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    METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID
    1.
    发明申请
    METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID 审中-公开
    用于合成氨基 - 氨基亚磷酸的方法

    公开(公告)号：WO2014012990A1

    公开(公告)日：2014-01-23

    申请号：PCT/EP2013/065124

    申请日：2013-07-17

    申请人： STRAITMARK HOLDING AG

    发明人： NOTTÉ, Patrick ,  COGELS, Samuel ,  BURCK, Sebastian

    IPC分类号： C07F9/38 ,  C07F9/572 ,  C07F9/6524 ,  C07F9/6533 ,  A01N57/20 ,  C08F8/40

    CPC分类号： C07F9/3808 ,  C07F9/3813 ,  C07F9/5726 ,  C07F9/5728 ,  C07F9/6524 ,  C07F9/6533

    摘要： The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P-O-P anhydride moiety comprising compound, having one P-atom at the oxidation state (+111) and the other P-atom at the oxidation state (+111) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P-O-P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

    摘要翻译： 本发明涉及一种用于合成α-氨基亚烷基膦酸或其膦酸酯的新方法，包括以下步骤：通过混合包含化合物的POP酸酐部分形成反应混合物，所述化合物具有处于氧化态的一个P-原子（+111 ）和处于氧化态（+111）或（+ V）的另一个P-原子，氨基烷烃羧酸和酸催化剂，其中所述反应混合物包含至少为α-氨基亚烷基羧酸与POP酐部分的当量比 0.2，并从反应混合物中回收所得的α-氨基亚烷基膦酸化合物或其酯。

    NOVEL CATALYSTS
    3.
    发明申请
    NOVEL CATALYSTS 审中-公开

    公开(公告)号：WO2012068335A3

    公开(公告)日：2012-05-24

    申请号：PCT/US2011/061130

    申请日：2011-11-17

    申请人： DALHOUSIE UNIVERSITY ,  LUNDGREN, Rylan, J. ,  STRADIOTTO, Mark

    发明人： LUNDGREN, Rylan, J. ,  STRADIOTTO, Mark

    IPC分类号： C07F9/50 ,  C07F9/553 ,  C07F9/568 ,  C07F9/59 ,  C07F9/645 ,  C07F9/6509 ,  C07F9/6524 ,  C07F9/6533 ,  C07F9/6536 ,  C07F9/6544 ,  C07F9/6558 ,  B01J31/02 ,  C07C45/65 ,  C07C209/06 ,  C07C209/60 ,  C07D231/56 ,  C07F1/12 ,  C07F15/00

    摘要： The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions. The ligands are of formula (I) wherein each of R 1 and R 2 is independently selected from tert-butyl, cyclohexyl, 2-tolyl, or 1-adamantyl; each of R 3 and R 4 is independently selected from a C 1-5 alkyl, or R 3 , R 4 , and the nitrogen atom to which they are attached form an optionally substituted 4 -10 membered heterocyclic ring; each of X 1a and X 1b , is independently selected from N or C-R 5 ; each of X 2a and X 2b , is independently selected from N or C- R 6 ; each R 5 is independently selected from -H, -CH 3 , -OCH 3 , halogen, or -CF 3 ; each R 6 is independently selected from -H, -CH 3 , -OCH 3 , -N(CH 3 ) 2 , halogen, or -CF 3 ; or an R 5 and an R 6 located on adjacent carbon atoms together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or carbocyclic ring; or two R 6 groups together with the carbon atoms to which they are attached form an optionally substituted 5-7 membered heterocyclic or carbocyclic ring; and wherein no more than one of X 1a , X 1b , X 2a , or X 2b is N.

    NOVEL AMIDITE DERIVATIVES FOR SYNTHESISING POLYMERS ON SURFACES
    5.
    发明申请
    NOVEL AMIDITE DERIVATIVES FOR SYNTHESISING POLYMERS ON SURFACES 审中-公开
    新AMIDITDERIVATE用于聚合物在表面上合成

    公开(公告)号：WO02016375A1

    公开(公告)日：2002-02-28

    申请号：PCT/EP2001/009812

    申请日：2001-08-24

    IPC分类号： C07F9/141 ,  C07F9/24 ,  C07F9/572 ,  C07F9/6524 ,  C07F9/6533 ,  C07H21/00

    CPC分类号： C07H21/00 ,  C07B2200/11 ,  C07F9/1411 ,  C07F9/2408 ,  C07F9/5721 ,  C07F9/6524 ,  C07F9/6533

    摘要： The invention relates to novel amidite derivatives and the use thereof as linker elements for synthesising polymers, especially biopolymers such as nucleic acids, peptides and saccharides, on the surface of solid carriers. The use of the inventive linker derivatives enables surfaces to be regenerated in a non-destructive manner.

    摘要翻译： 本发明涉及新的Amiditderivate及其作为接头构建块使用用于聚合物的合成，特别是生物聚合物，如核酸，肽和糖类例如，固体支持物的表面上。 使用新衍生物接头允许表面的非破坏性的恢复。

    BIFUNCTIONAL CHELATING AGENT
    7.
    发明申请
    BIFUNCTIONAL CHELATING AGENT 审中-公开
    双功能螯合剂

    公开(公告)号：WO01068618A1

    公开(公告)日：2001-09-20

    申请号：PCT/EP2001/002648

    申请日：2001-03-09

    IPC分类号： A61K31/395 ,  A61K31/555 ,  A61K51/00 ,  A61P35/00 ,  C07D259/00 ,  C07F9/6524 ,  A61K51/06

    CPC分类号： C07F9/6524 ,  C07D259/00

    摘要： The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents -NO2, -NH2, -NCS, -NHCOCH2-Z, NHCO-W-COCNHS, -NH-Q, -NHCS-Q, -NHCOCH2-Q, or -NHCO(CH2)m -Q where Q is an hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, Y is CO2H or PO3H2 W is -(CH2)m- m is an integer from 1 to 10, Z is chloride, bromide or iodine.

    摘要翻译： 本发明涉及一种配体，其中n为1至5的整数，X表示-NO 2，-NH 2，-NCS，-NHCOCH 2 -Z，NHCO-W-COCNHS，-NH-Q，-NHCS-Q，-NHCOCH 2 -Q或-NHCO（CH 2）m -Q其中Q是选自类固醇，酶，蛋白质，单克隆抗体，嵌合抗体或其片段的半抗原或任何准备用于偶联反应的活化接头，Y是CO 2 H 或PO 3 H 2 W为 - （CH 2）m-m为1至10的整数，Z为氯，溴或碘。