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1.发明申请
公开(公告)号：WO2009045902A3
公开(公告)日：2010-04-08
申请号：PCT/US2008077878
申请日：2008-09-26
Applicant: ADVANCED MEDICAL OPTICS INC , HU CAN B , LOWERY MICHAEL D
Inventor： HU CAN B , LOWERY MICHAEL D
IPC: A61F2/16 , A61L27/18 , C08F230/08 , C08G77/38
CPC classification number: A61F2/16 , A61F2/15 , A61F2/1613 , A61F2002/1681 , A61F2002/1682 , A61F2250/0018 , A61L27/18 , A61L2430/16 , C08F230/08 , C08G77/20 , C08G77/70 , C08L83/04 , Y10T156/10
Abstract: A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.
Abstract translation: 具有分子响应时间的聚合材料，使其适合在脆弱的身体组织附近使用。 聚合物材料可用于低模量和高模量应用，从而简化了多部件聚合物制品的制造过程，并且形成了更好的集成的多部分聚合物制品。 具有不同模量的交联聚合物可以利用相同或相似的起始材料获得，但改变催化剂的量，交联剂的量和/或甲基乙烯基环状的量。
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公开(公告)号：WO2007112209A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064039
申请日：2007-03-15
Applicant: ADVANCED MEDICAL OPTICS, INC. , LOWERY, Michael, D. , MAKKER, Harish, C.
Inventor： LOWERY, Michael, D. , MAKKER, Harish, C.
CPC classification number: A61F2/1616 , A61L27/18 , A61L2430/16 , C08F30/08 , C08F290/068 , C08G77/20 , C08L51/085 , G02B1/043 , C08L83/04 , C08L33/10 , C08L33/08 , C08L2666/02
Abstract: Intraocular lenses comprised of an acrylic-silicone hybrid polymer are disclosed. The intraocular lenses described herein are suitable for insertion through incisions of 2 mm or less.
Abstract translation: 公开了由丙烯酸 - 硅氧烷杂化聚合物组成的人造眼镜。 本文所述的眼内透镜适合于通过2mm以下的切口插入。
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公开(公告)号：WO2007112209A3
公开(公告)日：2008-01-03
申请号：PCT/US2007064039
申请日：2007-03-15
Applicant: ADVANCED MEDICAL OPTICS INC , LOWERY MICHAEL D , MAKKER HARISH C
Inventor： LOWERY MICHAEL D , MAKKER HARISH C
CPC classification number: A61F2/1616 , A61L27/18 , A61L2430/16 , C08F30/08 , C08F290/068 , C08G77/20 , C08L51/085 , G02B1/043 , C08L83/04 , C08L33/10 , C08L33/08 , C08L2666/02
Abstract: Intraocular lenses comprised of an acrylic-silicone hybrid polymer are disclosed. The intraocular lenses described herein are suitable for insertion through incisions of 2 mm or less.
Abstract translation: 公开了由丙烯酸 - 硅氧烷杂化聚合物组成的人造眼镜。 本文所述的眼内透镜适合于通过2mm以下的切口插入。
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公开(公告)号：WO2007100979A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062111
申请日：2007-02-14
Applicant: ADVANCED MEDICAL OPTICS, INC. , LOWERY, Michael, D. , HOFFMANN, Laurent
Inventor： LOWERY, Michael, D. , HOFFMANN, Laurent
CPC classification number: A61L27/50 , A61F2/16 , A61L27/34 , A61L2430/16 , C08L71/02
Abstract: An intraocular lens with a hydrophilic polymer coating composition and methods for using same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lens is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition. Methods for making an intraocular lens with a hydrophilic polymer coating are also provided.
Abstract translation: 提供具有亲水性聚合物涂层组合物的人工晶状体及其使用方法。 具体地说，提供一种适用于降低人工晶状体粘合性的组合物，其中丙烯酸类眼内透镜通过气相沉积用烷氧基甲硅烷基封端的聚乙二醇聚合物组合物进行处理。 还提供了制备具有亲水性聚合物涂层的眼内透镜的方法。
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5.发明申请
公开(公告)号：WO2005066694A3
公开(公告)日：2006-01-26
申请号：PCT/US2004043627
申请日：2004-12-28
Applicant: ADVANCED MEDICAL OPTICS INC , PAUL MARLENE L , LOWERY MICHAEL D , LAGUETTE STEPHEN W , BANDHAUER MARK H
Inventor： PAUL MARLENE L , LOWERY MICHAEL D , LAGUETTE STEPHEN W , BANDHAUER MARK H
CPC classification number: A61F2/1613 , A61F2/1659 , A61F2002/1696 , A61F2240/001
Abstract: Intraocular lenses (300) are provided having a visible-light selective transmissive zone (304, 306) defined therein. The visible light-selective transmissive zone can be located near the lens center and designed to reduce the transmission of any wave-length of visible light specifically light in the blue light region having wavelength between approximately 400 λ to 550 λ.
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Patent Agency Ranking6.发明申请INTRAOCULAR LENS MATERIALS SUITABLE FOR INSERTION THROUGH A SMALL BORE CARTRIDGE 审中-公开内镜镜片材料适用于通过一个小孔卡盒进行插入
公开(公告)号：WO2005066662A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043846
申请日：2004-12-29
Applicant: ADVANCED MEDICAL OPTICS, INC. , MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
Inventor： MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
IPC: G02B1/04
Abstract: A polymer material useful for manufacturing an intraocular lens (IOL) suitable for insertion through an IOL inserter barrel having an inner diameter of less than 3 mm is provided. Specifically, acrylic-silicone hybrids having a tensile strength of approximately 100 psi to 400 psi and a percent elongation at break of between 50% and 400% are disclosed.
Abstract translation: 提供了一种用于制造适于通过内径小于3mm的IOL插入筒插入的眼内透镜（IOL）的聚合物材料。 具体地，公开了具有约100psi至400psi的拉伸强度和50％至400％的断裂伸长率的丙烯酸 - 硅氧烷杂化物。
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公开(公告)号：WO2010027519A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/030113
申请日：2009-01-05
Applicant: ADVANCED MEDICAL OPTICS , HU, Can, B. , PHAM, Derek, D. , LOWERY, Michael, D.
Inventor： HU, Can, B. , PHAM, Derek, D. , LOWERY, Michael, D.
CPC classification number: A61F2/16 , A61F2002/16905 , C08G77/20 , G02B1/043 , C08L83/04
Abstract: Described herein are silicone fluids and silicone materials that posses high glass transition temperatures (T g s) when compared to conventional silicone materials. In one embodiment, an increased T g allows the formation of objects and materials by cryogenic lathing. The fluids and materials can be formed by curing silicone fluid with a cross-linker mixture comprising a cross-linker and a monofunctional hydride compound. Upon formation, the silicone materials can be extracted over long periods of time without loss of optical quality. The silicone materials can be sufficiently soft allowing folding and insertion through small incisions in the eye. Additionally, methods of forming optical silicone materials, lenses and silicone materials in general are also disclosed. In one embodiment, the method of forming a silicone based lens using cryogenic lathing techniques is described.
Abstract translation: 这里描述的是与常规硅氧烷材料相比具有高玻璃化转变温度（Tg）的有机硅流体和硅氧烷材料。 在一个实施例中，增加的Tg允许通过低温车辙形成物体和材料。 流体和材料可以通过用包含交联剂和单官能氢化物化合物的交联剂混合物固化硅氧烷流体来形成。 在形成时，可以长时间地提取硅酮材料而不损失光学质量。 硅胶材料可以足够柔软，允许通过眼睛中的小切口进行折叠和插入。 此外，还公开了形成光学硅氧烷材料，透镜和硅酮材料的方法。 在一个实施例中，描述了使用低温车床技术形成硅氧烷基透镜的方法。
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公开(公告)号：WO2007100979A3
公开(公告)日：2007-11-22
申请号：PCT/US2007062111
申请日：2007-02-14
Applicant: ADVANCED MEDICAL OPTICS INC , LOWERY MICHAEL D , HOFFMANN LAURENT
Inventor： LOWERY MICHAEL D , HOFFMANN LAURENT
CPC classification number: A61L27/50 , A61F2/16 , A61L27/34 , A61L2430/16 , C08L71/02
Abstract: An intraocular lens with a hydrophilic polymer coating composition and methods for using same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lens is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition. Methods for making an intraocular lens with a hydrophilic polymer coating are also provided.
Abstract translation: 提供具有亲水性聚合物涂层组合物的人工晶状体及其使用方法。 具体地说，提供一种适用于降低人工晶状体粘合性的组合物，其中丙烯酸类眼内透镜通过气相沉积用烷氧基甲硅烷基封端的聚乙二醇聚合物组合物进行处理。 还提供了制备具有亲水性聚合物涂层的眼内透镜的方法。
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公开(公告)号：WO2006110696A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/013392
申请日：2006-04-10
Applicant: ADVANCED MEDICAL OPTICS, INC. , HU, Can, B. , LOWERY, Michael, D. , MAKKER, Harish, C.
Inventor： HU, Can, B. , LOWERY, Michael, D. , MAKKER, Harish, C.
IPC: A61L27/34 , A61L29/08 , A61L31/10 , C09D175/04 , C08L39/06
CPC classification number: A61F2/1675 , A61L27/34 , C08G18/0823 , C08G18/833 , C08L39/06 , C09D175/04 , Y10T428/31536 , Y10T428/31551 , Y10T428/31663 , C08L5/08 , C08L2666/04
Abstract: Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.
Abstract translation: 提供用于聚合物IOL插入盒的柔软，柔性高光泽的涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。
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10.发明申请
公开(公告)号：WO2005066694A8
公开(公告)日：2005-09-01
申请号：PCT/US2004043627
申请日：2004-12-28
Applicant: ADVANCED MEDICAL OPTICS INC , PAUL MARLENE L , LOWERY MICHAEL D , LAGUETTE STEPHEN W , BANDHAUER MARK H
Inventor： PAUL MARLENE L , LOWERY MICHAEL D , LAGUETTE STEPHEN W , BANDHAUER MARK H
CPC classification number: A61F2/1613 , A61F2/1659 , A61F2002/1696 , A61F2240/001
Abstract: Intraocular lenses (300) are provided having a visible-light selective transmissive zone (304, 306) defined therein. The visible light-selective transmissive zone can be located near the lens center and designed to reduce the transmission of any wave-length of visible light specifically light in the blue light region having wavelength between approximately 400 ? to 550 ?.
Abstract translation: 提供了具有限定在其中的可见光选择透射区（304,306）的人造眼镜（300）。 可见光选择性透射区域可以位于透镜中心附近，并且被设计成在波长在约400μm之间的蓝色光区域中减少任何波长的可见光的光的透射。 到550？
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