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    A TRANSFUSION REGISTRY AND EXCHANGE NETWORK
    1.
    发明申请
    A TRANSFUSION REGISTRY AND EXCHANGE NETWORK 审中-公开
    转移注册和交换网络

    公开(公告)号：WO2009064280A3

    公开(公告)日：2009-07-02

    申请号：PCT/US2007072193

    申请日：2007-11-14

    Applicant: BIOARRAY SOLUTIONS LTD ,  ZHANG YI ,  SEUL MICHAEL

    Inventor： ZHANG YI ,  SEUL MICHAEL

    IPC: A61B5/00

    CPC classification number: G06Q10/00 ,  G06Q50/22

    Abstract: Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors,

    Abstract translation: 公布了候选人输血捐助者的登记册，该登记处援引了库存管理政策，以创建和主动管理候选人捐助者名单，以便最大限度地减少多个地区和多个捐助者和接受者之间的需求与供应之间的不平衡。 与基因分型实验室一起，注册管理机构确实针对招募潜在的捐赠者，这些捐赠者是针对一系列与临床相关抗原相关的遗传标记，包括人类红细胞抗原（HEA）的突变，Rh的遗传变异体和可能的其他抗原如HLA 和HPA。 注册管理机监测输血抗原基因型的输入需求，最好将需求分为一组代表稳定亚群体的类别，并将应用本文所披露的策略来调整候选捐献者名单的组成以匹配需求，从而避免过多和不必要的 ，候选人的打字，

    PROBE DENSITY CONSIDERATIONS AND ELONGATION OF SELF-COMPLEMENTARY LOOPED PROBES
    2.
    发明申请
    PROBE DENSITY CONSIDERATIONS AND ELONGATION OF SELF-COMPLEMENTARY LOOPED PROBES 审中-公开
    探索密度考虑和自组织循环探测的延伸

    公开(公告)号：WO2007121018A3

    公开(公告)日：2008-12-04

    申请号：PCT/US2007064118

    申请日：2007-03-16

    Applicant: BIOARRAY SOLUTIONS LTD ,  SEUL MICHAEL ,  ZHANG YI ,  BANARJEE SUKANTA ,  YANG JIACHENG ,  CHAU CHIU

    Inventor： SEUL MICHAEL ,  ZHANG YI ,  BANARJEE SUKANTA ,  YANG JIACHENG ,  CHAU CHIU

    IPC: C12Q1/68

    CPC classification number: C12Q1/6837 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q2565/1015 ,  C12Q2537/143 ,  C12Q2533/101 ,  C12Q2535/125 ,  C12Q2525/301

    Abstract: This invention relates to a multiplexed assay method earned out in solution, wherein the solution contains nucleic aad targets and, wherein several different types of oligonucleotide probes are used to detect the nucleic acid targets The assay method includes a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, including (?) selecting a particular probe density on the surface of the bead, (??) selecting a solution having an ionic strength greater than a threshold, (??) selecting a target domain of a size less than a threshold, or (in) selecting target domains within a specified proximity to a terminal end of the targets

    Abstract translation: 本发明涉及在溶液中获得的多重测定方法，其中所述溶液含有核酸靶，并且其中使用几种不同类型的寡核苷酸探针来检测所述核酸靶。所述测定方法包括增加所述核酸靶的有效浓度的方法 通过一个或多个以下步骤调节测定条件以增加可用于结合探针的靶标的有效浓度，包括（？）选择的寡核苷酸探针结合的珠粒表面上的核酸靶标 选择具有大于阈值的离子强度的溶液，选择小于阈值的目标区域的（Δε）选择靶区域， 在目标的终端的指定接近度内

    CREATION OF FUNCTIONALIZED MICROPARTICLE LIBRARIES BY OLIGONUCLEOTIDE LIGATION OR ELONGATION
    3.
    发明申请
    CREATION OF FUNCTIONALIZED MICROPARTICLE LIBRARIES BY OLIGONUCLEOTIDE LIGATION OR ELONGATION 审中-公开
    通过寡核苷酸结合或延伸产生功能化的微生物图谱

    公开(公告)号：WO2006130347A2

    公开(公告)日：2006-12-07

    申请号：PCT/US2006/019203

    申请日：2006-05-17

    Applicant: BIOARRAY SOLUTIONS, LTD. ,  SEUL, Michael ,  YANG, Jiacheng ,  BANERJEE, Sukanta

    Inventor： SEUL, Michael ,  YANG, Jiacheng ,  BANERJEE, Sukanta

    CPC classification number: B01J19/0046 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  C12N15/1093 ,  C40B20/04 ,  C40B50/14

    Abstract: Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5 '-end, (or possibly at the 3' end) to an encoded carrier such as a color-coded microparticle ("bead"). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.

    Abstract translation: 公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法 在5'端，（或可能在3'端）与经编码的载体（如着色微粒（“珠”））相连。 也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

    NUCLEIC ACID AMPLIFICATION WITH INTEGRATED MULTIPLEX DETECTION
    4.
    发明申请
    NUCLEIC ACID AMPLIFICATION WITH INTEGRATED MULTIPLEX DETECTION 审中-公开

    公开(公告)号：WO2006028987A3

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/031357

    申请日：2005-09-02

    Applicant: BIOARRAY SOLUTIONS LTD. ,  SEUL, Michael ,  KORZHEVA, Nataliya ,  YANG, Jiacheng ,  ZHANG, Yi

    Inventor： SEUL, Michael ,  KORZHEVA, Nataliya ,  YANG, Jiacheng ,  ZHANG, Yi

    IPC: C12Q1/68 ,  C12P19/34

    Abstract: A method mediated with in-vitro transcription ("IVT") which permits miniaturization of multiplexed DNA and RN analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP®) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7­-tagged double a stranded DNA: wherein, the selected strand forms the template for RNA synthesis. In one embodiment, double stranded DNA incorporating the T7 (or other) promoter sequence at the 3' end or the 5'end is produced, for example, by amplification of genomic DNA using the Polymerase Chain Reaction (PCR). Also disclosed are nested PCR designs permitting allele analysis in combination with strand selection by IVT. Further, in one embodiment of a homogeneous format for transcription-mediated amplification and multiplexed detection (which may be particularly suited for viral or pathogen detection), encoded microparticles display "looped" capture probe configurations permitting the generation of a signal upon capture of RNA product and real-time assay monitoring.

    OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CAPTURE PROBES
    6.
    发明申请
    OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CAPTURE PROBES 审中-公开

    公开(公告)号：WO2005042763A3

    公开(公告)日：2005-05-12

    申请号：PCT/US2004/035426

    申请日：2004-10-26

    Applicant: BIOARRAY SOLUTIONS LTD. ,  SEUL, Michael ,  BANERJEE, Sukanta ,  YANG, Jiacheng ,  VENER, Tatiana

    Inventor： SEUL, Michael ,  BANERJEE, Sukanta ,  YANG, Jiacheng ,  VENER, Tatiana

    IPC: C12Q1/68

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target "engineering", as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized ("grafted") probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU­-rich subsequences located near the 3' terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    ANALYSIS AND FRACTIONATION OF PARTICLES NEAR SURFACES
    10.
    发明申请
    ANALYSIS AND FRACTIONATION OF PARTICLES NEAR SURFACES 审中-公开
    颗粒附近的表面分析和分离

    公开(公告)号：WO2002076585A1

    公开(公告)日：2002-10-03

    申请号：PCT/US2002/008706

    申请日：2002-03-21

    Applicant: BIOARRAY SOLUTIONS, LTD. ,  SEUL, Michael ,  BANERJEE, Sukanta ,  PODUAL, Kairali

    Inventor： SEUL, Michael ,  BANERJEE, Sukanta ,  PODUAL, Kairali

    IPC: B01D57/02

    CPC classification number: G01N15/0266 ,  B03C5/026 ,  C02F1/469 ,  G01N2015/0294

    Abstract: A method and apparatus for fractionation of a mixture of particles and for particle analysis are provided, in which LEAPS ("Light-controlled Electrokinetic Assembly of Particles near Surfaces") is used to fractionate and analyze a plurality of particles suspended in an interface between an electrode and an electrolyte solution. A mixture of particles are fractionated according to their relaxation frequencies, which in turn reflect differences in size or surface composition of the particles. Particles may also be analyzed to determine their physical and chemical properties based on particle relaxation frequency and maximal velocity.

    Abstract translation: 提供了一种用于分级颗粒混合物和用于颗粒分析的方法和装置，其中使用LEAPS（“靠近表面的颗粒的光控电动组装”）分级分析悬浮在 电极和电解质溶液。 颗粒的混合物根据它们的松弛频率进行分级，这又反映了颗粒的尺寸或表面组成的差异。 还可以分析颗粒以基于颗粒松弛频率和最大速度确定其物理和化学性质。

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