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    SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS
    1.
    发明申请
    SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS 审中-公开
    取代的四氢萘制造方法相同，它们作为药物

    公开(公告)号：WO2009021740A3

    公开(公告)日：2009-05-14

    申请号：PCT/EP2008006700

    申请日：2008-08-14

    Applicant: SANOFIS AVENTIS ,  SCHWINK LOTHAR ,  STENGELIN SIEGFRIED ,  GOSSEL MATTHIAS ,  HAACK TORSTEN ,  LENNIG PETRA

    Inventor： SCHWINK LOTHAR ,  STENGELIN SIEGFRIED ,  GOSSEL MATTHIAS ,  HAACK TORSTEN ,  LENNIG PETRA

    IPC: C07D307/12 ,  A61P3/00

    CPC classification number: C07D405/12 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4525 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  C07D307/12

    Abstract: The invention relates to substituted tetrahydronaphthalenes of formula (I), the physiologically tolerated salts thereof, the use thereof, medicaments containing at least one substituted tetrahydronaphthalene according to the invention and the use of the substituted tetrahydronaphthalenes according to the invention and derivatives thereof as MCH antagonists, wherein in the case that X = O, C(R43)(R43'), B = (C1-C6)alkyI, (C1-C4)alkoxy-(C1-C4)alkyl, hydroxy-(C1-C6)alkyl, a 3- to 10-membered mono-, bi- or spirocyclic non-aromatic ring, which can contain 0 to 3 heteroatoms, selected from the group oxygen, nitrogen and sulfur, wherein the ring system can be additionally substituted with one or several of the following substituents: F, CF3, (C1-C6)alkyI, O-(C1-C8)alkyl, (C1-C4)alkoxy-(C1-C4)alkyI, hydroxy-(C1-C4)alkyl, oxo, CO(R64), hydroxy; wherein in the case that X = C(R43)(R43'), L3 = C(R62)(R63)O, and a 4- to 10-membered mono-, bi- or spirocyclic non-aromatic ring, which contains 1 to 3 heteroatoms, selected from the group oxygen, nitrogen and sulfur, wherein the ring system can be additionally substituted with one or several of the following substituents: F, CF3, (C1-C6)alkyl, (C1-C4)alkyl, (C1-C4)alkoxy-(C1-C4)alkyl, hydroxy-(C1-C4)alkyl, oxo, CO(R64), hydroxy.

    Abstract translation: 本发明涉及式（I），以及它们的生理学可接受的盐，其制备的取代的四氢萘，含有至少一种本发明的取代的四氢化萘和使用本发明的取代的四氢萘和它们作为MCH拮抗剂的衍生物的药物，和当X = O，C （R43）（R43“），B =（C1-C6）-AlkyI，（C1-C4）烷氧基 - （C1-C4）烷基，羟基（C1-C6）烷基，3-至10- 元单 - ，二环或螺环非芳香环，其可以包括选自氧，氮和硫，其中该环系可以另外被一个或多个下列取代基取代选择0至3个杂原子：F，CF 3， （C1-C6）-AlkyI，O-（C1-C8）烷基，（C1-C4）烷氧基 - （C1-C4）-alkyI，羟基（C1-C4） - 烷基，氧代，CO（R64） ，羟基; 其中，在X = C（R43）（R43“），L3 = C（R62）（R63）O，和4-至10-元单环，双环或含有1至3个杂原子的螺环非芳族环 包括选自氧，氮和硫的，其中该环系可以另外被一个或多个下列取代基取代选自：F，CF 3，（C1-C6）烷基，（C1-C4）烷基，（C 1 -C C4）烷氧基（C1-C4）烷基，羟基（C1-C4） - 烷基，氧代，CO（R64），羟基; 意思。

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