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    PRODUCTION AND PURIFICATION OF ESTERS OF CONJUGATED LINOLEIC ACIDS
    1.
    发明申请
    PRODUCTION AND PURIFICATION OF ESTERS OF CONJUGATED LINOLEIC ACIDS 审中-公开
    生产和纯化结合的亚油酸酯

    公开(公告)号：WO2005067888A1

    公开(公告)日：2005-07-28

    申请号：PCT/US2003/041289

    申请日：2003-12-23

    申请人： STEPAN COMPANY ,  RONGIONE, Joseph, C. ,  GALANTE, Jenifer, Heydinger ,  CLAUSS, Steven, L. ,  BERNHARDT, Randal, J. ,  XAYARIBOUN, Phouvieng

    发明人： RONGIONE, Joseph, C. ,  GALANTE, Jenifer, Heydinger ,  CLAUSS, Steven, L. ,  BERNHARDT, Randal, J. ,  XAYARIBOUN, Phouvieng

    IPC分类号： A61K9/00

    CPC分类号： C11C1/10 ,  C07C67/03 ,  C07C67/333 ,  C07C67/54 ,  C11B3/12 ,  C11C1/025 ,  C11C3/003 ,  C11C3/10 ,  C11C3/14 ,  C07C69/587

    摘要： A process to refine esters of conjugated linoleic acids via distillation in a single or multi-pass distillation operation is provided. Thermal rearrangement of conjugated linoleic acid components during distillation is prevented or reduced by the use of a low residence time and/or reduced pressure distillation apparatus. A process to produce refined esters of conjugated linoleic acids is also provided. The process transesterifies a linoleic acid-containing oil to generate an alkyl ester composition which further undergoes isomerization at a temperatures typically between about 90-140 °C to form an ester stream containing conjugated linoleic acid esters, which is then distilled to obtain the refined esters of conjugated linoleic acids. The transesterification and isomerization steps can be performed in one reaction vessel without an intervening distillation step. The transesterification and isomerization steps can occur concurrently in a continuous reaction system using a dual reaction zone apparatus. Refined ester compositions produced by the processes and enriched in desirable conjugated linoleic acid isomers are also contemplated.

    摘要翻译： 提供了在单次或多次蒸馏操作中通过蒸馏来改进共轭亚油酸酯的方法。 通过使用低停留时间和/或减压蒸馏装置来防止或减少蒸馏期间共轭亚油酸组分的热重排。 还提供了生产共轭亚油酸精制酯的方法。 该方法酯交换含亚油酸的油以产生烷基酯组合物，其通常在约90-140℃的温度下进一步进行异构化，以形成含有共轭亚油酸酯的酯流，然后将其蒸馏得到精制酯 的共轭亚油酸。 酯交换和异构化步骤可以在一个反应​​容器中进行，而不需要中间蒸馏步骤。 酯交换和异构化步骤可以在使用双重反应区装置的连续反应体系中同时发生。 还考虑了通过该方法制备并富集所需共轭亚油酸异构体的精制酯组合物。

    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS
    4.
    发明申请
    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS 审中-公开
    共混盐酸盐和酸的制备

    公开(公告)号：WO2004101719A2

    公开(公告)日：2004-11-25

    申请号：PCT/US2004/012387

    申请日：2004-04-21

    申请人： STEPAN COMPANY ,  RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    发明人： RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    IPC分类号： C11C

    CPC分类号： C07C51/09 ,  C07C57/12

    摘要： A process to manufacture conjugated linoleic acid (CLA)-containing materials including conjugated linoleic salts and acids that are enriched in desirable cis-9, trans-11- and trans-10, cis-12-CLA isomers and are low in certain undesirable isomers. The process generally entails isomerization of an alkyl ester of a linoleic acid-containing material, such as sunflower oil or safflower oil, to effectuate conjugation of the double bonds, followed by saponification of the resultant CLA-containing fatty acid ester to produce a CLA-containing fatty acid salt, optionally followed by neutralization of the CLA-containing fatty acid salt with an acid source to produce a CLA-containing fatty acid.

    摘要翻译： 包含共轭亚油酸盐和酸的共轭亚油酸（CLA）材料的制备方法，其富含希望的顺式-9，反式-11-和反式-10，顺式-12-CLA异构体，并且在某些不需要的异构体中是低的 。 该方法通常需要含亚油酸的材料的烷基酯如向日葵油或红花油的异构化，以实现双键的缀合，然后将所得的含CLA脂肪酸酯皂化以产生CLA- 任选地随后用酸源中和含CLA的脂肪酸盐以产生含CLA的脂肪酸。

    ELIMINATION OF ORGANOHALO AND OXIRANE SPECIES IN CARBOXYLIC ACID ESTER STREAMS
    5.
    发明申请
    ELIMINATION OF ORGANOHALO AND OXIRANE SPECIES IN CARBOXYLIC ACID ESTER STREAMS 审中-公开
    有机酸和氧化物质在羧酸酯酶中的消除

    公开(公告)号：WO2012031176A1

    公开(公告)日：2012-03-08

    申请号：PCT/US2011/050289

    申请日：2011-09-02

    申请人： STEPAN COMPANY ,  Rongione, Joseph, C. ,  Heydinger-Galante, Jenifer

    发明人： Rongione, Joseph, C. ,  Heydinger-Galante, Jenifer

    IPC分类号： C07C51/43

    CPC分类号： C07C67/48 ,  C07C51/412 ,  C07C51/487 ,  C11B3/001 ,  C11B3/06 ,  C11B7/0083 ,  C11C1/08

    摘要： The present technology provides a process of reducing, removing or eliminating organohalo, glycidol, and oxirane species from carboxylic acid esters streams and crude and refined triglyceride oils to provide a carboxylic acid ester stream or triglyceride oil with reduced levels or essentially free of organohalo, glycidyl or other oxirane species. The process includes adding to the carboxylic acid ester stream or triglyceride oil an amount of a carboxylate anion and a cation counterion sufficient to react with the organohalo, glycidyl and oxirane species present.

    摘要翻译： 本技术提供了一种从羧酸酯流和粗精制甘油三酯油中还原，除去或除去有机卤代，缩水甘油和环氧乙烷物质的方法，以提供具有降低的水平或基本上没有有机卤代的缩水甘油基的羧酸酯流或甘油三酸酯油 或其他环氧乙烷物种。 该方法包括向羧酸酯流或甘油三酯油中加入一定量的羧酸根阴离子和足以与存在的有机卤代，缩水甘油基和环氧乙烷物质反应的阳离子抗衡离子。

    PROCESS AND CATALYSTS FOR THE CONJUGATION OF DOUBLE BONDS IN FATTY ACIDS AND DERIVATIVES THEREOF
    6.
    发明申请
    PROCESS AND CATALYSTS FOR THE CONJUGATION OF DOUBLE BONDS IN FATTY ACIDS AND DERIVATIVES THEREOF 审中-公开
    脂肪酸和其衍生物双重结合的过程和催化剂

    公开(公告)号：WO2006101473A1

    公开(公告)日：2006-09-28

    申请号：PCT/US2005/008639

    申请日：2005-03-15

    申请人： STEPAN COMPANY ,  RONGIONE, Joseph C.

    发明人： RONGIONE, Joseph C.

    IPC分类号： C11C3/14 ,  C07C51/353 ,  C07C67/333 ,  B01J31/02

    CPC分类号： B01J31/0252 ,  B01J31/0204 ,  B01J31/0212 ,  B01J2531/12 ,  B01J2531/13 ,  C11C3/14

    摘要： A process to manufacture conjugated fatty acids or their derivatives, in particular long chain polyunsaturated fatty acids (e.g., CLAs) or their derivatives, using an improved catalyst system that isomerizes the fatty acids and their derivatives in an efficient, cost-effective manner. The improved catalyst system includes a metal alkoxide or amide catalyst chelated with an appropriate chelating agent or a metal alkoxide formed from another metal alkoxide in the described process.

    摘要翻译： 使用改进的催化剂体系制造共轭脂肪酸或其衍生物，特别是长链多不饱和脂肪酸（例如CLA）或其衍生物的方法，其以有效，成本有效的方式异构化脂肪酸及其衍生物。 改进的催化剂体系包括在所述方法中与合适的螯合剂或由另一种金属醇盐形成的金属醇盐螯合的金属醇盐或酰胺催化剂。

    GLYCERIDE ESTERS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH REDUCED NEURONAL METABOLISM OF GLUCOSE
    7.
    发明申请
    GLYCERIDE ESTERS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH REDUCED NEURONAL METABOLISM OF GLUCOSE 审中-公开
    用于治疗与减少葡萄糖的神经代谢有关的疾病的甘油三酯

    公开(公告)号：WO2008005818A1

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/072441

    申请日：2007-06-29

    申请人： STEPAN COMPANY ,  HASHIM, Sami A. ,  JUSIS, Joanna ,  HEYDINGER GALANTE, Jenifer ,  RONGIONE, Joseph C.

    发明人： HASHIM, Sami A. ,  JUSIS, Joanna ,  HEYDINGER GALANTE, Jenifer ,  RONGIONE, Joseph C.

    IPC分类号： A61K31/22 ,  A61K47/00

    CPC分类号： A61K31/22

    摘要： Provided are alternative sources of ketone bodies for reducing or eliminating symptoms of Parkinson's disease, amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease), Alzheimer's disease, Huntington's disease, epilepsy and other diseases or disorders characterized by impaired glucose metabolism. The alternative sources of ketone bodies include mono-, di- and triglyceride esters of acetoacetate and mixtures thereof, and/or mono-, di- and triglyceride esters of 3-hydroxybutyrate and mixtures thereof. These glyceride esters can be administered orally as a dietary supplement or in a nutritional composition.

    摘要翻译： 提供用于减少或消除帕金森病，肌萎缩性侧索硬化（ALS，也称为Lou Gehrig病），阿尔茨海默病，亨廷顿病，癫痫以及以葡萄糖代谢紊乱为特征的其他疾病或病症的症状的酮体的替代来源。 酮体的替代来源包括乙酰乙酸酯的单酯，二甘油酯和甘油三酸酯及其混合物，和/或3-羟基丁酸酯的单酯，二甘油三酯和甘油三酯及其混合物。 这些甘油酯可以作为膳食补充剂或营养组合物口服给药。

    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS
    10.
    发明申请
    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS 审中-公开
    共混盐酸盐和酸的制备

    公开(公告)号：WO2004101719A3

    公开(公告)日：2005-05-06

    申请号：PCT/US2004012387

    申请日：2004-04-21

    申请人： STEPAN CO ,  RONGIONE JOSEPH C ,  GALANTE JENIFER HEYDINGER ,  CLAUSS STEVEN L ,  BERNHARDT RANDAL J ,  XAYARIBOUN PHOUVIENG

    发明人： RONGIONE JOSEPH C ,  GALANTE JENIFER HEYDINGER ,  CLAUSS STEVEN L ,  BERNHARDT RANDAL J ,  XAYARIBOUN PHOUVIENG

    IPC分类号： C07C51/09 ,  C07C51/347

    CPC分类号： C07C51/09 ,  C07C57/12

    摘要： A process to manufacture conjugated linoleic acid (CLA)-containing materials including conjugated linoleic salts and acids that are enriched in desirable cis-9, trans-11- and trans-10, cis-12-CLA isomers and are low in certain undesirable isomers. The process generally entails isomerization of an alkyl ester of a linoleic acid-containing material, such as sunflower oil or safflower oil, to effectuate conjugation of the double bonds, followed by saponification of the resultant CLA-containing fatty acid ester to produce a CLA-containing fatty acid salt, optionally followed by neutralization of the CLA-containing fatty acid salt with an acid source to produce a CLA-containing fatty acid.

    摘要翻译： 包含共轭亚油酸盐和酸的共轭亚油酸（CLA）材料的制备方法，其富含希望的顺式-9，反式-11-和反式-10，顺式-12-CLA异构体，并且在某些不需要的异构体中是低的 。 该方法通常需要含亚油酸的材料的烷基酯如向日葵油或红花油的异构化，以实现双键的缀合，然后将所得的含CLA脂肪酸酯皂化以产生CLA- 任选地随后用酸源中和含CLA的脂肪酸盐以产生含CLA的脂肪酸。