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    IMPROVED STABILITY FOR OPTICAL COMPUTING SYSTEM
    1.
    发明申请
    IMPROVED STABILITY FOR OPTICAL COMPUTING SYSTEM 审中-公开
    光学计算系统的改进稳定性

    公开(公告)号：WO2008121693A1

    公开(公告)日：2008-10-09

    申请号：PCT/US2008/058396

    申请日：2008-03-27

    Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  SOLTMANN, William ,  PERKINS, David, L. ,  ZHELEZNYAK, Leonard

    Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  SOLTMANN, William ,  PERKINS, David, L. ,  ZHELEZNYAK, Leonard

    IPC: G01N15/06

    CPC classification number: G01N21/31 ,  G01N35/021

    Abstract: The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. Temperature within the analysis system is monitored and the output signals of the optical detectors are compensated or corrections are made within the analysis calculations to compensate or correct for the system temperature. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

    Abstract translation: 本主题涉及产品样品的高速分析方法。 光被引导到被分析的产品的一部分，从产品反射或透过产品朝向光学检测器。 基于通过参考元件的照明光的一部分，将检测器的信号与参考信号进行比较，以确定被分析产品的特性。 监测分析系统内的温度，并在分析计算中对光学检测器的输出信号进行补偿或校正，以补偿或校正系统温度。 被分析的产品可以是固定的，由检查点通过输送机或其他方式移动，或者可以容纳在容器内，该容器包括产品照明光通过的窗口部分。

    TABLET ANALYSIS AND MEASUREMENT SYSTEM
    2.
    发明申请
    TABLET ANALYSIS AND MEASUREMENT SYSTEM 审中-公开
    片材分析与测量系统

    公开(公告)号：WO2008121692A1

    公开(公告)日：2008-10-09

    申请号：PCT/US2008/058393

    申请日：2008-03-27

    Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael L. ,  FREESE, Robert P. ,  BLACKBURN, John ,  PERKINS, David L. ,  ZHELEZNYAK, Leonard ,  PRIORE, Ryan

    Inventor： MYRICK, Michael L. ,  FREESE, Robert P. ,  BLACKBURN, John ,  PERKINS, David L. ,  ZHELEZNYAK, Leonard ,  PRIORE, Ryan

    IPC: G01N35/00

    CPC classification number: G01N21/25 ,  G01N21/31 ,  G01N21/9508 ,  G01N2201/1293

    Abstract: The present subject matter relates to multivariate optical analysis systems employ multivariate optical elements and utilize multivariate optical computing methods to determine information about a product carried by light reflected from or transmitted through the product. An exemplary method of processing and monitoring the product includes introducing the product at an inspection point; illuminating the product with a spectral-specific light though an optic lens; directing the light that has passed through at least a section of the product through at least one multivariate optical element to produce a first signal, the directed light carrying information about the product; detecting the signal at a detector; and determining at least one property of the product based upon the detector output.

    Abstract translation: 本主题涉及采用多变量光学元件的多变量光学分析系统，并且利用多变量光学计算方法来确定关于从产品反射或透过产品运送的光携带的产品的信息。 处理和监测产品的示例性方法包括在检查点引入产品; 通过光学透镜照射具有光谱特定光的产品; 将通过至少一部分产品的光引导通过至少一个多变量光学元件以产生第一信号，所述导光携带关于产品的信息; 在检测器处检测信号; 以及基于所述检测器输出来确定所述产品的至少一个属性。

    DESIGN OF MULTIVARIATE OPTICAL ELEMENTS FOR NONLINEAR CALIBRATION
    3.
    发明申请
    DESIGN OF MULTIVARIATE OPTICAL ELEMENTS FOR NONLINEAR CALIBRATION 审中-公开
    用于非线性校准的多元光学元件的设计

    公开(公告)号：WO2008106391A1

    公开(公告)日：2008-09-04

    申请号：PCT/US2008/054860

    申请日：2008-02-25

    Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  PROFETA, Luisa

    Inventor： MYRICK, Michael, L. ,  PROFETA, Luisa

    IPC: G01J1/42

    CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/12 ,  G01N21/274 ,  G01N21/31 ,  G01N2201/12769

    Abstract: The present subject matter is direct to methodologies for calibrating data obtained from an optical analysis system. An initial calibration matrix of sampled analyte concentrations is modified using mean-centering techniques and selection of low and high analyte concentration spectra to produce a two-point calibration. A modified calibration matrix is produced by generating a non-linear calibration matrix by multiplying the initial calibration matrix by the two-point calibration. In an alternate embodiment, an initial multivariate optical element design is modified by iteratively adjusting the design based on standard error of calibration determination based on non-linerly fitted functions.

    Abstract translation: 本主题直接涉及用于校准从光学分析系统获得的数据的方法。 使用平均定心技术和低分辨率和高分析物浓度光谱的选择来修改采样分析物浓度的初始校准矩阵，以产生两点校准。 通过将初始校准矩阵乘以两点校准来生成非线性校准矩阵来产生修改的校准矩阵。 在替代实施例中，通过基于非线性拟合函数的校准确定的标准误差迭代地调整设计来修改初始多变量光学元件设计。

    THERMAL SELECTIVITY MULTIVARIATE OPTICAL COMPUTING
    4.
    发明申请
    THERMAL SELECTIVITY MULTIVARIATE OPTICAL COMPUTING 审中-公开
    热选择性多光学计算

    公开(公告)号：WO2006137902A2

    公开(公告)日：2006-12-28

    申请号：PCT/US2005/035617

    申请日：2005-10-04

    Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  PERKINS, David, L. ,  PRIORE, Ryan, J.

    Inventor： MYRICK, Michael, L. ,  PERKINS, David, L. ,  PRIORE, Ryan, J.

    IPC: G02F3/00

    CPC classification number: G01N21/3504 ,  G01N2021/1704

    Abstract: A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample

    Abstract translation: 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息

    DATA VALIDATION AND CLASSIFICATION IN OPTICAL ANALYSIS SYSTEMS
    6.
    发明申请
    DATA VALIDATION AND CLASSIFICATION IN OPTICAL ANALYSIS SYSTEMS 审中-公开
    光学分析系统中的数据验证和分类

    公开(公告)号：WO2008002903A2

    公开(公告)日：2008-01-03

    申请号：PCT/US2007072095

    申请日：2007-06-26

    Applicant: UNIV SOUTH CAROLINA ,  MYRICK MICHAEL L ,  PRIORE RYAN J ,  FREESE ROBERT P ,  BLACKBURN JOHN C

    Inventor： MYRICK MICHAEL L ,  PRIORE RYAN J ,  FREESE ROBERT P ,  BLACKBURN JOHN C

    IPC: G11C29/00 ,  G11C7/00

    CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/10 ,  G01J2003/1213 ,  G01J2003/2866 ,  G01N2201/129

    Abstract: A method of classifying information in an optical analysis system includes obtaining calibration data defining a plurality of data points, each data point representing values for two or more detectors when sampling a material used to construct a multivariate optical element. Based on the calibration data, one or more validation models can be developed to indicate one or more ranges of expected results. Validation data comprising the models can be used to compare data points representing values for two or more detectors when performing a measurement of a material to determine if the data points fall within an expected range. Classification data can be generated based on the comparison and, in some embodiments, one or more indicators, such as a confidence level in a measurement, can be provided.

    Abstract translation: 在光学分析系统中对信息进行分类的方法包括：获取定义多个数据点的校准数据，当对用于构造多变量光学元件的材料进行采样时，每个数据点表示两个或更多个检测器的值。 基于校准数据，可以开发一个或多个验证模型来指示预期结果的一个或多个范围。 包括模型的验证数据可用于比较在执行材料测量时确定两个或多个检测器的值的数据点，以确定数据点是否落在预期范围内。 可以基于比较来生成分类数据，并且在一些实施例中，可以提供一个或多个指标，例如测量中的置信水平。

    SELF CALIBRATION METHODS FOR OPTICAL ANALYSIS SYSTEM
    9.
    发明申请
    SELF CALIBRATION METHODS FOR OPTICAL ANALYSIS SYSTEM 审中-公开
    自适应光学分析系统的校准方法

    公开(公告)号：WO2007061436A1

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/008952

    申请日：2006-03-10

    Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PERKINS, David, L.

    Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PERKINS, David, L.

    IPC: G01N21/27 ,  G01N21/31 ,  G01J3/433 ,  G01J3/28

    CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/08 ,  G01J2003/1217 ,  G01N21/274 ,  G01N21/31

    Abstract: Disclosed is a system and methodologies for providing self-calibration in an optical analysis system. Illumination light is directed toward a material to be sampled while provisions are made to modify the characteristics of at least a portion of the illumination light falling on a reference detector. The modified characteristics may include light presence and/or spectral characteristics. Light presence may be modified by rotating or moving mirror assemblies to cause light to fall on either a sample detector or a reference detector while spectral characteristics may be modified by placing materials having known spectral characteristics in the path of the illumination light.

    Abstract translation: 公开了一种用于在光学分析系统中提供自校准的系统和方法。 照明光指向要采样的材料，同时进行调整以改变落在基准检测器上的照明光的至少一部分的特性。 修改的特征可以包括光存在和/或光谱特性。 可以通过旋转或移动镜组件来改变光存在，以使光落在样品检测器或参考检测器上，同时可以通过将具有已知光谱特性的材料放置在照明光的路径中来修改光谱特性。

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