Abstract:
The present invention relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diabetes, containing the same as an active ingredient. According to the present invention, it is possible to increase the yield of a PEGylated exendin-4 analogue and to enhance the therapeutic effect of a drug through the selective PEGylation of cysteine using exendin-4 in which said cysteine (Cys) is introduced at position 40 of the C terminal, and thus it is possible to usefully employ the same in a composition for preventing or treating diseases caused by the hypersecretion of insulin.
Abstract:
Disclosed is a functional synthetic fiber and a method of producing the same. The method includes wet-pulverizing a functional material so that a particle size of the functional material does not exceed 1/3 of a desired fiber diameter, drying the pulverized functional material, and re- pulverizing the dried functional material so that the particle size of the dried functional material does not exceed 3/4 of the desired fiber diameter, to produce a master batch chip. The production of the functional synthetic fiber is consecutively carried out for 3 days or more, and the functional synthetic fiber has deodorization, antibacterial properties, whiteness of 93 % or more, and tenacity of 3.8 g/d or more. The functional synthetic fiber is advantageous in that it is possible to conduct consecutive production for 3 days or more, excellent deodorization and an¬ tibacterial properties are assured, and whiteness and tenacity are improved to a level similar to a typical synthetic fiber, thereby avoiding the disadvantages of conventional functional synthetic fiber.
Abstract:
The present invention relates to an extract of Artemisia (A. asiatica, A. mongolica, A. princeps, and A. argyi) from which harmful ingredients showing blood coagulation inhibitory action were removed selectively without loss of eupatilin, jaceosidin and artemicapin C contents, a method to prepare said Artemisia extract, a therapeutic or preventive pharmaceutical composition for gastrointestinal disease containing said Artemisia extract as an effective ingredient, a therapeutic or preventive pharmaceutical composition for gastrointestinal disease containing artemicapin C of a constituent of said Artemisia extract as an effective ingredient, and a pharmaceutical composition of Artemisia extract comprising said Artemisia extract, surfactant and co-solvent.
Abstract:
Disclosed is a synthetic fiber, including hollow sphere-shaped particles each formed of any one selected from among an inorganic material, an organic material, or combinations thereof, which is advantageous in terms of a low specific gravity, thereby effectively solving conventional wearing problems.
Abstract:
Provided is a method for manufacturing a mixed catalyst containing a metal oxide nanowire, and an electrode and a fuel cell which include a mixed catalyst manufactured by said method. The method for manufacturing the mixed catalyst comprises the steps of: forming a metal/polymer mixture nanowire by electrospinning a polymer solution containing a first metal precursor and a second metal precursor; forming a metal oxide nanowire by heat-treating the metal/polymer mixture nanowire; and mixing the metal oxide nanowire with active metal nanoparticles. Here, the metal of the second metal precursor is used as a dopant for the metal oxide nanowire. In the event an electrode catalyst layer of a fuel cell is formed using the manufactured mixed catalyst, the fuel cell has the advantages of significantly improved performance and reduced costs in generating electricity.
Abstract:
The present invention relates to a DNA vaccine that can effectively induce immune responses specific to multiple antigens for treating chronic Hepatitis B, and to a method for preparing the DNA vaccine, wherein said DNA vaccine comprises antigenic genes encoding hepatitis B surface antigen (HBsAg), an L protein, a core, and a polymerase, and preferably further IL-12 variant as an adjuvant. The antigenic genes of said vaccine enhance the expression of antigens through codon-optimization, and effectively induce antibody responses specific to antigen used and cell-mediated immune responses. Accordingly, the DNA vaccine of the invention can be effectively used for curing chronic Hepatitis B.
Abstract:
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG- TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.
Abstract:
The present invention relates to novel flavone/flavanone compounds or their pharmaceutically acceptable salts and process for preparation thereof for protecting gastrointestinal tracts against gastritis, ulcers and inflammatory bowel disease.
Abstract:
The present invention relates to a neck pillow having a hair insertion opening, which enables a user, whose hair is tied back and who is sitting in an automobile seat or chair, to amply and comfortably recline the back of the head and neck thereof rearward and also to receive a massage on the rear of the neck due to a storage pocket capable of receiving a hot pack or ice pack on one side of the neck pillow. To achieve the above, the present invention relates to a neck pillow having a body tube formed in a rounded U-shape so as to fit the circumference of the neck of the user, wherein the neck pillow comprises a supporting portion extending vertically upward from the rounded portion of the body tube so as to support the back of the head when the body tube encloses the neck, and the supporting portion defines an insertion opening in the center thereof to receive a tied hair portion at the back of the head of the user when inserted therein.
Abstract:
The present invention relates to a method for mass-production of human follicle stimulating hormone, more precisely, to an expression vector containing human follicle stimulating hormone gene, a transformant transfected with the expression vector and a method for mass-production of human follicle stimulating hormone by using the same. Human follicle stimulating hormone can be produced largely by using an expression vector and a transformant of the present invention. Therefore the expression vector and the transformant of the present invention can be effectively used for the treatment of infertility.