公开(公告)号：WO2004085437A1

公开(公告)日：2004-10-07

申请号：PCT/CA2003/001409

申请日：2003-09-15

Applicant: BOEHRINGER INGELHEIM (CANADA) LTD. ,  YOAKIM, Christiane ,  MALENFANT, Eric ,  THAVONEKHAM, Bounkham ,  OGILVIE, William, W. ,  DEZIEL, Robert

Inventor： YOAKIM, Christiane ,  MALENFANT, Eric ,  THAVONEKHAM, Bounkham ,  OGILVIE, William, W. ,  DEZIEL, Robert

IPC: C07D471/14

CPC classification number: C07D471/14

Abstract: Compounds represented by formula (I): wherein R 1 is H, halogen, (C 1-4 ) alkyl, O(C 1-4 ) alkyl, and haloalkyl; R 2 is H or (C 1-4 )alkyl; R 3 is H or (C 1 - 4 ) alkyl; R 4 is (C 1 . 4 )alkyl, (C 1 - 4 )alkyl(C 3 . 7 ) cycloalkyl, or (C 3 _ 7 ) cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C 1 . 4 ) alkyl which in turn maybe optionally substituted with pyridinyl-N­oxide or C(O) OR wherein R is H or (C 1-4 ) alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

Abstract translation: 由式（I）表示的化合物：其中R 1是H，卤素，（C 1-4）烷基，O（C 1-4）烷基和卤代烷基; R 2是H或（C 1-4）烷基; R 3是H或（C 1-4）烷基; R 4是（C 1-4）烷基，（C 1-4）烷基（C 3-7）环烷基或（C 3-7）环烷基; 且Q为具有一至二个选自O和N的杂原子的稠合苯基-5或6元饱和杂环，所述Q任选被羟基取代，或（C 1-4）烷基，其又可任选被吡啶基 - 或C（O）OR，其中R是H或（C 1-4）烷基; 或其盐。 该化合物对野生型具有抑制活性，并具有HIV和HIV的单和双突变株。

公开(公告)号：WO2008039850A2

公开(公告)日：2008-04-03

申请号：PCT/US2007079557

申请日：2007-09-26

Applicant: NEXGEN SPINE INC ,  LEE CASEY K ,  MAKRIS GEORGE ,  CLEMOW ALASTAIR J T ,  OGILVIE WILLIAM F

Inventor： LEE CASEY K ,  MAKRIS GEORGE ,  CLEMOW ALASTAIR J T ,  OGILVIE WILLIAM F

IPC: A61F2/30 ,  A61B17/16 ,  A61F2/44

CPC classification number: A61B17/1671 ,  A61B17/1659 ,  A61F2/30771 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30069 ,  A61F2002/30125 ,  A61F2002/30563 ,  A61F2002/30884 ,  A61F2002/3092 ,  A61F2230/0008 ,  A61F2230/008

Abstract: An endplate for an intervertebral prosthesis prosthesis endplate of the invention includes: a generally- planar base plate, a first elevated region, or dome, within the base plate periphery, and a second elevated region, or dome, within the boundary of the first elevated region. The antero-posterior and side-to-side (medial-lateral) dimensions of the first elevated region are made to be unequal in order to provide resistance to torsional stresses, and the laterally opposite sidewalls of the first elevated region are defined by arcs that terminate in sagittal planes of the endplate, and are symmetrical with respect to a coronal plane of the endplate. A bone rasp for preparing a surgical site for implantation of the prosthesis has a rasp head having a pivot point and rasp teeth arranged to produce a recess or seat of predetermined shape. A groove-cutter for preparing a medial antero- posterior groove in a vertebral body without damaging the anterior rim of the vertebral body has a guide head that is seated ina prepared recess in the vertebral body and a reciprocable tooth that can be stowed in a recess while the cutter is initially positioned within the intervertebral space.

Abstract translation: 用于本发明的椎间假体假体终板的终板包括：在基板周边内的基本平面的基板，第一升高区域或圆顶，以及在第一升高的边界内的第二升高区域或圆顶 地区。 使第一升高区域的前后和侧向（侧向）（内侧）的尺寸不相等以提供抵抗扭转应力的阻力，并且第一升高区域的横向相对的侧壁由弧定义 终止于终板的矢状平面，并且相对于端板的冠状面对称。 用于准备用于植入假体的手术部位的骨锉具有具有枢轴点和锉齿的锉刀头，所述锉刀头被设置成产生预定形状的凹部或座。 用于在椎体中制备内侧前后槽而不损害椎体前缘的槽切割器具有位于椎体内的预备凹槽中的引导头和可收纳在凹部中的可往复运动的牙齿 而切割器最初位于椎间空间内。

公开(公告)号：WO2005053367A3

公开(公告)日：2005-08-25

申请号：PCT/GB2004004205

申请日：2004-10-01

Applicant: YAZAKI EUROPE LTD ,  OGILVIE WILLIAM

Inventor： OGILVIE WILLIAM

IPC: H05K1/00 ,  H05K3/10 ,  H05K3/14 ,  H05K3/38 ,  H05K3/46

CPC classification number: H05K3/388 ,  H05K1/0284 ,  H05K3/102 ,  H05K3/14 ,  H05K3/467

Abstract: A method of manufacturing a patterned electric circuit. The method comprises the steps of providing a cold gas-dynamic spraying (CGDS) device, providing a substrate, and depositing a pattern of electrically conductive material with the CGDS device on the substrate by relative movement between the CGDS device to the substrate.

Abstract translation: 一种图案化电路的制造方法。 该方法包括以下步骤：通过CGDS器件与衬底之间的相对运动，提供冷气体动态喷涂（CGDS）器件，提供衬底，以及通过CGDS器件在衬底上沉积导电材料图案。

公开(公告)号：WO2004093767A1

公开(公告)日：2004-11-04

申请号：PCT/US2004/011995

申请日：2004-04-16

Applicant: ASCENSION ORTHOPEDICS, INC. ,  OGILVIE, William, F.

Inventor： OGILVIE, William, F.

IPC: A61F21/42

CPC classification number: A61F2/4225 ,  A61F2/4241 ,  A61F2002/302 ,  A61F2002/30311 ,  A61F2002/30685 ,  A61F2002/30754 ,  A61F2002/4238 ,  A61F2002/4256 ,  A61F2002/4258 ,  A61F2230/0065 ,  A61F2310/00574

Abstract: An interpositional biarticular disk implant (11) having a circular peripheral rim, a generally toroidal axial center opening (13) and convex upper and lower surfaces (15, 17) is implanted between resected concave surfaces of the metacarpal base and the trapezium or other carpal bone in a CMC joint replacement. The disk (11) is anchored in operative position through the use of a flexible cord, such as a harvested tendon, that passes through the center opening (13) and through osseous passageways created in the two facing bones.

公开(公告)号：WO2003080612A1

公开(公告)日：2003-10-02

申请号：PCT/CA2003/000418

申请日：2003-03-24

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  O'MEARA, Jeffrey ,  SIMONEAU, Bruno ,  YOAKIM, Christiane ,  DÉZIEL, Robert ,  OGILVIE, William, W.

Inventor： O'MEARA, Jeffrey ,  SIMONEAU, Bruno ,  YOAKIM, Christiane ,  DÉZIEL, Robert ,  OGILVIE, William, W.

IPC: C07D471/14

CPC classification number: A61K31/55 ,  C07D471/14

Abstract: Disclosed are compounds of formula I:whereinR2 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, NH(C1-4alkyl) or N(C1-4alkyl)2;R4 is H or CH3;R5 is H or CH3;R12 is H, halogen, (C1-4)alkyl, CF3, or NO2; R13 is H, (C1-4)alkyl, halogen, OH, or NH2, with the proviso that R12 and R13 are not both H; andR14 is COOR14a wherein R14a is H or (C1-6)alkyl; or R14 is (C2-4)alkenyl-COOR14a wherein R14a is as defined herein; or R14 is (C1-4)alkyl-COOR14a wherein R14a is as defined above;or a salt or a prodrug thereof, useful as inhibitors of HIV reverse transcriptase.

Abstract translation: 公开了式I的化合物：其中R2是H，卤素，（C1-4）烷基，O（C1-4）烷基，NH（C1-4烷基）或N（C1-4烷基）2; R4是H或CH3; R5 是H或CH 3; R 12是H，卤素，（C 1-4）烷基，CF 3或NO 2; R 13是H，（C 1-4）烷基，卤素，OH或NH 2，条件是R 12和R 13不同时为H; R14是COOR14a，其中R14a是H或（C1-6）烷基; 或R 14为（C 2-4）烯基-COOR 14a，其中R 14a如本文所定义; 或R14是（C 1-4）烷基-COOR14a，其中R14a如上定义;或其盐或其前药，可用作HIV逆转录酶的抑制剂。

公开(公告)号：WO1998029435A1

公开(公告)日：1998-07-09

申请号：PCT/CA1997001004

申请日：1997-12-23

Applicant: BOEHRINGER INGELHEIM (CANADA) LTD. ,  BAILEY, Murray ,  FAZAL, Gulrez ,  LAVALLEE, Pierre ,  OGILVIE, William ,  POUPART, Marc-André

Inventor： BOEHRINGER INGELHEIM (CANADA) LTD.

IPC: C07K05/10

CPC classification number: C07K5/1027 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/06191 ,  C07K5/0827

Abstract: A compound of formula (I), wherein X is CF3, C2F5, 2-benzothiazole, CF2CONHR6, CONHR6, wherein R6 is CH2C6H5, CH2(4-iodophenyl), CH3, (CH2)2OCH2C6H5, CH2-2-benzimidazole, CH2-(3,4-methylenedioxybenzene), CH(CH3)C6H5 or CH(CH2CH3)C6H5; or X is 2-benzoxazole-R7 wherein R7 is H, 4-CH3, 5-CH3, 6-CH3 or 7-CH3; R1 is H, CH3 or CH2CH3; R2 is CH2CONH2, CH2CH2CONH2, CH2-thiazole, CH2CON(CH3)2, CH2CO-(pyrrolidino), CH2CH(CH3)2 or CH2C6H5; R3 is Et, CH(CH3)2, C(CH3)3, adamantyl, CH2C(CH3)3 or C(CH3)2CO2H; and R20 is COCH2C(CH3)3, COCH2CH2C6H4OH, COCH2CH(CH3)2, CO2C(CH3)3, CONHC(CH3)3, COCH2N(CH3)2, CO(CH2)3CO2H, CO-(S)-CH(NH2)C(CH3)3, CO-(S)-CH{NHC(O)O-C(CH3)3}C(CH3)3, CO-(S)-CH{NHCO(CH2)5NHC(O)OC(CH3)3}C(CH3)3 or CO-(S)-CH{NHCO(CH2)5NH2}C(CH3)3. These compounds are useful for the treatment of human cytomegalovirus infection.

Abstract translation: 式（I）化合物，其中X为CF 3，C 2 F 5，2-苯并噻唑，CF 2 CONHR 6，CONHR 6，其中R 6为CH 2 C 6 H 5，CH 2（4-碘苯基），CH 3，（CH 2）2 OCH 2 C 6 H 5，CH 2 -2-苯并咪唑， （3,4-亚甲二氧基苯），CH（CH3）C6H5或CH（CH2CH3）C6H5; 或X是2-苯并恶唑-R 7，其中R 7是H，4-CH 3，5-CH 3，6-CH 3或7-CH 3; R1是H，CH3或CH2CH3; R2是CH2CONH2，CH2CH2CONH2，CH2-噻唑，CH2CON（CH3）2，CH2CO-（吡咯烷子基），CH2CH（CH3）2或CH2C6H5; R3是Et，CH（CH3）2，C（CH3）3，金刚烷基，CH2C（CH3）3或C（CH3）2CO2H; 和R 20是COCH 2 C（CH 3）3，COCH 2 CH 2 C 6 H 4 OH，COCH 2 CH（CH 3）2，CO 2 C（CH 3）3，CONHC（CH 3）3，COCH 2 N（CH 3）2，CO（CH 2）3 CO 2 H，CO-（S） ）C（CH 3）3，CO-（S）-CH（NHC（O）OC（CH 3）3} C（CH 3）3，CO-（S）-CH（NHCO（CH 2）5 NHC（O） ）3} C（CH 3）3或CO-（S）-CH（NHCO（CH 2）5 NH 2）C（CH 3）3。 这些化合物可用于治疗人巨细胞病毒感染。

公开(公告)号：WO2009137518A1

公开(公告)日：2009-11-12

申请号：PCT/US2009/042896

申请日：2009-05-05

Applicant: NEXGEN SPINE, INC. ,  OGILVIE, William, F.

Inventor： OGILVIE, William, F.

IPC: A61F2/44 ,  A61F2/00 ,  A61F2/30

CPC classification number: A61F2/442 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30563 ,  A61F2002/30884 ,  A61F2002/3093 ,  A61F2230/0006 ,  A61F2230/0008

Abstract: An endplate for an intervertebral disc prosthesis includes: a plate member having a generally planar rim for contacting the peripheral cortical rim of a vertebral body, and an elevated region within the rim having an anterior region and a posterior region, wherein the anterior region of the elevated region is preferably recessed with respect to the posterior region and is treated to promote bone ingrowth. The endplate may be provided with a medial fin extending partway from the anterior edge of the endplate toward the posterior edge of the endplate.

Abstract translation: 用于椎间盘假体的终板包括：板构件，其具有用于接触椎体的外围皮质边缘的大致平面的边缘，以及具有前部区域和后部区域的边缘内的升高区域，其中， 升高区域优选地相对于后部区域凹陷并且被处理以促进骨向内生长。 端板可以设置有从端板的前边缘朝向端板的后边缘的中间延伸的中间翅片。

公开(公告)号：WO2009042935A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077975

申请日：2008-09-26

Applicant: NEXGEN SPINE, INC. ,  OGILVIE, William, F. ,  MAKRIS, George

Inventor： OGILVIE, William, F. ,  MAKRIS, George

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/4611 ,  A61F2002/3013 ,  A61F2002/30492 ,  A61F2002/30495 ,  A61F2002/30563 ,  A61F2002/30604 ,  A61F2002/30884 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/001 ,  Y10T29/49826

Abstract: The present invention provides an orthopedic device assembly comprising a first assembly element (200), a second assembly element (300), and a retaining mechanism (400). The first assembly element has a recess (214) that receives the second assembly element, and the retaining mechanism holds the second element in an assembled state with the first assembly element. The retaining mechanism includes a retaining member with an angular cross-section defined by a base portion and a lateral flange portion projecting from the base portion. The retaining member is inserted through an aperture (226) of the first assembly element into a groove in a wall of the recess of the first assembly element, with the flange portion projecting laterally of the groove and overhanging a shoulder portion of the second assembly element so as to retain the second assembly element in the assembled state with the first assembly element.

Abstract translation: 本发明提供一种矫形装置组件，其包括第一组件元件（200），第二组件元件（300）和保持机构（400）。 第一组装元件具有容纳第二组件元件的凹槽（214），并且保持机构将第二元件与第一组件元件组装在一起。 保持机构包括具有由基部限定的角度横截面的保持构件和从基部突出的侧向凸缘部。 保持构件通过第一组合元件的孔（226）插入到第一组件的凹部的壁中的凹槽中，凸缘部分突出于凹槽的横向并且突出于第二组件的肩部 以便将第二组装元件与第一组件元件保持在组装状态。

公开(公告)号：WO2008039850A3

公开(公告)日：2008-04-03

申请号：PCT/US2007/079557

申请日：2007-09-26

Applicant: NEXGEN SPINE, INC. ,  LEE, Casey, K. ,  MAKRIS, George ,  CLEMOW, Alastair, J., T. ,  OGILVIE, William, F.

Inventor： LEE, Casey, K. ,  MAKRIS, George ,  CLEMOW, Alastair, J., T. ,  OGILVIE, William, F.

IPC: A61F2/30 ,  A61F2/44 ,  A61B17/16

Abstract: An endplate for an intervertebral prosthesis includes : a generally- planar base plate (162 ), a f irst elevated region ( 152 ), or dome, within the base plate periphery, and a second elevated region ( 153 ), or dome, within the boundary (164 ) of the f irst elevated region. The antero-posterior and side-to-side (medial-lateral ) dimensions of the f irst elevated region are made to be unequal in order to provide resistance to torsional stresses, and the laterally opposite sidewalls of the f irst elevated region are def ined by arcs that terminate in sagittal planes of the endplate, and are symmetrical with respect to a coronal plane of the endplate. A bone rasp (201 ) for preparing a surgical site for implantation of the prosthesis has a rasp head (202 ) having a pivot point and rasp teeth (224 ) arranged to produce a recess or seat of predetermined shape. A groove-cutter (300 ) for preparing a medial antero- posterior groove in a vertebral body without damaging the anterior rim of the vertebral body has a guide head that is seated in a prepared recess in the vertebral body and a reciprocable tooth ( 301 ) that can be stowed in a recess while the cutter is initially positioned within the intervertebral space.

公开(公告)号：WO2007034130A1

公开(公告)日：2007-03-29

申请号：PCT/GB2006/002141

申请日：2006-06-12

Applicant: YAZAKI EUROPE LIMITED ,  OGILVIE, William

Inventor： OGILVIE, William

IPC: H01H85/11

CPC classification number: H01H85/11 ,  H01H69/02

Abstract: A method of creating a fuse. The method comprises the steps of creating a fusible link electrically connecting a first terminal portion to a second terminal portion, the fusible link, the first terminal portion and the second terminal portion being made of a first electrically conductive material; and spraying a coating of a second electrically conductive material onto the fusible link. The second electrically conductive material has a lower melting point than the first electrically conductive material and is absorbable in the first electrically conductive material.

Abstract translation: 一种创建保险丝的方法。 该方法包括以下步骤：产生将第一端子部分与第二端子部分电连接的熔丝，第一端子部分和第二端子部分由第一导电材料制成; 以及将第二导电材料的涂层喷涂到所述可熔连接件上。 第二导电材料具有比第一导电材料更低的熔点，并且可吸收在第一导电材料中。