公开(公告)号：WO0067845B1

公开(公告)日：2001-02-01

申请号：PCT/US0011849

申请日：2000-05-02

Applicant: PRECISION VASCULAR SYSTEMS INC

Inventor： JACOBSEN STEPHEN C ,  LIPPERT JOHN A ,  BACKMAN KENT ,  DAVIS CLARK C

IPC: A61M36/04 ,  A61N5/10 ,  A61N5/00

CPC classification number: A61N5/1002 ,  A61N5/1007 ,  A61N2005/1005

Abstract: A device, and method for irradiating with a desired radioactive emission the interior walls of blood vessels, body cavities or the like. The device (50) includes a catheter (52) for placement in the blood vessels, body cavities or the like, adapted for disposition adjacent the walls thereof. The distal end (52a) of the catheter (52) is preferably configured to expand into a helical coil shape when unconstrained, but may be straightened within a second catheter (64).

Abstract translation: 用于对所需放射性发射照射血管，体腔等的内壁的装置和方法。 装置（50）包括用于放置在血管，体腔等中的导管（52），适于邻近其壁布置。 导管（52）的远端（52a）优选地被构造成在不受约束的情况下膨胀成螺旋线圈形状，但是可以在第二导管（64）内被拉直。

公开(公告)号：WO2004012804A2

公开(公告)日：2004-02-12

申请号：PCT/US0324604

申请日：2003-08-05

Applicant: PRECISION VASCULAR SYSTEMS INC ,  DAVIS CLARK C ,  OLSON KEVIN T ,  FOX DEWAYNE C

Inventor： DAVIS CLARK C ,  OLSON KEVIN T ,  FOX DEWAYNE C

IPC: A61M25/00 ,  A61B18/08 ,  A61B18/14 ,  A61M25/01

CPC classification number: A61M25/0013 ,  A61B18/082 ,  A61B18/14 ,  A61M25/0043 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0053 ,  A61M25/0054 ,  A61M25/0138 ,  A61M25/09 ,  A61M25/09025 ,  A61M2025/0059 ,  A61M2025/09066 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/09108 ,  A61M2025/09175

Abstract: A medical device for guiding through anatomy, such as a catheter or guidewire, with a tubular body that has been slotted to enhance bending flexibility, and a polymer liner with an anti-collapsing structure, and a method of making a medical device with a kink-resistant corrugated tubular member and an anti-collapsing structure. Anti collapsing structures may be helical or annular, and may be wire, such as ribbon wire, grooves in the liner, corrugations, or a braid. Liners may be bonded to the anti­collapsing structure, or may have two layers, with the anti-collapsing structure between the layers. Corrugations may be formed between sections of the anti-collapsing 'structure with heat, pressure, stretching, compression, a mold, or a combination thereof, and may extend inward or outward. Shape or wall thickness may vary along the length to provide a varying bending stiffness. Slots may be formed in groups of two, three, or more, and adjacent groups may be rotated about the axis forming a helical pattern.

Abstract translation: 一种用于引导穿过解剖结构的医疗装置，例如导管或导丝，其具有开槽以增强弯曲柔性的管状主体，以及具有防塌结构的聚合物衬里，以及制造具有弯折的医疗装置的方法 耐波纹管状部件和防塌结构。 防塌陷结构可以是螺旋形或环形的，并且可以是线，例如带状线，衬里中的凹槽，波纹或编织物。 内衬可以粘合到抗崩塌结构上，或者可以具有两层，在层之间具有抗塌陷结构。 可以在抗热塌陷结构的部分与热，压力，拉伸，压缩，模具或其组合之间形成波纹，并且可以向内或向外延伸。 形状或壁厚可以沿着长度变化以提供变化的弯曲刚度。 狭槽可以以两个，三个或更多个的组形成，并且相邻的组可以围绕形成螺旋图案的轴线旋转。

公开(公告)号：WO0128620A9

公开(公告)日：2002-08-15

申请号：PCT/US0041219

申请日：2000-10-18

Applicant: PRECISION VASCULAR SYSTEMS INC

Inventor： JACOBSEN STEPHEN C ,  LIPPERT JOHN ,  DAVIS CLARK C ,  BACKMAN KENT

IPC: A61B17/00 ,  A61B17/12 ,  A61B18/00 ,  A61F2/82 ,  A61M25/01 ,  A61M31/00

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12168 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/12059 ,  A61B2090/037

Abstract: Apparatus and method are disclosed by which a hollow distal end portion of a wire may be deposited at selected sites in body passageways. The apparatus includes an elongate wire (16) (solid or hollow) having a distal end section for detachment and delivery to a target location, the wire (16) also having a discontinuity (20) located rearwardly of the distal end section for rupturing when vibrational energy is applied to the wire (16). The discontinuities may take the form of cuts (38) formed in the wire (30), reduced diameter sections (49) in the wire (40), adhesive, welded or soldered couplings between the wire (50, 55, 60) and the distal end section, or the wire (200) transitioning from the wire (200) to a large mass (204) disposed on the distal end section. A catheter (304) is coupled to or surrounds the elongate wire (302) to deliver therapeutic liquid to a target body location. The apparatus includes a vibrational energy source (400) couplable to the proximal end of the wire (16) for selectively applying vibrational energy to the wire (16) to travel to the discontinuity (20) and cause detachment of the end section.

Abstract translation: 公开了一种装置和方法，通过该装置和方法，线的中空末端部分可以在身体通道中的选定位置沉积。 该设备包括具有用于分离和传送到目标位置的远端部分的细长线（16）（实心或中空），还具有位于远端部分后方的不连续部分（20）的线（16）用于破裂， 振动能量施加到线（16）上。 不连续性可以采取形成在线材（30）中的切口（38），线材（40）中的直径减小部分（49），线材（50,55,60）之间的粘合剂，焊接或焊接接头 远端部分或从线（200）转移到设置在远端部分上的大质量（204）的线（200）。 导管（304）联接到细长线（302）或围绕细长线（302）以将治疗液体输送到目标身体位置。 该装置包括可耦合到线（16）的近端的振动能量源（400），用于选择性地向线（16）施加振动能以行进到不连续点（20）并导致端部部分的分离。

公开(公告)号：WO0145773A9

公开(公告)日：2002-05-16

申请号：PCT/US0035266

申请日：2000-12-22

Applicant: PRECISION VASCULAR SYSTEMS INC

Inventor： JACOBSEN STEPHEN C ,  DAVIS CLARK ,  WELLS DAVID

IPC: A61M25/01 ,  A61M5/00 ,  A61M25/00 ,  A61M25/09

CPC classification number: A61M25/0054 ,  A61M25/0138 ,  A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: A catheter guidewire (500) configured for use in a body lumen to facilitate guiding of a catheter to a target location, including a thin elongate body of material forming a guidewire, having a proximal end (504), a distal end (518), and a mid portion disposed therebetween, and a longitudinal axis; and the elongate body having a plurality of transverse cuts therein forming transverse beams (514) extending generally crosswise of the longitudinal axis and spaced apart along the length of the body and axial beams generally parallel with the longitudinal axis, the configuration increasing the lateral flexibility of the body significantly more than it reduces the torsional stiffness thereof.

Abstract translation: 导管导丝（500），其构造成用于体腔以便于将导管引导到目标位置，包括形成导丝的细长体材料，其具有近端（504），远端（518）， 和设置在其间的中间部分和纵向轴线; 并且所述细长主体具有多个横向切口，其形成横向横梁（514），所述横向横梁（514）大致横向于所述纵向轴线延伸并且沿着所述主体的长度和与所述纵向轴线平行的轴向梁间隔开，所述构造增加了横向柔性 身体明显多于减少其扭转刚度。

公开(公告)号：WO2004011076A9

公开(公告)日：2004-04-15

申请号：PCT/US0324837

申请日：2003-07-25

Applicant: PRECISION VASCULAR SYSTEMS INC ,  DAVIS CLARK C ,  NORTHRUP CLAY W ,  LAYMAN TED W ,  OLSON KEVIN T ,  SNYDER EDWARD J ,  BACKMAN D KENT ,  TURNLUND TODD H

Inventor： DAVIS CLARK C ,  NORTHRUP CLAY W ,  LAYMAN TED W ,  OLSON KEVIN T ,  SNYDER EDWARD J ,  BACKMAN D KENT ,  TURNLUND TODD H

IPC: A61M25/00 ,  A61M25/01 ,  A61M25/08 ,  A61M25/088

CPC classification number: A61M25/09 ,  A61M25/0013 ,  A61M25/01 ,  A61M25/09016

Abstract: Medical devices for navigation through anatomy, including guidewires (100), which may have a core wire (150), a slotted tubular member (130), or both. Embodiments may have coils (200; 345; 600; 114 1; 1143; 1243; 2238; 2266; 2441), including non-circular cross-section edge-wound marker coils (200), extended coil tips (300), and soldered or glued mesial joint coils (1141; 1143; 1243). Core wires (150) may have a step (1551; 2151; 2152), ridge (1351), or taper (1253) at the joint (140) to the tubular member (130), and may have a flattened section (1057) at the distal tip (257). Radiopaque material (801; 802) may be located inside the tubular member (130), and the distal tip (138) may be heat treated to make it shapeable. Additional tubular members (730; 2062; 2130; 2162; 2439) or coils (200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441) may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members (130; 730; 2062; 2130; 2162; 2439) may be chamfered (231) or tapered continuously or incrementally. Slots (135) maybe arranged in-groups (235; 1635), such as groups of three (1635), and may be equal in depth or unequal in depth to provide a steerable or compressible tip.

Abstract translation: 用于通过解剖学进行导航的医疗装置，包括可具有芯线（150），开槽管状构件（130）或两者的导丝（100）。 实施例可具有线圈（200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441），包括非圆形横截面边缘缠绕标记线圈（200），延伸线圈端部（300） 或胶合的近中关节线圈（1141; 1143; 1243）。 芯线（150）可以在与管状构件（130）的接合处（140）具有台阶（1551; 2151; 2152），脊（1351）或锥形（1253），并且可以具有扁平部分（1057） 在远端（257）。 不透射线材料（801; 802）可以位于管状构件（130）内部，并且可以对远侧末端（138）进行热处理以使其成形。 额外的管状构件（730; 2062; 2130; 2162; 2439）或线圈（200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441）可以同心地或成直线地使用并且可以增强挠性，提供射线不透性， 减少摩擦，或减少材料或制造成本。 管状构件（130; 730; 2062; 2130; 2162; 2439）可以被倒角（231）或者连续或逐渐变细。 槽（135）可以按组（235; 1635）排列，例如三个组（1635），并且深度相等或深度不相等以提供可操纵或可压缩的尖端。

公开(公告)号：WO2003004086A3

公开(公告)日：2003-01-16

申请号：PCT/US2002/021150

申请日：2002-07-03

Applicant: PRECISION VASCULAR SYSTEMS, INC. ,  SNYDER, Edward, J. ,  DAVIS, Clark, C. ,  TURNLUND, Todd, H.

Inventor： SNYDER, Edward, J. ,  DAVIS, Clark, C. ,  TURNLUND, Todd, H.

IPC: A61M25/01

Abstract: A medical device (100) or intravascular device, and methods of use. The devices may be tubular and may have a flexible polymer tip (120). The body (105) may be nitinol and may have cuts part (110) way through along its length to facilitate bending. The device (100) may have a liner (203) which may extend through the tip or form the tip. The device (100) may have markers (122, 123) readily visible on an X-ray viewer during insertion. The tip (120) may have an anti-collapsing (1032, 1333) structure and may be shaped before use to perform a medical procedure such as treating an aneurysm. The device (100) may have a strong fiber (840) through it for complete removal. The method may include selecting the device, bending the tip, setting the shape, and inserting the device into the patient's anatomy. The shape of the tip may be set by heating with steam (1848) and then removing a mandrel (1840).

公开(公告)号：WO03004086A2

公开(公告)日：2003-01-16

申请号：PCT/US0221150

申请日：2002-07-03

Applicant: PRECISION VASCULAR SYSTEMS INC ,  SNYDER EDWARD J ,  DAVIS CLARK C ,  TURNLUND TODD H

Inventor： SNYDER EDWARD J ,  DAVIS CLARK C ,  TURNLUND TODD H

IPC: A61M25/00 ,  A61M25/01

CPC classification number: A61M25/0051 ,  A61M25/005 ,  A61M25/0052 ,  A61M25/0053 ,  A61M25/0054 ,  A61M25/0138 ,  A61M2025/0081

Abstract: A medical device or intravascular device, and methods of use. The devices may be tubular and may have a flexible polymer tip. The body may be nitinol and may have cuts part way through along its length to facilitate bending. The device may have a liner which may extend through the tip or form the tip. The device may have markers readily visible on an X-ray viewer during insertion. The tip may have an anti-collapsing structure and may be shaped before use to perform a medical procedure such as treating an aneurysm. The device may have a strong fiber through it for complete removal. The method may include selecting the device, bending the tip, setting the shape, and inserting the device into the patient's anatomy. The shape of the tip may be set by heating with steam and then removing a mandrel.

Abstract translation: 医疗器械或血管内装置及其使用方法。 这些装置可以是管状的并且可以具有柔性聚合物末端。 身体可以是镍钛诺，并且可以沿其长度部分地穿过切口以促进弯曲。 该装置可以具有可延伸穿过尖端或形成尖端的衬里。 在插入期间，该装置可能具有在X射线观察器上容易可见的标记。 尖端可以具有抗塌缩结构，并且可以在使用前成形以执行诸如治疗动脉瘤的医疗过程。 该设备可以具有通过其的强光纤以便完全去除。 该方法可以包括选择装置，弯曲尖端，设置形状，以及将装置插入病人的解剖结构中。 尖端的形状可以通过用蒸汽加热然后去除心轴来设定。

公开(公告)号：WO2001028620A1

公开(公告)日：2001-04-26

申请号：PCT/US2000/041219

申请日：2000-10-18

Applicant: PRECISION VASCULAR SYSTEMS, INC.

Inventor： JACOBSEN, Stephen, C. ,  LIPPERT, John ,  DAVIS, Clark, C. ,  BACKMAN, Kent

IPC: A61M31/00

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12168 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/12059 ,  A61B2090/037

Abstract: Apparatus and method are disclosed by which a hollow distal end portion of a wire may be deposited at selected sites in body passageways. The apparatus includes an elongate wire (16) (solid or hollow) having a distal end section for detachment and delivery to a target location, the wire (16) also having a discontinuity (20) located rearwardly of the distal end section for rupturing when vibrational energy is applied to the wire (16). The discontinuities may take the form of cuts (38) formed in the wire (30), reduced diameter sections (49) in the wire (40), adhesive, welded or soldered couplings between the wire (50, 55, 60) and the distal end section, or the wire (200) transitioning from the wire (200) to a large mass (204) disposed on the distal end section. A catheter (304) is coupled to or surrounds the elongate wire (302) to deliver therapeutic liquid to a target body location. The apparatus includes a vibrational energy source (400) couplable to the proximal end of the wire (16) for selectively applying vibrational energy to the wire (16) to travel to the discontinuity (20) and cause detachment of the end section.

Abstract translation: 公开了一种装置和方法，通过该装置和方法，线的中空末端部分可以在身体通道中的选定位置沉积。 该设备包括具有用于分离和传送到目标位置的远端部分的细长线（16）（实心或中空），还具有位于远端部分后方的不连续部分（20）的线（16）用于破裂， 振动能量施加到线（16）上。 不连续性可以采取形成在线材（30）中的切口（38），线材（40）中的直径减小部分（49），线材（50,55,60）之间的粘合剂，焊接或焊接接头 远端部分或从线（200）转移到设置在远端部分上的大质量（204）的线（200）。 导管（304）联接到细长线（302）或围绕细长线（302）以将治疗液体递送到目标身体位置。 该装置包括可耦合到线（16）的近端的振动能量源（400），用于选择性地向线（16）施加振动能以行进到不连续点（20）并导致端部部分的分离。

公开(公告)号：WO2004011076A3

公开(公告)日：2004-06-24

申请号：PCT/US0324837

申请日：2003-07-25

Applicant: PRECISION VASCULAR SYSTEMS INC ,  DAVIS CLARK C ,  NORTHRUP CLAY W ,  LAYMAN TED W ,  OLSON KEVIN T ,  SNYDER EDWARD J ,  BACKMAN D KENT ,  TURNLUND TODD H

Inventor： DAVIS CLARK C ,  NORTHRUP CLAY W ,  LAYMAN TED W ,  OLSON KEVIN T ,  SNYDER EDWARD J ,  BACKMAN D KENT ,  TURNLUND TODD H

IPC: A61M25/00 ,  A61M25/01 ,  A61M25/08 ,  A61M25/088 ,  A61B1/005

CPC classification number: A61M25/09 ,  A61M25/0013 ,  A61M25/01 ,  A61M25/09016

Abstract: Medical devices for navigation through anatomy, including guidewires (100), which may have a core wire (150), a slotted tubular member (130), or both. Embodiments may have coils (200; 345; 600; 114 1; 1143; 1243; 2238; 2266; 2441), including non-circular cross-section edge-wound marker coils (200), extended coil tips (300), and soldered or glued mesial joint coils (1141; 1143; 1243). Core wires (150) may have a step (1551: 2151: 2152), ridge (1351), or taper (1253) at the joint (140) to the tubular member (130), and may have a flattened section (1057) at the distal tip (257). Radiopaque material (801: 802) may be located inside the tubular member (130), and the distal tip (138) may be heat treated to make it shapeable. Additional tubular members (730; 2062; 2130; 2162; 2439) or coils (200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441) may be used concentrically or in line.

Abstract translation: 用于通过解剖学导航的医疗装置，包括可以具有芯线（150），开槽管状构件（130）或两者的导线（100）。 实施例可以包括线圈（200; 345; 600; 114 1; 1143; 1243; 2238; 2266; 2441），包括非圆形横截面边缘缠绕标记线圈（200），延伸线圈尖端（300） 或粘合的中间关节线圈（1141; 1143; 1243）。 芯线（150）可以在接头（140）处具有到管状构件（130）的台阶（1551：2151：2152），脊（1351）或锥形（1253），并且可以具有扁平部分（1057） 在远端（257）处。 不透射线材料（801：802）可以位于管状构件（130）内，并且远侧末端（138）可以被热处理以使其成形。 额外的管状构件（730; 2062; 2130; 2162; 2439）或线圈（200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441）可以同心或一致地使用。

公开(公告)号：WO2004011076A2

公开(公告)日：2004-02-05

申请号：PCT/US2003/024837

申请日：2003-07-25

Applicant: PRECISION VASCULAR SYSTEMS, INC. ,  DAVIS, Clark, C. ,  NORTHRUP, Clay, W. ,  LAYMAN, Ted, W. ,  OLSON, Kevin, T. ,  SNYDER, Edward, J. ,  BACKMAN, D., Kent ,  TURNLUND, Todd, H.

Inventor： DAVIS, Clark, C. ,  NORTHRUP, Clay, W. ,  LAYMAN, Ted, W. ,  OLSON, Kevin, T. ,  SNYDER, Edward, J. ,  BACKMAN, D., Kent ,  TURNLUND, Todd, H.

IPC: A61M25/01

CPC classification number: A61M25/09 ,  A61M25/0013 ,  A61M25/01 ,  A61M25/09016

Abstract: Medical devices for navigation through anatomy, including guidewires (100), which may have a core wire (150), a slotted tubular member (130), or both. Embodiments may have coils (200; 345; 600; 114 1; 1143; 1243; 2238; 2266; 2441), including non-circular cross-section edge-wound marker coils (200), extended coil tips (300), and soldered or glued mesial joint coils (1141; 1143; 1243). Core wires (150) may have a step (1551; 2151; 2152), ridge (1351), or taper (1253) at the joint (140) to the tubular member (130), and may have a flattened section (1057) at the distal tip (257). Radiopaque material (801; 802) may be located inside the tubular member (130), and the distal tip (138) may be heat treated to make it shapeable. Additional tubular members (730; 2062; 2130; 2162; 2439) or coils (200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441) may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members (130; 730; 2062; 2130; 2162; 2439) may be chamfered (231) or tapered continuously or incrementally. Slots (135) maybe arranged in-groups (235; 1635), such as groups of three (1635), and may be equal in depth or unequal in depth to provide a steerable or compressible tip.

Abstract translation: 用于通过解剖学导航的医疗装置，包括可以具有芯线（150），开槽管状构件（130）或两者的导线（100）。 实施例可以包括线圈（200; 345; 600; 114 1; 1143; 1243; 2238; 2266; 2441），包括非圆形横截面边缘缠绕标记线圈（200），延伸线圈尖端（300） 或粘合的中间关节线圈（1141; 1143; 1243）。 芯线（150）可以在与管状构件（130）的接头处具有台阶（1551; 2151; 2152），脊（1351）或锥形（1253），并且可以具有扁平部分（1057） 在远端（257）处。 不透射线材料（801; 802）可以位于管状构件（130）内，并且远侧末端（138）可以被热处理以使其成形。 额外的管状构件（730; 2062; 2130; 2162; 2439）或线圈（200; 345; 600; 1141; 1143; 1243; 2238; 2266; 2441）可以同心或一致地使用，并且可以增强柔性， 减少摩擦，或减少材料或制造成本。 管状构件（130; 730; 2062; 2130; 2162; 2439）可以被倒角（231）或连续地或递增地逐渐变细。 插槽（135）可以排列成组（235; 1635），例如三组（1635），并且可以在深度上相等或深度不等，以提供可导向或可压缩的尖端。