公开(公告)号：WO2009110523A3

公开(公告)日：2009-12-10

申请号：PCT/JP2009054107

申请日：2009-02-26

Applicant: UNIV KYOTO ,  CANON KK ,  YOSHIMURA KIMIHIRO ,  TSUZUKI HIDETOSHI ,  YANO TETSUYA ,  TOMIDA YOSHINORI ,  ITO SHINZABURO ,  NITAHARA SATOSHI ,  AOKI HIROYUKI

Inventor： YOSHIMURA KIMIHIRO ,  TSUZUKI HIDETOSHI ,  YANO TETSUYA ,  TOMIDA YOSHINORI ,  ITO SHINZABURO ,  NITAHARA SATOSHI ,  AOKI HIROYUKI

IPC: A61K49/10 ,  C08F10/00 ,  C08G69/00

CPC classification number: C08G83/003 ,  A61K49/124 ,  C08G73/028 ,  C08L101/04

Abstract: Provided is a dendrimer particle having a unit that contains a fluorine atom at a plurality of branch ends of an aliphatic branched polymer (dendrimer). Further, the dendrimer particle is produced using an atom transfer radical polymerization method or the like. Thus, an F-MRI contrast medium, dendrimer particles with high contrast sensitivity and a rigorously controlled size and a method of manufacturing the same are provided.

Abstract translation: 本发明提供具有在脂肪族支化聚合物（树枝状大分子）的多个分支末端含有氟原子的单元的树枝状大分子粒子。 此外，树枝状聚合物粒子使用原子转移自由基聚合法等来制造。 因此，提供了具有高对比敏感度和严格控制尺寸的F-MRI造影剂，树枝状大分子颗粒及其制造方法。

公开(公告)号：WO2012026608A1

公开(公告)日：2012-03-01

申请号：PCT/JP2011/069370

申请日：2011-08-23

Applicant: CANON KABUSHIKI KAISHA ,  ITO, Shinzaburo ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  FUKUI, Tatsuki ,  KATO, Kouichi ,  YAMAUCHI, Fumio ,  TOMIDA, Yoshinori ,  YUASA, Satoshi ,  YANO, Tetsuya ,  OGAWA, Satoshi ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

Inventor： ITO, Shinzaburo ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  FUKUI, Tatsuki ,  KATO, Kouichi ,  YAMAUCHI, Fumio ,  TOMIDA, Yoshinori ,  YUASA, Satoshi ,  YANO, Tetsuya ,  OGAWA, Satoshi ,  KANAZAKI, Kengo ,  SASAGURI, Daisuke ,  TAKAHASHI, Atsushi

IPC: A61K49/00 ,  A61K49/22 ,  B82Y5/00 ,  A61K9/51

CPC classification number: A61K49/0093 ,  A61K9/5153 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/225 ,  B82Y15/00 ,  B82Y30/00

Abstract: There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

Abstract translation: 提供了一种负载ICG的聚合物纳米颗粒，其动态稳定，防止所含ICG的泄漏和所得的变色，并具有高的摩尔吸光系数。 该颗粒含有具有磺酸盐基团和疏水性聚合物的亲水性染料，并且该颗粒还含有具有带正电荷区域的脂质，烟酸衍生物和硫胺衍生物中的至少一种。

公开(公告)号：WO2009110523A2

公开(公告)日：2009-09-11

申请号：PCT/JP2009/054107

申请日：2009-02-26

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  YOSHIMURA, Kimihiro ,  TSUZUKI, Hidetoshi ,  YANO, Tetsuya ,  TOMIDA, Yoshinori ,  ITO, Shinzaburo ,  NITAHARA, Satoshi ,  AOKI, Hiroyuki

Inventor： YOSHIMURA, Kimihiro ,  TSUZUKI, Hidetoshi ,  YANO, Tetsuya ,  TOMIDA, Yoshinori ,  ITO, Shinzaburo ,  NITAHARA, Satoshi ,  AOKI, Hiroyuki

IPC: A61K49/10 ,  C08G69/00 ,  C08F10/00

CPC classification number: C08G83/003 ,  A61K49/124 ,  C08G73/028 ,  C08L101/04

Abstract: Provided is a dendrimer particle having a unit that contains a fluorine atom at a plurality of branch ends of an aliphatic branched polymer (dendrimer). Further, the dendrimer particle is produced using an atom transfer radical polymerization method or the like. Thus, an F-MRI contrast medium, dendrimer particles with high contrast sensitivity and a rigorously controlled size and a method of manufacturing the same are provided.

Abstract translation: 提供了在脂肪族支链聚合物（树枝状大分子）的多个分支端具有含有氟原子的单元的树枝状大分子粒子。 此外，使用原子转移自由基聚合法等制造树枝状大分子粒子。 因此，提供了F-MRI造影剂，具有高对比度灵敏度的树枝状大分子颗粒和严格控制的尺寸及其制造方法。

公开(公告)号：WO2009107859A3

公开(公告)日：2009-09-03

申请号：PCT/JP2009/054108

申请日：2009-02-26

Applicant: KYOTO UNIVERSITY ,  CANON KABUSHIKI KAISHA ,  ITO, Shinzaburo ,  NITAHARA, Satoshi ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  TOMIDA, Yoshinori ,  YANO, Tetsuya ,  YOSHIMURA, Kimihiro

Inventor： ITO, Shinzaburo ,  NITAHARA, Satoshi ,  AOKI, Hiroyuki ,  MINAMI, Masato ,  TOMIDA, Yoshinori ,  YANO, Tetsuya ,  YOSHIMURA, Kimihiro

IPC: C09B67/00

Abstract: Provided are polymer nanoparticles each having a fluorescent dye dispersed in the matrix of a fluorescent polymer, characterized in that the surface of the nanoparticles is protected by a surfactant and fluorescence is emitted via FRET between the fluorescent polymer and the fluorescent dye, and a contrast agent for optical molecular imaging using the polymer nanoparticles.

公开(公告)号：WO2009107859A2

公开(公告)日：2009-09-03

申请号：PCT/JP2009054108

申请日：2009-02-26

Applicant: UNIV KYOTO ,  CANON KK ,  ITO SHINZABURO ,  NITAHARA SATOSHI ,  AOKI HIROYUKI ,  MINAMI MASATO ,  TOMIDA YOSHINORI ,  YANO TETSUYA ,  YOSHIMURA KIMIHIRO

Inventor： ITO SHINZABURO ,  NITAHARA SATOSHI ,  AOKI HIROYUKI ,  MINAMI MASATO ,  TOMIDA YOSHINORI ,  YANO TETSUYA ,  YOSHIMURA KIMIHIRO

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0036 ,  A61K49/0093 ,  C09B23/083 ,  C09B23/086 ,  C09B67/0097 ,  C09B69/10 ,  C09B69/105

Abstract: Provided are polymer nanoparticles each having a fluorescent dye dispersed in the matrix of a fluorescent polymer, characterized in that the surface of the nanoparticles is protected by a surfactant and fluorescence is emitted via FRET between the fluorescent polymer and the fluorescent dye, and a contrast agent for optical molecular imaging using the polymer nanoparticles.

Abstract translation: 所提供的聚合物纳米粒子各自具有分散在荧光聚合物基体中的荧光染料，其特征在于纳米颗粒的表面被表面活性剂保护，荧光通过荧光聚合物和荧光染料之间的FRET发射，造影剂 用于使用聚合物纳米颗粒的光学分子成像。