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    ROBOTIC SYSTEM
    2.
    发明申请
    ROBOTIC SYSTEM 审中-公开

    公开(公告)号：WO2020144714A1

    公开(公告)日：2020-07-16

    申请号：PCT/IN2020/050031

    申请日：2020-01-10

    申请人： INDIAN COUNCIL OF MEDICAL RESEARCH ,  INDIAN INSTITUTE OF TECHNOLOGY, BOMBAY

    发明人： PRASANNA S., Gandhi ,  CHINMAY PRAKASH, Nakhwa ,  SANA NASSAR, Syed ,  SURAJ SANJAY, Shimpi

    IPC分类号： A61B34/30

    摘要： The present disclosure relates to a robotic system (100) used for performing minimally invasive surgery. The robotic system (100) comprises a first actuator (104-1), a second actuator (106-1), a third actuator (110-1) and a tool (116). The second actuator (106-1) is connected with the first actuator (104-1) configured to move the second actuator (106-1) about a first axis (X). The third actuator (110-1) is connected with the second actuator (106-1) configured to move the third actuator (110-1) about a second axis (Y) orthogonal to the first axis (X). The third actuator (110-1) is configured to move a tool (116) along a third axis (Z) orthogonal to the second axis (Y) and first axis (X). The robotic system (100) further comprises at least one compliant RCM mechanism (104-2, 106-2) configured to connect the first actuator (104-1) to the second actuator (106-1) and, the second actuator (106-1) to the third actuator (110-1).

    RNAI AGENT FOR INHIBITION OF CHIKUNGUNYA VIRUS
    5.
    发明申请
    RNAI AGENT FOR INHIBITION OF CHIKUNGUNYA VIRUS 审中-公开
    用于抑制CHIKUNGUNYA病毒的RNAI代理

    公开(公告)号：WO2015001570A1

    公开(公告)日：2015-01-08

    申请号：PCT/IN2014/000441

    申请日：2014-07-02

    申请人： INDIAN COUNCIL OF MEDICAL RESEARCH

    发明人： PARASHAR, DEEPTI ,  ARANKALLE, A. , VIDYA ,  PAINGANKAR, S., MANDAR ,  KUMAR, SATYENDRA ,  GOKHALE, D., MANGESH ,  SUDEEP, B., A. ,  SHINDE, S., SAPNA

    IPC分类号： C12N15/113 ,  A61P31/14 ,  A61K31/713

    CPC分类号： C12N15/1131 ,  A61K31/713 ,  C12N2310/14 ,  C12N2320/30

    摘要： The present invention relates to RNAi agents for inhibition of Chikungunya virus are described herein. The present invention provides RNAi agents for inhibition of Chikungunya virus, particularly by targeting the E2 gene and nsPl gene or both of the Chikungunya virus; the RNAi agents comprising of the entire nucleotide sequence set forth is SEQ ID 1 or SEQ ID 5 or combination thereof; or comprising of 15 or more contiguous nucleotides as set forth is SEQ ID 1 or SEQ ID 5 or combination thereof along with the addition nucleotides from the contiguous region of the E2 and nsPl target gene. The invention further provides a RNAi composition for reducing the E2 protein and nsPl protein level of Chikungunya virus and inhibition of Chikungunya virus replication. The combination of RNAi agents provides an excellent therapeutic composition for treatment of Chikungunya virus infection.

    摘要翻译： 本发明涉及用于抑制基孔肯雅病毒的RNAi剂。 本发明提供用于抑制基孔肯雅病毒的RNAi试剂，特别是通过靶向E2基因和nsP1基因或两者基孔肯雅病毒; 包含所述全部核苷酸序列的RNAi试剂是SEQ ID 1或SEQ ID 5或其组合; 或包含15个或更多个连续核苷酸，如SEQ ID 1或SEQ ID 5或其组合以及来自E2和nsP1靶基因的连续区域的加成核苷酸。 本发明还提供了用于降低基孔肯雅病毒的E2蛋白和nsP1蛋白水平的RNAi组合物，并抑制基孔肯雅病毒复制。 RNAi剂的组合提供了治疗基孔肯雅病毒感染的极好的治疗组合物。

    A RAPID AND SENSITIVE METHOD FOR DETECTING SARS-COV-2
    7.
    发明申请
    A RAPID AND SENSITIVE METHOD FOR DETECTING SARS-COV-2 审中-公开

    公开(公告)号：WO2021245708A1

    公开(公告)日：2021-12-09

    申请号：PCT/IN2021/050549

    申请日：2021-06-05

    申请人： INDIAN COUNCIL OF MEDICAL RESEARCH

    发明人： NANDI, Shyam Sundar ,  LAMBE, Upendra Pradeep ,  SAWANT, Sonali Ankush ,  GOHIL, Trupti Shashikant ,  DESHPANDE, Jagadish Mohan

    IPC分类号： C12Q1/70 ,  C12Q1/68

    摘要： The present invention provides a rapid and sensitive method for detecting SARS-CoV-2. More particularly, the present invention provides a method comprising the steps: (i) providing a biological sample and extracting RNA; (ii) adding RNA sample of step (i) to a set of loop-mediated isothermal amplification (LAMP) primers specific for genes selected from envelope protein (E), membrane glycoprotein (M), spike glycoprotein (S), nucleocapsid protein (N) and RNA dependent RNA polymerase (RdRp); wherein the set of primers are selected from the group consisting of SEQ ID NOs: 1-50; (iii) incubating the sample of step (ii) with a colorimetric LAMP reagent in a reaction mixture at a temperature 65ºC for 30 minutes; and (iv) obtaining a visual change in the reaction mixture. The present method is specific and results can be observed by naked eyes.

    A PEPTIDE TO NEUTRALIZE LIPOPOLYSACCHARIDE MOLECULE
    10.
    发明申请
    A PEPTIDE TO NEUTRALIZE LIPOPOLYSACCHARIDE MOLECULE 审中-公开
    一种使中性脂多糖分子中和的肽

    公开(公告)号：WO2016132377A1

    公开(公告)日：2016-08-25

    申请号：PCT/IN2016/000040

    申请日：2016-02-09

    申请人： INDIAN COUNCIL OF MEDICAL RESEARCH ,  BOSE INSTITUTE

    发明人： DAS, SANTASABUJ ,  BHUNIA, ANIRBUN

    IPC分类号： C07K7/06

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： A peptide to neutralize lipopolysaccharide molecule comprising an amino acid sequence set forth in sequence ID 2. A peptide that could be a prime target for pharmacological intervention towards development of effective anti- sepsis drugs.

    摘要翻译： 用于中和包含序列ID 2所示的氨基酸序列的脂多糖分子的肽。可以作为用于开发有效抗脓毒症药物的药物干预的主要靶标的肽。