公开(公告)号：WO0020042A2

公开(公告)日：2000-04-13

申请号：PCT/US9922990

申请日：1999-09-30

Applicant: MAGNETIC IMAGING TECHNOLOGIES ,  ZOLLINGER DAVID L ,  ZOLLINGER GERI T K ,  HASSON KENTON C ,  BOGORAD PAUL L ,  DRIEHUYS BASTIAAN

Inventor： ZOLLINGER DAVID L ,  ZOLLINGER GERI T K ,  HASSON KENTON C ,  BOGORAD PAUL L ,  DRIEHUYS BASTIAAN

IPC: G01R33/28 ,  A61B5/055 ,  A61K49/18 ,  A61K49/00

CPC classification number: G01R33/282 ,  A61K49/1815 ,  Y10T436/11 ,  Y10T436/24 ,  Y10T436/25

Abstract: Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.

Abstract translation: 从容器中提取和去除超极化气体的方法包括将提取液引入容器中以迫使超极化气体离开出口。 超极化的气体被从容器中分离出来并从萃取液中分离出来。 或者，如果流体是气体，则一部分气体与超极化气体混合以形成适于引入患者的无菌混合流体产品。 另一种方法包括将诸如注射器的气体传输源接合到运输容器并以受控方式将一定量的超极化气体从容器中拉出。 另一种方法包括将一定量的液体引入到容器中并用液体覆盖至少一个预定的内表面或部件以掩盖表面并使超极化的气体远离预定的内表面，由此抑制来自其的去极化效应。 适于掩蔽的表面或部件的例子包括阀门，密封件等。 又一种提取方法包括使容器内的弹性构件膨胀以迫使超极化气体从其中排出。 容器包括定位成与容器中的超极化气体流体连通的弹性构件。 另外的容器包括与腔室流体连通并定位在容器的相对侧或端部上的入口和出口端口。 另一个容器包括构造成在其中接收注射器的一部分的端口。 本公开的另一方面涉及用于识别气体的超极化状态的校准方法和装置。

公开(公告)号：WO9934189A3

公开(公告)日：1999-09-30

申请号：PCT/US9826450

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES ,  DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON KENTON C ,  LANGHORN ALAN

Inventor： DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON KENTON C ,  LANGHORN ALAN

IPC: A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  A61K49/00

CPC classification number: G01R33/282 ,  A61K49/1815 ,  B01J19/26 ,  B01J2219/00099 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2215/36 ,  F25J2270/904

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

Abstract translation: 收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热流路的一部分和/或直接液化冷冻气体。 还包括具有延长的极化寿命产品的极化惰性气体产品。 用于收集，储存和运输偏振惰性气体的诸如蓄能器和加热套的相关装置包括二次流动通道，其在积聚期间和解冻期间向收集路径的一部分提供热量。

公开(公告)号：WO9966255A3

公开(公告)日：2000-04-27

申请号：PCT/US9913597

申请日：1999-06-16

Applicant: MAGNETIC IMAGING TECHNOLOGIES ,  ZOLLINGER DAVID L ,  DEATON DANIEL M ,  DRIEHUYS BASTIAAN ,  HASSON KENTON C

Inventor： ZOLLINGER DAVID L ,  DEATON DANIEL M ,  DRIEHUYS BASTIAAN ,  HASSON KENTON C

IPC: F17B1/26 ,  A61B5/055 ,  A61K49/18 ,  F17C1/00 ,  F17C1/16 ,  F17C3/00 ,  F17C13/00 ,  G01N24/08 ,  G01N15/08 ,  G01R33/28

CPC classification number: G01R33/282 ,  A61K49/1815 ,  F17C1/00 ,  F17C1/16 ,  F17C3/00 ,  F17C13/002 ,  F17C13/005 ,  F17C2201/0128 ,  F17C2201/0157 ,  F17C2201/0176 ,  F17C2203/032 ,  F17C2203/0604 ,  F17C2203/0619 ,  F17C2203/0646 ,  F17C2203/066 ,  F17C2203/0697 ,  F17C2205/0115 ,  F17C2205/0323 ,  F17C2205/0329 ,  F17C2205/0364 ,  F17C2205/0394 ,  F17C2221/017 ,  F17C2221/07 ,  F17C2223/0123 ,  F17C2260/013 ,  F17C2260/018 ,  F17C2260/02 ,  F17C2260/026 ,  F17C2260/05 ,  F17C2270/02 ,  F17C2270/025

Abstract: A resilient multi-layer container is configured to receive a quantity of hyperpolarized noble fluid such as gas and includes a wall with at least two layers, a first layer with a surface which minimizes contact-induced spin-relaxation and a first or second layer which is substantially impermeable to oxygen. The container is especially suitable for collecting and transporting He. The resilient container can be formed of material layers which are concurrently responsive to pressure such as polymers, deuterated polymers, or metallic films. The container can include a capillary stem and/or a port or valve isolation means to inhibit the flow of gas from the main volume of the container during transport. The resilient container can be configured to directly deliver the hyperpolarized noble gas to a target interface by deflating or collapsing the inflated resilient container. In addition, single layer resilient containers with T1's of above 4 hours for Xe and above 6 hours for He include materials with selected relaxivity values. In addition, a bag with a port fitting or valve member and one or more of a capillary stem and port isolation means is configured to minimize the depolarizing effect of the container valve or fitting(s). Also disclosed is a method for determining the gas solubility in an unknown polymer or liquid using the measured relaxation time of a hyperpolarized gas.

Abstract translation: 弹性多层容器被配置为接收一定量的超极化惰性流体，例如气体，并且包括具有至少两层的壁，具有使接触引起的自旋弛豫最小化的表面的第一层和第一层或第二层， 基本上不透氧。 该容器特别适合收集和运送他。 弹性容器可以由与聚合物，氘化聚合物或金属膜等压力同时响应的材料层形成。 容器可以包括毛细管杆和/或端口或阀隔离装置，以在运输期间阻止气体从容器的主体积流出。 弹性容器可以构造成通过使膨胀的弹性容器放气或折叠来将超极化惰性气体直接输送到目标界面。 此外，T1层高于4小时，<129> Xe和6小时以上的单层弹性容器，其中包括具有选择的松弛度值的材料。 此外，具有端口配件或阀构件以及毛细管杆和端口隔离装置中的一个或多个的袋被配置为最小化容器阀或配件的去极化效应。 还公开了使用测量的超极化气体的弛豫时间来确定未知聚合物或液体中的气体溶解度的方法。

公开(公告)号：WO9934189A8

公开(公告)日：1999-11-04

申请号：PCT/US9826450

申请日：1998-12-11

Applicant: MAGNETIC IMAGING TECHNOLOGIES ,  DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON KENTON C ,  LANGHORN ALAN

Inventor： DRIEHUYS BASTIAAN ,  ZOLLINGER DAVID ,  DEATON DANIEL ,  HASSON KENTON C ,  LANGHORN ALAN

IPC: A61K49/18 ,  B01J19/26 ,  F17C13/00 ,  F25J1/00 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  A61K49/00

CPC classification number: G01R33/282 ,  A61K49/1815 ,  B01J19/26 ,  B01J2219/00099 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2215/36 ,  F25J2270/904

Abstract: Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.

Abstract translation: 收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热一部分流动路径和/或直接液化冷冻气体。 还包括具有延长的极化寿命产品的极化惰性气体产品。 用于收集，储存和输送极化惰性气体的相关装置，例如收集器和加热夹套包括次级流动通道，该次级流动通道在积聚期间和解冻期间向收集通道的一部分提供热量。