公开(公告)号：WO2003078383A1

公开(公告)日：2003-09-25

申请号：PCT/KR2002/001377

申请日：2002-07-22

Applicant: PARK, Yong Serk ,  KIM, Hong Sung ,  MOON, Jae Ho ,  JANG, Doo Ok ,  HEO, Yeon

Inventor： PARK, Yong Serk ,  KIM, Hong Sung ,  MOON, Jae Ho ,  JANG, Doo Ok ,  HEO, Yeon

IPC: C07C237/12

CPC classification number: C12N15/88 ,  A61K9/1272 ,  A61K38/00 ,  C07K5/06086

Abstract: The present invention relates to positively charged lipids prepared by linking salt forms of acidic amino acid with a variety of lengths of hydrocarbon chain, a process for preparing the lipids, and liposomes comprising the said positively charged lipids. Positively charged lipids of the invention can be practically applied for the preparation of liposomes for gene therapy, since they provide better characteristics than the conventional positively charged lipids in terms of gene delivery efficiency and biocompatibility.

Abstract translation: 本发明涉及通过将酸性氨基酸的盐形式与多种长度的烃链连接而制备的带正电荷的脂质，制备脂质的方法和包含所述带正电荷的脂质的脂质体。 本发明的带正电荷的脂质可以实际应用于制备用于基因治疗的脂质体，因为它们在基因递送效率和生物相容性方面提供比常规带正电荷的脂质更好的特征。

公开(公告)号：WO2008072850A1

公开(公告)日：2008-06-19

申请号：PCT/KR2007/006192

申请日：2007-12-03

Applicant: AMOREPACIFIC CORPORATION ,  CRYSTALGENOMICS, INC. ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY of Yonsei University ,  JOO, Yung Hyup ,  KANG, Seung-hyun ,  HONG, Yong Deog ,  KIM, Yeonjoon ,  BYOUN, KyoungHee ,  WOO, Byoung Young ,  PARK, Miyoung ,  HA, Jun Yong ,  KOH, Hyunju ,  LIM, Kyung Min ,  KIM, Chae-wook ,  LEE, Byoung-seok ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  LEE, Kyung Ho ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

Inventor： JOO, Yung Hyup ,  KANG, Seung-hyun ,  HONG, Yong Deog ,  KIM, Yeonjoon ,  BYOUN, KyoungHee ,  WOO, Byoung Young ,  PARK, Miyoung ,  HA, Jun Yong ,  KOH, Hyunju ,  LIM, Kyung Min ,  KIM, Chae-wook ,  LEE, Byoung-seok ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  LEE, Kyung Ho ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

IPC: C07D413/14 ,  C07D251/72 ,  C07D251/02 ,  C07D215/00 ,  C07D265/00 ,  C07D207/00 ,  C07D221/00 ,  A61K31/47 ,  A61K31/53 ,  A61P7/00

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a novel triazine derivative or a pharmaceutically acceptable salt thereof, and an Acetyl-CoA Carboxylase (ACC) comprising same as an active ingredient. The triazine derivative of the present invention effectively inhibits the activity of ACC and it may be used for preventing or treating obesity, diabetes, dyslipidemia and diseases related to metabolic syndrome.

Abstract translation: 本发明涉及一种新型的三嗪衍生物或其药学上可接受的盐，以及含有作为活性成分的乙酰辅酶A羧化酶（ACC）。 本发明的三嗪衍生物有效抑制ACC的活性，可用于预防或治疗肥胖症，糖尿病，血脂异常和与代谢综合征有关的疾病。

公开(公告)号：WO2008069500A1

公开(公告)日：2008-06-12

申请号：PCT/KR2007/006136

申请日：2007-11-30

Applicant: AMOREPACIFIC CORPORATION ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  CRYSTALGENOMICS, INC. ,  HONG, Yong Deog ,  KANG, Seung-hyun ,  KIM, Yeonjoon ,  BYOUN, Kyoung Hee ,  WOO, Byoung Young ,  PARK, Miyoung ,  JOO, Yung Hyup ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  CHEON, Younghoon ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

Inventor： HONG, Yong Deog ,  KANG, Seung-hyun ,  KIM, Yeonjoon ,  BYOUN, Kyoung Hee ,  WOO, Byoung Young ,  PARK, Miyoung ,  JOO, Yung Hyup ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  CHEON, Younghoon ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to a novel triazolopyridazine derivative or a pharmaceutically acceptable salt thereof, and an Acetyl-CoA Carboxylase2 (ACC2) comprising same as an active ingredient. The triazolopyridazine derivative of the present invention effectively inhibits the activity of ACC2 and it may be used for preventing or treating obesity, diabetes, dyslipidemia and diseases related to metabolic syndrome.

Abstract translation: 本发明涉及一种新的三唑并哒嗪衍生物或其药学上可接受的盐，以及含有作为活性成分的乙酰辅酶A羧化酶2（ACC2）。 本发明的三唑并哒嗪衍生物有效抑制ACC2的活性，可用于预防或治疗肥胖症，糖尿病，血脂异常和与代谢综合征有关的疾病。