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    METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND
    5.
    发明申请
    METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND 审中-公开

    公开(公告)号：WO2009008951A3

    公开(公告)日：2009-01-15

    申请号：PCT/US2008/007200

    申请日：2008-06-09

    申请人： APOGEE TECHNOLOGY, INC. ,  ANDRIANOV, Alexander, K. ,  MARIN, Alexander

    发明人： ANDRIANOV, Alexander, K. ,  MARIN, Alexander

    IPC分类号： A61K9/00 ,  A61M37/00 ,  A61L31/10 ,  A61L31/16

    摘要： Methodologies and systems are disclosed for coating one or more microneedles, particularly in a microneedle array, for administering a predetermined dosage of biologically active compound through the skin to a recipient. The microneedles of the array are each immersed into at least one reservoir of a fluid liquid formulation of the biologically active compound wherein the at least one reservoir receives a metered predetermined amount of the formulation that corresponds to the dosage to be coated on each microneedle. The microneedles are immersed into the at least one reservoir one or more times to consume the entire amount of formulation in the at least one reservoir such the consumed amount forms the coating comprising one or more layers comprising the predetermined dose on each microneedle. Various embodiments are disclosed for immersing the microneedles one needle at a time, one or more times into the reservoir, or in an array into corresponding reservoirs in one or more repetitive immersions. The reservoirs may be repetitively filled to the predetermined amount to produce the desired single dosage on a microneedle.

    METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND
    6.
    发明申请
    METHODS AND SYSTEMS FOR COATING A MICRONEEDLE WITH A DOSAGE OF A BIOLOGICALLY ACTIVE COMPOUND 审中-公开
    用生物活性化合物给药一种麦芽糖的方法和系统

    公开(公告)号：WO2009008951A2

    公开(公告)日：2009-01-15

    申请号：PCT/US2008007200

    申请日：2008-06-09

    申请人： APOGEE TECHNOLOGY INC ,  ANDRIANOV ALEXANDER K ,  MARIN ALEXANDER

    发明人： ANDRIANOV ALEXANDER K ,  MARIN ALEXANDER

    IPC分类号： A61L31/16 ,  A61L31/10

    CPC分类号： A61K9/0021 ,  A61M37/0015

    摘要： Methodologies and systems are disclosed for coating one or more microneedles, particularly in a microneedle array, for administering a predetermined dosage of biologically active compound through the skin to a recipient. The microneedles of the array are each immersed into at least one reservoir of a fluid liquid formulation of the biologically active compound wherein the at least one reservoir receives a metered predetermined amount of the formulation that corresponds to the dosage to be coated on each microneedle. The microneedles are immersed into the at least one reservoir one or more times to consume the entire amount of formulation in the at least one reservoir such the consumed amount forms the coating comprising one or more layers comprising the predetermined dose on each microneedle. Various embodiments are disclosed for immersing the microneedles one needle at a time, one or more times into the reservoir, or in an array into corresponding reservoirs in one or more repetitive immersions. The reservoirs may be repetitively filled to the predetermined amount to produce the desired single dosage on a microneedle.

    摘要翻译： 公开了用于涂覆一个或多个微针的方法和系统，特别是在微针阵列中，用于通过皮肤向接受者施用预定剂量的生物活性化合物。 阵列的微针各自浸入生物活性化合物的流体液体制剂的至少一个储存器中，其中至少一个储存器接收与计量的预定量的制剂相当于要涂覆在每个微针上的剂量。 将微针浸入至少一个储存器中一次或多次以消耗至少一个储存器中的整个量的制剂，从而消耗量形成包含一个或多个包含每个微针上的预定剂量的层的涂层。 公开了各种实施例，用于将一根针一次或多次的一只针浸入储存器中，或者以一次或多次重复浸渍将其放入相应的储存器中。 储存器可以重复地填充到预定量，以在微针上产生所需的单一剂量。