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    FULLY SYNTHETIC IMPLANTABLE MUTLI-PHASED SCAFFOLD
    2.
    发明申请
    FULLY SYNTHETIC IMPLANTABLE MUTLI-PHASED SCAFFOLD 审中-公开
    全合成可植入的MUTLI-PHASED SCAFFOLD

    公开(公告)号：WO2008154035A1

    公开(公告)日：2008-12-18

    申请号：PCT/US2008/007357

    申请日：2008-06-11

    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  LU, Helen, H. ,  SPALAZZI, Jeffrey

    Inventor： LU, Helen, H. ,  SPALAZZI, Jeffrey

    IPC: A61F2/08

    CPC classification number: A61F2/08 ,  A61L27/3804 ,  A61L27/48 ,  A61L27/58 ,  A61L2430/10 ,  C08L67/04

    Abstract: A fully synthetic implantable multiphased scaffold includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. A fully synthetic implantable multi-phased scaffold for ligament repair having a first phase that includes a synthetic graft material suitable for implantation into a mammal, the synthetic graft material dimensioned to have a body with first and second ends, two second phases, each second phase including microspheres and a body and first and second ends, the first end of the respective second phases disposed at each end of the first phase, and two third phases each third phase disposed at the second end of each respective second phase, so the first phase is separated from the respective third phases by the second phases, the third phases including a material for anchoring the scaffold to bone or soft tissue.

    Abstract translation: 完全合成的可植入多支架在单一连续构造中包括多个阶段以模拟肌腱或韧带的自然解剖结构及其插入位点。 一种用于韧带修复的完全合成的植入式多阶段支架，其具有第一相，其包括适于植入哺乳动物的合成移植物材料，所述合成移植材料的尺寸设计为具有第一和第二末端的主体，两个第二相，每个第二相 包括微球体和主体以及第一和第二端，设置在第一相的每一端的相应的第二相的第一端以及设置在每个相应的第二相的第二端的每个第三相的两个第三相，因此第一相 通过第二相从相应的第三相分离，第三相包括用于将支架锚定到骨或软组织的材料。

    MULTI-PHASED SCAFFOLD FOR FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE
    5.
    发明申请
    MULTI-PHASED SCAFFOLD FOR FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE 审中-公开
    用于固定骨髓软骨组织的多阶段SCAFF

    公开(公告)号：WO2008154030A3

    公开(公告)日：2009-02-26

    申请号：PCT/US2008007323

    申请日：2008-06-11

    Applicant: UNIV COLUMBIA ,  LU HELEN ,  SPALAZZI JEFFREY

    Inventor： LU HELEN ,  SPALAZZI JEFFREY

    IPC: C09K3/00

    CPC classification number: A61F2/0811 ,  A61F2002/087 ,  A61F2250/0051

    Abstract: Scaffold apparatuses are provided for musculoskeletal tissue engineering. In one example, a scaffold apparatus can be configured as an interference screw comprising multiple phases for fixing musculoskeletal soft tissue to bone. In another example, a degradable cell barrier is inserted between adjacent phases of the scaffold apparatus. In another example, the scaffold apparatus, is coupled to a synthetic graft for a ligament. In another example, the scaffold apparatus can comprise a graft collar and a polymer-fiber mesh, and the polymer-fiber mesh applies compressive mechanical loading to the graft collar.

    Abstract translation: 支架装置用于肌肉骨骼组织工程。 在一个示例中，支架装置可以被配置为包括用于将肌肉骨骼软组织固定到骨上的多个相的干涉螺钉。 在另一个实例中，可降解细胞屏障被插入在支架装置的相邻相之间。 在另一个实例中，支架装置与合成移植物连接用于韧带。 在另一个示例中，支架装置可以包括移植物套环和聚合物纤维网，并且聚合物纤维网将压缩机械负载施加到移植物套环。

    MULTI-PHASED SCAFFOLD FOR FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE
    6.
    发明申请
    MULTI-PHASED SCAFFOLD FOR FIXATION OF MUSCULOSKELETAL SOFT TISSUE TO BONE 审中-公开
    用于固定骨髓软骨组织的多阶段SCAFF

    公开(公告)号：WO2008154030A2

    公开(公告)日：2008-12-18

    申请号：PCT/US2008/007323

    申请日：2008-06-11

    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  LU, Helen ,  SPALAZZI, Jeffrey

    Inventor： LU, Helen ,  SPALAZZI, Jeffrey

    IPC: A61F2/02

    CPC classification number: A61F2/0811 ,  A61F2002/087 ,  A61F2250/0051

    Abstract: Scaffold apparatuses are provided for musculoskeletal tissue engineering. In one example, a scaffold apparatus can be configured as an interference screw comprising multiple phases for fixing musculoskeletal soft tissue to bone. In another example, a degradable cell barrier is inserted between adjacent phases of the scaffold apparatus. In another example, the scaffold apparatus, is coupled to a synthetic graft for a ligament. In another example, the scaffold apparatus can comprise a graft collar and a polymer-fiber mesh, and the polymer-fiber mesh applies compressive mechanical loading to the graft collar.

    Abstract translation: 支架装置用于肌肉骨骼组织工程。 在一个示例中，支架装置可以被配置为包括用于将肌肉骨骼软组织固定到骨上的多个相的干涉螺钉。 在另一个实例中，可降解细胞屏障被插入在支架装置的相邻相之间。 在另一个实例中，支架装置与合成移植物连接用于韧带。 在另一个示例中，支架装置可以包括移植物套环和聚合物纤维网，并且聚合物纤维网将压缩机械负载施加到移植物套环。

    SCAFFOLD APPARATUS FOR PROMOTING TENDON-TO-BONE FIXATION
    7.
    发明申请
    SCAFFOLD APPARATUS FOR PROMOTING TENDON-TO-BONE FIXATION 审中-公开
    用于促进TENDON到BONE固定的SCAFFOLD装置

    公开(公告)号：WO2008070186A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007025127

    申请日：2007-12-06

    Applicant: UNIV COLUMBIA ,  LU HELEN H ,  SPALAZZI JEFFREY

    Inventor： LU HELEN H ,  SPALAZZI JEFFREY

    IPC: A61F2/02

    CPC classification number: A61L27/52 ,  A61F2/0811 ,  A61F2002/087 ,  A61L27/3804 ,  A61L27/3843 ,  A61L27/446 ,  A61L27/46 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/604

    Abstract: This invention provides a graft collar for fixing tendon to bone. In one embodiment, the graft collar comprises a sheet of biopolymer mesh. In another embodiment, the graft collar comprises a polymer-fiber mesh. In another embodiment, the graft collar comprises (a) a first region comprising a biopolymer mesh and hydrogel and (b) a second region adjoining the first region and comprising a biopolymer mesh. In another embodiment, the graft collar comprises (a) a first region comprising a polymer-fiber mesh and hydrogel and (b) a second region adjoining the first region and comprising a polymer-fiber mesh.

    Abstract translation: 本发明提供一种用于将腱固定到骨头上的移植套环。 在一个实施例中，移植物套环包括一片生物聚合物网。 在另一个实施方案中，接枝环包含聚合物纤维网。 在另一个实施方案中，移植物颈圈包括（a）包含生物聚合物网和水凝胶的第一区域和（b）邻接第一区域并包含生物聚合物网的第二区域。 在另一个实施方案中，接枝环包括（a）包含聚合物纤维网和水凝胶的第一区域和（b）邻接第一区域并包含聚合物纤维网的第二区域。

    SCAFFOLD APPARATUS FOR PROMOTING TENDON-TO-BONE FIXATION
    9.
    发明申请
    SCAFFOLD APPARATUS FOR PROMOTING TENDON-TO-BONE FIXATION 审中-公开

    公开(公告)号：WO2008070186A3

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/025127

    申请日：2007-12-06

    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  LU, Helen, H. ,  SPALAZZI, Jeffrey

    Inventor： LU, Helen, H. ,  SPALAZZI, Jeffrey

    IPC: A61F13/00

    Abstract: This invention provides a graft collar for fixing tendon to bone. In one embodiment, the graft collar comprises a sheet of biopolymer mesh. In another embodiment, the graft collar comprises a polymer-fiber mesh. In another embodiment, the graft collar comprises (a) a first region comprising a biopolymer mesh and hydrogel and (b) a second region adjoining the first region and comprising a biopolymer mesh. In another embodiment, the graft collar comprises (a) a first region comprising a polymer-fiber mesh and hydrogel and (b) a second region adjoining the first region and comprising a polymer-fiber mesh.

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