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    COMPOSITION AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
    1.
    发明申请
    COMPOSITION AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES 审中-公开
    用于治疗增殖性疾病的组合物和方法

    公开(公告)号：WO2006104668A3

    公开(公告)日：2007-12-06

    申请号：PCT/US2006008704

    申请日：2006-03-10

    申请人： UNIV TEMPLE ,  SINAI SCHOOL MEDICINE ,  REDDY E PREMKUMAR ,  HOLLAND JAMES F

    发明人： REDDY E PREMKUMAR ,  HOLLAND JAMES F

    IPC分类号： A61K31/704

    CPC分类号： A61K31/10 ,  A61K31/136 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula (I), wherein R 1 is selected from the group consisting of -OH, -NH 2 , -NH-CH 2 -CO 2 H, -NH-CH(CH 3 )-CO 2 H, and -NH-C(CH 3 ) 2 -CO 2 H, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 提供了用于治疗增殖性疾病的方法和组合物，其中所述组合物包含至少一种根据式（I）的化合物，其中R 1选自-OH，-NH 2， 2，-NH-CH 2 -CO 2 H，-NH-CH（CH 3） - CO 2， 2 H和-NH-C（CH 3 3）2 -CO 2 H，或其药学上可接受的盐 化合物 和蒽环类，例如 多柔比星或其药学上可接受的盐，或铂，例如， 奥沙利铂或其药学上可接受的盐。

    ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS
    4.
    发明申请
    ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS 审中-公开
    用于治疗MAMMALIAN疾病病症治疗分子的活化细胞毒性化合物

    公开(公告)号：WO2008033475A3

    公开(公告)日：2008-08-14

    申请号：PCT/US2007019943

    申请日：2007-09-14

    申请人： ONCONOVA THERAPEUTICS INC ,  FEGLEY GLENN ,  BELL STANLEY C ,  COSTENZA STEVEN ,  DUKE JODIE ,  REDDY E PREMKUMAR ,  REDDY M V RAMANA

    发明人： FEGLEY GLENN ,  BELL STANLEY C ,  COSTENZA STEVEN ,  DUKE JODIE ,  REDDY E PREMKUMAR ,  REDDY M V RAMANA

    IPC分类号： C07D207/12 ,  A61K31/4015

    CPC分类号： A61K31/4015 ,  A61K38/00 ,  A61K47/6803 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6855 ,  C07D207/36

    摘要： Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND- HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

    摘要翻译： 描述活化的细胞毒性化合物用于与用于治疗哺乳动物疾病状况的靶向分子连接，所述哺乳动物疾病状态包括活化剂，间隔物连接体，连接体（例如自体免疫）和选自由以下组成的组的细胞毒性药物：AMINO- 取代的（E）-2,6-二烷氧基甲硅烷基4-取代的苯甲醚，氨基和羟基取代的苯乙烯磺酸纤维素，以及取代的苯氧基和苯基 - 苯乙烯基衍生物。 描述了与靶向分子连接的活化的细胞毒性化合物，其中靶向分子选自基本上由抗体，受体，配体，细胞因子，激素和信号转导分子组成的组。 本发明还涉及治疗疾病状况的方法。

    PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS
    6.
    发明申请
    PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS 审中-公开
    由ABL抑制剂对放射性辐射的细胞毒性作用的组织和细胞的保护

    公开(公告)号：WO2005044181A3

    公开(公告)日：2006-03-09

    申请号：PCT/US2004028658

    申请日：2004-09-02

    申请人： UNIV TEMPLE ,  REDDY E PREMKUMAR ,  REDDY M V RAMANA ,  COSENZA STEPHEN C ,  GUMIREDDY KIRANMAI

    发明人： REDDY E PREMKUMAR ,  REDDY M V RAMANA ,  COSENZA STEPHEN C ,  GUMIREDDY KIRANMAI

    IPC分类号： A61K31/40 ,  A61K31/517

    CPC分类号： A61K31/40 ,  A61K31/517

    摘要： Pre-treatment with one or more compounds of formula (I), as described herein, protects normal cells from the toxic side effects of ionizing radiation. Administration of one or more radioprotective compounds of formula (I) to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of one or more compounds of formula (I) allows for the safe increase the dosage of anticancer radiation. Amelioration of toxicity following inadvertent radiation exposure may also be mitigated with administration of one or more compounds of formula (I).

    摘要翻译： 如本文所述用一种或多种式（I）化合物预处理可保护正常细胞免受电离辐射的毒副作用。 在抗癌放射治疗之前向患者施用一种或多种式（I）的放射保护性化合物降低了辐射对正常细胞的细胞毒性副作用。 一种或多种式（I）化合物的放射防护作用允许安全地增加抗癌辐射的剂量。 通过施用一种或多种式（I）化合物，也可以缓解无意的辐射暴露后毒性的改善。