公开(公告)号：WO2012060910A3

公开(公告)日：2013-10-24

申请号：PCT/US2011044241

申请日：2011-07-15

Applicant: BELL HELICOPTER TEXTRON INC ,  MISHRA SUVANKAR ,  MCCULLOUGH JOHN R ,  CHRIS MARK ,  WOYCHESIN STANLEY B

Inventor： MISHRA SUVANKAR ,  MCCULLOUGH JOHN R ,  CHRIS MARK ,  WOYCHESIN STANLEY B

IPC: B32B3/00

CPC classification number: B29C44/0415 ,  B29C44/128 ,  B29C70/865 ,  B32B3/04 ,  B32B3/12 ,  B32B3/263 ,  B32B5/18 ,  B32B5/245 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B27/065 ,  B32B27/08 ,  B32B27/12 ,  B32B2262/101 ,  B32B2262/106 ,  B32B2307/542 ,  B32B2605/18 ,  Y02T50/433 ,  Y10T428/24149 ,  Y10T428/249953

Abstract: A composite structure includes a first face sheet, a second face sheet, and a foam member located between the first face sheet and the second face sheet. The foam member has a molded contour, the mold contour being configured to provide tooling surface for at least one of the first face sheet and the second face sheet prior to curing of the composite structure. A method of making the foam member includes creating a mold tool having an interior surface which resembles the desired outer contour of the foam member. A mixture is poured into a pour opening in the mold tool. The mixture is allowed to polymerize into a foam as the foam expands and distributes within the mold tool. Vent openings in the mold tool are selectively tailored to control the density of the foam member. The foam member is cured in the mold tool.

Abstract translation: 复合结构包括第一面板，第二面板和位于第一面板和第二面板之间的泡沫构件。 泡沫构件具有模制轮廓，模具轮廓被配置为在复合结构的固化之前为第一面板和第二面板中的至少一个提供工具表面。 制造泡沫构件的方法包括产生具有类似于泡沫构件的期望外轮廓的内表面的模具。 将混合物倒入模具中的倾倒开口中。 当泡沫膨胀并分布在模具中时，允许混合物聚合成泡沫。 选择性地定制模具中的排气孔以控制泡沫构件的密度。 泡沫构件在模具中固化。

公开(公告)号：WO2012060910A2

公开(公告)日：2012-05-10

申请号：PCT/US2011/044241

申请日：2011-07-15

Applicant: BELL HELICOPTER TEXTRON INC. ,  MISHRA, Suvankar ,  MCCULLOUGH, John, R. ,  CHRIS, Mark ,  WOYCHESIN, Stanley, B.

Inventor： MISHRA, Suvankar ,  MCCULLOUGH, John, R. ,  CHRIS, Mark ,  WOYCHESIN, Stanley, B.

IPC: B32B3/26 ,  B32B1/06 ,  B32B7/12 ,  B29C44/02 ,  B32B37/00 ,  B32B38/00

CPC classification number: B29C44/0415 ,  B29C44/128 ,  B29C70/865 ,  B32B3/04 ,  B32B3/12 ,  B32B3/263 ,  B32B5/18 ,  B32B5/245 ,  B32B5/26 ,  B32B7/02 ,  B32B7/12 ,  B32B27/065 ,  B32B27/08 ,  B32B27/12 ,  B32B2262/101 ,  B32B2262/106 ,  B32B2307/542 ,  B32B2605/18 ,  Y02T50/43 ,  Y10T428/24149 ,  Y10T428/249953

Abstract: A composite structure includes a first face sheet, a second face sheet, and a foam member located between the first face sheet and the second face sheet. The foam member has a molded contour, the mold contour being configured to provide tooling surface for at least one of the first face sheet and the second face sheet prior to curing of the composite structure. A method of making the foam member includes creating a mold tool having an interior surface which resembles the desired outer contour of the foam member. A mixture is poured into a pour opening in the mold tool. The mixture is allowed to polymerize into a foam as the foam expands and distributes within the mold tool. Vent openings in the mold tool are selectively tailored to control the density of the foam member. The foam member is cured in the mold tool.

Abstract translation: 复合结构包括第一面板，第二面板和位于第一面板和第二面板之间的泡沫构件。 泡沫构件具有模制轮廓，模具轮廓被配置为在复合结构的固化之前为第一面板和第二面板中的至少一个提供工具表面。 制造泡沫构件的方法包括产生具有类似于泡沫构件的期望外轮廓的内表面的模具。 将混合物倒入模具中的倾倒开口中。 当泡沫膨胀并分布在模具中时，允许混合物聚合成泡沫。 选择性地定制模具中的排气孔以控制泡沫构件的密度。 泡沫构件在模具中固化。

公开(公告)号：WO1998000141A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011643

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K31/445

CPC classification number: C07D295/092 ,  A61K31/00 ,  A61K31/4453 ,  C07B2200/07 ,  Y10S514/878 ,  Y10S514/906

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-trihexyphenidyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-trihexyphenidyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集的（S） - 己烯苯基酯治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用治疗有效量的基本上不含（R） - 己烯缩苯基
对映异构体的对映异构体富集的（S） - 己烯缩水甘油基或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（S） - 三己菲基，或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO1998000133A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011645

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K31/40

CPC classification number: A61K31/40

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S,S)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (R,R)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集（S，S） - 乙酰丙酸酯治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用治疗有效量的基本上不含（R，R） - 乙酰丙酸酰对映异构体的对映异构体富集的（S，S） - 乙酰基吡咯烷酸酯或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（S，S） - 乙酰丙酸酯或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO1998000122A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011611

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K31/14

CPC classification number: A61K31/14 ,  C07C215/30

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-tridihexethyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-tridihexethyl, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-tridihexethyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-tridihexethyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集（S） - 二乙基己基治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用基本上不含（R） - 十二乙基对映异构体的治疗有效量的对映异构体富集的（S） - 二乙基己基或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（S） - 十二乙基或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO2012091695A1

公开(公告)日：2012-07-05

申请号：PCT/US2010/062211

申请日：2010-12-28

Applicant: BELL HELICOPTER TEXTRON INC. ,  MCCULLOUGH, John, R. ,  CARLSON, David, Gordon ,  HETHCOCK, James, Donn ,  OLDROYD, Paul, K. ,  MAY, Carl, A.

Inventor： MCCULLOUGH, John, R. ,  CARLSON, David, Gordon ,  HETHCOCK, James, Donn ,  OLDROYD, Paul, K. ,  MAY, Carl, A.

IPC: B64C3/18

CPC classification number: B64C1/12 ,  B29C65/4835 ,  B29C65/5021 ,  B29C65/5057 ,  B29C65/5078 ,  B29C65/5085 ,  B29C65/562 ,  B29C66/1122 ,  B29C66/1142 ,  B29C66/1162 ,  B29C66/1282 ,  B29C66/12881 ,  B29C66/43441 ,  B29C66/721 ,  B29C66/72525 ,  B29C66/8416 ,  B29D99/001 ,  B29L2031/3076 ,  B64C1/06 ,  B64C2001/0072 ,  F16B5/01 ,  F16B5/12 ,  F16B17/00 ,  Y02T50/43 ,  Y10T29/49622 ,  Y10T403/70

Abstract: A structural joint includes a first member having a first base portion and a first leg portion. The structural joint further includes a second member having a second base portion and a second base portion. The first base portion and the second base portion are coupled together at an overlapping portion. The first leg portion and the second leg portion form a cavity for structurally coupling to a structural member.

Abstract translation: 结构接头包括具有第一基部和第一腿部的第一构件。 结构接头还包括具有第二基部和第二基部的第二构件。 第一基部和第二基部在重叠部分处连接在一起。 第一腿部分和第二腿部部分形成用于结构上结合到结构构件的空腔。

公开(公告)号：WO1998000109A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011639

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K09/08

CPC classification number: C07D207/12 ,  A61K31/40 ,  C07B2200/07

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S,R)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S,R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (R,S)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S,R)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集的（S，R） - 乙酰丙酸酯治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用治疗有效量的基本上不含（R，S） - 乙酰丙酸酰对映异构体的对映异构体富集的（S，R） - 乙酰基吡咯烷酸酯或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（S，R） - 乙酰丙酸酯，或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO1998000011A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011647

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A01N33/18

CPC classification number: A61K31/14

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-tridihexethyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-tridihexethyl or a pharmaceutically acceptable salt thereof, substantially free of the (S)-tridihexethyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-tridihexethyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集的（R） - 二乙基己基酯治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用基本上不含（S） - 十二乙基对映异构体的治疗有效量的对映异构体富集的（R） - 二乙基己基或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（R） - 二乙基己基或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO1998000140A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011640

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K31/445

CPC classification number: A61K31/445 ,  A61K31/4453

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-trihexyphenidyl. The method comprises administering a therapeutically effective amount of enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, substantially free of the (S)-trihexyphenidyl enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (R)-trihexyphenidyl, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集的（R） - 己烯茴香酰基治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用治疗有效量的基本上不含（S） - 间苯代苯基对映异构体的对映异构体富集的（R） - 己烯苯基或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（R） - 己烯茴香基或其药学上可接受的盐和可接受的载体。

公开(公告)号：WO1998000139A1

公开(公告)日：1998-01-08

申请号：PCT/US1997011259

申请日：1997-06-27

Applicant: SEPRACOR, INC. ,  FABIANO, Vincent, L. ,  McCULLOUGH, John, R.

Inventor： SEPRACOR, INC.

IPC: A61K31/435

CPC classification number: A61K31/439 ,  C07D453/02

Abstract: A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-clidinium. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-clidinium, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-clidinium enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-clidinium, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

Abstract translation: 使用对映异构体富集（S） - idin啶治疗尿失禁的方法，例如由膀胱逼尿肌不稳定引起的失禁。 该方法包括施用治疗有效量的基本上不含（R） - 吡啶鎓对映异构体的对映异构体富集的（S）吖啶鎓或其药学上可接受的盐。 还公开了用于治疗尿失禁的药物组合物，其包含对映异构体富集的（S） - 脒鎓盐或其药学上可接受的盐和可接受的载体。