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    STABLE SALTS OF NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES
    7.
    发明申请
    STABLE SALTS OF NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES 审中-公开

    公开(公告)号：WO0135957A3

    公开(公告)日：2001-12-27

    申请号：PCT/EP0011309

    申请日：2000-11-15

    申请人： SANOL ARZNEI SCHWARZ GMBH ,  MEESE CLAUS

    发明人： MEESE CLAUS

    IPC分类号： A61P13/00 ,  A61K31/24 ,  A61P13/06 ,  C07B61/00 ,  C07C213/06 ,  C07C215/54 ,  C07C219/28 ,  C07C229/38

    CPC分类号： C07C215/54 ,  C07B2200/07 ,  C07C219/28 ,  C07C229/38

    摘要： The invention relates to highly pure, crystalline, stable compounds of 3,3-diphenylpropylamine derivatives, in the form of their salts, a method for their production and highly pure, stable, intermediate products. The method is particularly characterized by regio- and chemo-selectivity and high yields and provides salts of phenolic monoesters of 3,3-diphenylpropylamines, which are particularly suitable for application in technical pharmaceutic formulations. Preferred compounds are R -(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenyl isobutyrate hydrogenfumarate and R -(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenyl isobutyrate hydrochloride hydrate. The method further provides essential, stable, crystalline intermediate products for the production of the above salts. A preferred intermediate product is R -(-)-3-(3-diisopropylaminophenylpropyl)-4-hydroxybenzoic acid methyl ester.

    PARA-SUBSTITUTED BENZYL AMINES AND THEIR USE AS ANTIMYCOTICS AND FOR THE TREATMENT OF CARDIAC AND CIRCULATORY DISEASES
    8.
    发明申请
    PARA-SUBSTITUTED BENZYL AMINES AND THEIR USE AS ANTIMYCOTICS AND FOR THE TREATMENT OF CARDIAC AND CIRCULATORY DISEASES 审中-公开
    对位取代苄胺及其作为抗真菌剂和用于治疗心脏和循环病症的

    公开(公告)号：WO1993024445A1

    公开(公告)日：1993-12-09

    申请号：PCT/EP1993001176

    申请日：1993-05-12

    申请人： BASF AKTIENGESELLSCHAFT ,  HELLENDAHL, Beate ,  ROEHL, Franz ,  RASCHACK, Manfred ,  HAFNER, Matthias

    发明人： BASF AKTIENGESELLSCHAFT

    IPC分类号： C07C215/50

    CPC分类号： C07C215/50 ,  C07C211/49 ,  C07C217/58 ,  C07C219/28 ,  C07C233/43 ,  C07C2601/14

    摘要： Para-substitued benzyl amines of general formula (I) in which W is a carbonyl group or a single bond, R1 is a lower alkyl group, R2 is an alkyl radical with 5 to 20 carbon atoms which may be branched and contain 1 to 3 double bonds, in addition a saturated cycle of 3 to 7 carbon atoms may be integrated into the chain or included as substituents, and may be substitued by one or more aromatic rings and contain a sulphur or oxygen atom, X is a group of the general formula: OR?3 or NR4R5¿ in which R3 stands for a lower alkyl, lower alkyl carbonyl, lower alkoxycarbonyl, mono lower alkyl aminocarbonyl, di lower alkyl aminocarbonyl group or a hydrogen atom, R4 is a lower alkyl group or a hydrogen atom and R5 is a hydrogen atom, a lower alkyl, lower alkyl carbonyl, lower alkoxy carbonyl, aminocarbonyl, mono lower alkyl aminocarbonyl or di lower alkyl aminocarbonyl group, Y is a hydrogen atom or a methyl group, and addition salts with physiologically acceptable acids and medicaments containing them.