公开(公告)号：WO2004069147A2

公开(公告)日：2004-08-19

申请号：PCT/IL2004/000104

申请日：2004-02-03

Applicant: MEDIWOUND LTD. ,  ROSENBERG, Lior

Inventor： ROSENBERG, Lior

IPC: A61K

CPC classification number: A61B17/22004 ,  A61B2017/00761 ,  A61B2017/320004 ,  A61N7/00

Abstract: A device, system and method for enhancing the functionality and efficiency of a chemical and/or enzymatic debriding agent with a physical debriding mechanism. The debriding agent alone and the physical mechanism alone are each capable of at least some debriding activity separately, without being used in the combination. In combination, however, they are more effective, such that the debriding efficacy is increased for the combination. Preferably, the physical debriding mechanism comprises an ultrasound source.

Abstract translation: 一种用物理清创机制增强化学和/或酶促清除剂的功能和效率的装置，系统和方法。 单独的清创剂和单独的物理机制各自能够分开进行至少一些清创活动，而不用于组合。 然而，它们组合更有效，使得组合的清创功效增加。 优选地，物理清创机构包括超声源。

公开(公告)号：WO2003049783A3

公开(公告)日：2003-06-19

申请号：PCT/IL2002/000878

申请日：2002-11-05

Applicant: MEDGENICS, INC. ,  BELLOMO, Stephen, F. ,  ROSENBERG, Lior ,  BUKHMAN, Mordechay ,  PEARLMAN, Andrew, L. ,  LIPPIN, Itzhak ,  SHAVITT, Menachem, D.

Inventor： BELLOMO, Stephen, F. ,  ROSENBERG, Lior ,  BUKHMAN, Mordechay ,  PEARLMAN, Andrew, L. ,  LIPPIN, Itzhak ,  SHAVITT, Menachem, D.

IPC: A61B10/00

Abstract: A method of harvesting a tissue sample (318) from a subject (311), comprising: attaching an outer surface of a portion of the tissue sample (318) to a substantially flat surface area; lifting the surface area, together with the portion of the tissue (318); and slicing the tissue (318) at a given distance below the surface area of said portion to separate the portion to separate the tissue portion (318) from the subject (311).

公开(公告)号：WO2002058774A2

公开(公告)日：2002-08-01

申请号：PCT/IL2002/000073

申请日：2002-01-24

Applicant: L.R. R & D LTD. ,  ROSENBERG, Lior

Inventor： ROSENBERG, Lior

IPC: A61M25/00

CPC classification number: A61M25/02 ,  A61B17/3401

Abstract: Method of holding in place a transcutaneous implant by applying an adhesive in liquid form to the implant and the area of the patient's skin about the needle and allowing the adhesive to set. The implant is constituted by an infusion needle, a catheter or any transcutaneous implant. Whenever the adhesive is in liquid form, it has such a surface tension that it will flow along the implant and the skin to reach a terminal point, which is the point at which the implant is inserted. The adhesive is applied in liquid form and flows along the implant and the skin to reach the point at which the implant is inserted, and then allowed to set, to hold the implant in place.

Abstract translation: 通过将液体形式的粘合剂施加到植入物以及患者皮肤周围针的区域并允许粘合剂凝固来保持经皮植入物的方法。 植入物由输液针，导管或任何经皮植入物构成。 无论何时粘合剂为液体形式，其具有这样的表面张力，以致其将沿着植入物和皮肤流动到达终点，该终点是植入物插入的点。 粘合剂以液体形式施用，并沿着植入物和皮肤流动以达到植入物插入的位置，然后允许固定，以将植入物固定到位。

公开(公告)号：WO2013011514A1

公开(公告)日：2013-01-24

申请号：PCT/IL2012/050261

申请日：2012-07-19

Applicant: MEDIWOUND LTD. ,  ROSENBERG, Lior ,  RUBIN, Guy ,  ASCULAI, Eilon

Inventor： ROSENBERG, Lior ,  RUBIN, Guy ,  ASCULAI, Eilon

IPC: A61K36/88 ,  A61K38/48 ,  A61P19/02 ,  A61P19/04

CPC classification number: A61K38/4873 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/14 ,  A61K36/88 ,  A61K38/1732 ,  A61K45/06 ,  C12Y304/22031 ,  C12Y304/22032 ,  A61K2300/00

Abstract: The present invention relates to a proteolytic extract obtained from bromelain for the treatment of connective tissue diseases. In particular, the present invention relates to a pharmaceutical composition comprising a proteolytic extract obtained from bromelain for the treatment of diseases such as Dupuytren's disease and Peyronie's disease.

Abstract translation: 本发明涉及由菠萝蛋白酶获得的用于治疗结缔组织疾病的蛋白水解提取物。 特别地，本发明涉及药物组合物，其包含从菠萝蛋白酶获得的蛋白水解提取物，用于治疗诸如Dupuytren氏病和Peyronie氏病的疾病。

公开(公告)号：WO2006054301A3

公开(公告)日：2006-07-06

申请号：PCT/IL2005001222

申请日：2005-11-17

Applicant: 4 MED LTD ,  ROSENBERG LIOR

Inventor： ROSENBERG LIOR

IPC: A61B1/24

CPC classification number: A61B1/24 ,  A61B90/14

Abstract: The present invention discloses a safe surgical mouth gag (MG) (30) comprising a substantially planar frame larger than the maximal mouth aperture which is defined by at least two cross members, i.e., a longitudinal maxillary cross member (33) and a mandibular cross member (32) and by at least one rod (29) connecting said maxillary and said mandibular cross members; and modules maneuverably interconnected to the same. Said modules are selected from a tongue blade (50) approximately perpendicular to said frames' plane, which is vertically displaceable with respect to said mandibular cross member; a retaining member (53) within which said tongue blade shaft is slidably displaceable; retraction elements (35) for urging the cheeks away from the oral cavity; abutment members (40) for contacting the upper teeth or upper maxilla; and at least one light auxiliary (101) located adjacent to oral cavity, adapted to illuminate the same effectively.

Abstract translation: 本发明公开了一种安全的手术口腔（MG）（30），其包括大于最大口孔的基本上平面的框架，所述最大口孔由至少两个横向构件限定，即纵向上颌横构件（33）和下颌十字 构件（32）和连接所述上颌骨和所述下颌十字构件的至少一个杆（29） 和模块可操纵地互连到相同的模块。 所述模块选自大致垂直于所述框架平面的舌片（50），所述舌片可相对于所述下颌横向构件垂直移位; 保持构件（53），其中所述舌片轴可滑动地位移; 用于将面颊推出口腔的收缩元件（35）; 邻接构件（40），用于接触上牙或上颌骨; 以及位于邻近口腔的至少一个轻型辅助器（101），适于有效地照射它。

公开(公告)号：WO2006006167A2

公开(公告)日：2006-01-19

申请号：PCT/IL2005/000744

申请日：2005-07-13

Applicant: MEDIWOUND LTD. ,  TOREN, Amir ,  ROSENBERG, Lior ,  GORECKI, Marian

Inventor： TOREN, Amir ,  ROSENBERG, Lior ,  GORECKI, Marian

IPC: A61K38/48

CPC classification number: A61K45/06 ,  A61K33/38 ,  A61K2300/00

Abstract: The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present invention further relates to kit and methods for topical debridement of damaged skin, particularly of burned skin.

Abstract translation: 本发明涉及用于清除受损皮肤的组合物，其包含至少一种酶促清除剂和至少一种包含重金属离子的防腐化合物。 本发明还涉及用于局部清创损伤的皮肤，特别是烧伤皮肤的试剂盒和方法。

公开(公告)号：WO2004069147A3

公开(公告)日：2004-12-02

申请号：PCT/IL2004000104

申请日：2004-02-03

Applicant: MEDIWOUND LTD ,  ROSENBERG LIOR

Inventor： ROSENBERG LIOR

IPC: A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61K20060101 ,  A61N7/00

CPC classification number: A61B17/22004 ,  A61B2017/00761 ,  A61B2017/320004 ,  A61N7/00

Abstract: A device (10), system and method for enhancing the functionality and efficiency of a chemical and/or enzymatic debriding agent with a physical debriding mechanism includes a container (11) which is optionallz implemented as a round cup and features an acoustic chamber (12) with an ultrasound source (18) at the top of the acoustic chamber (12).

Abstract translation: 一种用于通过物理清创机构增强化学和/或酶促清除剂的功能和效率的装置（10），系统和方法包括：容器（11），其可选择性地实施为圆杯并具有声室（12 ），在声学室（12）的顶部具有超声波源（18）。

公开(公告)号：WO2004099363A2

公开(公告)日：2004-11-18

申请号：PCT/US2004/013194

申请日：2004-04-29

Applicant: MEDGENICS INC. ,  BELLOMO, Stephen, F. ,  LIPPIN, Itzhak ,  PIVA, Guillermo, Alberto ,  ROSENBERG, Lior ,  BUKHMAN, Mordechay ,  STERN, Baruch, S. ,  SHALHEVET, David ,  SHAVITT, Menachem, D. ,  PEARLMAN, Andrew, L.

Inventor： BELLOMO, Stephen, F. ,  LIPPIN, Itzhak ,  PIVA, Guillermo, Alberto ,  ROSENBERG, Lior ,  BUKHMAN, Mordechay ,  STERN, Baruch, S. ,  SHALHEVET, David ,  SHAVITT, Menachem, D. ,  PEARLMAN, Andrew, L.

IPC: C12M

CPC classification number: A61B17/3468 ,  A61B10/0275 ,  A61B17/32053 ,  A61B17/322 ,  A61B2017/0023 ,  A61B2017/00969 ,  A61B2017/2808 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2017/3225 ,  A61B2217/005 ,  A61F2/105 ,  A61K35/36 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/2066 ,  A61K38/215 ,  A61K38/27 ,  A61K38/28 ,  A61M5/425 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2510/00 ,  Y10T83/929

Abstract: Embodiments of the present invention provide Dermal Micro Organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure. Other embodiments are described and claimed.

Abstract translation: 本发明的实施方案提供了皮肤微器官（DMO），其制造方法和装置。 本发明的一些实施方案提供了包含多个皮肤成分的DMO，其基本上保留了衍生自它们的真皮组织的微结构和三维结构，其尺寸被选择为允许适当营养物和气体的被动扩散 到DMO的细胞并将细胞废物扩散出细胞，以便最小化细胞毒性和由于DMO中的营养不足和废物积聚引起的伴随死亡。 本发明的一些实施例提供了用于收获DMO的方法和装置。 根据一些示例性实施例，用于收获DMO的装置可以包括用于支撑要从其中收获DMO的与皮肤相关的组织结构的支撑构型，以及能够将DMO与皮肤相关组织分离的切割工具 结构体。 描述和要求保护其他实施例。

公开(公告)号：WO2003090598A3

公开(公告)日：2003-11-06

申请号：PCT/IL2003/000326

申请日：2003-04-21

Applicant: MEDIWOUND, LTD. ,  ROSENBERG, Lior

Inventor： ROSENBERG, Lior

IPC: A61K38/48

Abstract: The present invention relates to a device and methods suitable for use in the prevention and treatment of burn induced compartment syndrome, and to specifically designed applications means for the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn, as well as to methods of using these enzymatic compositions in conjunction with the applications means.

公开(公告)号：WO2006054301B1

公开(公告)日：2006-08-17

申请号：PCT/IL2005001222

申请日：2005-11-17

Applicant: 4 MED LTD ,  ROSENBERG LIOR

Inventor： ROSENBERG LIOR

IPC: A61B1/24

CPC classification number: A61B1/24 ,  A61B90/14

Abstract: The present invention discloses a safe surgical mouth gag (MG) (30) comprising a substantially planar frame larger than the maximal mouth aperture which is defined by at least two cross members, i.e., a longitudinal maxillary cross member (33) and a mandibular cross member (32) and by at least one rod (29) connecting said maxillary and said mandibular cross members; and modules maneuverably interconnected to the same. Said modules are selected from a tongue blade (50) approximately perpendicular to said frames' plane, which is vertically displaceable with respect to said mandibular cross member; a retaining member (53) within which said tongue blade shaft is slidably displaceable; retraction elements (35) for urging the cheeks away from the oral cavity; abutment members (40) for contacting the upper teeth or upper maxilla; and at least one light auxiliary (101) located adjacent to oral cavity, adapted to illuminate the same effectively.

Abstract translation: 本发明公开了一种安全的手术口咽嘴（MG）（30），其包括大于最大嘴孔的基本上平面的框架，所述框架由至少两个横向构件（即，纵向上颌横向构件（33）和下颌十字形构件 （32）以及连接所述上颌骨和所述下颌骨横向构件的至少一根杆（29）; 并且模块可操作地与其相互连接。 所述模块选自大致垂直于所述框架平面的舌片（50），所述平面相对于所述下颚横向构件可垂直移位; 一个保持件（53），所述舌片轴可在其中滑动地移动; 用于推动脸颊离开口腔的缩回元件（35） 邻接构件（40），用于接触上牙齿或上颌骨; 和至少一个位于口腔附近的光辅助装置（101），适于有效地照亮口腔。