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    NOVEL LIPID COMPOUNDS
    1.
    发明申请
    NOVEL LIPID COMPOUNDS 审中-公开
    新型脂肪化合物

    公开(公告)号：WO2008132552A2

    公开(公告)日：2008-11-06

    申请号：PCT/IB2007/004588

    申请日：2007-11-01

    Applicant: PRONOVA BIOPHARMA NORGE AS ,  HOLMEIDE, Anne, Kristin ,  ROSMAN, Jenny

    Inventor： HOLMEIDE, Anne, Kristin ,  ROSMAN, Jenny

    IPC: C07C33/02 ,  C07C43/178 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587

    CPC classification number: C07H15/04 ,  A23D9/00 ,  A61K31/045 ,  A61K31/047 ,  A61K31/075 ,  A61K31/10 ,  A61K31/22 ,  A61K31/225 ,  A61K31/232 ,  A61K31/255 ,  A61K31/265 ,  A61K31/661 ,  A61K45/06 ,  A61K49/0004 ,  C07C57/03 ,  C07C57/12 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587 ,  C07C69/96 ,  C07C211/20 ,  C07C229/30 ,  C07C305/14 ,  C07C323/14 ,  C07C323/54 ,  C07F9/091 ,  C07F9/106 ,  C07F9/113 ,  A61K2300/00

    Abstract: Omega-3 lipid compounds of the general formula (I): wherein R 1 and R 2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; P represents a hydrogen atom, (Formula II) wherein P 2 , P 3 , and P 4 are chosen from a hydrogen atom, an alkyl group, and a C 14 -C 22 alkenyl group, wherein the alkyl and alkenyl groups are optionally substituted with a hydroxy group, (Formula III), (Formula IV), or (Formula V); and Y is a C 14 -C 22 alkenyl group with at least one double bond, having E and/or Z configuration; or any pharmaceutically acceptable complex, solvate, salt or pro-drug thereof, with the proviso that R 1 and R 2 are not simultaneously a hydrogen atom. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments, in particular for the treatment of cardiovascular and metabolic diseases.

    Abstract translation: 通式（I）的ω-3脂质化合物：其中R 1和R 2相同或不同，选自氢原子，羟基， 烷基，卤素原子，烷氧基，酰氧基，酰基，烯基，炔基，芳基，烷硫基，烷氧基羰基，羧基，烷基亚磺酰基，烷基磺酰基 基团，氨基和烷基氨基; P表示氢原子，（式II）其中P 2，P 3，和P 4选自氢原子，烷基 基团和C 14 -C 22烯基，其中烷基和烯基任选被羟基取代，（式III），（式IV）， 或（式V）; 并且Y是具有至少一个具有E和/或Z构型的双键的C 14-14 -C 22烯基; 或其任何药学上可接受的复合物，溶剂合物，盐或前药，条件是R 1和R 2不同时为氢原子。 还公开了包含这些化合物的药物组合物和脂质组合物，以及用作药物的这种化合物，特别是用于治疗心血管和代谢疾病。

    COMPOSITION
    2.
    发明申请
    COMPOSITION 审中-公开
    组成

    公开(公告)号：WO2008142482A2

    公开(公告)日：2008-11-27

    申请号：PCT/IB2007004613

    申请日：2007-11-01

    Applicant: PRONOVA BIOPHARMA NORGE AS ,  HOLMEIDE ANNE KRISTIN ,  ROSMAN JENNY

    Inventor： HOLMEIDE ANNE KRISTIN ,  ROSMAN JENNY

    CPC classification number: C07F9/113 ,  A61K31/045 ,  A61K31/047 ,  A61K31/075 ,  A61K31/10 ,  A61K31/22 ,  A61K31/225 ,  A61K31/232 ,  A61K31/255 ,  A61K31/265 ,  A61K31/661 ,  A61K45/06 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587 ,  C07C69/96 ,  C07C305/14 ,  C07C323/14 ,  A61K2300/00

    Abstract: The present invention relates to compositions comprising at least omega-3 lipid compounds substituted at the 2-positions having therapeutic activity. More specifically, the present invention relates to a composition comprising at least omega-3 lipid compounds substituted at the 2-position, counted from the functional group (X) of the omega-3 lipid compound, wherein the omega-3 lipid compounds comprise: a compound of general formula (I): and a compound of formula (II): wherein R1 and R2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride, a hydroxymethyl (-CH2OH) or a pro-drug thereof, or a carboxamide, or any pharmaceutically acceptable complex, salt, solvate, or pro-drug, with the provisos that: R1 and R2 are not simultaneously hydrogen.

    Abstract translation: 本发明涉及包含至少在具有治疗活性的2位置取代的ω-3脂质化合物的组合物。 更具体地说，本发明涉及从ω-3脂质化合物的官能团（X）计数的至少包含在2位被取代的ω-3脂类化合物的组合物，其中ω-3脂质化合物包含： 通式（I）的化合物和式（II）的化合物：其中R 1和R 2相同或不同，并且选自氢原子，羟基，烷基，卤素原子，烷氧基 酰氧基，烯基，炔基，芳基，烷硫基，烷氧基羰基，羧基，烷基亚磺酰基，烷基磺酰基，氨基和烷基氨基; 羧酸酐，羧酸酐，羟甲基（-CH 2 OH）或其前药或羧酰胺，或任何药学上可接受的复合物，盐，溶剂合物或前药， 条件是：R1和R2不同时为氢。

    OMEGA-3 LIPID COMPOUNDS
    6.
    发明申请
    OMEGA-3 LIPID COMPOUNDS 审中-公开

    公开(公告)号：WO2008142482A3

    公开(公告)日：2008-11-27

    申请号：PCT/IB2007/004613

    申请日：2007-11-01

    Applicant: PRONOVA BIOPHARMA NORGE AS ,  HOLMEIDE, Anne Kristin ,  ROSMAN, Jenny

    Inventor： HOLMEIDE, Anne Kristin ,  ROSMAN, Jenny

    IPC: C07C33/02 ,  C07C43/178 ,  C07C69/007 ,  C07C69/24 ,  C07C69/40 ,  C07C69/587 ,  C07C69/96 ,  C07C309/67 ,  C07C323/14 ,  C07F9/113 ,  A61K31/045 ,  A61K31/075 ,  A61K31/10 ,  A61K31/047 ,  A61K31/22

    Abstract: The present invention relates to compositions comprising at least omega-3 lipid compounds substituted at the 2-positions having therapeutic activity. More specifically, the present invention relates to a composition comprising at least omega-3 lipid compounds substituted at the 2-position, counted from the functional group (X) of the omega-3 lipid compound, wherein the omega-3 lipid compounds comprise: a compound of general formula (I): and a compound of formula (II): wherein R 1 and R 2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride, a hydroxymethyl (-CH 2 OH) or a pro-drug thereof, or a carboxamide, or any pharmaceutically acceptable complex, salt, solvate, or pro-drug, with the provisos that: R 1 and R 2 are not simultaneously hydrogen.

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