公开(公告)号：WO2012160551A3

公开(公告)日：2013-03-28

申请号：PCT/IL2012000201

申请日：2012-05-23

Applicant: ROSETTA GENOMICS LTD ,  MOR RESEARCH APPLIC LTD ,  GOREN YARON ,  AMIR OFER

Inventor： GOREN YARON ,  AMIR OFER

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention is based in part on the discovery of a panel of miRs whose levels are increased or decreased in the circulation of chronic systolic HF patients. Accordingly, an extensive panel of miRs was screened in the sera of stable chronic systolic HF patients and the results were compared to an age, gender and ethnically matched control group.

Abstract translation: 本发明部分基于在慢性收缩期HF患者的循环中水平升高或降低的一组miR的发现。 因此，在稳定的慢性收缩期HF患者的血清中筛选出广泛的miRs组，并将结果与​​年龄，性别和种族匹配的对照组进行比较。

公开(公告)号：WO2009024834A3

公开(公告)日：2011-12-29

申请号：PCT/IB2007004718

申请日：2007-12-05

Applicant: ROSETTA GENOMICS LTD

IPC: C12Q1/68 ,  C12N15/11 ,  C12Q1/70

CPC classification number: C12N15/1133 ,  A61K48/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2330/31 ,  C12N2710/16022 ,  C12N2760/16122 ,  C12N2760/18522

Abstract: Provided are isolated viral and human nucleic acids including microRNAs associated with different viral infection, including HSV1, HSV2, RSV, EBV, Influenza A, HIV, HPV, HIV, HBV, and Vaccinia viral infection. The disclosure further provides methods for detecting viral infection using the nucleic acids, and methods of inhibiting and treating viral infection using pharmaceutical composition comprising associated nucleic acids.

Abstract translation: 提供了分离的病毒和人类核酸，包括与不同病毒感染相关的微RNA，包括HSV1，HSV2，RSV，EBV，甲型流感，HIV，HPV，HIV，HBV和痘苗病毒感染。 本公开进一步提供了使用核酸检测病毒感染的方法，以及使用包含相关核酸的药物组合物来抑制和治疗病毒感染的方法。

公开(公告)号：WO2011039757A2

公开(公告)日：2011-04-07

申请号：PCT/IL2010/000806

申请日：2010-10-04

Applicant: ROSETTA GENOMICS LTD. ,  TEL HASHOMER MEDICAL INFRASTRUCTURE AND SERVICES LTD. ,  HOSHEN, Moshe ,  DOTAN, Zohar

Inventor： HOSHEN, Moshe ,  DOTAN, Zohar

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for the prognosis of renal cancer patients after surgical operation. Specifically the invention relates to microRNA molecules associated with the prognosis of renal cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.

Abstract translation: 本文描述了外科手术后肾癌患者预后的组合物和方法。 具体地说，本发明涉及与肾癌预后相关的微小RNA分子，以及与之相关的或从其衍生的各种核酸分子。

公开(公告)号：WO2011024157A1

公开(公告)日：2011-03-03

申请号：PCT/IL2010/000462

申请日：2010-06-10

Applicant: ROSETTA GENOMICS LTD. ,  SITBON, Einat ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  DROMI, Nir ,  LEVY, Asaf

Inventor： SITBON, Einat ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  DROMI, Nir ,  LEVY, Asaf

IPC: C07H21/00 ,  A61K31/7088 ,  G01N33/48

CPC classification number: C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Disclosed are microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom Further disclosed are methods and compositions that can be used for diagnosis of cancer.

Abstract translation: 公开了微小RNA分子以及与其相关或衍生的各种核酸分子。进一步公开了可用于诊断癌症的方法和组合物。

公开(公告)号：WO2004044123A9

公开(公告)日：2010-06-10

申请号：PCT/IL0300970

申请日：2003-11-16

Applicant: ROSETTA GENOMICS LTD ,  BENTWICH ITZHAK

Inventor： BENTWICH ITZHAK

IPC: C12N20060101 ,  C12N1/00 ,  C12N15/00 ,  C12N15/113 ,  C12N15/12 ,  C12Q1/68 ,  G06F19/00

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2330/10 ,  G06F19/16 ,  G06F19/18

Abstract: The present invention relates to a first group of novel genes, here identified as "genomic address messenger" or "GAM" genes, and a second group of novel operon-like genes, here identified as "genomic record" or "GR" genes. GAM genes selectively inhibit translation of known 'target' genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 20600 GAM genes, and 6635 GR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM and GR genes and specific functions and utilities thereof, for detecting expression of GAM and GR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

公开(公告)号：WO2009093254A3

公开(公告)日：2010-03-11

申请号：PCT/IL2009000101

申请日：2009-01-26

Applicant: ROSETTA GENOMICS LTD ,  MOR RES APPLIC ,  GOREN YARON ,  GILAD SHLOMIT ,  HOD MOSHE ,  YOGEV YARIV

Inventor： GOREN YARON ,  GILAD SHLOMIT ,  HOD MOSHE ,  YOGEV YARIV

IPC: A01N43/04 ,  A61K31/70 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.

Abstract translation: 本发明提供了用于鉴定发生怀孕并发症风险的受试者的方法和组合物，例如先兆子痫或早产。 组合物是微小RNA和相关核酸。

公开(公告)号：WO2010023658A3

公开(公告)日：2010-03-04

申请号：PCT/IL2009/000809

申请日：2009-08-18

Applicant: ROSETTA GENOMICS LTD. ,  TEL HASHOMER MEDICAL INFRASTRUCTURE AND SERVICES LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  GIVOL, David ,  RECHAVI, Gideon ,  ROSENFELD, Nitzan

Inventor： GIVOL, David ,  RECHAVI, Gideon ,  ROSENFELD, Nitzan

IPC: C12N15/11 ,  A61K31/7088 ,  A61K35/00

Abstract: The invention relates in general to microRNA molecules associated with glioblastoma, as well as various molecules relating thereto. More specifically, the invention relates to methods and compositions for the treatment of glioblastoma and for treatment by a combination of microRNA molecules and Imatinib mesylate.

公开(公告)号：WO2010023658A2

公开(公告)日：2010-03-04

申请号：PCT/IL2009000809

申请日：2009-08-18

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL INFRASTRU ,  YEDA RES & DEV ,  GIVOL DAVID ,  RECHAVI GIDEON ,  ROSENFELD NITZAN

Inventor： GIVOL DAVID ,  RECHAVI GIDEON ,  ROSENFELD NITZAN

IPC: A61K31/7088 ,  A61K35/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/141 ,  C12N2330/10

Abstract: The invention relates in general to microRNA molecules associated with glioblastoma, as well as various molecules relating thereto. More specifically, the invention relates to methods and compositions for the treatment of glioblastoma and for treatment by a combination of microRNA molecules and Imatinib mesylate.

Abstract translation: 本发明一般涉及与成胶质细胞瘤相关的微RNA分子以及与其相关的各种分子。 更具体地说，本发明涉及用于治疗成胶质细胞瘤和通过微RNA分子和甲磺酸伊马替尼的组合治疗的方法和组合物。

公开(公告)号：WO2010004562A3

公开(公告)日：2010-01-14

申请号：PCT/IL2009/000683

申请日：2009-07-08

Applicant: ROSETTA GENOMICS LTD. ,  MOR RESEARCH APPLICATIONS LTD. ,  BRENNER, Baruch ,  GILAD, Shlomit ,  GOREN, Yaron ,  CHAJUT, Ayelet

Inventor： BRENNER, Baruch ,  GILAD, Shlomit ,  GOREN, Yaron ,  CHAJUT, Ayelet

IPC: C12Q1/68

Abstract: The invention provides a method for conducting minimally-invasive early detection of colorectal cancer and/or of colorectal cancer precursor cells, by using microRNA molecules associated with colorectal cancer, as well as various nucleic acid molecules relating thereto or derived thereof.

公开(公告)号：WO2009066291A3

公开(公告)日：2009-07-09

申请号：PCT/IL2008001525

申请日：2008-11-20

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES LTD ,  ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  NASS DVORA

Inventor： ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  NASS DVORA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/178

Abstract: The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.

Abstract translation: 本发明提供了通过分析特定微RNA和与其相关的核酸分子的表达模式来分类特定癌症和肿瘤起源的方法。 根据microRNA表达框架进行分类可以优化治疗，并确定具体的治疗方法。