公开(公告)号：WO2023090015A1

公开(公告)日：2023-05-25

申请号：PCT/JP2022/038480

申请日：2022-10-14

申请人： 富士フイルム株式会社

发明人： 杉田　惟

IPC分类号： G01N21/65 ,  C12M1/34 ,  C12M3/00 ,  G01N33/483 ,  G06N3/02 ,  G06N20/00

摘要： 生物学的分子が成分として液体中に分散された懸濁液から発せられる電磁波のスペクトルを測定したスペクトル測定データに基づいて、懸濁液中の成分の状態を予測する情報処理装置であって、プロセッサを備え、プロセッサは、第１校正データと第２校正データの少なくとも２種類の校正データを用いて校正された校正済み状態予測モデルであり、第１校正データは、第１成分を含む第１懸濁液から得られたスペクトル測定データである第１スペクトル測定データ、および第１成分に関する第１成分関連情報を説明変数とし、かつ、第１成分の状態に関する第１状態関連情報を目的変数とし、第２校正データは、第２成分を含む第２懸濁液から得られたスペクトル測定データである第２スペクトル測定データ、および第２成分に関する第２成分関連情報を説明変数とし、かつ、第２成分の状態に関する第２状態関連情報を目的変数とする、校正済み状態予測モデルを用い、状態の予測の対象である対象成分に関する対象成分関連情報、および対象成分を含む対象懸濁液から得られたスペクトル測定データである対象スペクトル測定データを取得し、対象成分関連情報および対象スペクトル測定データを校正済み状態予測モデルに適用し、校正済み状態予測モデルから対象懸濁液中の対象成分の状態を予測した対象状態予測結果を出力させる。

公开(公告)号：WO2023089043A1

公开(公告)日：2023-05-25

申请号：PCT/EP2022/082301

申请日：2022-11-17

申请人： INSPHERO AG

发明人： FREY, Olivier ,  LOHASZ, Christian ,  MODENA, Mario Matteo ,  MISUN, Patrick Mark ,  RENGGLI, Kasper

IPC分类号： C12M3/06

摘要： The present invention relates to a microfluidic device (10) suitable for accommodating an aqueous liquid, the device having essentially a planar shape, which device comprises at least one conduit (11) fluidically connecting at least two structures selected from compartments, reservoirs (14) and/or ports (15, 62). The conduit comprises at least one bend (12) describing an angle of between ≥ 85° and ≤ 275° around an axis orthogonal to the planar shape. The planar shape is arranged in an angle of between +45° and -45° relative to the direction of the force of gravity (G), or a centrifugal force (Fc) applied to the microfluidic device.

公开(公告)号：WO2023087171A1

公开(公告)日：2023-05-25

申请号：PCT/CN2021/131151

申请日：2021-11-17

申请人： 王锦弘

发明人： 王锦弘 WANG, Chin Hung

IPC分类号： C12Q1/6806 ,  G01N1/00 ,  C12M1/00 ,  B01L3/00 ,  A61B10/02

摘要： 一种采检棒容置构件（1），包含第一开口（11）及第二开口（12），第一开口（11）与第二开口（12）相连，且相连处包含窄口（13），且采检棒容置构件（1）在z轴方向具有第一厚度；其中当采检棒（200）置入设置在离心管（100）中的所述采检棒容置构件（1）的所述第一开口（11）且离心时，所述采检棒（200）自所述第一开口（11）通过所述窄口（13）进入所述第二开口（12）。

公开(公告)号：WO2023082179A1

公开(公告)日：2023-05-19

申请号：PCT/CN2021/130332

申请日：2021-11-12

申请人： 深圳华大生命科学研究院

发明人： 苏泽宇 ,  梁元庆 ,  沈梦哲 ,  倪洁蕾

IPC分类号： G01N21/64 ,  C12M1/34

摘要： 一种提高测序分辨率的方法、测序装置和系统；方法包括，以至少一种激发光对含有荧光染料的待测样进行照射激发，产生荧光信号，且激发光中，最大的波长小于红光波长；对产生的荧光信号通过光路传输后，收集并成像。

公开(公告)号：WO2023081975A1

公开(公告)日：2023-05-19

申请号：PCT/AU2022/051348

申请日：2022-11-11

申请人： HYDROBE PTY LTD

发明人： ANDERSON, Duncan Royce ,  SILVA, Cristian Coelho

IPC分类号： C12M1/00 ,  C12M1/02 ,  C12M1/107 ,  C12M1/26 ,  C12M1/34 ,  C12M1/36 ,  B01D53/84 ,  C12N1/12 ,  C12N1/20 ,  C12N1/32 ,  C12R1/07 ,  C12R1/11 ,  C12R1/125 ,  C12R1/22 ,  C12R1/89 ,  C05F11/08 ,  C12P3/00 ,  C12P5/00

摘要： The disclosure relates to a process for sequestering carbon from a gas stream that comprises carbon dioxide and a process for producing biomass. The process comprises: (i) producing an organic feedstock using a phototrophic source and a gas stream comprising carbon dioxide in a photosynthesis step; and (ii) converting the organic feedstock to biomass; wherein converting the organic feedstock to biomass comprises an aerobic bio-decomposition step that employs bacteria comprising at least one facultative anaerobic species. The present disclosure is also directed to biomass, and hydrogen, produced in accordance with the process and systems suitable for performing the process.

公开(公告)号：WO2023079104A1

公开(公告)日：2023-05-11

申请号：PCT/EP2022/080863

申请日：2022-11-04

申请人： MARINE BIOENERGY AS

发明人： HAUGEN, Arnstein ,  FRANTZEN, Torstein ,  ELJE, Eirik ,  DUSTAN, Andrew Charles ,  LIASET, Bjørn ,  SANDNES, Kjartan

IPC分类号： C12M1/00 ,  C12M1/06 ,  C12M3/04 ,  C12P21/06 ,  C12N9/50 ,  A23J1/10 ,  A23L13/00 ,  A23L17/00

摘要： A method of processing an organic feedstock comprising mineralised tissues comprise: carrying out enzymatic hydrolysis of the organic feedstock to produce hydrolysis fractions and mineralised tissue remnants, wherein the mineralised tissue remnants comprise a proteinaceous portion; separating the mineralised tissue remnants from the hydrolysis fractions; and demineralising the mineralised tissue remnants to produce solubilised minerals and demineralised tissue remnants.

公开(公告)号：WO2023077096A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078924

申请日：2022-10-28

申请人： NEXTERN INNOVATION, LLC

发明人： URBAN, Jon F. ,  ISLAM, Riazul ,  SWOYER, John ,  BUARQUE, Fernando ,  FOLEY, John D.

IPC分类号： C12M1/12 ,  C12M1/04 ,  C12M1/00 ,  C12M3/00 ,  C12M1/34 ,  C12M1/36

摘要： Apparatus and associated methods relate to cell culture systems having controlled gas concentration boundary conditions around cell culture. In an illustrative example, a programmable cell culture system (PCCS) may include one or more manifolds, each releasably coupled to multiple cell culture modules. The cell culture modules, for example, may include a nutrient capacitive medium (NCM) in fluid communication with a concentration-controlled gas source through at least two gas transfer interfaces. The gas transfer interfaces (GTIs) may, for example, be spatially distributed in relation to a cell growth surface in the NCM. Each GTI, for example, may include a gas permeable membrane (GPM) and a plenum. The GPM may be disposed between the plenum and the NCM. Various embodiments may advantageously selectively control a concentration of at least one target gas in the NCM by maintaining predetermined boundary conditions of the cell growth surface via the GTIs.

公开(公告)号：WO2023076706A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048497

申请日：2022-10-31

申请人： WASHINGTON UNIVERSITY

发明人： SULEIMAN, Hani ,  GENIN, Guy ,  MINER, Jeffrey ,  JIANG, Shumeng ,  QU, Chengqing

IPC分类号： C12M3/06 ,  A61L27/38 ,  A61L27/50 ,  A61L27/36 ,  B29C64/106 ,  B29C64/40

摘要： Among the various aspects of the present disclosure is the provision of systems and methods for growing or culturing podocytes and uses thereof. In one aspect, a podocyte culture system including an ECM-patterned substrate is disclosed. The ECM-patterned substrate includes a compliant substrate. The compliant substrate includes a predetermined stiffness ranging from about 0.1 kPa to about 10 kPa. The ECM-patterned substrate further includes a plurality of patterned elements deposited over an exposed surface of the compliant substrate.

公开(公告)号：WO2023076275A2

公开(公告)日：2023-05-04

申请号：PCT/US2022/047734

申请日：2022-10-25

申请人： REGENERATIVE RESEARCH FOUNDATION

发明人： BERTUCCI, Taylor ,  LOTZ, Steven ,  TEMPLE, Sally ,  STERN, Jeffrey

IPC分类号： C12N1/38 ,  C12M1/00 ,  C12N1/00 ,  C12N9/00

摘要： A non-degradable device for use in controlled feeding of mammalian cell cultures including by way of example cultures of stem cells such as induced pluripotent stem cells (iPSCs). Methods of making and using the device are also disclosed.

公开(公告)号：WO2023074946A2

公开(公告)日：2023-05-04

申请号：PCT/KR2021/015321

申请日：2021-10-28

申请人： 조재연

发明人： 조재연 CHO, Jaeyeaon

IPC分类号： C12N5/00 ,  C12N5/077 ,  C12M1/12 ,  C12N5/071

摘要： 본 명세서에서는 섬유아세포(fibroblast) 및 세포외 기질을 포함하는 섬유아세포 패치(patch)가 형성되도록, 섬유아세포를 자극 배지(stimulation medium)에서 배양하는 단계; 형성된 상기 섬유아세포 패치에 단백질 분해효소를 처리하는 단계; 단백질 분해효소가 처리된 상기 섬유아세포 패치를 냉동시키는 단계; 상기 섬유아세포 패치에서 섬유아세포가 탈세포화(decellularization)되도록, 냉동된 상기 섬유아세포 패치를 해동하는 단계, 및 탈세포화된 상기 섬유아세포 패치로부터 세포외 기질을 수득하는 단계를 포함하는, 세포외 기질의 제조 방법 및 이를 기초로 제조된 콜라겐(collagne), 액티닌(actinin) 및 액틴-결합 유사 단백질(filamin-C)을 포함하고, 나노 섬유(nano fiber)가 뒤엉킨 형태로 존재하는, 세포외 기질을 제공한다.