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19 条记录 (耗时 0.039 秒)

    METHODS AND COMPOSITIONS FOR STIMULATING CELLS
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR STIMULATING CELLS 审中-公开
    刺激细胞的方法和组合物

    公开(公告)号：WO2008147551A1

    公开(公告)日：2008-12-04

    申请号：PCT/US2008/006667

    申请日：2008-05-23

    申请人： MEDIVATION NUEROLOGY, INC. ,  HUNG, David, T. ,  PROTTER, Andrew, Asher

    发明人： HUNG, David, T. ,  PROTTER, Andrew, Asher

    IPC分类号： A61K31/44

    CPC分类号： A61K31/44

    摘要： The invention provides compositions and methods for treating, preventing, delaying the onset, and/or delaying the development of a disease or condition for which the activation, differentiation, and/or proliferation of one or more cell types is beneficial. These compositions and methods include, for example, a hydrogenated pyrido [4,3 -b] indole such as dimebon and/or a cell that has been incubated with a hydrogenated pyrido [4,3 -b] indole such as dimebon. In some embodiments, the compositions and methods also include a growth factor and/or an anti-cell death compound. The invention also provides methods of activating a cell, promoting the differentiation of a cell, and/or promoting the proliferation of a cell by incubating the cell with one or more hydrogenated pyrido [4,3 -b] indoles or pharmaceutically acceptable salts thereof. In some embodiments, the cell is also incubated with one or more growth factors and/or anti-cell death compounds.

    摘要翻译： 本发明提供用于治疗，预防，延缓发作和/或延缓一种或多种细胞类型的活化，分化和/或增殖有益的疾病或病症的发展的组合物和方法。 这些组合物和方法包括例如氢化吡啶并[4,3-b]吲哚（如二甲氧基）和/或已经与氢化吡啶并[4,3-b]吲哚（如二甲氧基）温育的细胞。 在一些实施方案中，组合物和方法还包括生长因子和/或抗细胞死亡化合物。 本发明还提供了通过将细胞与一种或多种氢化吡啶并[4,3-b]吲哚或其药学上可接受的盐一起孵育来激活细胞，促进细胞分化和/或促进细胞增殖的方法。 在一些实施方案中，细胞还与一种或多种生长因子和/或抗细胞死亡化合物一起温育。

    COMPOUNDS AND METHODS OF TREATING DIABETES
    4.
    发明申请
    COMPOUNDS AND METHODS OF TREATING DIABETES 审中-公开
    化合物和治疗糖尿病的方法

    公开(公告)号：WO2012112962A1

    公开(公告)日：2012-08-23

    申请号：PCT/US2012/025751

    申请日：2012-02-17

    申请人： MEDIVATION TECHNOLOGIES, INC. ,  PROTTER, Andrew, Asher ,  CHAKRAVARTY, Sarvajit

    发明人： PROTTER, Andrew, Asher ,  CHAKRAVARTY, Sarvajit

    IPC分类号： A61K31/55 ,  C07D471/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/55 ,  A61K45/06 ,  C07D471/08 ,  C07D471/14 ,  C07D471/18 ,  C07D487/04 ,  C07D487/08 ,  C07D487/14 ,  C07D487/18

    摘要： Hydrogenated pyrido[4,3-b]indoles, pyrido [3, 4-b] indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor a 2A . The compounds may also bind to and are an antagonist of the adrenergic receptor α 2B ; or the compounds are not antagonists of the adrenergic receptor α2β and the compounds are administered in conjunction with a second agent that reduces, or is expected to reduce, blood pressure in an individual. The compounds may find use in therapy, e.g., to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. Use of the compounds to treat type 2 diabetes is particularly described.

    摘要翻译： 描述了氢化吡啶并[4,3-b]吲哚，吡啶并[3,4-b]吲哚和氮杂环[4,5-b]吲哚。 该化合物可以结合肾上腺素能受体a2A并且是拮抗剂。 该化合物还可以结合并且是肾上腺素受体a2B的拮抗剂; 或者化合物不是肾上腺素能受体α2β的拮抗剂，并且化合物与减少或预期降低个体血压的第二药剂一起施用。 该化合物可用于治疗，例如调节血糖水平，增加胰岛素分泌并治疗对胰岛素产生增加或预期是响应的疾病或病症。 特别描述了化合物治疗2型糖尿病的用途。

    METHODS AND COMPOSITIONS FOR STIMULATING CELLS
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR STIMULATING CELLS 审中-公开
    刺激细胞的方法和组合物

    公开(公告)号：WO2008147551A8

    公开(公告)日：2010-01-07

    申请号：PCT/US2008006667

    申请日：2008-05-23

    申请人： MEDIVATION NEUROLOGY INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER

    发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER

    IPC分类号： A61K31/44

    CPC分类号： A61K31/44

    摘要： The invention provides compositions and methods for treating, preventing, delaying the onset, and/or delaying the development of a disease or condition for which the activation, differentiation, and/or proliferation of one or more cell types is beneficial. These compositions and methods include, for example, a hydrogenated pyrido [4,3 -b] indole such as dimebon and/or a cell that has been incubated with a hydrogenated pyrido [4,3 -b] indole such as dimebon. In some embodiments, the compositions and methods also include a growth factor and/or an anti-cell death compound. The invention also provides methods of activating a cell, promoting the differentiation of a cell, and/or promoting the proliferation of a cell by incubating the cell with one or more hydrogenated pyrido [4,3 -b] indoles or pharmaceutically acceptable salts thereof. In some embodiments, the cell is also incubated with one or more growth factors and/or anti-cell death compounds.

    摘要翻译： 本发明提供用于治疗，预防，延缓发作和/或延缓一种或多种细胞类型的活化，分化和/或增殖有益的疾病或病症的发展的组合物和方法。 这些组合物和方法包括例如氢化吡啶并[4,3-b]吲哚（如二甲氧基）和/或已经与氢化吡啶并[4,3-b]吲哚（如二甲氧基）温育的细胞。 在一些实施方案中，组合物和方法还包括生长因子和/或抗细胞死亡化合物。 本发明还提供了通过将细胞与一种或多种氢化吡啶并[4,3-b]吲哚或其药学上可接受的盐一起孵育来激活细胞，促进细胞分化和/或促进细胞增殖的方法。 在一些实施方案中，细胞还与一种或多种生长因子和/或抗细胞死亡化合物一起温育。

    METHODS AND COMPOSITIONS FOR TREATING PSYCHOTIC DISORDERS USING ANTIPSYCHOTIC COMBINATION THERAPY
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING PSYCHOTIC DISORDERS USING ANTIPSYCHOTIC COMBINATION THERAPY 审中-公开
    使用抗生素联合治疗治疗心理疾病的方法和组合物

    公开(公告)号：WO2011103448A1

    公开(公告)日：2011-08-25

    申请号：PCT/US2011/025461

    申请日：2011-02-18

    申请人： MEDIVATION TECHNOLOGIES, INC. ,  GIORGETTI, Marco ,  HUNG, David, T. ,  PROTTER, Andrew, Asher

    发明人： GIORGETTI, Marco ,  HUNG, David, T. ,  PROTTER, Andrew, Asher

    IPC分类号： A01N43/42

    CPC分类号： A61K45/06 ,  A61K31/407 ,  A61K2300/00

    摘要： The present invention provides methods, compositions, and kits for use in combination therapy for treating, preventing, delaying the onset and/or delaying the development of (i) a psychotic disorder in an individual in need thereof, (ii) a psychotic disorder in an individual who is also in need of improved cognition, or (iii) a disorder characterized by causing at least one psychotic symptom and at least one cognitive symptom in an individual in need thereof, comprising compound I and a second agent (e.g., an antipsychotic) or pharmaceutically acceptable salt of any of the foregoing.

    摘要翻译： 本发明提供了用于组合治疗的方法，组合物和试剂盒，用于治疗，预防，延迟发作和/或延缓（i）有需要的个体中的精神障碍的发展，（ii）精神障碍 还需要改善认知的个体，或（iii）特征在于在有需要的个体中引起至少一种精神病症状和至少一种认知症状的疾病，包括化合物I和第二药剂（例如抗精神病药 ）或任何前述的药学上可接受的盐。

    METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE
    10.
    发明申请
    METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE 审中-公开
    治疗阿尔茨海默病的方法和组合治疗

    公开(公告)号：WO2008051599A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007022645

    申请日：2007-10-26

    申请人： MEDIVATION INC ,  HUNG DAVID T ,  PROTTER ANDREW ASHER

    发明人： HUNG DAVID T ,  PROTTER ANDREW ASHER

    CPC分类号： A61K31/437 ,  A61K31/445 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides methods and combination therapies for treating and/or preventing and/or slowing the onset and/or development of Alzheimer's disease using a hydrogenated pyrido (4,3-b) indole (e.g., dimebon) in conjunction with another compound, pharmaceutically acceptable salt thereof or therapy for Alzheimer's disease.

    摘要翻译： 本发明提供了使用氢化吡啶并（4,3-b）吲哚（例如，二甲氧基）与另一种化合物结合治疗和/或预防和/或预防和/或预防和/或减缓阿尔茨海默氏病的发病和/或发展的方法和组合疗法 可接受的盐或阿尔茨海默氏病的治疗。