公开(公告)号：WO2007077510A3

公开(公告)日：2007-11-01

申请号：PCT/IB2006055010

申请日：2006-12-21

Applicant: RANBAXY LAB LTD ,  KUMAR NARESH ,  KAUR JASKIRAN ,  PALLE VENKATA P ,  BHATT BEENU ,  JINDAL SHELLY ,  CHUGH ANITA ,  GUPTA SUMAN ,  RAY ABHIJIT ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJ KUMAR

Inventor： KUMAR NARESH ,  KAUR JASKIRAN ,  PALLE VENKATA P ,  BHATT BEENU ,  JINDAL SHELLY ,  CHUGH ANITA ,  GUPTA SUMAN ,  RAY ABHIJIT ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJ KUMAR

IPC: C07D233/14 ,  A61K31/4164 ,  A61K31/4439 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  C07D233/60 ,  C07D233/61 ,  C07D401/12

CPC classification number: C07D233/54 ,  C07D233/14 ,  C07D233/56 ,  C07D233/64 ,  C07D401/12

Abstract: Compounds of Formula (I), wherein represents a single bond when G is -OH and double bond when G is -O; R 1 and R 2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R 3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, -NH, -NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.

Abstract translation: 式（I）的化合物，当G为-OH时，当G为-O时，表示单键; R 1和R 2独立地选自氢，烷基，烯基，炔基，芳烷基，环烷基，芳基，杂芳基，杂环基，杂环基烷基或杂芳基烷基; R 3选自氢，羟基，烷氧基，烯氧基或炔氧基; X选自氧，-NH，-NR（其中R是烷基，烯基，烯基，炔基或芳基），硫或无原子; Het是杂环基或杂芳基; n为1〜6的整数， 是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸道，尿和4I胃肠系统的各种疾病。

公开(公告)号：WO2007110782A1

公开(公告)日：2007-10-04

申请号：PCT/IB2007/050003

申请日：2007-01-02

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  CLIFFE, Ian, Anthony ,  SALMAN, Mohammad ,  PALLE, Venkata, P. ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  CHUGH, Anita ,  GUPTA, Suman ,  RAY, Abhijit ,  MALHOTRA, Shivani ,  SHIRUMALLA, Raj, Kumar

Inventor： KUMAR, Naresh ,  CLIFFE, Ian, Anthony ,  SALMAN, Mohammad ,  PALLE, Venkata, P. ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  CHUGH, Anita ,  GUPTA, Suman ,  RAY, Abhijit ,  MALHOTRA, Shivani ,  SHIRUMALLA, Raj, Kumar

IPC: C07D487/08 ,  A61K31/403

CPC classification number: C07D209/52

Abstract: This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：WO2008104955A1

公开(公告)日：2008-09-04

申请号：PCT/IB2008/050734

申请日：2008-02-28

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Kirandeep ,  KAUR, Jaskiran ,  AERON, Shelly ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Kirandeep ,  KAUR, Jaskiran ,  AERON, Shelly ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

IPC: C07D451/10 ,  A61K31/46 ,  A61P11/06

CPC classification number: C07D451/10

Abstract: This present invention relates to muscarinic receptor antagonists of formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of the disclosed compounds, pharmaceutical composition containing the disclosed compounds and methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，包含所公开的化合物的药物组合物和用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：WO2008041184A2

公开(公告)日：2008-04-10

申请号：PCT/IB2007054008

申请日：2007-10-02

Applicant: RANBAXY LAB LTD ,  KUMAR NARESH ,  KAUR JASKIRAN ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

Inventor： KUMAR NARESH ,  KAUR JASKIRAN ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

CPC classification number: C07D233/64 ,  C07D211/70 ,  C07D213/30

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及所述化合物的制备方法，包含所公开的化合物的药物组合物，以及通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：WO2008117229A4

公开(公告)日：2009-12-17

申请号：PCT/IB2008051088

申请日：2008-03-24

Applicant: RANBAXY LAB LTD ,  KUMAR NARESH ,  KAUR KIRANDEEP ,  GARG MALVIKA ,  PALLE VENKATA P ,  SALMAN MOHAMMAD ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

Inventor： KUMAR NARESH ,  KAUR KIRANDEEP ,  GARG MALVIKA ,  PALLE VENKATA P ,  SALMAN MOHAMMAD ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

IPC: C07D451/00 ,  A61K31/439 ,  A61P11/00 ,  A61P13/00

CPC classification number: C07D451/00

Abstract: The present invention relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Also provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists and at least one or more therapeutic agent selected from histamine antagonists, corticosteroids, beta agonists, leukotriene antagonists, EGFR kinase inhibitors, PAF antagonists, 5-lipoxygenase inhibitors, chemokine inhibitors, PDE-4 inhibitors or p38 MAP Kinase inhibitors.

Abstract translation: 本发明涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 本文还提供了包含一种或多种毒蕈碱受体拮抗剂和至少一种或多种选自组胺拮抗剂，皮质类固醇，β激动剂，白细胞三烯拮抗剂，EGFR激酶抑制剂，PAF拮抗剂，5-脂肪氧合酶抑制剂，趋化因子抑制剂，PDE -4抑制剂或p38 MAP激酶抑制剂。

公开(公告)号：WO2008041184A3

公开(公告)日：2008-04-10

申请号：PCT/IB2007/054008

申请日：2007-10-02

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Jaskiran ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Jaskiran ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

IPC: A61K31/4166 ,  C07D211/70 ,  C07D213/30 ,  C07D233/60 ,  C07D233/58 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61P11/00 ,  A61P13/00

Abstract: The present invention generally relates to muscarinic receptor antagonists of formula I, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Formula (I) wherein Het : is heterocyclyl or heteroaryl X : O, S or NR1 and the other substituents are defined as in the claims.

公开(公告)号：WO2007045979A1

公开(公告)日：2007-04-26

申请号：PCT/IB2006/002930

申请日：2006-10-19

Applicant: RANBAXY LABORATORIES LIMITED ,  RAY, Abhijit ,  DASTIDAR, Sunanda, G. ,  SHIRUMALLA, Rajkumar ,  MALHOTRA, Shivani

Inventor： RAY, Abhijit ,  DASTIDAR, Sunanda, G. ,  SHIRUMALLA, Rajkumar ,  MALHOTRA, Shivani

IPC: A61K31/401 ,  A61P11/00 ,  A61P37/00

CPC classification number: A61K31/401

Abstract: Provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists ("MRA"), and at least one additional active ingredients selected from one or more ß 2-agonists, p38 MAP kinase inhibitors, PDE-IV inhibitors, corticosteroids or a mixture thereof and optionally one or more pharmaceutically acceptable carriers, excipients or diluents. In addition, methods of treating autoimmune, inflammatory or allergic diseases or disorders are provided.

Abstract translation: 本文提供了包含一种或多种毒蕈碱受体拮抗剂（“MRA”）和至少一种选自一种或多种β2激动剂，p38 MAP激酶抑制剂，PDE-IV抑制剂，皮质类固醇或其混合物的另外的活性成分的药物组合物， 任选的一种或多种药学上可接受的载体，赋形剂或稀释剂。 此外，提供了治疗自身免疫性，炎性或过敏性疾病或病症的方法。

公开(公告)号：WO2008104942A3

公开(公告)日：2008-12-18

申请号：PCT/IB2008050706

申请日：2008-02-27

Applicant: RANBAXY LAB LTD ,  KUMAR NARESH ,  KAUR JASKIRAN ,  AERON SHELLY ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

Inventor： KUMAR NARESH ,  KAUR JASKIRAN ,  AERON SHELLY ,  RAY ABHIJIT ,  GUPTA SUMAN ,  MALHOTRA SHIVANI ,  SHIRUMALLA RAJKUMAR

IPC: C07D235/08 ,  A61K31/4164 ,  A61K31/4178 ,  A61P1/00 ,  A61P13/00 ,  C07D409/06

CPC classification number: C07D235/08 ,  C07D233/54 ,  C07D409/06

Abstract: This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：WO2008117229A1

公开(公告)日：2008-10-02

申请号：PCT/IB2008/051088

申请日：2008-03-24

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Kirandeep ,  GARG, Malvika ,  PALLE, Venkata, P. ,  SALMAN, Mohammad ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Kirandeep ,  GARG, Malvika ,  PALLE, Venkata, P. ,  SALMAN, Mohammad ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

IPC: C07D451/00 ,  A61K31/439 ,  A61P11/00 ,  A61P13/00

CPC classification number: C07D451/00

Abstract: The present invention relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Also provided herein are pharmaceutical compositions comprising one or more muscarinic receptor antagonists and at least one or more therapeutic agent selected from histamine antagonists, corticosteroids, beta agonists, leukotriene antagonists, EGFR kinase inhibitors, PAF antagonists, 5-lipoxygenase inhibitors, chemokine inhibitors, PDE-4 inhibitors or p38 MAP Kinase inhibitors.

Abstract translation: 本发明涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。 本文还提供了包含一种或多种毒蕈碱受体拮抗剂和至少一种或多种选自组胺拮抗剂，皮质类固醇，β激动剂，白细胞三烯拮抗剂，EGFR激酶抑制剂，PAF拮抗剂，5-脂肪氧合酶抑制剂，趋化因子抑制剂，PDE -4抑制剂或p38 MAP激酶抑制剂。

公开(公告)号：WO2008029349A2

公开(公告)日：2008-03-13

申请号：PCT/IB2007/053561

申请日：2007-09-04

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

Inventor： KUMAR, Naresh ,  KAUR, Kirandeep ,  SHEJUL, Yogesh, D. ,  RAY, Abhijit ,  GUPTA, Suman ,  MALHOTRA, Shivani ,  SHIRUMALLA, Rajkumar

CPC classification number: C07D221/24 ,  C07D209/12 ,  C07D209/14

Abstract: The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The present invention also relates to processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备本文所述化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。