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    SYSTEM FOR DELIVERING NEUROSTIMULATION FROM PULMONARY ARTERY
    1.
    发明申请
    SYSTEM FOR DELIVERING NEUROSTIMULATION FROM PULMONARY ARTERY 审中-公开
    从脉动神经递送神经系统的系统

    公开(公告)号：WO2009075750A2

    公开(公告)日：2009-06-18

    申请号：PCT/US2008/013306

    申请日：2008-12-03

    Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yunlong ,  SACHANANDANI, Haresh G. ,  LI, Dan ,  MI, Bin

    Inventor： ZHANG, Yunlong ,  SACHANANDANI, Haresh G. ,  LI, Dan ,  MI, Bin

    IPC: A61N1/372

    CPC classification number: A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

    Abstract: Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

    Abstract translation: 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地将神经刺激器，电源和至少一个电极植入肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

    SYSTEMS AND METHODS FOR COLLECTING PATIENT EVENT INFORMATION
    3.
    发明申请
    SYSTEMS AND METHODS FOR COLLECTING PATIENT EVENT INFORMATION 审中-公开
    收集患者事件信息的系统和方法

    公开(公告)号：WO2010009322A1

    公开(公告)日：2010-01-21

    申请号：PCT/US2009/050861

    申请日：2009-07-16

    Applicant: CARDIAC PACEMAKERS, INC. ,  HAHN, Stephen, J. ,  DONG, Yanting ,  SACHANANDANI, Haresh, G. ,  HOYME, Kenneth, P. ,  GILKERSON, James, O.

    Inventor： HAHN, Stephen, J. ,  DONG, Yanting ,  SACHANANDANI, Haresh, G. ,  HOYME, Kenneth, P. ,  GILKERSON, James, O.

    IPC: A61N1/372

    CPC classification number: A61N1/37247 ,  A61N1/37258 ,  A61N1/3962

    Abstract: A method of and system for collecting patient event information from a cardiac rhythm management system (CRM system) is described, where the CRM system includes a cardiac rhythm management device (CRM device) and an external interface device. The method includes the steps of initiating a transmission session wherein the interface device communicates with the CRM device, prompting a user of the CRM system to select a reason for the transmission session, inputting the selected reason for the transmission session to the interface device, and storing the selected reason for the transmission session and timestamp information for the transmission session.

    Abstract translation: 描述了一种从心律管理系统（CRM系统）收集患者事件信息的方法和系统，其中CRM系统包括心律管理装置（CRM装置）和外部接口装置。 该方法包括以下步骤：启动传输会话，其中接口设备与CRM设备通信，提示CRM系统的用户选择传输会话的原因，向接口设备输入传输会话的选择原因;以及 存储用于传输会话的选择原因和用于传输会话的时间戳信息。

    SYSTEM FOR DELIVERING NEUROSTIMULATION FROM PULMONARY ARTERY
    5.
    发明申请
    SYSTEM FOR DELIVERING NEUROSTIMULATION FROM PULMONARY ARTERY 审中-公开
    从脉动神经递送神经系统的系统

    公开(公告)号：WO2009075750A3

    公开(公告)日：2010-01-14

    申请号：PCT/US2008013306

    申请日：2008-12-03

    Applicant: CARDIAC PACEMAKERS INC ,  ZHANG YUNLONG ,  SACHANANDANI HARESH G ,  LI DAN ,  MI BIN

    Inventor： ZHANG YUNLONG ,  SACHANANDANI HARESH G ,  LI DAN ,  MI BIN

    IPC: A61N1/36

    CPC classification number: A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

    Abstract: Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

    Abstract translation: 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地将神经刺激器，电源和至少一个电极植入肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

    DECOMPENSATION DETECTION BASED ON HEART FAILURE CO-MORBIDITIES
    6.
    发明申请
    DECOMPENSATION DETECTION BASED ON HEART FAILURE CO-MORBIDITIES 审中-公开
    基于心脏失败的不良反应的分解检测

    公开(公告)号：WO2009051658A1

    公开(公告)日：2009-04-23

    申请号：PCT/US2008/011643

    申请日：2008-10-10

    Applicant: CARDIAC PACEMAKERS, INC. ,  SACHANANDANI, Haresh G. ,  YUNLONG, Zhang

    Inventor： SACHANANDANI, Haresh G. ,  YUNLONG, Zhang

    IPC: A61B5/0452

    CPC classification number: A61B5/7275 ,  A61B5/0002 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/029 ,  A61B5/0408 ,  A61B5/042 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/1118 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7282 ,  A61B7/02 ,  A61B7/04 ,  A61N1/3627 ,  A61N1/3704 ,  A61N1/3956 ,  G06F19/00

    Abstract: This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

    Abstract translation: 该文件尤其涉及一种包括传感器信号处理器的系统，该传感器信号处理器被配置为接收由多个传感器产生的多个电传感器信号和由可植入传感器产生的至少一个传感器信号，存储器，其包括指示co 根据所指示的并发症，从所述多个传感器信号中选择要监视的传感器信号的传感器信号选择电路，根据所述传感器信号选择电路调整所选择的传感器信号的检测阈值的阈值调整电路， 指示的并发症，以及决定电路，其将所调整的检测阈值应用于所选择的传感器信号，以确定与所述受试者中是否发生与恶化的心力衰竭（HF）有关的事件，并且输出与恶化HF相关的事件的指示 发生在用户或进程。

    DIAGNOSIS OF LEAD FRACTURE AND CONNECTION PROBLEMS
    7.
    发明申请
    DIAGNOSIS OF LEAD FRACTURE AND CONNECTION PROBLEMS 审中-公开
    诊断铅损和连接问题

    公开(公告)号：WO2012099615A1

    公开(公告)日：2012-07-26

    申请号：PCT/US2011/034337

    申请日：2011-04-28

    Applicant: MEDTRONIC, INC. ,  SWERDLOW, Charles, D. ,  SACHANANDANI, Haresh, G. ,  GUNDERSON, Bruce, D.

    Inventor： SWERDLOW, Charles, D. ,  SACHANANDANI, Haresh, G. ,  GUNDERSON, Bruce, D.

    IPC: A61N1/372

    CPC classification number: A61N1/37 ,  A61N1/372 ,  A61N2001/083

    Abstract: Techniques for diagnosing lead fractures and lead connection problems are described. One or more medical leads may be coupled to an implantable medical device (IMD) to position electrodes or other sensors at different locations within a patient than the IMD. The IMD may include a lead diagnostic module configured to diagnose problems with a coupled lead and automatically select between a lead fracture problem and a lead connection problem based on the diagnosis. The diagnosis of either lead fracture problems or lead connection problems may be based on a timing of an increased impedance value with respect to connection of the lead to the IMD, a return to baseline impedance values after the increased impedance value, an abrupt rise of the increased impedance value, maximum impedance values, or oversensing. An external device may present the diagnosis to a user to facilitate appropriate corrective action.

    Abstract translation: 描述了用于诊断铅骨折和铅连接问题的技术。 可以将一个或多个医疗引线耦合到可植入医疗装置（IMD）以将电极或其他传感器定位在患者内的不同于IMD的位置。 IMD可以包括引导诊断模块，其被配置为诊断耦合引线的问题，并且基于诊断自动选择引线断裂问题和引线连接问题。 铅断裂问题或引线连接问题的诊断可能是基于相对于引线与IMD的连接的增加的阻抗值的时序，在增加的阻抗值之后返回到基线阻抗值，突然上升 增加的阻抗值，最大阻抗值或过强。 外部设备可以向用户呈现诊断以促进适当的校正动作。

    CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE
    8.
    发明申请
    CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE 审中-公开
    使用脉搏压力的心脏输出估计

    公开(公告)号：WO2010027652A1

    公开(公告)日：2010-03-11

    申请号：PCT/US2009/054180

    申请日：2009-08-18

    Applicant: CARDIAC PACEMAKERS, INC. ,  SOFFER, Leah ,  SACHANANDANI, Haresh, G. ,  MI, Bin ,  ZHANG, Yunlong

    Inventor： SOFFER, Leah ,  SACHANANDANI, Haresh, G. ,  MI, Bin ,  ZHANG, Yunlong

    IPC: A61B5/0215 ,  A61B5/029

    CPC classification number: A61B5/029 ,  A61B5/0002 ,  A61B5/02028 ,  A61B5/02116 ,  A61B5/0215 ,  G06F19/00

    Abstract: A system and method sense a pressure signal in a pulmonary artery and compute a stroke volume and cardiac output. A pressure signal is received from an implantable pressure sensor disposed in a pulmonary artery. The pressure signal includes a systolic period and a diastolic period for determining a heart rate (HR) and a heart cycle. An iteratively-updating model can relate pressure signal and HR to a stroke volume (SV) and a cardiac output (CO). The model extracts a mean pulse pressure (MPP) from the PAP signal and receives a patient-specific vascular resistance model parameter and a patient-specific arterial compliance model parameter. CO can be calculated using the HR, the PAP signal, and the model. The vascular resistance model parameter and the arterial compliance model parameter are iteratively updated using the output of the model.

    Abstract translation: 系统和方法检测肺动脉中的压力信号并计算出行程体积和心输出量。 从设置在肺动脉中的可植入压力传感器接收压力信号。 压力信号包括用于确定心率（HR）和心脏周期的收缩期和舒张期。 迭代更新模型可以将压力信号和HR相关联到行程体积（SV）和心输出量（CO）。 该模型从PAP信号中提取平均脉压（MPP），并接收患者特异性血管阻力模型参数和患者特异性动脉顺应性模型参数。 CO可以使用HR，PAP信号和模型来计算。 使用模型的输出迭代地更新血管阻力模型参数和动脉顺应性模型参数。

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