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公开(公告)号：WO2010075061A3
公开(公告)日：2010-07-01
申请号：PCT/US2009/068005
申请日：2009-12-15
Applicant: JOHNSON & JOHNSON RESEARCH PTY LIMITED , MACPHERSON, Janet, Lesley , PERITT, David , HENRICHSEN, Kevin , SYMONDS, Geoffrey, Phillip , POND, Susan , WONG, Philip
Inventor： MACPHERSON, Janet, Lesley , PERITT, David , HENRICHSEN, Kevin , SYMONDS, Geoffrey, Phillip , POND, Susan , WONG, Philip
IPC: A61M1/34
Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
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2.发明申请CNGH0011 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES, AND COMPOSITIONS, AND METHODS OF PRODUCTION AND USE 审中-公开CNGH0011多核苷酸，多肽，抗体和组合物，以及生产和使用方法
公开(公告)号：WO2005094356A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/010607
申请日：2005-03-31
Applicant: CENTOCOR, INC. , JOHNSON & JOHNSON RESEARCH PTY LTD. , HUANG, Chong , SYED, Farhat , LI, Xilin , LI, Li , ARNDT, Gregory , POND, Susan
Inventor： HUANG, Chong , SYED, Farhat , LI, Xilin , LI, Li , ARNDT, Gregory , POND, Susan
CPC classification number: C07K14/705
Abstract: CNGH0011 polypeptides and nucleic acids encoding a variety of proteins have diagnostic, preventive, therapeutic, and other uses for a number of human and other animal disorders. Nucleic acid antagonist molecules (siRNA, shRNA, among others), expression vectors containing nucleic acid molecules, host cells into which the expression vectors have been introduced, fusion polypeptides, antigenic peptides and antibodies can be utilized to control the level of protein and regulate a variety of cellular processes in diagnostic, screening, and therapeutic methods.
Abstract translation: CNGH0011多肽和编码多种蛋白质的核酸对许多人类和其他动物疾病具有诊断，预防，治疗和其他用途。 可以使用核酸拮抗剂分子（siRNA，shRNA等），含有核酸分子的表达载体，其中引入了表达载体的宿主细胞，融合多肽，抗原肽和抗体，以控制蛋白质的水平并调节 诊断，筛选和治疗方法中各种细胞过程。
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3.发明申请
公开(公告)号：WO2006063168A3
公开(公告)日：2006-06-15
申请号：PCT/US2005/044486
申请日：2005-12-08
Applicant: CENTOCOR, INC. , JOHNSON & JOHNSON RESEARCH PTY LIMITED , HUANG, Chong , SYED, Farhat , LI, Li , LI, Xilin , ARNDT, Gregory , POND, Susan
Inventor： HUANG, Chong , SYED, Farhat , LI, Li , LI, Xilin , ARNDT, Gregory , POND, Susan
IPC: A61K31/70 , A61K38/00 , A61K39/395 , C07K7/16 , C07K16/28
Abstract: Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD.
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4.发明申请OXYTOCIN RECEPTOR ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF PULMONARY RELATED DISEASES 审中-公开氧自由基受体拮抗剂及其用于治疗肺炎相关疾病的用途
公开(公告)号：WO2006063168A2
公开(公告)日：2006-06-15
申请号：PCT/US2005044486
申请日：2005-12-08
Applicant: CENTOCOR INC , JOHNSON & JOHNSON RES PTY LTD , HUANG CHONG , SYED FARHAT , LI LI , LI XILIN , ARNDT GREGORY , POND SUSAN
Inventor： HUANG CHONG , SYED FARHAT , LI LI , LI XILIN , ARNDT GREGORY , POND SUSAN
IPC: A61K38/06
CPC classification number: C07K16/286 , A61K2039/505
Abstract: Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD.
Abstract translation: 治疗与催产素受体活性相关的疾病的方法使用OXYTOCIN受体拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，小分子药物，siRNA，shRNA和DNA酶的抗体。 与催产素受体活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD。
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Patent Agency Ranking
公开(公告)号：WO2003006612A3
公开(公告)日：2003-01-23
申请号：PCT/US2002/021713
申请日：2002-07-10
Applicant: J & J RESEARCH PTY LTD , MURRAY, John , FANNING, Greg , MACPHERSON, Janet , POND, Susan , SYMONDS, Geoffrey
Inventor： MURRAY, John , FANNING, Greg , MACPHERSON, Janet , POND, Susan , SYMONDS, Geoffrey
IPC: A01N63/00
Abstract: The present invention relates to a method for introducing exogenous nucleic acid-containing hematopoietic progenitor cells into a patient.
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公开(公告)号：WO2010075061A2
公开(公告)日：2010-07-01
申请号：PCT/US2009068005
申请日：2009-12-15
Applicant: JOHNSON & JOHNSON RES PTY LTD , MACPHERSON JANET LESLEY , PERITT DAVID , HENRICHSEN KEVIN , SYMONDS GEOFFREY PHILLIP , POND SUSAN , WONG PHILIP
Inventor： MACPHERSON JANET LESLEY , PERITT DAVID , HENRICHSEN KEVIN , SYMONDS GEOFFREY PHILLIP , POND SUSAN , WONG PHILIP
IPC: A61M1/34
CPC classification number: A61M1/3496 , A61M1/362 , A61M1/3626 , A61M1/3672 , A61M1/3689 , A61M1/3696 , A61M1/38 , A61M2202/0439 , B03C1/015 , B04B5/10 , B04B11/02 , A61M2202/0064
Abstract: Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.
Abstract translation: 描述了方法（300），装置和血液处理系统。 该方法（300）包括以下步骤：从耦合到单个血液处理装置的患者获得（312）血液以在患者和血液处理装置之间形成闭环; 通过使用血液处理装置在闭环中实施的白细胞分离术从血液收集（314）大量单核血细胞; 以及使用闭环中的血液处理装置同时富集（316）在大批量单核血细胞中从非靶细胞分离的靶细胞。
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7.发明申请CNGH0011 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES, AND COMPOSITIONS, AND METHODS OF PRODUCTION AND USE 审中-公开CNGH0011多核苷酸，多肽，抗体和组合物，以及生产和使用方法
公开(公告)号：WO2005094356A3
公开(公告)日：2006-06-01
申请号：PCT/US2005010607
申请日：2005-03-31
Applicant: CENTOCOR INC , JOHNSON & JOHNSON RES PTY LTD , HUANG CHONG , SYED FARHAT , LI XILIN , LI LI , ARNDT GREGORY , POND SUSAN
Inventor： HUANG CHONG , SYED FARHAT , LI XILIN , LI LI , ARNDT GREGORY , POND SUSAN
IPC: C07K14/705 , C07H21/04 , C07K16/28 , C12N15/09 , C12N15/12 , C12P21/06 , C12Q1/68 , G01N33/566
CPC classification number: C07K14/705
Abstract: CNGH0011 polypeptides and nucleic acids encoding a variety of proteins have diagnostic, preventive, therapeutic, and other uses for a number of human and other animal disorders. Nucleic acid antagonist molecules (siRNA, shRNA, among others), expression vectors containing nucleic acid molecules, host cells into which the expression vectors have been introduced, fusion polypeptides, antigenic peptides and antibodies can be utilized to control the level of protein and regulate a variety of cellular processes in diagnostic, screening, and therapeutic methods.
Abstract translation: CNGH0011多肽和编码多种蛋白质的核酸对许多人类和其他动物疾病具有诊断，预防，治疗和其他用途。 可以使用核酸拮抗剂分子（siRNA，shRNA等），含有核酸分子的表达载体，其中引入了表达载体的宿主细胞，融合多肽，抗原肽和抗体，以控制蛋白质的水平并调节 诊断，筛选和治疗方法中各种细胞过程。
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8.发明申请A MEANS OF PRODUCING AND UTILISING A POPULATION OF DISEASE SPECIFIC CYTOTOXIC T-LYMPHOCTYES 审中-公开生产和利用疾病人群特异性CYTOTOXIC T淋巴细胞的手段
公开(公告)号：WO2004042041A1
公开(公告)日：2004-05-21
申请号：PCT/AU2003/001476
申请日：2003-11-07
Applicant: JOHNSON & JOHNSON RESEARCH PTY LIMITED , SYMONDS, Geoffrey, Philip , POND, Susan, Margaret
Inventor： SYMONDS, Geoffrey, Philip , POND, Susan, Margaret
IPC: C12N5/08
CPC classification number: C12N5/0636 , A61K2039/5156 , C12N5/0647 , C12N2510/00 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/466
Abstract: The present invention relates to the production of a population of virus-specific CTLs in which the population contains an anti-virus specific gene expression construct. This population can be combined with a population of CD4+ T lymphocytes or a population of CD34+ hematopoietic progenitor cells and one or more of these populations of cells can be delivered to an autologous virus-positive individual. The present invention also relates to therapeutic cell products and to methods of treating diseases, particularly infectious diseases.
Abstract translation: 本发明涉及其中群体含有抗病毒特异性基因表达构建体的病毒特异性CTL群体的产生。 该群体可以与CD4 + T淋巴细胞群体或CD34 +造血祖细胞群体组合，并且这些这些细胞群体中的一个或多个可以递送到自体病毒阳性个体。 本发明还涉及治疗性细胞产物和治疗疾病，特别是感染性疾病的方法。
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9.发明申请
公开(公告)号：WO03006612A2
公开(公告)日：2003-01-23
申请号：PCT/US0221713
申请日：2002-07-10
Applicant: J & J RES PTY LTD , SYMONDS GEOFFREY , MURRAY JOHN , FANNING GREG , MACPHERSON JANET , POND SUSAN
Inventor： SYMONDS GEOFFREY , MURRAY JOHN , FANNING GREG , MACPHERSON JANET , POND SUSAN
IPC: C12N15/09 , A01N63/00 , A61K20060101 , A61K35/12 , A61K35/14 , A61K35/28 , A61K48/00 , A61P7/00 , A61P31/12 , A61P31/18 , A61P43/00 , C12N20060101 , C12N5/0789 , C12N5/10 , C12N15/63 , C12N15/85 , C12Q1/68 , C12N
CPC classification number: C12N5/0647 , A61K48/00 , A61K2035/124 , C12N2510/00
Abstract: The present invention relates to a method for introducing exogenous nucleic acid-containing hematopoietic progenitor cells into a patient.
Abstract translation: 本发明涉及将外源核酸的造血祖细胞引入患者体内的方法。
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