公开(公告)号：WO2007062201A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/045358

申请日：2006-11-27

Applicant: OMETRIC CORPORATION ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  BLACKBURN, John, C. ,  PRIORE, Ryan, J.

Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  BLACKBURN, John, C. ,  PRIORE, Ryan, J.

IPC: G01J3/36

CPC classification number: G01J3/08 ,  A61K8/046 ,  A61K8/25 ,  A61K8/26 ,  A61K8/44 ,  A61Q11/00 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0291 ,  G01J3/28 ,  G01N21/274 ,  G01N21/31

Abstract: A method of arranging and utilizing a multivariate optical computing and analysis system includes transmitting a first light from a light source; generating a second light by reflecting the first light from the sample; directing a portion of the second light with a beamsplitter; and arranging an optical filter mechanism in a normal incidence orientation to receive the portion of the second light, the optical filter mechanism being configured to optically filter data carried by the portion of the second light.

Abstract translation: 一种布置和利用多变量光学计算和分析系统的方法包括从光源发射第一光; 通过反射来自样品的第一光产生第二光; 用分束器引导第二光的一部分; 以及将法兰入射方向的光学滤光器机构布置成接收所述第二光的一部分，所述光学滤光器机构被配置为光学地过滤由所述第二光的所述部分携带的数据。

公开(公告)号：WO2008002903A3

公开(公告)日：2008-01-03

申请号：PCT/US2007/072095

申请日：2007-06-26

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael L. ,  PRIORE, Ryan J. ,  FREESE, Robert P. ,  BLACKBURN, John C.

Inventor： MYRICK, Michael L. ,  PRIORE, Ryan J. ,  FREESE, Robert P. ,  BLACKBURN, John C.

IPC: G06F15/00 ,  H04B15/00 ,  G06F19/00

Abstract: A method of classifying information in an optical analysis system includes obtaning calibration data defining a plurality of data points, each data point representing values for two or more detectors when sampling a material [W] used to construct a multivariate optical element [38]. Based on the calibration data, one or more validation models can be developed to indicate one or more ranges of expected results. Validation data comprising the models can be used to compare data points representing values for two or more detectors when performing a measurement of a material to determine if the data points fall within an expected range. Classification data can be generated based on the comparison and, in some embodiments, one or more indicators, such as a confidence level in a measurement, can be provided.

公开(公告)号：WO2006137902A3

公开(公告)日：2007-12-06

申请号：PCT/US2005035617

申请日：2005-10-04

Applicant: UNIV SOUTH CAROLINA ,  MYRICK MICHAEL L ,  PERKINS DAVID L ,  PRIORE RYAN J

Inventor： MYRICK MICHAEL L ,  PERKINS DAVID L ,  PRIORE RYAN J

IPC: G01N21/00

CPC classification number: G01N21/3504 ,  G01N2021/1704

Abstract: A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample

Abstract translation: 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息

公开(公告)号：WO2007064579A1

公开(公告)日：2007-06-07

申请号：PCT/US2006/045364

申请日：2006-11-27

Applicant: OMETRIC CORPORATION ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PROFETA, Luisa ,  JAMES, Jonathan ,  BLACKBURN, John, C. ,  PRIORE, Ryan, J.

Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PROFETA, Luisa ,  JAMES, Jonathan ,  BLACKBURN, John, C. ,  PRIORE, Ryan, J.

IPC: G01J3/36

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577

Abstract: A method of selecting components for a multivariate optical computing and analysis system to isolate a spectral region includes selecting a spectral region of interest; selecting a spectral element with a predetermined transmission characteristic to control a spectral range of an illumination source; illuminating a sample with the illumination source; and analyzing an optical frequency returned by the sample relative to the spectral region of interest.

Abstract translation: 选择用于多变量光学计算和分析系统以分离光谱区域的组件的方法包括选择感兴趣的光谱区域; 选择具有预定传输特性的频谱元件以控制照明源的光谱范围; 用照明源照射样品; 以及分析由样本相对于感兴趣的光谱区返回的光频率。

公开(公告)号：WO2008002903A2

公开(公告)日：2008-01-03

申请号：PCT/US2007072095

申请日：2007-06-26

Applicant: UNIV SOUTH CAROLINA ,  MYRICK MICHAEL L ,  PRIORE RYAN J ,  FREESE ROBERT P ,  BLACKBURN JOHN C

Inventor： MYRICK MICHAEL L ,  PRIORE RYAN J ,  FREESE ROBERT P ,  BLACKBURN JOHN C

IPC: G11C29/00 ,  G11C7/00

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/10 ,  G01J2003/1213 ,  G01J2003/2866 ,  G01N2201/129

Abstract: A method of classifying information in an optical analysis system includes obtaining calibration data defining a plurality of data points, each data point representing values for two or more detectors when sampling a material used to construct a multivariate optical element. Based on the calibration data, one or more validation models can be developed to indicate one or more ranges of expected results. Validation data comprising the models can be used to compare data points representing values for two or more detectors when performing a measurement of a material to determine if the data points fall within an expected range. Classification data can be generated based on the comparison and, in some embodiments, one or more indicators, such as a confidence level in a measurement, can be provided.

Abstract translation: 在光学分析系统中对信息进行分类的方法包括：获取定义多个数据点的校准数据，当对用于构造多变量光学元件的材料进行采样时，每个数据点表示两个或更多个检测器的值。 基于校准数据，可以开发一个或多个验证模型来指示预期结果的一个或多个范围。 包括模型的验证数据可用于比较在执行材料测量时确定两个或多个检测器的值的数据点，以确定数据点是否落在预期范围内。 可以基于比较来生成分类数据，并且在一些实施例中，可以提供一个或多个指标，例如测量中的置信水平。

公开(公告)号：WO2007062224A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/045436

申请日：2006-11-27

Applicant: OMETRIC CORPORATION ,  PRIORE, Ryan, J. ,  FREESE, Robert, P. ,  MYRICK, Michael, L. ,  BLACKBURN, John, C.

Inventor： PRIORE, Ryan, J. ,  FREESE, Robert, P. ,  MYRICK, Michael, L. ,  BLACKBURN, John, C.

IPC: G01J3/06

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/08 ,  G01N21/274 ,  G01N21/31 ,  G06F17/18 ,  G06F17/50 ,  G06F17/5009 ,  G06F17/5086

Abstract: Methods of selecting spectral elements and system components for a multivariate optical analysis system include providing spectral calibration data for a sample of interest; identifying a plurality of combinations of system components; modeling performance of a pilot system with one of the combinations of system components; determining optimal characteristics of the pilot system; and selecting optimal system components from among the combinations of system components.

Abstract translation: 为多变量光学分析系统选择光谱元素和系统组件的方法包括为感兴趣的样本提供光谱校准数据; 识别系统组件的多个组合; 使用系统组件的组合之一建模试点系统的性能; 确定试点系统的最优特性; 并从系统组件的组合中选择最佳系统组件。

公开(公告)号：WO2007061437A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/008972

申请日：2006-03-10

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C. ,  JAMES, Jonathan, H. ,  PERKINS, David, L.

Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C. ,  JAMES, Jonathan, H. ,  PERKINS, David, L.

IPC: G01N21/31

CPC classification number: G01N21/4738 ,  G01N21/31 ,  G01N21/9508

Abstract: A method of real-time processing and monitoring comprises the steps Of blending a material of interest (e.g., an active pharmceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element (148) and detecting said light with a first detector (152), detecting a deflected portion of the information carrying light with a second detector (156), and determining in real-time at least one selected property of the blended materials based on the detector outputs.

Abstract translation: 实时处理和监测的方法包括以下步骤：将感兴趣的材料（例如，活性药物材料）与辅助材料（例如赋形剂）混合，用光照射混合的材料，反射携带光的信息 关于通过至少一个多变量光学元件（148）的混合材料，并用第一检测器（152）检测所述光，利用第二检测器（156）检测携带光的信息的偏转部分，并且实时地确定 基于检测器输出的混合材料的至少一个选定的性质。

公开(公告)号：WO2007061435A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/008951

申请日：2006-03-10

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C. ,  JAMES, Jonathan, H. ,  PERKINS, David L.

Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C. ,  JAMES, Jonathan, H. ,  PERKINS, David L.

IPC: G01N21/31 ,  G01N21/85

CPC classification number: G01N21/4738 ,  G01N21/31 ,  G01N21/9508

Abstract: A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying invormation about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152), - detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.

Abstract translation: 产品（如药物粉末或片剂）的高速处理和监测方法包括：将产品（C）移动通过检查站; 用光照射产品的至少一部分; 通过使所述第一部分穿过至少一个多元光学元件（148）并且用第一检测器（152）检测所述滤波光，对通过所述产品，og，透射或反射光的携带入射的光的第一部分进行光谱滤波， - 检测 所述光的偏转的第二部分具有第二检测器（156）; 以及基于所述检测器输出来确定所述产品的至少一个所选属性。

公开(公告)号：WO2007062202A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/045365

申请日：2006-11-27

Applicant: OMETRIC CORPORATION ,  MYRICK, Michael, L. ,  FREESE, Robert, P. ,  JAMES, Jonathan ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C.

Inventor： MYRICK, Michael, L. ,  FREESE, Robert, P. ,  JAMES, Jonathan ,  PRIORE, Ryan, J. ,  BLACKBURN, John, C.

IPC: G01J3/28 ,  G01N21/35

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0291 ,  G01J3/08

Abstract: A method of developing a multivariate optical element for an optical analysis system includes forming an optically absorptive spectral element having an optically absorptive material, the optically absorptive material being absorbing in a predetermined spectral region; and utilizing the optically absorptive spectral element in the optical analysis system.

Abstract translation: 开发用于光学分析系统的多元光学元件的方法包括形成具有光学吸收材料的光吸收光谱元件，光学吸收材料在预定光谱区域中吸收; 并利用光学分析系统中的光吸收光谱元件。

公开(公告)号：WO2006137902A2

公开(公告)日：2006-12-28

申请号：PCT/US2005/035617

申请日：2005-10-04

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  MYRICK, Michael, L. ,  PERKINS, David, L. ,  PRIORE, Ryan, J.

Inventor： MYRICK, Michael, L. ,  PERKINS, David, L. ,  PRIORE, Ryan, J.

IPC: G02F3/00

CPC classification number: G01N21/3504 ,  G01N2021/1704

Abstract: A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample

Abstract translation: 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息