公开(公告)号：WO2022090735A1

公开(公告)日：2022-05-05

申请号：PCT/GB2021/052818

申请日：2021-10-29

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： GREEN, Brian Desmond

IPC: C08H8/00

Abstract: This invention relates to a polysaccharide that can be used to modulate immune responses.

公开(公告)号：WO2022090734A1

公开(公告)日：2022-05-05

申请号：PCT/GB2021/052817

申请日：2021-10-29

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  UNIVERSITY OF ULSTER

Inventor： GREEN, Brian Desmond ,  MCCLEAN, Paula

IPC: C08B37/00 ,  A61K31/715

Abstract: The invention relates to an isolated polysaccharide and a composition comprising the polysaccharide for use in treating a neurodegenerative disease.

公开(公告)号：WO2021130377A1

公开(公告)日：2021-07-01

申请号：PCT/EP2020/087888

申请日：2020-12-24

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： SCOTT, Christopher ,  LONGLEY, Daniel ,  HUMPHREYS, Luke ,  MCDAID, William

IPC: A61K39/12 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/585

Abstract: There is provided polymeric nanoparticles with non-tumour antigen payloads for use in tagging cells for destruction by a subject's immune system and the use thereof for the treatment of cancer. Suitably there is provided a method of treatment comprising administration of nanoparticle comprising a non-tumour protein payload to a subject with cancer, in particular to a cancer cell.

公开(公告)号：WO2021053047A1

公开(公告)日：2021-03-25

申请号：PCT/EP2020/075927

申请日：2020-09-17

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  AUCKLAND UNISERVICES LIMITED

Inventor： JONES, David ,  ANDREWS, Gavin ,  SVIRSKIS, Darren ,  HILL, Andrew ,  BHUSAL, Prabhat ,  SHARMA, Manisha ,  AGARWAL, Priyanka ,  LI, Shu

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/445 ,  A61P23/02 ,  A61P29/00

Abstract: The invention provides a device comprising: at least one biocompatible polymer; and an eutectic composition comprising a first agent and an agent capable of forming a eutectic composition with the first agent; or one or more fatty acids; or one or more fatty alcohols; or one or more fatty amines or combinations thereof. The device can be administered to a subject in need thereof an effective amount of one or more active agents. The at least one biocompatible polymer may be selected from the group comprising poly ethylene-vinyl-acetate, vinyl acetate, silicone, polycaprolactone, polylacticco-glycolic acid, polylactic acid or polyglycolic acid.

公开(公告)号：WO2020144377A1

公开(公告)日：2020-07-16

申请号：PCT/EP2020/050682

申请日：2020-01-13

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： TIAN, Yiwei ,  ANDREWS, Gavin ,  JONES, David

IPC: A61K9/51

Abstract: A water and solvent free Continuous Manufacturing platform for Nanoparticle Drug delivery systems (COMMAND), such as, self-dispersing solid lipid nanoparticles and proliposomal nanoparticles, and the nanoparticles made by such platform. Byremoving water and solvent from conventional processes, the formation of dry, solvent free self-dispersing solid lipid nanoparticles and dry, solvent free solid proliposomal nanoparticles can be performed using the COMMAND platform.

公开(公告)号：WO2020002906A1

公开(公告)日：2020-01-02

申请号：PCT/GB2019/051795

申请日：2019-06-25

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  INDIAN INSTITUTE OF TECHNOLOGY MADRAS

Inventor： RANADE, Vivek V. ,  PANDIT, Ajinkya V. ,  KHALDE, Chirag ,  SANGWAI, Jitendra

IPC: B01D9/00 ,  B01F5/04 ,  B01F15/02

Abstract: A method is provided for preparing a material in a fluidic oscillator (10) which comprises a chamber (12) having an inlet (14) and an outlet (16), and at least two feedback arms (18 a,b) through which fluid may pass from the chamber to the inlet to impart an oscillating flow onto a fluid as it is passed through the inlet. The method comprises passing a solution of the material, or a precursor to the material, through the inlet into the chamber; and precipitating the material in the chamber.

公开(公告)号：WO2019043232A1

公开(公告)日：2019-03-07

申请号：PCT/EP2018/073640

申请日：2018-09-03

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Inventor： MULCAHY, Grace ,  GARZA-CUARTERO, Laura ,  DALTON, John

IPC: C07K14/435 ,  A61K39/00

CPC classification number: C07K14/43536 ,  A61K39/0003

Abstract: The present invention is related to a Fasciola hepatica antigen and vaccine. Specifically, the present invention relates to a Fasciola hepatica antigen comprising a polypeptide, wherein the polypeptide comprises amino acid sequences from Fasciola hepatica, or fragments each thereof. Also disclosed are use of the antigen as a vaccine against Fasciola hepatica infection, and use of the antigen in the manufacture of a vaccine for vaccinating a subject against Fasciola hepatica infection.

公开(公告)号：WO2018141935A3

公开(公告)日：2018-08-09

申请号：PCT/EP2018/052709

申请日：2018-02-02

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： WARNOCK, Neil D. ,  MAULE, Aaron G. ,  DALZELL, Johnathan J

IPC: A61K38/04 ,  C07K14/435 ,  C12N15/75

Abstract: The invention relates to peptides, nematicidal compositions, transgenic microorganisms for expressing the peptides and methods of treating plant parasitic nematodes, the method comprising providing either a peptide or a nematicidal composition or a transgenic microorganism for expressing the peptide on or adjacent the plant parasitic nematodes.

公开(公告)号：WO2018033639A1

公开(公告)日：2018-02-22

申请号：PCT/EP2017/070972

申请日：2017-08-18

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST ,  MIGAUD, Marie ,  REDPATH, Philip

Inventor： MIGAUD, Marie ,  REDPATH, Philip

IPC: C07H1/00 ,  C07H19/048

Abstract: The present invention is directed to lactones of the following structural formula for use as precursors of NAD, and their use as nutritional supplements.

Abstract translation: 本发明涉及以下结构式的内酯用作NAD的前体，以及它们作为营养补剂的用途。

公开(公告)号：WO2017191457A1

公开(公告)日：2017-11-09

申请号：PCT/GB2017/051247

申请日：2017-05-04

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： DONNELLY, Ryan ,  WOOLFSON, David

IPC: A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K9/20 ,  A61K31/40 ,  A61K31/401 ,  A61K31/403 ,  A61K31/60

CPC classification number: A61K9/0021 ,  A61K9/2031 ,  A61K31/40 ,  A61K31/401 ,  A61K31/403 ,  A61K31/616 ,  A61K45/06 ,  A61K47/10 ,  A61K47/32 ,  A61K2300/00

Abstract: The invention is directed to a transdermal delivery device comprising a microneedle array and a reservoir portion, wherein said microneedles are composed of a swellable hydrogel polymer composition, the polymers being cross-linked polymers selected from at least one of the group consisting of poly(methylvinylether/maleic acid), esters thereof and poly(methyl/vinyl ether/maleic anhydride). The reservoir portion comprises at least one amphipathic component and at least one hydrophobic active agent, wherein in use, on insertion of the microneedles into the stratum corneum of skin, said microneedles swell and said amphipathic component and said at least one hydrophobic active agent diffuse down a concentration gradient from the reservoir layer via the microneedles into the skin.

Abstract translation: 本发明涉及包含微针阵列和储库部分的透皮递送装置，其中所述微针由可溶胀的水凝胶聚合物组合物组成，所述聚合物是交联聚合物，其选自至少一种 由聚（甲基乙烯基醚/马来酸），其酯和聚（甲基乙烯基醚/马来酸酐）组成的组。 储库部分包含至少一种两亲组分和至少一种疏水活性剂，其中在使用时，在将微针插入皮肤角质层时，所述微针膨胀，并且所述两性组分和所述至少一种疏水活性剂向下扩散 从储库层经微针进入皮肤的浓度梯度。