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11 条记录 (耗时 0.015 秒)

    COMPOSITIONS AND METHODS FOR ORAL DRUG DELIVERY
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR ORAL DRUG DELIVERY 审中-公开
    用于口服药物递送的组合物和方法

    公开(公告)号：WO2011084618A2

    公开(公告)日：2011-07-14

    申请号：PCT/US2010060809

    申请日：2010-12-16

    申请人： NOD PHARMACEUTICALS INC ,  LEE WILLIAM W ,  LU FENG ,  MIN YIN ,  SHAO LIUYING ,  SHE HAO ,  SHEN ZHOU

    发明人： LEE WILLIAM W ,  LU FENG ,  MIN YIN ,  SHAO LIUYING ,  SHE HAO ,  SHEN ZHOU

    IPC分类号： A61K9/28

    CPC分类号： A61K9/2072 ,  A61K9/2013 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/2893 ,  A61K38/2278 ,  A61K38/28

    摘要： The invention provides a pharmaceutical composition for oral drug delivery comprising a solid dosage form containing an effective amount of a therapeutic agent, a permeation enhancer and a pharmaceutically acceptable excipient and a bioadhesive layer containing a bioadhesive polymer, and optionally comprising an impermeable or semi-permeable layer having an opening capable of directing a unidirectional release of the therapeutic agent and the permeation enhancer from the solid dosage form. Methods of making and using the present pharmaceutical composition are also provided.

    摘要翻译： 本发明提供了用于口服药物递送的药物组合物，其包含含有有效量的治疗剂，渗透促进剂和药学上可接受的赋形剂的固体剂型和含有生物粘附聚合物的生物粘附层，并且任选地包含不渗透或半渗透性 层具有能够从固体剂型引导治疗剂和渗透促进剂的单向释放的开口。 还提供了制备和使用本药物组合物的方法。

    DISPOSABLE SELF-POWERED DRUG DELIVERY DEVICE
    2.
    发明申请
    DISPOSABLE SELF-POWERED DRUG DELIVERY DEVICE 审中-公开
    可配置自动送药装置

    公开(公告)号：WO2010062908A1

    公开(公告)日：2010-06-03

    申请号：PCT/US2009/065769

    申请日：2009-11-24

    申请人： NOD PHARMACEUTICALS, INC. ,  LEE, William, W. ,  ZHAO, Qianyu ,  RAO, Yan ,  SHEN, Zhou

    发明人： LEE, William, W. ,  ZHAO, Qianyu ,  RAO, Yan ,  SHEN, Zhou

    IPC分类号： A61M31/00

    CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

    摘要： The present invention provides a minimally invasive, disposable, self- powered, patch-like drug delivery device. The device generally comprises a microneedle; a drug reservoir in fluid communication with the microneedle and comprising a drug to be administered; a pressure chamber in gas communication with the drug reservoir and comprising a liquid medium; a trigger for initiating a chemical reaction in the pressure chamber; and a plunger disposed in the drug reservoir, adapted to move unidirectionally in response to a pressure increase in the pressure chamber and to insulate the drug in the drug reservoir from a reactant and/or a product of the chemical reaction. Kits and methods for using the device are also provided.

    摘要翻译： 本发明提供了微创的，一次性的，自供电的贴片状药物递送装置。 该装置通常包括微针; 与微针流体连通并包含待施用药物的药物储存器; 与药物储存器气体连通并包括液体介质的压力室; 用于在压力室中引发化学反应的触发器; 以及设置在所述药物储存器中的柱塞，其适于响应于所述压力室中的压力增加而单向移动并且使药物储存器中的药物与所述化学反应物的反应物和/或产物绝缘。 还提供了使用设备的工具包和方法。

    METHOD AND APPARATUS FOR EMULATING BRUSH STROKES ON MASS PRODUCED ART
    3.
    发明申请
    METHOD AND APPARATUS FOR EMULATING BRUSH STROKES ON MASS PRODUCED ART 审中-公开
    用于模拟大量生产艺术的布鲁氏菌的方法和装置

    公开(公告)号：WO2006026103A3

    公开(公告)日：2007-03-15

    申请号：PCT/US2005028501

    申请日：2005-08-10

    申请人： SILVERGRAPH LGT LLC ,  LEE WILLIAM W

    发明人： LEE WILLIAM W

    IPC分类号： B41C1/14 ,  B41M1/12 ,  B41N1/24

    CPC分类号： B41C1/148 ,  B41N1/247

    摘要： A screen printing method and apparatus is provided for emulating textured brushstrokes on prints that have been previously printed. The screen printing system and process include steps of forming the screen by providing a mesh (14) with a thread count between 86 and 230 threads per inch, applying emulsion (12) having a thickness between 50 and 200 microns to the mesh (14), positioning an image film (18) adjacent the emulsion, exposing the emulsion to a light source (22), removing non-hardened areas of emulsion from the mesh to form image openings (24a). The method also involves selecting appropriate ink formulations, preparing the squeegee/floodbar, and various press mechanics.

    摘要翻译： 提供了一种丝网印刷方法和装置，用于在先前印刷的印刷上模拟纹理笔触。 丝网印刷系统和方法包括以下步骤：通过提供丝网（14）形成筛网，其中纱线计数在每英寸86至230个螺纹之间，将具有50至200微米厚度的乳液（12）施加到筛网（14）上， 将图像膜（18）定位在乳液附近，将乳液暴露于光源（22），从网中除去未硬化的乳剂区域以形成图像孔（24a）。 该方法还涉及选择适当的油墨配方，制备刮板/堰架以及各种冲压机构。

    METHOD AND APPARATUS FOR EMULATING BRUSH STROKES ON MASS PRODUCED ART
    5.
    发明申请
    METHOD AND APPARATUS FOR EMULATING BRUSH STROKES ON MASS PRODUCED ART 审中-公开
    用于在大量生产艺术中模拟布鲁氏菌的方法和装置

    公开(公告)号：WO2006026103A2

    公开(公告)日：2006-03-09

    申请号：PCT/US2005/028501

    申请日：2005-08-10

    申请人： SILVERGRAPH LGT, LLC ,  LEE, William, W.

    发明人： LEE, William, W.

    CPC分类号： B41C1/148 ,  B41N1/247

    摘要： A method and apparatus for producing prints. The method comprises positioning a mesh having a first surface and a second surface and a thread count between approximately 86 and approximately 230 threads per inch in a substantially rigid frame and applying a photo-chemically active emulsion to the first surface of the mesh to a thickness of between approximately 50 microns and approximately 200 microns. The first side of the mesh is positioned relative to a top side of a photosensitive substrate and an image film is positioned against the bottom side of the photosensitive substrate. The photo-chemically active emulsion is exposed through the image film to a light source, and non-hardened photo-chemically active emulsion is removed from the mesh. The first surface of the mesh is positioned above a top surface of a print substrate and ink is applied to the second surface of the mesh so that ink travels through the mesh and the areas in which the photo-chemically active emulsion has been removed and onto the top surface of the print substrate.

    摘要翻译： 一种用于制作印刷品的方法和装置。 该方法包括在基本上刚性的框架中定位具有第一表面和第二表面以及螺纹计数在约86和约230螺纹/英寸之间的网格，并将光致化学活性乳液施加到网的第一表面以具有厚度 在约50微米和约200微米之间。 网状物的第一侧相对于感光基片的顶侧定位，并且图像膜抵靠感光基底的底侧定位。 光致化学活性乳剂通过图像膜暴露于光源，并且从网中除去未硬化的光化学活性乳液。 网的第一表面位于印刷基材的顶表面上方，并且油墨被施加到网的第二表面上，使得油墨通过网格和已经除去光化学活性乳液的区域移动到 印刷基板的顶面。

    POLYMERIC WATER SOLUBLE PRODRUGS
    8.
    发明申请
    POLYMERIC WATER SOLUBLE PRODRUGS 审中-公开
    聚合水溶性原料

    公开(公告)号：WO2005079861A3

    公开(公告)日：2007-03-15

    申请号：PCT/US2005004377

    申请日：2005-02-11

    申请人： SAFEWAY INVEST LTD ,  LEE WILLIAM W

    发明人： LEE WILLIAM W

    IPC分类号： A61K47/48 ,  A61P35/00

    CPC分类号： A61K47/645 ,  A61K47/60

    摘要： The present invention provides a conjugate comprising a chemotherapeutic agent (such as an anti-tumor drug) conjugated to a water soluble polyamino acid polymer, wherein the water soluble polyamino acid polymer is conjugated to a hydrophilic polymer such as polyethylene glycol. The present invention also provides a pharmaceutical composition comprising such a conjugate. Methods of making the pharmaceutical composition and methods of using the pharmaceutical composition for treating diseases and coating implantable medical devices are also provided.

    摘要翻译： 本发明提供了包含与水溶性聚氨基酸聚合物缀合的化学治疗剂（例如抗肿瘤药物）的缀合物，其中水溶性聚氨基酸聚合物与亲水性聚合物如聚乙二醇缀合。 本发明还提供包含这种缀合物的药物组合物。 还提供了制备药物组合物的方法和使用该药物组合物治疗疾病和涂覆可植入医疗器械的方法。

    POLYMERIC WATER SOLUBLE PRODRUGS
    10.
    发明申请
    POLYMERIC WATER SOLUBLE PRODRUGS 审中-公开
    聚合水溶性聚合物

    公开(公告)号：WO2005079861A2

    公开(公告)日：2005-09-01

    申请号：PCT/US2005/004377

    申请日：2005-02-11

    申请人： SAFEWAY INVESTMENTS LTD. ,  LEE, William, W.

    发明人： LEE, William, W.

    IPC分类号： A61K47/48

    CPC分类号： A61K47/645 ,  A61K47/60

    摘要： The present invention provides a conjugate comprising a chemotherapeutic agent (such as an anti-tumor drug) conjugated to a water soluble polyamino acid polymer, wherein the water soluble polyamino acid polymer is conjugated to a hydrophilic polymer such as polyethylene glycol. The present invention also provides a pharmaceutical composition comprising such a conjugate. Methods of making the pharmaceutical composition and methods of using the pharmaceutical composition for treating diseases and coating implantable medical devices are also provided.

    摘要翻译： 本发明提供包含与水溶性聚氨基酸聚合物缀合的化学治疗剂（例如抗肿瘤药物）的缀合物，其中水溶性聚氨基酸聚合物与亲水性聚合物如聚乙二醇缀合。 本发明还提供了包含这种缀合物的药物组合物。 还提供了制备药物组合物的方法和使用该药物组合物治疗疾病和涂覆可植入医疗器械的方法。