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公开(公告)号：WO2016049308A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/051931
申请日：2015-09-24
IPC分类号： A61K9/50 , A61K47/02 , A61K47/30 , A61K31/13 , A61K31/435 , C01B25/26 , C01B7/20 , C01F11/00
CPC分类号： A61K6/083 , A61K6/0052 , A61K6/0067 , A61K6/0076 , A61K6/0082 , A61K6/0091 , A61K6/09 , A61K6/093 , A61K31/14 , A61K31/4425 , A61K33/18 , B01J13/16 , C01B9/08 , C08F290/067 , C08G18/3203 , C08G18/672 , C08G18/72 , C08G18/8175
摘要： A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
摘要翻译： 一种组合物，其包含在所述微胶囊表面上用可聚合官能团官能化的微胶囊，其中所述官能团与连续相中的单体形成共价键，以增强组合物的机械性能。
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公开(公告)号：WO2014059249A3
公开(公告)日：2014-04-17
申请号：PCT/US2013/064504
申请日：2013-10-11
IPC分类号： A61K8/02
摘要： Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
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公开(公告)号：WO2014059143A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/064336
申请日：2013-10-10
摘要： A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.
摘要翻译： 一种局部维生素D和UBIQUINOL补充组合物，其可用于治疗口腔炎症和降低氧化应激，包括：在无水乳液中的维生素D和UBIQUINOL的补充混合物，其含有：Spillanthes提取物，用于UBIQUINOL的稳定组合物和经口服粘膜吸收促进剂 补充剂混合物; 其中乳液在唾液的存在下形成粘膜粘附凝胶，其通过补充混合物的口腔粘膜和调节：补体混合物的体内可用性和免疫应答以及维持足够水平的维生素D和 的联合应用UBIQUINOL，同时最大限度地降低高钙血症的风险。
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公开(公告)号：WO2006099515A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009434
申请日：2006-03-14
摘要： A dental articulator comprising a maxillary tray support member, a mandibular tray support member, and a hinge. The maxillary tray support member and mandibular tray support members are each provided with a locking member. The hinge is separated into an upper hinge arm and a lower hinge arm with each being provided with a key. The combination of the key in the upper and lower hinge arms coupled with the locking member in the maxillary and mandibular tray support members are used to lockingly engage the hinge to these members. The opposed ends of the upper hinge arm and the lower hinge arm are frictionally mountable to one another for forming a hinge joint at each end thereby enabling the rotatable movement of the maxillary and mandibular tray support members for moving the dental articulator from an open and closed position when in use.
摘要翻译： 一种牙科咬合器，包括上颌托盘支撑构件，下颌托盘支撑构件和铰链。 上颌托盘支撑构件和下颌托盘支撑构件各自设置有锁定构件。 铰链分为上铰链臂和下铰链臂，每个铰链臂设有钥匙。 与上部和下颌托盘支撑构件中的锁定构件联接的上部和下部铰链臂中的键的组合用于将铰链锁定地接合到这些构件。 上铰链臂和下铰链臂的相对端彼此摩擦地安装，以在每一端形成铰链接头，从而使得上颌和下颌托盘支撑构件能够可旋转运动，用于将牙科咬合器从打开和关闭 使用时的位置
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公开(公告)号：WO2016196960A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035759
申请日：2016-06-03
发明人： KHAN, Masood , MCHALE, William, A.
CPC分类号： A61C3/00
摘要： A dental tool includes: a hollow handle having an open end and a first channel along at least a portion of its longitudinal extent; a dowel fixedly arranged within the first channel such that a face at a longitudinal end of the dowel is aligned with the end opening of the hollow handle, the longitudinal extent of the dowel being arranged within the hollow handle; the dowel having a second channel, having a smaller diameter than the first channel, formed in the longitudinal end of the dowel; and a tool head. A pin portion of the tool head is fixedly arranged in the second channel to securely seat the pin portion of the tool head into the second channel so that a functional portion of the tool head extends beyond an end of the handle.
摘要翻译： 牙科工具包括：中空手柄，其具有沿其纵向范围的至少一部分的开口端和第一通道; 固定地布置在所述第一通道内的销钉，使得所述销钉的纵向端部处的表面与所述中空手柄的端部开口对准，所述销钉的纵向范围布置在所述中空手柄内; 所述榫钉具有形成在所述榫钉的纵向端部中的具有比所述第一通道更小的直径的第二通道; 和工具头。 工具头的销部分固定地布置在第二通道中，以将工具头的销部分牢固地固定到第二通道中，使得工具头的功能部分延伸超过手柄的端部。
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公开(公告)号：WO2014043385A2
公开(公告)日：2014-03-20
申请号：PCT/US2013/059513
申请日：2013-09-12
IPC分类号： A61K9/50 , A61P29/00 , A61P7/02 , A61P31/00 , A61P19/08 , A61K8/11 , A61Q11/00 , A61K6/08 , A61P17/00 , A61Q5/00 , A61Q19/00 , A61Q3/00 , B01J13/14
CPC分类号： B01J13/14 , A61K6/0005 , A61K8/11 , A61K8/64 , A61K8/87 , A61K9/5031 , A61K2800/56 , A61Q3/00 , A61Q5/00 , A61Q11/00 , A61Q19/00
摘要： A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
摘要翻译： 一种微胶囊组合物，其包含至少一种基本上作为围绕缓冲溶液的半渗透性壳而设置的聚合物和至少一种治疗剂，其中所述治疗剂渗透所述壳，并且其中所述组合物适用于 运送给哺乳动物。 本发明还提供了相关的组合物，产品和方法。
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公开(公告)号：WO2007024652A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032262
申请日：2006-08-18
申请人： PREMIER DENTAL PRODUCTS COMPANY , DODIUK-KENIG, Hanna , ZALSMAN, Barry , LISENBOIM, Kira , MCHALE, William, A.
IPC分类号： A61K6/08
CPC分类号： A61K6/0023 , A61K6/083 , C08L33/00 , C08L75/16
摘要： A dental material using nano material that will serve as reinforcement and will enhance mechanical properties with minimal sacrifice in other properties including processability of a dental material. The dental material may be used as a filling, restorative, cement, liner, adhesive or primer. This is achieved by combining several polymerizable monomers and/or oligomers, a polymerization initiator, at least one hyperbranched additive and at least one of an electrospun nanofiber, an electrospun nanosphere or a hyperbranched macromolecule. The hyperbranched additive may be hyperbranched molecules, dendridic molecules (such as dendrimers). In a preferred embodiment a caged silica (such as POSS) is used for a caged macromolecule. The material may also include nanoclay or traditional composite fillers. The material may optionally include accelerators (such as DEHPT), cross linkers or pigment.
摘要翻译： 使用纳米材料的牙科材料，其将用作增强物并且将以包括牙科材料的可加工性的其它性质的最小牺牲来增强机械性能。 牙科材料可用作填充，修复，水泥，衬垫，粘合剂或底漆。 这通过组合几种可聚合单体和/或低聚物，聚合引发剂，至少一种超支化添加剂和电纺丝纳米纤维，电纺丝纳米球或超支化高分子中的至少一种来实现。 超支化添加剂可以是超支化分子，树状分子（如树枝状大分子）。 在优选的实施方案中，笼式二氧化硅（例如POSS）用于笼式大分子。 该材料还可以包括纳米粘土或传统的复合填料。 该材料可以任选地包括促进剂（例如DEHPT），交联剂或颜料。
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公开(公告)号：WO2015157687A3
公开(公告)日：2015-10-15
申请号：PCT/US2015/025396
申请日：2015-04-10
摘要： Substantially aqueous-free, enamel protectant and enamel repair toothpaste treatments containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpaste treatments indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
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公开(公告)号：WO2015157683A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/025391
申请日：2015-04-10
摘要： Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
摘要翻译： 含有无水釉质保护剂和牙釉质修复牙膏，其含有：氟化亚锡，钙和直接剂，其包含：聚二甲基硅氧烷在非离子表面活性剂中的乳液，其中：（a）所述氟化亚锡和钙直接存在于釉质上的生物膜中 在氟化亚锡存在下通过钙结合从双齿转变为单齿增强; 和（b）与具有相当或更高氟化物水平的氟化物刷洗处理相比，所述牙膏表明显着改善的釉质保护因子（EPF）和釉质修复因子（ERF）值。
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公开(公告)号：WO2015157679A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/025385
申请日：2015-04-10
CPC分类号： A61K8/90 , A61K8/042 , A61K8/19 , A61K8/21 , A61K8/8164 , A61K2800/31 , A61Q11/00
摘要： Substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
摘要翻译： 基本无水的搪瓷保护剂和修复刷牙凝胶，其含有：氟化亚锡，钙和直接剂，其包含：非离子表面活性剂中的聚二甲基硅氧烷的乳液，其中通过钙结合增强所述氟化亚锡和钙到存在于釉质上的生物膜的亲和性 在氟化亚锡的存在下从二齿转变为单齿; 并且与具有相当或更高氟化物水平的氟化物刷洗治疗相比，所述刷牙凝胶具有显着改善的釉质保护因子（EPF）和釉质修复因子（ERF）值。
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