公开(公告)号：WO2007140385A3

公开(公告)日：2007-12-06

申请号：PCT/US2007/069921

申请日：2007-05-30

申请人： ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

发明人： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC分类号： C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：WO2009067613A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084216

申请日：2008-11-20

申请人： ABBOTT LABORATORIES ,  FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

发明人： FLORJANCIC, Alan, S. ,  DART, Michael, J. ,  RYTHER, Keith, B. ,  PEREZ-MEDRANO, Arturo ,  CARROLL, William, A. ,  PATEL, Meena, V. ,  TIETJE, Karin, Rosemarie ,  LI, Tongmei ,  KOLASA, Teodozyj ,  GALLAGHER, Megan, E. ,  PEDDI, Sridhar ,  FROST, Jennifer, M. ,  NELSON, Derek, W.

IPC分类号： A01N43/42

CPC分类号： C07D417/12 ,  C07D277/46 ,  C07D417/06 ,  C07D513/04 ,  C07D513/20

摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R 1 , R 2 , R 3 , R 4 , and L 1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R 1a , R 2a , R x , and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本发明涉及式（I）的化合物或其药物盐，前药，前药的盐或其组合，式（I）。 其中R1，R2，R3，R4和L1在具体实施方案中被定义，包含这些化合物的组合物以及使用这些化合物和组合物治疗病症和病症的方法。 本发明还涉及式（II）的化合物或其药物盐，前药，前药盐或其组合，式（II）。 其中R1a，R2a，Rx和n如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2007140439A3

公开(公告)日：2008-01-24

申请号：PCT/US2007070029

申请日：2007-05-31

申请人： ABBOTT LAB ,  DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMARIE

发明人： DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMARIE

IPC分类号： C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08

CPC分类号： C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。

公开(公告)号：WO2007140439A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/070029

申请日：2007-05-31

申请人： ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

发明人： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC分类号： C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC分类号： C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。

公开(公告)号：WO2007140385A2

公开(公告)日：2007-12-06

申请号：PCT/US2007069921

申请日：2007-05-30

申请人： ABBOTT LAB ,  DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMARIE ,  KOLASA TEODOZYJ

发明人： DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMARIE ,  KOLASA TEODOZYJ

CPC分类号： C07D277/82 ,  C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D477/14 ,  C07D513/04

摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2 , R3 , R4 , and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a和（R x）n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。

公开(公告)号：WO2005028477A1

公开(公告)日：2005-03-31

申请号：PCT/US2004/030735

申请日：2004-09-17

申请人： ABBOTT LABORATORIES ,  LI, Tao ,  BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R.

发明人： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R.

IPC分类号： C07D471/04

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

摘要翻译： 式（I）化合物Z-Ar 1 -Ar 2其中Z是二氮杂双环胺，Ar 1是5-或6-元芳环，Ar 2选自未取代或取代的5-或 6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑; tetrahydrocarbazolyl; 萘; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。