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    HYPERPOLARIZED NOBLE GAS EXTRACTION METHODS, MASKING METHODS, AND ASSOCIATED TRANSPORT CONTAINERS
    4.
    发明申请
    HYPERPOLARIZED NOBLE GAS EXTRACTION METHODS, MASKING METHODS, AND ASSOCIATED TRANSPORT CONTAINERS 审中-公开

    公开(公告)号：WO0020042A9

    公开(公告)日：2000-11-09

    申请号：PCT/US9922990

    申请日：1999-09-30

    Applicant: MEDI PHYSICS INC ,  ZOLLINGER DAVID L ,  ZOLLINGER GERI T K ,  HASSON KENTON C ,  BOGORAD PAUL L ,  DRIEHUYS BASTIAAN

    Inventor： ZOLLINGER DAVID L ,  ZOLLINGER GERI T K ,  HASSON KENTON C ,  BOGORAD PAUL L ,  DRIEHUYS BASTIAAN

    IPC: G01R33/28 ,  A61B5/055 ,  A61K49/18 ,  A61K49/00

    CPC classification number: G01R33/282 ,  A61K49/1815 ,  Y10T436/11 ,  Y10T436/24 ,  Y10T436/25

    Abstract: Methods of extracting and removing hyperpolarized gas from a container include introducing an extraction fluid into the container to force the hyperpolarized gas out of an exit port. The hyperpolarized gas is forced out of the container separate and apart from the extraction fluid. Alternatively, if the fluid is a gas, a portion of the gas is mixed with the hyperpolarized gas to form a sterile mixed fluid product suitable for introduction to a patient. An additional method includes engaging a gas transfer source such as a syringe to a transport container and pulling a quantity of the hyperpolarized gas out of the container in a controlled manner. Another method includes introducing a quantity of liquid into a container and covering at least one predetermined internal surface or component with the liquid to mask the surfaces and keep the hyperpolarized gas away from the predetermined internal surface, thereby inhibiting any depolarizing affect from same. Examples of surfaces or components suitable for masking include valves, seals, and the like. Yet another extraction method includes expanding a resilient member inside the container to force the hyperpolarized gas to exit therefrom. Containers include a resilient member positioned in fluid communication with the hyperpolarized gas in the container. An additional container includes inlet and outlet ports in fluid communication with the chamber and positioned on opposing sides or end portions of the container. Another container includes a port configured to receive a portion of a syringe therein. An additional aspect of the disclosure relates to calibration methods and apparatus for identifying the hyperpolarization status of the gas.

    METHODS AND COMPOSITIONS FOR MOLECULAR IMAGING
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR MOLECULAR IMAGING 审中-公开
    用于分子成像的方法和组合物

    公开(公告)号：WO2009129482A1

    公开(公告)日：2009-10-22

    申请号：PCT/US2009/040995

    申请日：2009-04-17

    Applicant: DUKE UNIVERSITY ,  DRIEHUYS, Bastiaan ,  BRANCA, Rosa, Tamara

    Inventor： DRIEHUYS, Bastiaan ,  BRANCA, Rosa, Tamara

    IPC: A61K49/00 ,  A61B5/055

    CPC classification number: A61K49/00 ,  G01R33/0213 ,  G01R33/022

    Abstract: Methods for imaging a target cell, tissue, or organ in a subject. In some embodiments, the methods include the steps of (a) administering to the subject a contrast agent that includes a paramagnetic or superparagmanetic material and a targeting moiety that targets the contrast agent to the cell, tissue, or organ; (b) introducing into the target cell, tissue, or organ, or into the vicinity thereof, a hyperpolarized gas; and (c) imaging the target cell, tissue, or organ by detecting the presence of the contrast agent in, on, or near the target cell, tissue, or organ. Also provided are methods for screening for metastasis of a tumor and/or a cancer to the lung of a subject, methods for imaging a cavity in a subject, methods for imaging a target cell, tissue, or organ in a cavity, compositions for performing the disclosed methods, and systems and kits that include the disclosed compositions and/or reagents for performing the disclosed methods.

    Abstract translation: 成像对象中靶细胞，组织或器官的方法。 在一些实施方案中，所述方法包括以下步骤：（a）向受试者施用包含顺磁性或超临床材料的造影剂和靶向造影剂的细胞，组织或器官的靶向部分; （b）向目标细胞，组织或器官或其附近引入超极化气体; 和（c）通过检测靶细胞，组织或器官中，上或附近的造影剂的存在来对靶细胞，组织或器官进行成像。 还提供了用于筛选肿瘤和/或癌症对受试者肺的转移的方法，用于对受试者中的空腔成像的方法，用于在腔中成像靶细胞，组织或器官的方法，用于执行 公开的方法以及包括用于执行所公开的方法的所公开的组合物和/或试剂的系统和试剂盒。

    DIAGNOSTIC PROCEDURES USING DIRECT INJECTION OF GASEOUS HYPERPOLARIZED <129>XE AND ASSOCIATED SYSTEMS AND PRODUCTS
    8.
    发明申请
    DIAGNOSTIC PROCEDURES USING DIRECT INJECTION OF GASEOUS HYPERPOLARIZED <129>XE AND ASSOCIATED SYSTEMS AND PRODUCTS 审中-公开
    使用直接注射气相超高效液相色谱和相关系统和产品的诊断程序

    公开(公告)号：WO0167955A3

    公开(公告)日：2002-07-25

    申请号：PCT/US0107812

    申请日：2001-03-12

    Applicant: MEDI PHYSICS INC ,  UNIV VIRGINIA ,  DRIEHUYS BASTIAAN ,  FUJII DENNIS ,  BROOKEMAN JAMES R ,  HAGSPIEL KLAUS D

    Inventor： DRIEHUYS BASTIAAN ,  FUJII DENNIS ,  BROOKEMAN JAMES R ,  HAGSPIEL KLAUS D

    IPC: A61B5/055 ,  A61K49/00 ,  A61K49/18 ,  A61M5/148 ,  G01R33/28 ,  A61M5/14

    CPC classification number: A61K49/1815 ,  A61B5/055 ,  A61B5/416 ,  A61M5/1483 ,  G01R33/5601

    Abstract: A method of screening for pulmonary embolism uses gaseous phase polarized Xe-129 which is injected directly into the vasculature of a subject. The gaseous Xe-129 can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. The injectable formulation of polarized Xe-129 gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized Xe-129 and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. The direct injection of small quantities of gas at particular sites along the vasculature targets specific target regions to provide increased signal intensity NMR images. The disclosure also includes related methods directed to other diagnostic vasculature regions physiological and conditions. Associated delivery and dispensing systems and methods, containers, and quantitative formulations of the polarized gas are also described.

    Abstract translation: 一种筛选肺栓塞的方法使用气相极化Xe-129，其直接注射到受试者的脉管系统中。 可以以受控的方式递送气态Xe-129，使得气体基本上溶解在靠近注射部位的脉管系统中。 极化Xe-129气体的可注射制剂呈现少量（优选同位素富集）超极化Xe-129，并且可以提供具有临床有用的信号分辨率或强度的高质量脉管系统MRI图像或NMR光谱信号。 沿着脉管系统的特定部位直接注入少量气体针对特定靶区域以提供增加的信号强度NMR图像。 本公开还包括针对其他诊断性脉管系统区域生理学和病症的相关方法。 还描述了相关的递送和分配系统和方法，容器和极化气体的定量配方。

    DIAGNOSTIC PROCEDURES USING <129>XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY IN VIVO
    9.
    发明申请
    DIAGNOSTIC PROCEDURES USING <129>XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY IN VIVO 审中-公开
    诊断程序使用XE光谱特征化学转换检测病毒性病变

    公开(公告)号：WO0205709A9

    公开(公告)日：2003-04-10

    申请号：PCT/US0121998

    申请日：2001-07-12

    Applicant: MEDI PHYSICS INC ,  DRIEHUYS BASTIAAN

    Inventor： DRIEHUYS BASTIAAN

    IPC: G01R33/48 ,  A61B5/0275 ,  A61B5/055 ,  G01R33/28 ,  G01R33/46 ,  A61B5/00

    CPC classification number: G01R33/5601 ,  A61B5/02755 ,  A61B5/055 ,  A61B5/4088 ,  A61B5/415 ,  A61B5/418 ,  G01R33/4625 ,  Y10T436/24

    Abstract: An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chemical shifts and comparing the observed magnitudes to those of healthy individuals. Preferably, the method includes subtracting substantial backgrounds and accounting for secondary conditions such as the polarization of hyperpolarized gas administered. Additionally, a quantitative analysis of hyperpolarized Xe spectra advantageously allows a physician to establish the extent of disease progression. Advantageously, this method can be used regardless of the method of hyperpolarized Xe administration.

    Abstract translation: 公开了一种使用超极化Xe光谱法检测和/或诊断病理状况的体内非侵入性方法。 一般来说，该方法包括确定代表特定化学位移的光谱峰值的大小，并将观察到的幅度与健康个体的值进行比较。 优选地，该方法包括减去实质背景并考虑二次条件，例如所施用的超极化气体的极化。 另外，超极化Xe光谱的定量分析有利地允许医师建立疾病进展的程度。 有利地，可以使用该方法，而不管超极化Xe施用的方法如何。

    NMR POLARIZATION MONITORING COILS, HYPERPOLARIZERS WITH SAME, AND METHODS FOR DETERMINING THE POLARIZATION LEVEL OF ACCUMULATED HYPERPOLARIZED NOBLE GASES DURING PRODUCTION
    10.
    发明申请
    NMR POLARIZATION MONITORING COILS, HYPERPOLARIZERS WITH SAME, AND METHODS FOR DETERMINING THE POLARIZATION LEVEL OF ACCUMULATED HYPERPOLARIZED NOBLE GASES DURING PRODUCTION 审中-公开
    核磁极化监测线圈，超纯化器及其测定方法，用于测定生产过程中累积的超临界低温气体的极化水平

    公开(公告)号：WO0101164A3

    公开(公告)日：2001-08-09

    申请号：PCT/US0017118

    申请日：2000-06-22

    Applicant: MEDI PHYSICS INC ,  DRIEHUYS BASTIAAN

    Inventor： DRIEHUYS BASTIAAN

    IPC: G01N24/00 ,  A61B5/055 ,  G01R33/28 ,  G01R33/32

    CPC classification number: G01R33/28 ,  G01R33/281

    Abstract: Hyperpolarizers which produce hyperpolarized noble gases include one or more on-board NMR monitoring coils configured to monitor the polarization level of the hyperpolarized gas at various production points in the polarized gas production cycle. A dual symmetry NMR coil is positioned adjacent the optical pumping cell and is in fluid communication with a secondary reservoir in fluid communication with the polarized gas dispensing or exit flow path. This can measure the post-thaw polarization of the gas "on-board" the polarizer. Alternately or additionally, a NMR monitoring coil is assembled to the exit port portion of the optical pumping cell to give a more reliable indication of the polarization level of the gas as it flows out of the gas optical pumping cell. Another NMR monitoring coil can be positioned in a cryogenic bath adjacent a quantity of frozen polarized Xe to determine the polarization level of the frozen gas.

    Abstract translation: 产生超极化惰性气体的超极化器包括一个或多个板上NMR监测线圈，其被配置为监测极化气体生产周期中各个生产点处超极化气体的极化水平。 双对称NMR线圈定位在光泵电池附近并与与极化气体分配或流出流动路径流体连通的第二储存器流体连通。 这可以测量偏振器“板上”气体的解冻后极化。 可选地或另外地，NMR监测线圈被组装到光抽运单元的出口部分，以在气体流出气体光抽运单元时给出气体极化水平的更可靠的指示。 可以将另一个NMR监测线圈置于邻近一定数量的冷冻偏振χ129 Xe的低温浴中以确定冷冻气体的极化水平。

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