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    SYSTEM AND METHODS FOR THE PRODUCTION OF PERSONALIZED DRUG PRODUCTS
    1.
    发明申请
    SYSTEM AND METHODS FOR THE PRODUCTION OF PERSONALIZED DRUG PRODUCTS 审中-公开
    用于生产个人化药品的系统和方法

    公开(公告)号：WO2012021899A2

    公开(公告)日：2012-02-16

    申请号：PCT/US2011/047809

    申请日：2011-08-15

    Applicant: KRAFT, Daniel, L. ,  INTELLIMEDICINE, INC.

    Inventor： KRAFT, Daniel, L.

    IPC: G06Q50/00 ,  G06F7/00 ,  B65D41/00 ,  A61B19/02 ,  A61M35/00

    CPC classification number: B65D51/2828 ,  A61J1/03 ,  A61J3/074 ,  A61J2200/30 ,  A61J2205/60 ,  A61M35/00 ,  A61M2205/52 ,  A61M2205/6009 ,  A61M2205/6054 ,  G06F19/00 ,  G06F19/3456 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26

    Abstract: A system and method for determining an optimal combination drug product for a particular patient includes a processor that receives patient information and determines an optimal combination drug product based on the received information. A system which can provide information regarding predicted events or pathologies based on received patient information and guidance on subsequent steps to ameliorate, treat or intervent. A drug production device includes a plurality of drug containers, each of which are coupled to a drug dispensing channel. A controller controls the dispensing of drug through each channel, and a combination drug product is produced from the dispensed drugs. A combination drug product includes a plurality of discrete units of a first drug, and a plurality of discrete units of a second drug. A transdermal patch includes a plurality of drug compartments, each containing a quantity of drug product, and a controller for controlling the release of drugs from each compartment. Feedback loop elements can enable iterations to optimized personalized doses.

    Abstract translation: 用于确定特定患者的最佳组合药物产品的系统和方法包括接收患者信息并基于所接收的信息确定最佳组合药物产品的处理器。 可以基于接收到的患者信息提供关于预测事件或病变的信息的系统，以及关于随后的改善，治疗或干预的步骤的指导。 药物生产装置包括多个药物容器，每个药物容器联接到药物分配通道。 控制器通过每个通道控制药物的分配，并且从分配的药物产生组合药物产品。 组合药物产品包括第一药物的多个离散单元和第二药物的多个离散单元。 透皮贴剂包括多个药物隔室，每个药物隔室含有一定数量的药物产品，以及用于控制药物从每个隔室释放的控制器。 反馈回路元素可以实现迭代以优化个性化剂量。

    SYSTEM AND METHODS FOR THE PRODUCTION OF PERSONALIZED DRUG PRODUCTS
    3.
    发明申请
    SYSTEM AND METHODS FOR THE PRODUCTION OF PERSONALIZED DRUG PRODUCTS 审中-公开
    用于生产个人化药品的系统和方法

    公开(公告)号：WO2012021899A3

    公开(公告)日：2012-05-10

    申请号：PCT/US2011047809

    申请日：2011-08-15

    Applicant: KRAFT DANIEL L ,  INTELLIMEDICINE INC

    Inventor： KRAFT DANIEL L

    IPC: G06Q50/00

    CPC classification number: B65D51/2828 ,  A61J1/03 ,  A61J3/074 ,  A61J2200/30 ,  A61J2205/60 ,  A61M35/00 ,  A61M2205/52 ,  A61M2205/6009 ,  A61M2205/6054 ,  G06F19/3456 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Determining an optimal combination drug product for a particular patient includes a processor that receives patient information and determines an optimal combination drug product based on the received information. A system provides information regarding predicted events or pathologies based on received patient information and guidance on subsequent steps to ameliorate, treat or intervent. A drug production device includes a plurality of drug containers, coupled to a drug dispensing channel. A controller controls the dispensing of drug through each channel, a combination drug product is produced from dispensed drugs. A combination drug product includes a plurality of discrete units of a first drug, and a plurality of discrete units of a second drug. A transdermal patch includes a plurality of drug compartments, each containing a quantity of drug product, and a controller for controlling the release of drugs from each compartment. Feedback loop elements can enable iterations to optimized personalized doses.

    Abstract translation: 确定特定患者的最佳组合药物产品包括接收患者信息并基于接收的信息确定最佳组合药物产品的处理器。 系统根据接收到的患者信息提供关于预测事件或病变的信息，以及关于随后的改善，治疗或干预的步骤的指导。 药物生产装置包括多个联接到药物分配通道的药物容器。 控制器通过每个通道控制药物的分配，由分配的药物产生组合药物。 组合药物产品包括第一药物的多个离散单元和第二药物的多个离散单元。 透皮贴剂包括多个药物隔室，每个药物隔室含有一定数量的药物产品，以及用于控制药物从每个隔室释放的控制器。 反馈回路元素可以实现迭代以优化个性化剂量。

    PORTABLE DRUG DISPENSER
    6.
    发明申请
    PORTABLE DRUG DISPENSER 审中-公开
    便携式药物分配器

    公开(公告)号：WO2013033033A1

    公开(公告)日：2013-03-07

    申请号：PCT/US2012/052551

    申请日：2012-08-27

    Applicant: KRAFT, Daniel, L. ,  PARAZYNSKI, Scott

    Inventor： KRAFT, Daniel, L. ,  PARAZYNSKI, Scott

    IPC: G05B13/02

    CPC classification number: A61J7/0084 ,  A61J7/0418 ,  A61J7/0445 ,  A61J7/0481 ,  A61J2200/30 ,  A61J2205/70 ,  G06F19/00 ,  G06F19/3462

    Abstract: A portable drug dispenser includes a chamber for holding a plurality of separately contained drug products, a dispensing mechanism for dispensing one or more of the plurality of drug products, and may optionally include a processor to determine the time of each activation of the dispensing mechanism and to transmit the determined time of activation to a computer located remote to the dispenser. The dispenser may include more than one chamber for holding drugs.

    Abstract translation: 便携式药物分配器包括用于容纳多个单独容纳的药物的腔室，用于分配多种药物产品中的一种或多种的分配机构，并且可以可选地包括处理器，以确定分配机构的每次激活的时间，以及 将确定的激活时间发送到位于远离分配器的计算机。 分配器可以包括多于一个用于容纳药物的室。

    DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE
    7.
    发明申请
    DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE 审中-公开
    装置和方法，用于快速吸收和收集身体内部的身体组织

    公开(公告)号：WO2003101308A1

    公开(公告)日：2003-12-11

    申请号：PCT/US2003/017511

    申请日：2003-06-04

    Applicant: OFFICE OF TECHNOLOGY LICENSING STANFORD UNIVERSITY ,  KRAFT, Daniel ,  HOLE, James

    Inventor： KRAFT, Daniel ,  HOLE, James

    IPC: A61B10/00

    CPC classification number: A61M25/0082 ,  A61B10/025 ,  A61B10/0283 ,  A61B17/1615 ,  A61B17/2202 ,  A61B17/320068 ,  A61B17/3415 ,  A61B17/3423 ,  A61B17/3472 ,  A61B2010/0258 ,  A61B2017/00292 ,  A61B2017/00309 ,  A61B2017/320032 ,  A61B2017/3413 ,  A61B2090/378 ,  A61M3/0279 ,  A61M3/0283 ,  A61M2202/09 ,  A61M2202/10 ,  A61M2210/02

    Abstract: Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula (101) with optional core element (104) provides entry into body tissue space such as bone marrow. Aspiration cannula (105) is inserted through entry cannula (101) into body tissue and is manipulated to advance directionally through body cavity. Optional stylet (106) within aspiration cannula (105) aids in advancing aspiration cannula (105) through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula (105). Inlet openings (150) near distal tip (130) of aspiration cannula (105) allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula (105) providing controlled negative pressure. Aspiration cannula (105) may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

    Abstract translation: 从封闭体腔快速提取人体组织的装置和方法。 具有可选的芯元件（104）的空心入口套管（101）提供进入诸如骨髓的身体组织空间。 吸入套管（105）通过进入套管（101）插入身体组织中，并被操纵以定向地穿过体腔。 抽吸插管（105）内的可选探针（106）有助于将抽吸插管（105）推进穿过身体组织，并被移除以便于通过抽吸插管（105）抽取身体组织。 在抽吸套管（105）的远侧末端（130）附近的入口开口（150）允许组织抽吸，抽吸套管（105）的近端处的负压源提供受控的负压。 抽吸插管（105）可以被撤回，并且通过经过组织空间的不同路径之后通过相同入口点对多个入口进行调节，以便随后抽吸更多的组织。

    EYE DROP DISPENSER
    8.
    发明申请
    EYE DROP DISPENSER 审中-公开
    眼药水分配器

    公开(公告)号：WO2013043607A1

    公开(公告)日：2013-03-28

    申请号：PCT/US2012/055927

    申请日：2012-09-18

    Applicant: KRAFT, Daniel, L.

    Inventor： KRAFT, Daniel, L.

    IPC: A61F9/00

    CPC classification number: A61F9/0008 ,  A61F9/0026 ,  A61J1/067 ,  A61J1/2093 ,  G06F19/3462 ,  G07F13/06 ,  G07F15/04 ,  G07F17/0092

    Abstract: The present disclosure provides a portable drug dispenser which includes one or more chambers for holding a plurality of separately contained drug products, a dispensing mechanism for accurately dispensing one or more of the plurality of separately contained drugs upon activation of the dispensing mechanism in a specified dose (e.g. specified volume/ number of drops) at specified times, and a processor configured to determine the time, and potentially other information such as, e.g. location, patient variables, user data input of each activation of the dispensing mechanism, and an ability to transmit the determined time of activation to a computer located remote to the dispenser, optionally stored on the device as well for read out by a clinician managing the patient.

    Abstract translation: 本公开提供了一种便携式药物分配器，其包括用于保持多个单独容纳的药物产品的一个或多个腔室，用于在以特定剂量激活分配机构时精确分配多个单独容纳的药物中的一种或多种的分配机构 （例如指定的体积/数量的滴），以及被配置为确定时间的处理器，以及潜在的其他信息，例如 位置，患者变量，分配机构的每次激活的用户数据输入，以及将确定的激活时间发送到位于远离分配器的计算机的能力，可选地存储在设备上，以及由临床医生管理 患者。

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