公开(公告)号：WO2010008828A2

公开(公告)日：2010-01-21

申请号：PCT/US2009/048255

申请日：2009-06-23

Applicant: CODEXIS, INC. ,  MIJTS, Benjamin ,  MULEY, Sheela ,  LIANG, Jack ,  NEWMAN, Lisa, M. ,  ZHANG, Xiyun ,  LALONDE, James ,  CLAY, Michael, D. ,  ZHU, Jun ,  GRUBER, John, M. ,  COLBECK, Jeffrey ,  MUNGER, John, D., Jr. ,  MAVINHALLI, Jagadeesh ,  SHELDON, Roger

Inventor： MIJTS, Benjamin ,  MULEY, Sheela ,  LIANG, Jack ,  NEWMAN, Lisa, M. ,  ZHANG, Xiyun ,  LALONDE, James ,  CLAY, Michael, D. ,  ZHU, Jun ,  GRUBER, John, M. ,  COLBECK, Jeffrey ,  MUNGER, John, D., Jr. ,  MAVINHALLI, Jagadeesh ,  SHELDON, Roger

IPC: C07D487/04 ,  C07D487/02 ,  C07D403/12 ,  C07D403/02

CPC classification number: C07D403/04 ,  C07D209/02 ,  C07D403/12 ,  C07D487/04 ,  C12P13/24 ,  C12P17/10 ,  C12P17/188 ,  C12Y104/03004

Abstract: The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract translation: 本公开提供了本文所述的基本上立体异构纯的结构式II至VII的稠合双环脯氨酸化合物，以及其制备的生物催化方法以及用于这些方法的酶。

公开(公告)号：WO2010008828A3

公开(公告)日：2010-04-29

申请号：PCT/US2009048255

申请日：2009-06-23

Applicant: CODEXIS INC ,  MIJTS BENJAMIN ,  MULEY SHEELA ,  LIANG JACK ,  NEWMAN LISA M ,  ZHANG XIYUN ,  LALONDE JAMES ,  CLAY MICHAEL D ,  ZHU JUN ,  GRUBER JOHN M ,  COLBECK JEFFREY ,  MUNGER JOHN D JR ,  MAVINHALLI JAGADEESH ,  SHELDON ROGER

Inventor： MIJTS BENJAMIN ,  MULEY SHEELA ,  LIANG JACK ,  NEWMAN LISA M ,  ZHANG XIYUN ,  LALONDE JAMES ,  CLAY MICHAEL D ,  ZHU JUN ,  GRUBER JOHN M ,  COLBECK JEFFREY ,  MUNGER JOHN D JR ,  MAVINHALLI JAGADEESH ,  SHELDON ROGER

IPC: C07D487/04 ,  C07D403/02 ,  C07D403/12 ,  C07D487/02

CPC classification number: C07D403/04 ,  C07D209/02 ,  C07D403/12 ,  C07D487/04 ,  C12P13/24 ,  C12P17/10 ,  C12P17/188 ,  C12Y104/03004

Abstract: The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract translation: 本公开提供如本文所述的结构式II至VII的基本上立体异构纯的稠合双环脯氨酸化合物，以及涉及其制备的生物催化方法，以及涉及那些方法中使用的酶。

公开(公告)号：WO9904774A3

公开(公告)日：1999-04-15

申请号：PCT/US9815304

申请日：1998-07-23

Applicant: GILEAD SCIENCES INC ,  ARIMILLI MURTY N ,  LEE THOMAS T K ,  MANES LAWRENCE V ,  MUNGER JOHN D JR ,  PRISBE ERNEST J ,  SCHULTZE LISA M ,  KELLY DAPHNE E

Inventor： ARIMILLI MURTY N ,  LEE THOMAS T K ,  MANES LAWRENCE V ,  MUNGER JOHN D JR ,  PRISBE ERNEST J ,  SCHULTZE LISA M ,  KELLY DAPHNE E

IPC: A61K31/675 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  C07F9/6524 ,  C07F9/6561

CPC classification number: A61K31/675 ,  C07F9/65616

Abstract: The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.

Abstract translation: 本发明提供了阿德福韦酯的结晶形式和制备晶体的方法。 本发明的组合物和方法具有用于大规模合成结晶阿德福韦酯或其配制成治疗剂量的理想特性。 发明组合物包括阿德福韦酯的无水晶形。