公开(公告)号：WO2005110052A2

公开(公告)日：2005-11-24

申请号：PCT/US2005016428

申请日：2005-05-11

Applicant: PULMONOX TECHNOLOGIES CORP ,  MURRAY BRUCE ,  PERRY BRYAN ,  MILLER CHRISTOPHER ,  HOLE DOUG

Inventor： MURRAY BRUCE ,  PERRY BRYAN ,  MILLER CHRISTOPHER ,  HOLE DOUG

IPC: A61M16/00

CPC classification number: A61M16/024 ,  A61M2202/0275

Abstract: Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

Abstract translation: 提供了通过施用气体吸入一氧化氮作为粘液溶解剂或祛痰剂来治疗哺乳动物中过量粘液积累的方法和装置。 气态一氧化氮的输送可以鼻或口服制成，优选地基本上与哺乳动物的吸入或基于哺乳动物呼吸循环的同步参数一致。 根据过量粘液积聚的严重程度，不同的治疗方案可用于输送气态一氧化氮。 治疗特征的参数可以包括含有一氧化氮的气体的流速，含有一氧化氮的气体的施用持续时间，要施用一氧化氮的气体的呼吸次数和递送至气道的治疗性NO的浓度。

公开(公告)号：WO2007057763A3

公开(公告)日：2008-07-17

申请号：PCT/IB2006003265

申请日：2006-11-20

Applicant: PULMONOX TECHNOLOGIES CORP ,  MILLER CHRISTOPHER C

Inventor： MILLER CHRISTOPHER C

IPC: C12N7/06 ,  A61K9/72 ,  A61K33/00 ,  A61K35/12 ,  A61K39/145 ,  A61P31/12 ,  A61P31/16

CPC classification number: A61K33/00 ,  A61K9/007 ,  A61K45/06 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2760/16163

Abstract: The invention relates to uses of nitric oxide gas to inactivate any whole, part or subunit of a microbe, such as a virus. Such an inactivated or attenuated virus after treatment with NO gas may be used in formulations for a vaccine. Nitric oxide may be administered directly to create a vaccine through in vitro and/or in situ or by direct administration in vivo. Also provided are methods for treating patients with viral infections through the inhalation of nitric oxide gas.

Abstract translation: 本发明涉及一氧化氮气体用于灭活微生物（例如病毒）的任何全部，部分或亚基的用途。 用NO气体处理后的这种灭活或减毒的病毒可以用于疫苗的制剂中。 可以直接施用一氧化氮以通过体外和/或原位或通过体内直接给药来产生疫苗。 还提供了通过吸入一氧化氮气体治疗患有病毒感染的患者的方法。

公开(公告)号：WO2006110923A3

公开(公告)日：2007-07-19

申请号：PCT/US2006014414

申请日：2006-04-14

Applicant: PULMONOX TECHNOLOGIES CORP ,  SENSORMEDICS CORP ,  MILLER CHRISTOPHER C ,  STENZLER ALEX

Inventor： MILLER CHRISTOPHER C ,  STENZLER ALEX

IPC: A61M16/00 ,  A61M11/00 ,  A61M15/08 ,  A61M35/00 ,  A62B7/00

CPC classification number: A61M15/08 ,  A61M15/0091 ,  A61M15/0098 ,  A61M16/0084 ,  A61M16/0666 ,  A61M16/0672 ,  A61M16/0866 ,  A61M16/10 ,  A61M16/1055 ,  A61M16/1065 ,  A61M16/107 ,  A61M16/201 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2202/0275 ,  A61M2202/20 ,  A61M2230/43

Abstract: A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. Also provided are several designs for a nasal delivery device for the controlled nasal deliver the nitric oxide containing gas.

Abstract translation: 用一氧化氮暴露局部治疗哺乳动物呼吸道的方法包括提供一氧化氮的气体源并将一氧化氮含气体向鼻输送到哺乳动物的上呼吸道的步骤。 还提供了用于受控鼻腔输送含一氧化氮的气体的鼻输送装置的若干设计。

公开(公告)号：WO2005110441A3

公开(公告)日：2006-02-16

申请号：PCT/US2005016427

申请日：2005-05-11

Applicant: SENSORMEDICS CORP VIASYS HEALT ,  PULMONOX TECHNOLOGIES CORP ,  STENZLER ALEX ,  MILLER CHRIS ,  MCMULLIN BEVEN

Inventor： STENZLER ALEX ,  MILLER CHRIS ,  MCMULLIN BEVEN

IPC: A61H33/14 ,  A61K33/00 ,  A61M16/00 ,  A61M16/10 ,  A61M16/12 ,  A61M16/20 ,  A61M11/00 ,  A61M15/00 ,  A61M15/08 ,  A61M37/00 ,  A62B7/00

CPC classification number: A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

Abstract: A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

Abstract translation: 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。