公开(公告)号：WO2006091870A2

公开(公告)日：2006-08-31

申请号：PCT/US2006/006698

申请日：2006-02-24

Applicant: TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  ONCONOVA THERAPEUTICS INC. ,  REDDY, M.V. Ramana ,  REDDY,E. Premkumar ,  BELL, Stanley, C.

Inventor： REDDY, M.V. Ramana ,  REDDY,E. Premkumar ,  BELL, Stanley, C.

IPC: C07C311/37

CPC classification number: C07C323/29 ,  C07B2200/07 ,  C07C315/02 ,  C07C315/04 ,  C07C317/10 ,  C07C317/18 ,  C07C317/28 ,  C07C319/14 ,  C07C323/07 ,  C07C323/16 ,  C07C323/22 ,  C07C317/24

Abstract: α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula (I): wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.

Abstract translation: a，根据式（I）的β-不饱和硫化物，砜，亚砜和磺酰胺：其中Ar1，Ar2，X，n，*和R如本文所定义，是通过将β-羟基硫化物，砜，亚砜或 磺胺类药物。

公开(公告)号：WO2012149567A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/035880

申请日：2012-04-30

Applicant: MOUNT SINAI SCHOOL OF MEDICINE ,  REDDY, M.V. Ramana ,  REDDY, E., Premkumar

Inventor： REDDY, M.V. Ramana ,  REDDY, E., Premkumar

IPC: C07D513/04

CPC classification number: C07D513/04 ,  C07D239/47 ,  C07D239/48 ,  C07D239/56 ,  C07D239/58 ,  C07D401/12 ,  C07D403/12

Abstract: This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer. The method includes administering to the patient a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.

Abstract translation: 本公开涉及化合物，其制备方法，包括这些化合物的药物组合物和用于治疗细胞增殖性疾病（包括但不限于癌症）的方法。 该方法包括向患者施用治疗有效量的式（I）化合物或其药学上可接受的盐。

公开(公告)号：WO2006132947A3

公开(公告)日：2006-12-14

申请号：PCT/US2006/021389

申请日：2006-06-02

Applicant: TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  REDDY, M.V. Ramana ,  REDDY, E. Premkumar

Inventor： REDDY, M.V. Ramana ,  REDDY, E. Premkumar

IPC: A61K31/352 ,  C07D311/12 ,  C07D311/14 ,  C07D401/12 ,  C07D401/06

Abstract: Compounds of Formula:(I) wherein R 1 , R 2 , M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.