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    MICROSCOPY METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS
    2.
    发明申请
    MICROSCOPY METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
    用于操纵和/或检测生物样品和其他物体的微观方法和装置

    公开(公告)号：WO2007084345A1

    公开(公告)日：2007-07-26

    申请号：PCT/US2007/000779

    申请日：2007-01-12

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  HAM, Donhee ,  WESTERVELT, Robert ,  HUNT, Thomas ,  LIU, Yong ,  LEE, Hakho

    Inventor： HAM, Donhee ,  WESTERVELT, Robert ,  HUNT, Thomas ,  LIU, Yong ,  LEE, Hakho

    IPC: G02B21/32 ,  G01N21/00 ,  G01N15/00

    CPC classification number: G02B21/34 ,  B01J2219/00653 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2400/0415 ,  B01L2400/043 ,  G01N15/1463 ,  G02B21/32

    Abstract: Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope.

    Abstract translation: 显微镜方法和用于操纵，检测，成像，表征，分选和/或组装生物或其他材料的装置，涉及CMOS或其他基于半导体的技术和与显微镜相结合的微流体的集成。 在一个实施方式中，包括光学器件和阶段的显微镜配备有与在IC芯片上实现的电场和/或磁场的产生相关的各种组件。 微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境中引入和去除细胞，或者其他悬浮的颗粒/物体 在流体中。 由IC芯片产生的图案化电场和/或磁场可捕获和移动微流体系统内的生物细胞或其它物体，以便于通过显微镜观察。

    SYSTEM AND METHOD FOR CAPTURING AND POSITIONING PARTICLES
    3.
    发明申请
    SYSTEM AND METHOD FOR CAPTURING AND POSITIONING PARTICLES 审中-公开
    用于捕获和定位颗粒的系统和方法

    公开(公告)号：WO2003039753A1

    公开(公告)日：2003-05-15

    申请号：PCT/US2002/036280

    申请日：2002-11-05

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  WESTERVELT, Robert, M. ,  LEE, Chungsok ,  LEE, Hakho

    Inventor： WESTERVELT, Robert, M. ,  LEE, Chungsok ,  LEE, Hakho

    IPC: B03C1/24

    CPC classification number: B01L3/502761 ,  B01L3/502792 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/043 ,  B03C1/24 ,  B03C2201/22 ,  G01N15/1456

    Abstract: A micro-electromagnet matrix (35 of Figure 11) captures and controls the movement of particles with nanoscale resolution. The micro-electromagnet matrix (35 of Figure 11) includes multiple layers (40 and 50 of figure 11) of microconductors (41 and 51 of Figure 11), each layer of microconductors (41 of Figure 11) being orthogonal to an adjacent layer of microconductors (51 of Figure 11). The layers of microconductors (40 and 50 of Figure 11) are formed on a substrate (20 of Figure 11) and have insulating layers (45 of Figure 11) therebetween. The field patterns produced by the micro-electromagnet matrix (35 of Figure 11) enable precise manipulation of particles. The micro-electromagnet matrix (35 of Figure 11) produces single or multiple independent field peaks in the m agnetic field that are used to trap, move, or rotate the particles. The micro-electromagnet matrix (35 of Figure 11) also produces electromagnetic fields to probe and detect particles.

    Abstract translation: 微电磁矩阵（图11中的35）捕获并控制具有纳米尺度分辨率的颗粒的运动。 微电磁体矩阵（图11中的35）包括微层（图11的41和51）的多层（图11的40和50），每层微导体（图11的41）正交于相邻层 微导体（图11中的51）。 微导体层（图11的40和50）形成在衬底（图11的20）上，并具有绝缘层（图11中的45）。 由微电磁矩阵（图11中的35）产生的场图可以精确地操纵颗粒。 微电磁体矩阵（图11中的35）在用于捕获，移动或旋转颗粒的m场中产生单个或多个独立的场峰。 微电磁矩阵（图11中的35）还产生用于探测和检测颗粒的电磁场。

    METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS
    6.
    发明申请
    METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
    用于操作和/或检测生物样本和其他对象的方法和设备

    公开(公告)号：WO2005099419A2

    公开(公告)日：2005-10-27

    申请号：PCT/US2005/012719

    申请日：2005-04-13

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  HAM, Donhee ,  WESTERVELT, Robert ,  HUNT, Thomas ,  LIU, Yong ,  LEE, Hakho

    Inventor： HAM, Donhee ,  WESTERVELT, Robert ,  HUNT, Thomas ,  LIU, Yong ,  LEE, Hakho

    IPC: G01R33/30 ,  G01R33/465 ,  G01R33/56

    CPC classification number: G01R33/302 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  G01N15/1031 ,  G01N24/08 ,  G01N24/10 ,  G01R33/307 ,  G01R33/34092 ,  G01R33/3415 ,  G01R33/465 ,  G01R33/4808 ,  G01R33/5604

    Abstract: Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.

    Abstract translation: 用于生物或其他材料的操纵，检测，成像，表征，分类和/或组装的方法和设备，涉及CMOS或其他基于半导体的技术与微流体的集成。 在一个实施方式中，在使用标准协议制造的IC芯片上实现与产生电场和/或磁场有关的各种组件。 所产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。 微流体系统直接在IC芯片的顶部制造，或作为单独的实体制造，然后适当地粘合到IC芯片，以促进引入和移除生物相容性环境中的细胞或悬浮的其他粒子/目标物体 在流体中。 由IC芯片产生的图案化的电场和/或磁场可以捕获和移动微流体系统内部的生物细胞或其他物体。 还可以使用各种频率的信号来控制电和/或磁场生成组件，以便通过测量与相互作用相关联的共振特征来检测一个或多个细胞，感兴趣的粒子或物体，甚至感兴趣的粒子或物体的类型 样品与一个或多个场生成装置之间。 这样的系统可用于各种生物和医学相关应用，包括细胞分选和组织装配。

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