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公开(公告)号:WO2023083971A1
公开(公告)日:2023-05-19
申请号:PCT/EP2022/081496
申请日:2022-11-10
申请人: NOVOZYMES A/S
发明人: TAMS, Jeppe, Wegener
摘要: The present invention relates to a method of producing a dairy product comprising galacto-oligosaccharides (GOS) where a milk-based substrate is incubated with a Bifidobacterium de-rived beta-galactosidase having transgalactosylating activity and the beta-galactosidase is heat inactivated.
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公开(公告)号:WO2023038057A1
公开(公告)日:2023-03-16
申请号:PCT/JP2022/033563
申请日:2022-09-07
申请人: 合同酒精株式会社
IPC分类号: C12N15/56 , A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/38 , C12N15/63
摘要: 乳中における乳糖分解作用に優れたラクターゼ製剤を提供する。本発明のある態様のラクターゼは、ラクターゼ活性として、以下の(1)~(6)に記載の活性のうち、いずれか1つ、または複数の組み合わせを有する。 (1)牛乳に前記ラクターゼを添加したとき、10℃、16時間後における残存乳糖濃度が0.1%以下に達する前記ラクターゼのタンパク質の添加量が15.1mg/L以下である。 (2)牛乳に前記ラクターゼを添加したとき、10℃、16時間後における残存乳糖濃度が0.01%以下に達する前記ラクターゼのタンパク質の添加量が30.2mg/L以下である。 (3)牛乳に前記ラクターゼを添加したとき、10℃、24時間後における残存乳糖濃度が0.1%以下に達する前記ラクターゼのタンパク質の添加量が10.1mg/L以下である。 (4)牛乳に前記ラクターゼを添加したとき、10℃、24時間後における残存乳糖濃度が0.01%以下に達する前記ラクターゼのタンパク質の添加量が15.1mg/L以下である。 (5)牛乳に対して、終濃度1.4LYU/mlとなる量を添加したときの、10℃、24時間後における残存乳糖濃度が0.1%以下に達する。 (6)牛乳に対して、終濃度2.1LYU/mlとなる量を添加したときの、10℃、24時間後における残存乳糖濃度が0.01%以下に達する。
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公开(公告)号:WO2021231443A1
公开(公告)日:2021-11-18
申请号:PCT/US2021/031802
申请日:2021-05-11
IPC分类号: A61K48/00 , C12N9/38 , A61P25/00 , A01K2267/0362 , A61K48/005 , A61K48/0075 , C12N2750/14122 , C12N2750/14143 , C12N2800/22 , C12N2830/15 , C12N2830/42 , C12N9/2402 , C12Y302/01046
摘要: A pharmaceutical composition formulated for delivery of a recombinant adenoassociated virus (rAAV) vector comprising an AAV capsid and a vector genome having human galactosylceramidase (GALC) coding sequence is provided. Also provided are methods and uses of a pharmaceutical composition comprising a rAAV for the treatment of Krabbe disease.
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公开(公告)号:WO2021210659A1
公开(公告)日:2021-10-21
申请号:PCT/JP2021/015649
申请日:2021-04-16
申请人: 合同酒精株式会社
IPC分类号: C12N9/38 , A23L33/195
摘要: 本発明は、ろ過フィルターの目詰まりを起こしにくい容器詰めラクターゼ溶液を提供することを目的とする。本発明の容器詰めラクターゼ溶液は、容器内にラクターゼ溶液が存在する容器詰めラクターゼ溶液であって、当該容器内のヘッドスペースを当該容器内の全容積の20%以下にすることを特徴とする容器詰めラクターゼ溶液。前記ラクターゼ溶液のラクターゼ活性が10~100,000NLU/gの範囲内であることを特徴とする。
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公开(公告)号:WO2021170559A1
公开(公告)日:2021-09-02
申请号:PCT/EP2021/054398
申请日:2021-02-23
申请人: NOVOZYMES A/S
发明人: PACHE, Roland, Alexander , SANDSTRÖM, Anders, Gunnar, , VESTER, Jan, Kjoelhede , FRIIS-MADSEN, Henrik , NISSEN, Dorota
IPC分类号: C12N9/38
摘要: The present invention relates to novel lactase variants having improved properties relative to the parent lactase, such as decreased galactose inhibition or increased galactose inhibition. The variants of the invention are suitable for production of dairy products, such as low-lactose dairy products or lactose-free dairy products. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the lactase variants of the invention.
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公开(公告)号:WO2020182976A1
公开(公告)日:2020-09-17
申请号:PCT/EP2020/056766
申请日:2020-03-13
发明人: JEDRZEJOWSKI, Anäis , FREMAUX, Christophe , VAN DILLEN, Sabine , DESFOUGÈRES, Thomas , JODEAU, Max Charles , LUGAND, Damien
摘要: The invention relates to a polynucleotide comprising a lacZ gene ( lacZ FS ) encoding a β-galactosidase characterized by a particular profile regarding its efficiency of hydrolysis of lactose. The invention is also directed to a Streptococcus thermophilus strain comprising a lacZ FS allele and bacterial composition thereof, and their use to obtain fermented milk not undergoing post-acidification.
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公开(公告)号:WO2020079116A1
公开(公告)日:2020-04-23
申请号:PCT/EP2019/078150
申请日:2019-10-17
申请人: CHR. HANSEN A/S
摘要: The present invention relates to new improved peptide or dimeric peptides exhibiting betagalactosidase enzyme activity wherein the peptide has a pH optimum at acidic conditions.
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公开(公告)号:WO2019186452A1
公开(公告)日:2019-10-03
申请号:PCT/IB2019/052542
申请日:2019-03-28
摘要: An enzyme-polymer conjugate having the structure of Formula (I) in which f, i and k are each independently an integer from 1 to 19; g and j are each independently an integer from 0 to 100; l is an integer from 1 to 100; n is an integer from 5 to 1000; and R 1 is a hydrolase enzyme and R 2 is OH or O-, or R 1 is OH or O- and R 2 is a hydrolase enzyme is provided. The conjugate is characterised in that in at least some of subunits n, the hydrolase enzyme is an amylase, and in other subunits n, the hydrolase enzyme is a protease. The conjugate may be suitable for use in a biotechnological process or for protecting a surface from biofouling.
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公开(公告)号:WO2018210821A1
公开(公告)日:2018-11-22
申请号:PCT/EP2018/062542
申请日:2018-05-15
申请人: NOVOZYMES A/S
发明人: TAMS, Jeppe, Wegener
摘要: The present invention relates to milk products comprising a high amount of in situ produced galactooligosaccharides (GOS) and methods of producing same. Milk substrate having a lactose content of at least 20wt% lactose is treated with an enzyme having transgalactosylating activity. The transgalactosylating activity of said enzyme may have been increased via glycation of lysine and/or arginine residues by incubation of said enzyme with high concentrations of glucose at elevated temperatures.
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公开(公告)号:WO2018007573A1
公开(公告)日:2018-01-11
申请号:PCT/EP2017/067054
申请日:2017-07-07
申请人: NOVOZYMES A/S
摘要: The present invention relates to polypeptides having endo-beta-1-6-galactanase enzyme activity, detergent composition comprising such polypeptides and uses of the composition and/or polypeptide in methods of washing, such as laundering of textiles.
摘要翻译: 本发明涉及具有内-β-1-6-半乳聚糖酶活性的多肽,包含此类多肽的洗涤剂组合物以及组合物和/或多肽在洗涤方法中的用途,例如洗涤 纺织品。 p>
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