SYSTEM AND METHOD FOR INERTIAL FOCUSING MICROFILTRATION FOR INTRA-OPERATIVE BLOOD SALVAGE AUTOTRANSFUSION
    1.
    发明申请
    SYSTEM AND METHOD FOR INERTIAL FOCUSING MICROFILTRATION FOR INTRA-OPERATIVE BLOOD SALVAGE AUTOTRANSFUSION 审中-公开
    用于手术中血管造影术的手术聚焦的系统和方法

    公开(公告)号:WO2016044555A1

    公开(公告)日:2016-03-24

    申请号:PCT/US2015/050628

    申请日:2015-09-17

    Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

    Abstract translation: 提供了一种手术内救助自体输血系统。 所述系统包括至少一个入口,其构造成接收患者的全血; 至少一个与所述至少一个入口流体连通的曲线微通道,所述至少一个曲线微通道适于基于细胞大小,沿着所述至少一个入口的横截面的至少一部分来分离全血中的循环肿瘤细胞 所述至少一个曲线微通道; 以及至少两个与所述至少一个曲线微通道流体流动连接的出口,所述至少两个出口的至少一个出口构造成流过从全血分离的循环肿瘤细胞,以及至少一个其它出口 至少两个出口配置成流过全血的剩余部分的至少一部分,清洁分离的循环肿瘤细胞,以返回给患者。

    PORTABLE BLOOD FILTRATION DEVICES, SYSTEMS, AND METHODS
    3.
    发明申请
    PORTABLE BLOOD FILTRATION DEVICES, SYSTEMS, AND METHODS 审中-公开
    便携式血液过滤装置,系统和方法

    公开(公告)号:WO2011133287A1

    公开(公告)日:2011-10-27

    申请号:PCT/US2011/029854

    申请日:2011-03-24

    Abstract: A blood filtration device, system, and method that can and selectively remove or reduce an unwanted, in certain cases unknown, substance from a patient's blood stream. More specifically, a specific size or size range of unwanted substance is selectively removed. The unwanted substance includes one or more of a pathogen, a toxin, an activated cell, and an administered drug. The device and system employ a microfluidic separation device that minimizes thrombogenesis and can permit the use of anticoagulants to be avoided. The device or system can be portable and can include its own power supply. Sensors in the system may monitor for the presence and/or concentration of unwanted species including pathogens or drugs and invoke a blood cleansing process responsively to the sensor signals in closed loop control process. The control may combine the infusion of therapeutic agents into the blood of a patient as well.

    Abstract translation: 一种血液过滤装置,系统和方法,其可以并且选择性地从患者的血流中去除或减少在某些情况下不需要的物质。 更具体地,选择性地去除不需要的物质的具体尺寸或尺寸范围。 不想要的物质包括病原体,毒素,活化的细胞和给药的药物中的一种或多种。 该装置和系统采用使血栓形成最小化的微流体分离装置,并且可以允许避免使用抗凝剂。 该设备或系统可以是便携式的并且可以包括其自己的电源。 系统中的传感器可以监测不想要的物质(包括病原体或药物)的存在和/或浓度,并且在闭环控制过程中响应于传感器信号调节血液清洁过程。 该对照可以将治疗剂的输注组合到患者的血液中。

    PRION PROCESSING
    5.
    发明申请
    PRION PROCESSING 审中-公开
    PRION加工

    公开(公告)号:WO2008005960A3

    公开(公告)日:2008-03-06

    申请号:PCT/US2007072702

    申请日:2007-07-03

    CPC classification number: C07K14/47 A61M1/3633 A61M1/3693 A61M2202/20

    Abstract: A method for processing prions is disclosed, comprising contacting at least one porous medium with a pathogenic prion-containing fluid such that pathogenic prions are retained and/or captured by the porous medium; contacting the porous medium with another fluid such that pathogenic prions are released from the porous medium to provide a first released pathogenic prion-containing fluid; placing a fluid containing the released pathogenic prions in a first spin device including a separation medium; and, centrifuging the spin device to provide a first concentrated pathogenic prion-containing retentate.

    Abstract translation: 公开了一种处理朊病毒的方法,包括使至少一种多孔介质与致病性含朊病毒液体接触,使致病性朊病毒被多孔介质保留和/或捕获; 使多孔介质与另一种流体接触,使致病性朊病毒从多孔介质中释放以提供第一释放的致病性含朊病毒流体; 将含有释放的致病性朊病毒的流体置于包含分离介质的第一旋转装置中; 以及离心旋转装置以提供第一浓缩的致病性含朊病毒渗余物。

    SYSTEMS AND METHODS FOR REMOVING UNDESIRABLE MATERIAL WITHIN A CIRCULATORY SYSTEM DURING A SURGICAL PROCEDURE
    7.
    发明申请
    SYSTEMS AND METHODS FOR REMOVING UNDESIRABLE MATERIAL WITHIN A CIRCULATORY SYSTEM DURING A SURGICAL PROCEDURE 审中-公开
    在手术过程中在循环系统中移除不可消耗材料的系统和方法

    公开(公告)号:WO2012141969A3

    公开(公告)日:2014-05-01

    申请号:PCT/US2012032299

    申请日:2012-04-05

    Abstract: A method for capturing dislodged vegetative growth during a surgical procedure is provided. The method includes maneuvering, into a circulatory system, a first cannula having a distal end and an opposing proximal end, such that the first cannula is positioned to capture the vegetative growth en bloc. A second cannula is positioned in fluid communication with the first cannula, such that a distal end of the second cannula is situated in spaced relation to the distal end of the first cannula. A suction force is provided through the distal end of the first cannula so as to capture the vegetative growth. Fluid removed by the suction force is reinfused through the distal end of the second cannula. Subsequent to becoming dislodged, the vegetative growth is caputred by the first cannula. A method for capturing a vegetative growth during removal of a pacemaker lead is also provided.

    Abstract translation: 提供了一种在外科手术过程中捕获植物生长发育的方法。 该方法包括向循环系统操纵具有远端和相对近端的第一套管,使得第一套管被定位成捕获整个营养生长。 第二套管定位成与第一套管流体连通,使得第二套管的远端位于与第一套管的远端成间隔开的位置。 通过第一插管的远端提供吸力以捕获营养生长。 通过吸力除去的流体通过第二套管的远端被再灌注。 在脱落后,营养生长被第一个插管所吸引。 还提供了在去除起搏器引线期间捕获营养生长的方法。

    SYESTEM AND METHOD FOR COLLECTING AND TREATING PLASMA PROTEIN FRACTIONS
    8.
    发明申请
    SYESTEM AND METHOD FOR COLLECTING AND TREATING PLASMA PROTEIN FRACTIONS 审中-公开
    用于收集和处理等离子体蛋白质分解物的系统和方法

    公开(公告)号:WO2013152253A1

    公开(公告)日:2013-10-10

    申请号:PCT/US2013/035360

    申请日:2013-04-05

    Abstract: Method and apparatus for separating plasma from blood in a separation vessel (352), separating the separated plasma into desired plasma proteins in a plasma separator (205) fluidly connected to the separation vessel (352) to receive the separated plasma, and adding photosensitizer to the desired plasma proteins for viral inactivation treatment of such proteins.

    Abstract translation: 用于在分离容器(352)中分离血液中的血浆的方法和装置,将分离的血浆分离成与流体连接到分离容器(352)的等离子体分离器(205)中的所需血浆蛋白质,以接收分离的血浆,并将光敏剂加入 用于病毒灭活处理这种蛋白质的期望的血浆蛋白质。

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