. According to the present invention, the effective elimination of by-products formed during the culture of Sorangium celluosum enhances growth rate of the microorganism as well as dramatically improves productivity of epothilones, a useful secondary metabolite.

    摘要翻译： 本发明涉及通过在有用的次生代谢产物微生物的培养期间有效地消除生物副产物来提高有用的次级代谢产物的生产率的方法，更具体地说，为了有效地消除在 本发明涉及一种生产埃坡霉素的方法，包括将阳离子交换树脂加入到所述培养基中，或者所述培养液通过装有阳离子交换树脂的柱再循环。 根据本发明，有效消除了在培养山梨酸纤维素生长速率的微生物期间形成的副产物，并且显着地提高了有效的二次代谢物埃坡霉素的生产率。

    A METHOD FOR PREPARING A PURIFIED EXTRACT OF LONICERA JAPONICA THUNBERG AND THE COMPOSITION COMPRISING THE SAME FOR PREVENTING AND TREATING SEPSIS AND SEPTIC SHOCK.
    3.
    发明申请
    A METHOD FOR PREPARING A PURIFIED EXTRACT OF LONICERA JAPONICA THUNBERG AND THE COMPOSITION COMPRISING THE SAME FOR PREVENTING AND TREATING SEPSIS AND SEPTIC SHOCK. 审中-公开
    一种用于制备LONICERA JAPONICA THUNBERG的纯化提取物的方法和包含其的组合物，用于预防和治疗痉挛和分裂性震动。

    公开(公告)号：WO2013162135A1

    公开(公告)日：2013-10-31

    申请号：PCT/KR2012/009100

    申请日：2012-11-01

    申请人： HUONS CO., LTD.

    发明人： YOON, Sung Tae ,  KIM, Jeong Hoon ,  LIM, Bang Ho ,  KIM, Young Mok ,  YEON, Sung Hum ,  KIM, Hyun Soo ,  LEE, Sun-Mee

    IPC分类号： A61K36/355 ,  A61K36/35 ,  A61P29/00

    CPC分类号： A61K36/355 ,  A23L33/105 ,  A61K45/06 ,  A61K2236/00

    摘要： The present invention relates to a method for preparing a purified extract of Lonicera Japonica THUNBERG and the composition comprising the same for preventing and treating sepsis and septic shock. The purified extract of purified extract of Lonicera Japonica THUNBERG potent ant-sepsis activity in severe sepsis CLP model test, the effect on MODS, and the inhibitory effect on various pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IFN-gamma, HMGB-1 etc, as well as it showed unexpectedly synergistic effect on the treatment of sepsis and septic shock in case of combining with the commercially available anti-septic agent such as broad-spectrum anti-biotic to the person skilled in the art, therefore, it can be useful in treating and preventing the sepsis and septic shock as a medicament and health functional food.

    摘要翻译： 本发明涉及一种制备金银花精纯提取物的方法及其组合物，其用于预防和治疗败血症和败血性休克。 枸杞精纯提取物纯化提取物THUNBERG在严重脓毒症CLP模型试验中有效的抗脓毒症活性，对MODS的作用，以及对各种促炎细胞因子如TNF-α，IL-1β，IFN-γ的抑制作用 HMGB-1等，并且在与商业上可获得的抗脓毒剂如本领域技术人员的广谱抗生素抗性相结合的情况下，显示出对败血症和败血性休克治疗的意外协同效应， 因此，它可用于治疗和预防败血症和败血性休克作为药物和保健功能性食物。

    EYE-DROP COMPOSITION FOR PREVENTING OR TREATING OCULAR DISEASES
    5.
    发明申请
    EYE-DROP COMPOSITION FOR PREVENTING OR TREATING OCULAR DISEASES 审中-公开
    用于预防或治疗眼部疾病的眼药水组合物

    公开(公告)号：WO2012169849A3

    公开(公告)日：2013-03-07

    申请号：PCT/KR2012004578

    申请日：2012-06-09

    申请人： HUONS CO LTD ,  YOON SUNG-TAE ,  JUN JAE-KAP ,  YOU HUEON-SOOK ,  KIM GI HWAN

    发明人： YOON SUNG-TAE ,  JUN JAE-KAP ,  YOU HUEON-SOOK ,  KIM GI HWAN

    IPC分类号： A61K31/728 ,  A61K33/06 ,  A61P27/00 ,  A61P27/02

    CPC分类号： A61K31/728 ,  A61K9/0048 ,  A61K33/06 ,  A61K33/14 ,  A61K33/22 ,  A61K33/42 ,  A61K47/02 ,  A61K47/183 ,  A61K47/36 ,  A61K2300/00

    摘要： Disclosed herein is an eye-drop composition for preventing or treating ocular diseases, which includes hyaluronic acid or a salt thereof, a magnesium ion, a sodium ion, a potassium ion and a chloride ion. The eye-drop composition may further include a phosphate ion, an aminocaproate ion, an edetate ion and a tetraborate ion. The eye-drop composition can effectively prevent or treat xerophthalmia and corneal damage, and can effectively prevent the propagation of bacteria for a long period of time, and can thus be suitably used several times over a predetermined period of time as well as a single time.

    摘要翻译： 本文公开了一种用于预防或治疗眼部疾病的滴眼剂组合物，其包括透明质酸或其盐，镁离子，钠离子，钾离子和氯离子。 滴眼剂组合物可进一步包括磷酸根离子，氨基己酸根离子，乙二胺四乙酸离子和四硼酸根离子。 滴眼液组合物可以有效预防或治疗干眼症和角膜损伤，可以有效防止细菌长期繁殖，因此可以在预定的时间内单次适当使用多次 。